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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RFX5

Z-value: 0.57

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Transcription factors associated with RFX5

Gene Symbol Gene ID Gene Info
RFX5
ENSG00000143390.13 regulatory factor X5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RFX5hg19_v2_chr1_-_151319318_151319497-0.835.8e-06Click!

Activity profile of RFX5 motif

Sorted Z-values of RFX5 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_32908792 2.59 ENST00000418107.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr19_+_45417921 1.91 ENST00000252491.4
ENST00000592885.1
ENST00000589781.1
APOC1
apolipoprotein C-I
chr6_-_32920794 1.68 ENST00000395305.3
ENST00000395303.3
ENST00000374843.4
ENST00000429234.1
HLA-DMA
XXbac-BPG181M17.5
major histocompatibility complex, class II, DM alpha
Uncharacterized protein
chr6_-_32908765 1.63 ENST00000416244.2
HLA-DMB
major histocompatibility complex, class II, DM beta
chr6_+_32821924 1.61 ENST00000374859.2
ENST00000453265.2
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr19_+_45418067 1.51 ENST00000589078.1
ENST00000586638.1
APOC1
apolipoprotein C-I
chr20_+_306221 1.15 ENST00000342665.2
SOX12
SRY (sex determining region Y)-box 12
chr17_-_19265982 1.14 ENST00000268841.6
ENST00000261499.4
ENST00000575478.1
B9D1
B9 protein domain 1
chr6_+_32812568 1.13 ENST00000414474.1
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr17_-_19265855 1.09 ENST00000440841.1
ENST00000395615.1
ENST00000461069.2
B9D1
B9 protein domain 1
chr19_-_51014345 1.08 ENST00000391815.3
ENST00000594350.1
ENST00000601423.1
JOSD2
Josephin domain containing 2
chr17_-_19266045 1.04 ENST00000395616.3
B9D1
B9 protein domain 1
chr20_+_306177 1.00 ENST00000544632.1
SOX12
SRY (sex determining region Y)-box 12
chr16_+_57844549 0.98 ENST00000564282.1
CTD-2600O9.1
uncharacterized protein LOC388282
chr19_+_50031547 0.90 ENST00000597801.1
RCN3
reticulocalbin 3, EF-hand calcium binding domain
chr6_-_32812420 0.86 ENST00000374881.2
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8
chr16_+_67381263 0.72 ENST00000541146.1
ENST00000563189.1
ENST00000290940.7
LRRC36
leucine rich repeat containing 36
chr6_-_30658745 0.71 ENST00000376420.5
ENST00000376421.5
NRM
nurim (nuclear envelope membrane protein)
chr16_-_74808710 0.68 ENST00000219368.3
ENST00000544337.1
FA2H
fatty acid 2-hydroxylase
chr1_+_249132462 0.62 ENST00000306562.3
ZNF672
zinc finger protein 672
chr19_+_36103631 0.57 ENST00000203166.5
ENST00000379045.2
HAUS5
HAUS augmin-like complex, subunit 5
chr6_-_32821599 0.49 ENST00000354258.4
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr11_+_66624527 0.48 ENST00000393952.3
LRFN4
leucine rich repeat and fibronectin type III domain containing 4
chr1_+_46049706 0.45 ENST00000527470.1
ENST00000525515.1
ENST00000537798.1
ENST00000402363.3
ENST00000528238.1
ENST00000350030.3
ENST00000470768.1
ENST00000372052.4
ENST00000351223.3
NASP
nuclear autoantigenic sperm protein (histone-binding)
chr7_+_766320 0.37 ENST00000297440.6
ENST00000313147.5
HEATR2
HEAT repeat containing 2
chr11_-_72433346 0.37 ENST00000334211.8
ARAP1
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr17_+_38137050 0.34 ENST00000264639.4
PSMD3
proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
chr16_+_67381289 0.32 ENST00000435835.3
LRRC36
leucine rich repeat containing 36
chr3_+_9851558 0.28 ENST00000430718.1
TTLL3
tubulin tyrosine ligase-like family, member 3
chr3_+_9851384 0.26 ENST00000419081.1
ENST00000438596.1
ENST00000417065.1
ENST00000439814.1
ENST00000418745.1
TTLL3
tubulin tyrosine ligase-like family, member 3
chr9_-_69380597 0.24 ENST00000414341.2
CR769776.1
LOC441426 protein; Uncharacterized protein
chrX_+_19362011 0.24 ENST00000379806.5
ENST00000545074.1
ENST00000540249.1
ENST00000423505.1
ENST00000417819.1
ENST00000422285.2
ENST00000355808.5
ENST00000379805.3
PDHA1
pyruvate dehydrogenase (lipoamide) alpha 1
chr19_-_6057282 0.24 ENST00000592281.1
RFX2
regulatory factor X, 2 (influences HLA class II expression)
chr12_-_110841462 0.22 ENST00000455511.3
ENST00000450008.2
ANAPC7
anaphase promoting complex subunit 7
chr3_+_66271489 0.22 ENST00000536651.1
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr22_+_31518938 0.21 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr6_-_32731299 0.20 ENST00000435145.2
ENST00000437316.2
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr6_+_26383404 0.20 ENST00000416795.2
ENST00000494184.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr8_-_98290087 0.19 ENST00000322128.3
TSPYL5
TSPY-like 5
chr11_+_45868957 0.18 ENST00000443527.2
CRY2
cryptochrome 2 (photolyase-like)
chr6_-_32557610 0.18 ENST00000360004.5
HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr3_+_9850199 0.17 ENST00000452597.1
TTLL3
tubulin tyrosine ligase-like family, member 3
chr4_+_88529681 0.16 ENST00000399271.1
DSPP
dentin sialophosphoprotein
chr6_-_24666819 0.15 ENST00000341060.3
TDP2
tyrosyl-DNA phosphodiesterase 2
chr1_+_249132512 0.14 ENST00000505503.1
ZNF672
zinc finger protein 672
chr2_-_242088850 0.14 ENST00000358649.4
ENST00000452907.1
ENST00000403638.3
ENST00000539818.1
ENST00000415234.1
ENST00000234040.4
PASK
PAS domain containing serine/threonine kinase
chr6_-_32498046 0.13 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr5_-_55412774 0.12 ENST00000434982.2
ANKRD55
ankyrin repeat domain 55
chr3_-_169587621 0.12 ENST00000523069.1
ENST00000316428.5
ENST00000264676.5
LRRC31
leucine rich repeat containing 31
chr20_+_42875935 0.10 ENST00000438466.1
ENST00000372952.3
ENST00000537864.1
ENST00000445952.1
GDAP1L1
ganglioside induced differentiation associated protein 1-like 1
chr20_+_42875887 0.10 ENST00000342560.5
GDAP1L1
ganglioside induced differentiation associated protein 1-like 1
chr9_-_67925210 0.09 ENST00000543078.1
BX649567.1
Uncharacterized protein
chr1_+_109265033 0.08 ENST00000445274.1
FNDC7
fibronectin type III domain containing 7
chr13_-_47012325 0.08 ENST00000409879.2
KIAA0226L
KIAA0226-like
chr1_-_53608249 0.07 ENST00000371494.4
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr11_+_8008867 0.07 ENST00000309828.4
ENST00000449102.2
EIF3F
eukaryotic translation initiation factor 3, subunit F
chr2_+_173600514 0.07 ENST00000264111.6
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr1_-_79472365 0.07 ENST00000370742.3
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr6_-_133079022 0.06 ENST00000525289.1
ENST00000326499.6
VNN2
vanin 2
chr17_+_27052892 0.06 ENST00000579671.1
ENST00000579060.1
NEK8
NIMA-related kinase 8
chr6_-_32731243 0.06 ENST00000427449.1
ENST00000411527.1
HLA-DQB2
major histocompatibility complex, class II, DQ beta 2
chr6_+_26383318 0.05 ENST00000469230.1
ENST00000490025.1
ENST00000356709.4
ENST00000352867.2
ENST00000493275.1
ENST00000472507.1
ENST00000482536.1
ENST00000432533.2
ENST00000482842.1
BTN2A2
butyrophilin, subfamily 2, member A2
chr3_+_66271410 0.05 ENST00000336733.6
SLC25A26
solute carrier family 25 (S-adenosylmethionine carrier), member 26
chr11_+_1092184 0.04 ENST00000361558.6
MUC2
mucin 2, oligomeric mucus/gel-forming
chr1_-_53608289 0.02 ENST00000371491.4
SLC1A7
solute carrier family 1 (glutamate transporter), member 7
chr2_+_173600565 0.01 ENST00000397081.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr6_-_24667180 0.01 ENST00000545995.1
TDP2
tyrosyl-DNA phosphodiesterase 2
chr6_+_26365443 0.00 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
BTN3A2
butyrophilin, subfamily 3, member A2

Network of associatons between targets according to the STRING database.

First level regulatory network of RFX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 5.9 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.9 3.4 GO:0010900 negative regulation of phosphatidylcholine catabolic process(GO:0010900)
0.2 0.2 GO:0002399 MHC class II protein complex assembly(GO:0002399)
0.1 0.5 GO:0046967 cytosol to ER transport(GO:0046967)
0.1 0.7 GO:0018094 protein polyglycylation(GO:0018094)
0.1 0.4 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.1 0.2 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.1 0.7 GO:0032286 central nervous system myelin maintenance(GO:0032286)
0.0 0.5 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0 3.9 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.0 3.3 GO:0042733 embryonic digit morphogenesis(GO:0042733)
0.0 0.3 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.0 0.2 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 0.1 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.0 2.2 GO:0021510 spinal cord development(GO:0021510)
0.0 0.2 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 0.2 GO:0001675 acrosome assembly(GO:0001675)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.6 GO:1990111 spermatoproteasome complex(GO:1990111)
0.2 3.3 GO:0036038 MKS complex(GO:0036038)
0.1 3.4 GO:0042627 chylomicron(GO:0042627)
0.1 2.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.1 0.5 GO:0042825 TAP complex(GO:0042825)
0.0 0.6 GO:0070652 HAUS complex(GO:0070652)
0.0 0.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0 0.2 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.1 GO:0097543 ciliary inversin compartment(GO:0097543)
0.0 0.0 GO:0070703 inner mucus layer(GO:0070702) outer mucus layer(GO:0070703)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.4 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.3 3.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.1 0.7 GO:0070736 protein-glycine ligase activity, initiating(GO:0070736)
0.1 3.6 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 3.8 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 0.2 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.1 0.5 GO:0046979 TAP2 binding(GO:0046979)
0.1 0.2 GO:0070260 tyrosyl-RNA phosphodiesterase activity(GO:0036317) 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260)
0.0 0.3 GO:0051185 coenzyme transporter activity(GO:0051185)
0.0 2.2 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.4 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.2 GO:0052658 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0 0.2 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.9 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.5 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0 3.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.2 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex