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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for REST
Z-value: 2.08
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Transcription factors associated with REST
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| REST | hg19_v2_chr4_+_57774042_57774114 | -0.86 | 1.1e-06 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_+_175298487 Show fit | 14.02 |
ENST00000393745.3
|
complexin 2 |
|
| chr5_+_175298573 Show fit | 11.74 |
ENST00000512824.1
|
complexin 2 |
|
| chr20_+_5892037 Show fit | 11.72 |
ENST00000378961.4
|
chromogranin B (secretogranin 1) |
|
| chr20_+_5892147 Show fit | 9.65 |
ENST00000455042.1
|
chromogranin B (secretogranin 1) |
|
| chr2_-_27531313 Show fit | 9.07 |
ENST00000296099.2
|
urocortin |
|
| chr1_-_153517473 Show fit | 8.70 |
ENST00000368715.1
|
S100 calcium binding protein A4 |
|
| chr8_-_145752390 Show fit | 7.89 |
ENST00000529415.2
ENST00000533758.1 |
leucine rich repeat containing 24 |
|
| chr15_+_75287861 Show fit | 7.66 |
ENST00000425597.3
ENST00000562327.1 ENST00000568018.1 ENST00000562212.1 ENST00000567920.1 ENST00000566872.1 ENST00000361900.6 ENST00000545456.1 |
secretory carrier membrane protein 5 |
|
| chr9_-_123812542 Show fit | 7.18 |
ENST00000223642.1
|
complement component 5 |
|
| chr12_+_52695617 Show fit | 7.15 |
ENST00000293525.5
|
keratin 86 |
Network of associatons between targets according to the STRING database.
First level regulatory network of REST
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 32.6 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.0 | 18.9 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 2.3 | 9.1 | GO:0035483 | gastric motility(GO:0035482) gastric emptying(GO:0035483) |
| 0.0 | 8.7 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.1 | 7.9 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 0.2 | 7.5 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 1.2 | 7.2 | GO:0010760 | negative regulation of macrophage chemotaxis(GO:0010760) |
| 0.0 | 7.2 | GO:0070268 | cornification(GO:0070268) |
| 0.9 | 6.4 | GO:0036515 | serotonergic neuron axon guidance(GO:0036515) |
| 1.0 | 5.8 | GO:0000720 | pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 32.6 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.0 | 22.1 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 9.2 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 1.1 | 9.1 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 7.7 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.9 | 7.2 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 7.2 | GO:0045095 | keratin filament(GO:0045095) |
| 0.8 | 5.8 | GO:0000110 | nucleotide-excision repair factor 1 complex(GO:0000110) |
| 0.2 | 4.4 | GO:0030285 | integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) |
| 0.2 | 4.2 | GO:0042583 | chromaffin granule(GO:0042583) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 34.8 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 25.6 | GO:0005179 | hormone activity(GO:0005179) |
| 3.0 | 9.1 | GO:0035033 | histone deacetylase regulator activity(GO:0035033) |
| 0.4 | 8.7 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.2 | 7.0 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 6.0 | GO:0000149 | SNARE binding(GO:0000149) |
| 0.7 | 5.8 | GO:1990599 | 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599) |
| 0.0 | 5.3 | GO:0016651 | oxidoreductase activity, acting on NAD(P)H(GO:0016651) |
| 0.1 | 4.4 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.6 | 3.9 | GO:0044736 | acid-sensing ion channel activity(GO:0044736) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 2.0 | ST STAT3 PATHWAY | STAT3 Pathway |
| 0.0 | 2.0 | ST GRANULE CELL SURVIVAL PATHWAY | Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway. |
| 0.0 | 1.6 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.4 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.2 | REACTOME COMPLEMENT CASCADE | Genes involved in Complement cascade |
| 0.2 | 5.8 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.0 | 5.3 | REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION | Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| 0.1 | 5.0 | REACTOME KERATAN SULFATE BIOSYNTHESIS | Genes involved in Keratan sulfate biosynthesis |
| 0.0 | 4.1 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.0 | 3.9 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 3.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 3.0 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.0 | 2.5 | REACTOME REGULATION OF INSULIN SECRETION | Genes involved in Regulation of Insulin Secretion |
| 0.0 | 2.1 | REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH | Genes involved in NCAM signaling for neurite out-growth |