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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for REST

Z-value: 2.08

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Transcription factors associated with REST

Gene Symbol Gene ID Gene Info
REST
ENSG00000084093.11 RE1 silencing transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RESThg19_v2_chr4_+_57774042_57774114-0.861.1e-06Click!

Activity profile of REST motif

Sorted Z-values of REST motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_175298487 14.02 ENST00000393745.3
CPLX2
complexin 2
chr5_+_175298573 11.74 ENST00000512824.1
CPLX2
complexin 2
chr20_+_5892037 11.72 ENST00000378961.4
CHGB
chromogranin B (secretogranin 1)
chr20_+_5892147 9.65 ENST00000455042.1
CHGB
chromogranin B (secretogranin 1)
chr2_-_27531313 9.07 ENST00000296099.2
UCN
urocortin
chr1_-_153517473 8.70 ENST00000368715.1
S100A4
S100 calcium binding protein A4
chr8_-_145752390 7.89 ENST00000529415.2
ENST00000533758.1
LRRC24
leucine rich repeat containing 24
chr15_+_75287861 7.66 ENST00000425597.3
ENST00000562327.1
ENST00000568018.1
ENST00000562212.1
ENST00000567920.1
ENST00000566872.1
ENST00000361900.6
ENST00000545456.1
SCAMP5
secretory carrier membrane protein 5
chr9_-_123812542 7.18 ENST00000223642.1
C5
complement component 5
chr12_+_52695617 7.15 ENST00000293525.5
KRT86
keratin 86
chr5_+_175298674 6.82 ENST00000514150.1
CPLX2
complexin 2
chr3_-_48700310 6.45 ENST00000164024.4
ENST00000544264.1
CELSR3
cadherin, EGF LAG seven-pass G-type receptor 3
chr19_-_51845378 5.77 ENST00000335624.4
VSIG10L
V-set and immunoglobulin domain containing 10 like
chr19_-_39402798 5.68 ENST00000571838.1
CTC-360G5.1
coiled-coil glutamate-rich protein 2
chr11_-_66115032 5.04 ENST00000311181.4
B3GNT1
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1
chrX_-_49056635 4.37 ENST00000472598.1
ENST00000538567.1
ENST00000479808.1
ENST00000263233.4
SYP
synaptophysin
chr14_+_93389425 4.15 ENST00000216492.5
ENST00000334654.4
CHGA
chromogranin A (parathyroid secretory protein 1)
chr7_+_150748288 3.86 ENST00000490540.1
ASIC3
acid-sensing (proton-gated) ion channel 3
chr20_-_62284766 3.85 ENST00000370053.1
STMN3
stathmin-like 3
chr5_-_176037105 3.80 ENST00000303991.4
GPRIN1
G protein regulated inducer of neurite outgrowth 1
chr15_-_27018884 3.76 ENST00000299267.4
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr19_+_39759154 3.28 ENST00000331982.5
IFNL2
interferon, lambda 2
chr12_-_57443886 3.12 ENST00000300119.3
MYO1A
myosin IA
chr10_+_89419370 3.03 ENST00000361175.4
ENST00000456849.1
PAPSS2
3'-phosphoadenosine 5'-phosphosulfate synthase 2
chr1_-_40105617 2.99 ENST00000372852.3
HEYL
hes-related family bHLH transcription factor with YRPW motif-like
chr19_-_11639910 2.98 ENST00000588998.1
ENST00000586149.1
ECSIT
ECSIT signalling integrator
chr10_+_99609996 2.92 ENST00000370602.1
GOLGA7B
golgin A7 family, member B
chr19_-_45927622 2.77 ENST00000300853.3
ENST00000589165.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr20_+_30555805 2.73 ENST00000562532.2
XKR7
XK, Kell blood group complex subunit-related family, member 7
chr1_+_212606219 2.59 ENST00000366988.3
NENF
neudesin neurotrophic factor
chr12_-_12837423 2.46 ENST00000540510.1
GPR19
G protein-coupled receptor 19
chr17_+_72667239 2.41 ENST00000402449.4
RAB37
RAB37, member RAS oncogene family
chr19_-_11639931 2.30 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT
ECSIT signalling integrator
chr3_-_131753830 2.29 ENST00000429747.1
CPNE4
copine IV
chr15_-_32162833 2.29 ENST00000560598.1
OTUD7A
OTU domain containing 7A
chr7_-_100808394 2.26 ENST00000445482.2
VGF
VGF nerve growth factor inducible
chr19_+_41036371 2.11 ENST00000392023.1
SPTBN4
spectrin, beta, non-erythrocytic 4
chr19_-_45927097 2.10 ENST00000340192.7
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr11_-_72492878 2.08 ENST00000535054.1
ENST00000545082.1
STARD10
StAR-related lipid transfer (START) domain containing 10
chr14_-_51561784 2.06 ENST00000360392.4
TRIM9
tripartite motif containing 9
chr19_-_40724246 2.04 ENST00000311308.6
TTC9B
tetratricopeptide repeat domain 9B
chr20_+_36012051 2.03 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr11_+_45907177 1.99 ENST00000241014.2
MAPK8IP1
mitogen-activated protein kinase 8 interacting protein 1
chrX_+_153238220 1.98 ENST00000425274.1
TMEM187
transmembrane protein 187
chr16_+_3019309 1.95 ENST00000576565.1
PAQR4
progestin and adipoQ receptor family member IV
chr14_+_93897272 1.94 ENST00000393151.2
UNC79
unc-79 homolog (C. elegans)
chr6_+_25652432 1.83 ENST00000377961.2
SCGN
secretagogin, EF-hand calcium binding protein
chr7_-_100808843 1.82 ENST00000249330.2
VGF
VGF nerve growth factor inducible
chr11_+_64808675 1.82 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr14_-_51562037 1.82 ENST00000338969.5
TRIM9
tripartite motif containing 9
chrX_+_153237740 1.79 ENST00000369982.4
TMEM187
transmembrane protein 187
chr11_-_75141206 1.75 ENST00000376292.4
KLHL35
kelch-like family member 35
chr14_+_93897199 1.74 ENST00000553484.1
UNC79
unc-79 homolog (C. elegans)
chr11_-_92931098 1.60 ENST00000326402.4
SLC36A4
solute carrier family 36 (proton/amino acid symporter), member 4
chr6_+_25652501 1.47 ENST00000334979.6
SCGN
secretagogin, EF-hand calcium binding protein
chr8_+_6565854 1.39 ENST00000285518.6
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5
chr5_+_167956121 1.36 ENST00000338333.4
FBLL1
fibrillarin-like 1
chr1_+_33352036 1.28 ENST00000373467.3
HPCA
hippocalcin
chr18_-_40857493 1.16 ENST00000255224.3
SYT4
synaptotagmin IV
chr19_-_55691472 1.16 ENST00000537500.1
SYT5
synaptotagmin V
chr3_+_193853927 1.14 ENST00000232424.3
HES1
hes family bHLH transcription factor 1
chr1_+_154540246 1.13 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr15_-_72612470 1.07 ENST00000287202.5
CELF6
CUGBP, Elav-like family member 6
chr13_-_111214015 1.06 ENST00000267328.3
RAB20
RAB20, member RAS oncogene family
chr3_+_62304648 1.06 ENST00000462069.1
ENST00000232519.5
ENST00000465142.1
C3orf14
chromosome 3 open reading frame 14
chr6_+_35773070 1.06 ENST00000373853.1
ENST00000360215.1
LHFPL5
lipoma HMGIC fusion partner-like 5
chr17_-_7218403 1.05 ENST00000570780.1
GPS2
G protein pathway suppressor 2
chr10_-_50970382 1.03 ENST00000419399.1
ENST00000432695.1
OGDHL
oxoglutarate dehydrogenase-like
chr18_-_40857447 1.03 ENST00000590752.1
ENST00000596867.1
SYT4
synaptotagmin IV
chr12_+_113229543 1.02 ENST00000447659.2
RPH3A
rabphilin 3A homolog (mouse)
chr18_+_57567180 1.00 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr19_-_45926739 0.97 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
ERCC1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr3_+_62304712 0.94 ENST00000494481.1
C3orf14
chromosome 3 open reading frame 14
chr4_-_175750364 0.91 ENST00000340217.5
ENST00000274093.3
GLRA3
glycine receptor, alpha 3
chr10_+_60936921 0.91 ENST00000373878.3
PHYHIPL
phytanoyl-CoA 2-hydroxylase interacting protein-like
chr14_+_96039882 0.90 ENST00000556346.1
ENST00000553785.1
RP11-1070N10.4
RP11-1070N10.4
chr12_+_113229737 0.86 ENST00000551052.1
ENST00000415485.3
RPH3A
rabphilin 3A homolog (mouse)
chr19_-_55691614 0.79 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr11_+_637246 0.76 ENST00000176183.5
DRD4
dopamine receptor D4
chr5_-_135701164 0.75 ENST00000355180.3
ENST00000426057.2
ENST00000513104.1
TRPC7
transient receptor potential cation channel, subfamily C, member 7
chr16_+_3019246 0.73 ENST00000318782.8
ENST00000293978.8
PAQR4
progestin and adipoQ receptor family member IV
chr2_-_51259641 0.73 ENST00000406316.2
ENST00000405581.1
NRXN1
neurexin 1
chr3_+_149531607 0.71 ENST00000468648.1
ENST00000459632.1
RNF13
ring finger protein 13
chr2_+_131513864 0.71 ENST00000458606.1
ENST00000423981.1
AMER3
APC membrane recruitment protein 3
chr1_-_151689259 0.70 ENST00000420342.1
ENST00000290583.4
CELF3
CUGBP, Elav-like family member 3
chr4_+_96012614 0.69 ENST00000264568.4
BMPR1B
bone morphogenetic protein receptor, type IB
chr12_+_113229452 0.65 ENST00000389385.4
RPH3A
rabphilin 3A homolog (mouse)
chr4_+_158141899 0.64 ENST00000264426.9
ENST00000506284.1
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr12_-_99288536 0.64 ENST00000549797.1
ENST00000333732.7
ENST00000341752.7
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_51259528 0.63 ENST00000404971.1
NRXN1
neurexin 1
chr10_-_50970322 0.63 ENST00000374103.4
OGDHL
oxoglutarate dehydrogenase-like
chr3_-_8686479 0.59 ENST00000544814.1
ENST00000427408.1
SSUH2
ssu-2 homolog (C. elegans)
chr20_+_44657845 0.56 ENST00000243964.3
SLC12A5
solute carrier family 12 (potassium/chloride transporter), member 5
chr4_+_158141843 0.56 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr11_-_6677018 0.55 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chrX_-_47479246 0.53 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr19_-_55691377 0.52 ENST00000589172.1
SYT5
synaptotagmin V
chr7_-_65113280 0.50 ENST00000593865.1
AC104057.1
Protein LOC100996407
chr6_+_154360616 0.50 ENST00000229768.5
ENST00000419506.2
ENST00000524163.1
ENST00000414028.2
ENST00000435918.2
ENST00000337049.4
OPRM1
opioid receptor, mu 1
chr7_+_8474150 0.50 ENST00000602349.1
NXPH1
neurexophilin 1
chr12_-_57871853 0.46 ENST00000549602.1
ENST00000430041.2
ARHGAP9
Rho GTPase activating protein 9
chr8_-_145559943 0.44 ENST00000332135.4
SCRT1
scratch family zinc finger 1
chr2_-_47798044 0.44 ENST00000327876.4
KCNK12
potassium channel, subfamily K, member 12
chr12_-_57871825 0.43 ENST00000548139.1
ARHGAP9
Rho GTPase activating protein 9
chr3_+_120626919 0.41 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
STXBP5L
syntaxin binding protein 5-like
chr14_-_106478603 0.41 ENST00000390596.2
IGHV4-4
immunoglobulin heavy variable 4-4
chr4_+_158141806 0.38 ENST00000393815.2
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr15_-_22473353 0.37 ENST00000557788.2
IGHV4OR15-8
immunoglobulin heavy variable 4/OR15-8 (non-functional)
chr1_-_241520385 0.33 ENST00000366564.1
RGS7
regulator of G-protein signaling 7
chr12_+_113229725 0.30 ENST00000551198.1
RPH3A
rabphilin 3A homolog (mouse)
chr14_-_74892805 0.28 ENST00000331628.3
ENST00000554953.1
SYNDIG1L
synapse differentiation inducing 1-like
chr5_+_63802109 0.27 ENST00000334025.2
RGS7BP
regulator of G-protein signaling 7 binding protein
chr12_-_57871620 0.27 ENST00000552604.1
ARHGAP9
Rho GTPase activating protein 9
chr12_+_113229708 0.26 ENST00000550901.1
RPH3A
rabphilin 3A homolog (mouse)
chr1_-_175712665 0.25 ENST00000263525.2
TNR
tenascin R
chr12_-_57871567 0.23 ENST00000551452.1
ARHGAP9
Rho GTPase activating protein 9
chr2_+_226265364 0.23 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr2_-_51259292 0.22 ENST00000401669.2
NRXN1
neurexin 1
chr9_-_74061751 0.19 ENST00000357533.2
ENST00000423814.3
TRPM3
transient receptor potential cation channel, subfamily M, member 3
chr12_+_71833550 0.19 ENST00000266674.5
LGR5
leucine-rich repeat containing G protein-coupled receptor 5
chr6_+_153071925 0.17 ENST00000367244.3
ENST00000367243.3
VIP
vasoactive intestinal peptide
chr15_+_68117844 0.17 ENST00000554054.1
SKOR1
SKI family transcriptional corepressor 1
chr12_-_99288986 0.17 ENST00000552407.1
ENST00000551613.1
ENST00000548447.1
ENST00000546364.3
ENST00000552748.1
ANKS1B
ankyrin repeat and sterile alpha motif domain containing 1B
chr2_-_51259229 0.14 ENST00000405472.3
NRXN1
neurexin 1
chr12_+_113229337 0.12 ENST00000552667.1
RPH3A
rabphilin 3A homolog (mouse)
chr15_+_68117872 0.12 ENST00000380035.2
ENST00000389002.1
SKOR1
SKI family transcriptional corepressor 1
chr22_+_23054174 0.12 ENST00000390308.2
IGLV3-21
immunoglobulin lambda variable 3-21
chr15_-_83378611 0.09 ENST00000542200.1
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr2_+_46524537 0.09 ENST00000263734.3
EPAS1
endothelial PAS domain protein 1
chr14_-_105071083 0.09 ENST00000415614.2
TMEM179
transmembrane protein 179
chr17_-_3301704 0.07 ENST00000322608.2
OR1E1
olfactory receptor, family 1, subfamily E, member 1
chr15_-_83378638 0.07 ENST00000261722.3
AP3B2
adaptor-related protein complex 3, beta 2 subunit
chr12_+_119419294 0.06 ENST00000267260.4
SRRM4
serine/arginine repetitive matrix 4
chr9_+_138606400 0.02 ENST00000486577.2
KCNT1
potassium channel, subfamily T, member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of REST

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 9.1 GO:0035483 gastric motility(GO:0035482) gastric emptying(GO:0035483)
1.4 4.2 GO:1900738 dense core granule biogenesis(GO:0061110) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
1.2 7.2 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
1.2 32.6 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
1.0 3.0 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
1.0 5.8 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
1.0 3.9 GO:0035544 negative regulation of SNARE complex assembly(GO:0035544)
0.9 6.4 GO:0036515 serotonergic neuron axon guidance(GO:0036515)
0.8 3.9 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.8 3.0 GO:0000103 sulfate assimilation(GO:0000103)
0.5 2.0 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.5 0.5 GO:0032097 positive regulation of response to food(GO:0032097) positive regulation of appetite(GO:0032100)
0.5 1.4 GO:1990258 box C/D snoRNA 3'-end processing(GO:0000494) box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963) histone glutamine methylation(GO:1990258)
0.4 4.4 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.4 3.9 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.4 1.1 GO:2000974 auditory receptor cell fate determination(GO:0042668) negative regulation of auditory receptor cell differentiation(GO:0045608) regulation of timing of neuron differentiation(GO:0060164) negative regulation of pro-B cell differentiation(GO:2000974)
0.4 1.1 GO:0042320 regulation of circadian sleep/wake cycle, REM sleep(GO:0042320)
0.4 2.2 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.3 2.3 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.3 0.6 GO:0003192 mitral valve formation(GO:0003192)
0.3 2.6 GO:0032099 negative regulation of response to food(GO:0032096) negative regulation of appetite(GO:0032099)
0.2 4.4 GO:0048149 behavioral response to ethanol(GO:0048149)
0.2 2.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.2 2.1 GO:0010459 negative regulation of heart rate(GO:0010459)
0.2 1.7 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.2 7.5 GO:0045956 positive regulation of calcium ion-dependent exocytosis(GO:0045956)
0.2 3.8 GO:0034776 response to histamine(GO:0034776) cellular response to histamine(GO:0071420)
0.2 1.3 GO:1902075 cellular response to salt(GO:1902075)
0.2 1.6 GO:0015808 L-alanine transport(GO:0015808)
0.1 2.1 GO:0032782 bile acid secretion(GO:0032782)
0.1 2.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.4 GO:0040040 thermosensory behavior(GO:0040040)
0.1 0.3 GO:0048686 regulation of sprouting of injured axon(GO:0048686) regulation of axon extension involved in regeneration(GO:0048690)
0.1 4.1 GO:0002021 response to dietary excess(GO:0002021)
0.1 0.8 GO:1900383 regulation of synaptic plasticity by receptor localization to synapse(GO:1900383)
0.1 3.3 GO:0002385 mucosal immune response(GO:0002385)
0.1 0.9 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 1.1 GO:0090385 phagosome-lysosome fusion(GO:0090385)
0.1 7.9 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 3.1 GO:0030033 microvillus assembly(GO:0030033)
0.1 1.0 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.1 4.9 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 0.5 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.1 5.3 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 7.2 GO:0070268 cornification(GO:0070268)
0.0 2.4 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.0 0.8 GO:0006828 manganese ion transport(GO:0006828)
0.0 1.7 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.7 GO:0030575 nuclear body organization(GO:0030575)
0.0 8.7 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 2.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 18.9 GO:0043687 post-translational protein modification(GO:0043687)
0.0 0.4 GO:0030322 stabilization of membrane potential(GO:0030322)
0.0 1.1 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 1.1 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.2 GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.0 0.2 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.0 0.4 GO:0046676 negative regulation of insulin secretion(GO:0046676)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 32.6 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
1.1 9.1 GO:0043196 varicosity(GO:0043196)
0.9 7.2 GO:0005579 membrane attack complex(GO:0005579)
0.8 5.8 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.5 2.2 GO:0032127 dense core granule membrane(GO:0032127) microvesicle(GO:1990742)
0.4 2.5 GO:1990769 proximal neuron projection(GO:1990769)
0.3 0.9 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.2 2.1 GO:0070852 cell body fiber(GO:0070852)
0.2 4.4 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.2 1.4 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.2 1.6 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.2 2.0 GO:0044294 dendritic growth cone(GO:0044294)
0.2 4.2 GO:0042583 chromaffin granule(GO:0042583)
0.2 2.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.1 2.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.1 1.7 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 3.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 7.7 GO:0031201 SNARE complex(GO:0031201)
0.1 1.3 GO:0044327 dendritic spine head(GO:0044327)
0.1 7.2 GO:0045095 keratin filament(GO:0045095)
0.1 1.1 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.3 GO:0072534 perineuronal net(GO:0072534)
0.1 3.1 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 22.1 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 9.2 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.0 GO:0002102 podosome(GO:0002102)
0.0 3.3 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 3.8 GO:0030133 transport vesicle(GO:0030133)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.5 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 1.7 GO:0042734 presynaptic membrane(GO:0042734)
0.0 0.8 GO:0005801 cis-Golgi network(GO:0005801)
0.0 1.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0035033 histone deacetylase regulator activity(GO:0035033)
1.0 3.0 GO:0004781 adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781)
0.7 3.0 GO:0035939 microsatellite binding(GO:0035939)
0.7 5.8 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.6 3.9 GO:0044736 acid-sensing ion channel activity(GO:0044736)
0.6 34.8 GO:0017075 syntaxin-1 binding(GO:0017075)
0.5 1.4 GO:0036009 protein-glutamine N-methyltransferase activity(GO:0036009) histone-glutamine methyltransferase activity(GO:1990259)
0.4 1.6 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.4 8.7 GO:0050786 RAGE receptor binding(GO:0050786)
0.3 3.8 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.2 1.7 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.2 25.6 GO:0005179 hormone activity(GO:0005179)
0.2 2.0 GO:0071253 connexin binding(GO:0071253)
0.2 7.0 GO:0008009 chemokine activity(GO:0008009)
0.2 3.2 GO:0008430 selenium binding(GO:0008430) inositol 1,4,5 trisphosphate binding(GO:0070679)
0.2 0.8 GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.1 2.0 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 0.8 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 1.7 GO:0097109 neuroligin family protein binding(GO:0097109)
0.1 1.6 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.1 0.5 GO:0004977 melanocortin receptor activity(GO:0004977)
0.1 2.9 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 0.8 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 4.4 GO:0042169 SH2 domain binding(GO:0042169)
0.1 0.7 GO:0097322 7SK snRNA binding(GO:0097322)
0.1 2.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.0 2.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 6.0 GO:0000149 SNARE binding(GO:0000149)
0.0 1.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.4 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.3 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.0 5.3 GO:0016651 oxidoreductase activity, acting on NAD(P)H(GO:0016651)
0.0 3.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 0.4 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0 0.2 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 2.6 GO:0008083 growth factor activity(GO:0008083)
0.0 0.8 GO:0046875 ephrin receptor binding(GO:0046875)
0.0 3.3 GO:0005125 cytokine activity(GO:0005125)
0.0 3.1 GO:0003774 motor activity(GO:0003774)
0.0 0.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.4 GO:0034987 immunoglobulin receptor binding(GO:0034987)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 ST STAT3 PATHWAY STAT3 Pathway
0.0 2.0 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.0 1.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 8.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.1 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 1.4 PID RAC1 REG PATHWAY Regulation of RAC1 activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 7.2 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.1 3.8 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.1 5.0 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 3.0 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 2.0 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.1 0.8 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 1.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 0.8 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 0.5 REACTOME G PROTEIN ACTIVATION Genes involved in G-protein activation
0.0 4.1 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 1.6 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors
0.0 1.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 5.3 REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION Genes involved in TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
0.0 0.5 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.3 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 2.1 REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH Genes involved in NCAM signaling for neurite out-growth
0.0 2.5 REACTOME REGULATION OF INSULIN SECRETION Genes involved in Regulation of Insulin Secretion
0.0 3.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.2 REACTOME GLUCAGON TYPE LIGAND RECEPTORS Genes involved in Glucagon-type ligand receptors
0.0 0.4 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA