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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RFX7_RFX4_RFX1
Z-value: 2.37
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Transcription factors associated with RFX7_RFX4_RFX1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RFX7 | hg19_v2_chr15_-_56535464_56535521 | -0.83 | 5.1e-06 | Click! |
| RFX1 | hg19_v2_chr19_-_14117074_14117141 | 0.74 | 1.7e-04 | Click! |
| RFX4 | hg19_v2_chr12_+_106994905_106994954 | 0.42 | 6.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RFX7_RFX4_RFX1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 70.6 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 8.6 | 34.4 | GO:0090299 | regulation of neural crest formation(GO:0090299) negative regulation of neural crest formation(GO:0090301) negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000314) |
| 0.1 | 20.3 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) |
| 0.1 | 10.6 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 9.1 | GO:0006352 | DNA-templated transcription, initiation(GO:0006352) |
| 0.1 | 8.4 | GO:0060612 | adipose tissue development(GO:0060612) |
| 2.7 | 8.0 | GO:0050760 | negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
| 0.2 | 7.4 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.7 | 7.2 | GO:0007288 | sperm axoneme assembly(GO:0007288) |
| 0.6 | 7.0 | GO:0071907 | determination of digestive tract left/right asymmetry(GO:0071907) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 2.4 | 12.0 | GO:0002079 | inner acrosomal membrane(GO:0002079) |
| 0.0 | 8.6 | GO:0000779 | condensed chromosome, centromeric region(GO:0000779) |
| 0.8 | 8.0 | GO:1990812 | growth cone filopodium(GO:1990812) |
| 0.0 | 6.5 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 6.1 | GO:0005938 | cell cortex(GO:0005938) |
| 0.3 | 5.9 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 5.8 | GO:0044322 | endoplasmic reticulum quality control compartment(GO:0044322) |
| 0.0 | 5.7 | GO:0042995 | cell projection(GO:0042995) |
| 0.1 | 4.8 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 67.4 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 14.1 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.0 | 12.2 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.1 | 11.8 | GO:0043621 | protein self-association(GO:0043621) |
| 0.1 | 9.1 | GO:0001105 | RNA polymerase II transcription coactivator activity(GO:0001105) |
| 0.4 | 8.3 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.4 | 8.2 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.8 | 7.5 | GO:0070740 | tubulin-glutamic acid ligase activity(GO:0070740) |
| 2.1 | 6.4 | GO:0052857 | NADHX epimerase activity(GO:0052856) NADPHX epimerase activity(GO:0052857) |
| 0.7 | 6.3 | GO:0004396 | glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.2 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 8.0 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 4.3 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.7 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 2.7 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.0 | 2.2 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 2.2 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.1 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 0.0 | 2.1 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.0 | 2.0 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.6 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 0.0 | 4.0 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 3.7 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 3.5 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.0 | 3.2 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 3.0 | REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway |
| 0.0 | 2.6 | REACTOME NUCLEAR SIGNALING BY ERBB4 | Genes involved in Nuclear signaling by ERBB4 |
| 0.1 | 2.5 | REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION | Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression |
| 0.1 | 2.5 | REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER | Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER |
| 0.0 | 2.5 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |