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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RORC

Z-value: 0.39

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Transcription factors associated with RORC

Gene Symbol Gene ID Gene Info
RORC
ENSG00000143365.12 RAR related orphan receptor C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RORChg19_v2_chr1_-_151798546_1517985900.473.7e-02Click!

Activity profile of RORC motif

Sorted Z-values of RORC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_39759154 0.46 ENST00000331982.5
IFNL2
interferon, lambda 2
chr10_-_105845674 0.39 ENST00000353479.5
ENST00000369733.3
COL17A1
collagen, type XVII, alpha 1
chr19_-_39735646 0.38 ENST00000413851.2
IFNL3
interferon, lambda 3
chr19_-_49140692 0.35 ENST00000222122.5
DBP
D site of albumin promoter (albumin D-box) binding protein
chr10_-_105845536 0.35 ENST00000393211.3
COL17A1
collagen, type XVII, alpha 1
chr11_-_64527425 0.34 ENST00000377432.3
PYGM
phosphorylase, glycogen, muscle
chr4_+_85504075 0.33 ENST00000295887.5
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr15_+_31508174 0.31 ENST00000559292.2
ENST00000557928.1
RP11-16E12.1
RP11-16E12.1
chr17_-_46623441 0.28 ENST00000330070.4
HOXB2
homeobox B2
chr9_-_110251836 0.21 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr19_-_49140609 0.20 ENST00000601104.1
DBP
D site of albumin promoter (albumin D-box) binding protein
chr19_-_8567478 0.20 ENST00000255612.3
PRAM1
PML-RARA regulated adaptor molecule 1
chr19_-_7697857 0.19 ENST00000598935.1
PCP2
Purkinje cell protein 2
chr19_-_7698599 0.17 ENST00000311069.5
PCP2
Purkinje cell protein 2
chr4_-_87770416 0.17 ENST00000273905.6
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter), member 6
chr19_+_1269324 0.16 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP
cold inducible RNA binding protein
chr19_-_8567505 0.16 ENST00000600262.1
PRAM1
PML-RARA regulated adaptor molecule 1
chr14_+_21785693 0.16 ENST00000382933.4
ENST00000557351.1
RPGRIP1
retinitis pigmentosa GTPase regulator interacting protein 1
chr4_-_159094194 0.14 ENST00000592057.1
ENST00000585682.1
ENST00000393807.5
FAM198B
family with sequence similarity 198, member B
chr6_+_43738444 0.14 ENST00000324450.6
ENST00000417285.2
ENST00000413642.3
ENST00000372055.4
ENST00000482630.2
ENST00000425836.2
ENST00000372064.4
ENST00000372077.4
ENST00000519767.1
VEGFA
vascular endothelial growth factor A
chr4_-_1188922 0.14 ENST00000515004.1
ENST00000502483.1
SPON2
spondin 2, extracellular matrix protein
chr19_+_12780512 0.13 ENST00000242796.4
WDR83
WD repeat domain 83
chr11_-_47616210 0.13 ENST00000302514.3
C1QTNF4
C1q and tumor necrosis factor related protein 4
chr8_-_116673894 0.13 ENST00000395713.2
TRPS1
trichorhinophalangeal syndrome I
chr6_+_44094627 0.12 ENST00000259746.9
TMEM63B
transmembrane protein 63B
chr14_-_23755297 0.12 ENST00000357460.5
HOMEZ
homeobox and leucine zipper encoding
chr1_+_236849754 0.11 ENST00000542672.1
ENST00000366578.4
ACTN2
actinin, alpha 2
chr3_+_185303962 0.11 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr2_-_30144432 0.10 ENST00000389048.3
ALK
anaplastic lymphoma receptor tyrosine kinase
chrX_-_102531717 0.10 ENST00000372680.1
TCEAL5
transcription elongation factor A (SII)-like 5
chr10_-_103578182 0.10 ENST00000439817.1
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr4_+_140586922 0.10 ENST00000265498.1
ENST00000506797.1
MGST2
microsomal glutathione S-transferase 2
chr1_-_217311090 0.10 ENST00000493603.1
ENST00000366940.2
ESRRG
estrogen-related receptor gamma
chr2_+_119699864 0.10 ENST00000541757.1
ENST00000412481.1
MARCO
macrophage receptor with collagenous structure
chr12_+_56623827 0.10 ENST00000424625.1
ENST00000419753.1
ENST00000454355.2
ENST00000417965.1
ENST00000436633.1
SLC39A5
solute carrier family 39 (zinc transporter), member 5
chr22_-_32022280 0.10 ENST00000442379.1
PISD
phosphatidylserine decarboxylase
chrX_-_43832711 0.10 ENST00000378062.5
NDP
Norrie disease (pseudoglioma)
chr3_+_187461442 0.10 ENST00000450760.1
RP11-211G3.2
RP11-211G3.2
chr10_-_121296045 0.09 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr7_-_141541221 0.09 ENST00000350549.3
ENST00000438520.1
PRSS37
protease, serine, 37
chr1_+_104198377 0.09 ENST00000370083.4
AMY1A
amylase, alpha 1A (salivary)
chr6_+_138266498 0.09 ENST00000434437.1
ENST00000417800.1
RP11-240M16.1
RP11-240M16.1
chr12_-_82152444 0.09 ENST00000549325.1
ENST00000550584.2
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr2_+_119699742 0.08 ENST00000327097.4
MARCO
macrophage receptor with collagenous structure
chr12_-_82152420 0.08 ENST00000552948.1
ENST00000548586.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr11_+_65292884 0.08 ENST00000527009.1
SCYL1
SCY1-like 1 (S. cerevisiae)
chr17_+_47439733 0.08 ENST00000507337.1
RP11-1079K10.3
RP11-1079K10.3
chr1_-_62190793 0.08 ENST00000371177.2
ENST00000606498.1
TM2D1
TM2 domain containing 1
chr1_+_159796534 0.08 ENST00000289707.5
SLAMF8
SLAM family member 8
chr2_+_162016916 0.08 ENST00000405852.1
TANK
TRAF family member-associated NFKB activator
chr2_+_148778570 0.07 ENST00000407073.1
MBD5
methyl-CpG binding domain protein 5
chr1_+_67632083 0.07 ENST00000347310.5
ENST00000371002.1
IL23R
interleukin 23 receptor
chr8_+_71485681 0.07 ENST00000391684.1
AC120194.1
AC120194.1
chr11_-_69867159 0.07 ENST00000528507.1
RP11-626H12.2
RP11-626H12.2
chr14_+_23025534 0.07 ENST00000557595.1
AE000662.92
Uncharacterized protein
chr3_-_164914640 0.07 ENST00000241274.3
SLITRK3
SLIT and NTRK-like family, member 3
chr8_+_66955648 0.06 ENST00000522619.1
DNAJC5B
DnaJ (Hsp40) homolog, subfamily C, member 5 beta
chr12_+_56624436 0.06 ENST00000266980.4
ENST00000437277.1
SLC39A5
solute carrier family 39 (zinc transporter), member 5
chr14_-_104408645 0.06 ENST00000557640.1
RD3L
retinal degeneration 3-like
chr12_+_7167980 0.06 ENST00000360817.5
ENST00000402681.3
C1S
complement component 1, s subcomponent
chr17_-_37764128 0.06 ENST00000302584.4
NEUROD2
neuronal differentiation 2
chr10_-_21435488 0.06 ENST00000534331.1
ENST00000529198.1
ENST00000377118.4
C10orf113
chromosome 10 open reading frame 113
chr2_+_162016804 0.05 ENST00000392749.2
ENST00000440506.1
TANK
TRAF family member-associated NFKB activator
chr7_+_20687017 0.05 ENST00000258738.6
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chrX_-_110655391 0.05 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr21_+_17553910 0.05 ENST00000428669.2
LINC00478
long intergenic non-protein coding RNA 478
chr19_+_55385731 0.05 ENST00000469767.1
ENST00000355524.3
ENST00000391725.3
ENST00000345937.4
ENST00000353758.4
ENST00000359272.4
ENST00000391723.3
ENST00000391724.3
FCAR
Fc fragment of IgA, receptor for
chr7_+_20686946 0.05 ENST00000443026.2
ENST00000406935.1
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr16_-_69385681 0.05 ENST00000288025.3
TMED6
transmembrane emp24 protein transport domain containing 6
chr9_-_35042824 0.05 ENST00000595331.1
FLJ00273
FLJ00273
chrX_-_49089771 0.05 ENST00000376251.1
ENST00000323022.5
ENST00000376265.2
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr17_-_42992856 0.04 ENST00000588316.1
ENST00000435360.2
ENST00000586793.1
ENST00000588735.1
ENST00000588037.1
ENST00000592320.1
ENST00000253408.5
GFAP
glial fibrillary acidic protein
chr6_-_111927062 0.04 ENST00000359831.4
TRAF3IP2
TRAF3 interacting protein 2
chrX_+_69501943 0.04 ENST00000509895.1
ENST00000374473.2
ENST00000276066.4
RAB41
RAB41, member RAS oncogene family
chr13_+_109248500 0.04 ENST00000356711.2
MYO16
myosin XVI
chr20_-_33732952 0.04 ENST00000541621.1
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr1_-_150207017 0.04 ENST00000369119.3
ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr14_-_54418598 0.03 ENST00000609748.1
ENST00000558961.1
BMP4
bone morphogenetic protein 4
chr18_-_31603603 0.03 ENST00000586553.1
NOL4
nucleolar protein 4
chr16_+_16326352 0.03 ENST00000399336.4
ENST00000263012.6
ENST00000538468.1
NOMO3
NODAL modulator 3
chr4_+_110749143 0.03 ENST00000317735.4
RRH
retinal pigment epithelium-derived rhodopsin homolog
chr16_+_24266874 0.02 ENST00000005284.3
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr1_+_159796589 0.02 ENST00000368104.4
SLAMF8
SLAM family member 8
chr6_-_46922659 0.02 ENST00000265417.7
GPR116
G protein-coupled receptor 116
chr1_-_211752073 0.01 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr11_+_13299186 0.01 ENST00000527998.1
ENST00000396441.3
ENST00000533520.1
ENST00000529825.1
ENST00000389707.4
ENST00000401424.1
ENST00000529388.1
ENST00000530357.1
ENST00000403290.1
ENST00000361003.4
ENST00000389708.3
ENST00000403510.3
ENST00000482049.1
ARNTL
aryl hydrocarbon receptor nuclear translocator-like
chr2_+_20650796 0.01 ENST00000448241.1
AC023137.2
AC023137.2
chr3_+_45986511 0.01 ENST00000458629.1
ENST00000457814.1
CXCR6
chemokine (C-X-C motif) receptor 6
chr1_+_154540246 0.01 ENST00000368476.3
CHRNB2
cholinergic receptor, nicotinic, beta 2 (neuronal)
chr20_-_44007014 0.00 ENST00000372726.3
ENST00000537995.1
TP53TG5
TP53 target 5
chr4_-_120243545 0.00 ENST00000274024.3
FABP2
fatty acid binding protein 2, intestinal
chr2_+_162016827 0.00 ENST00000429217.1
ENST00000406287.1
ENST00000402568.1
TANK
TRAF family member-associated NFKB activator
chr1_+_171810606 0.00 ENST00000358155.4
ENST00000367733.2
ENST00000355305.5
ENST00000367731.1
DNM3
dynamin 3
chr1_-_145826450 0.00 ENST00000462900.2
GPR89A
G protein-coupled receptor 89A
chr3_-_184095923 0.00 ENST00000445696.2
ENST00000204615.7
THPO
thrombopoietin

Network of associatons between targets according to the STRING database.

First level regulatory network of RORC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 0.2 GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.0 0.1 GO:1903570 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.0 0.2 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
0.0 0.1 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.1 GO:0036269 swimming behavior(GO:0036269)
0.0 0.4 GO:0043313 regulation of neutrophil degranulation(GO:0043313)
0.0 0.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.1 GO:2000297 negative regulation of synapse maturation(GO:2000297)
0.0 0.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.1 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.0 0.1 GO:0038155 interleukin-23-mediated signaling pathway(GO:0038155)
0.0 0.5 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.1 GO:0060399 positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 GO:0030056 hemidesmosome(GO:0030056)
0.0 0.1 GO:0072536 interleukin-23 receptor complex(GO:0072536)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008184 glycogen phosphorylase activity(GO:0008184)
0.1 0.3 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.1 GO:0004464 leukotriene-C4 synthase activity(GO:0004464)
0.0 0.2 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.1 GO:0010861 thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375)
0.0 0.1 GO:0004556 alpha-amylase activity(GO:0004556)
0.0 0.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.0 GO:0019862 IgA binding(GO:0019862)
0.0 0.1 GO:0042020 interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0 0.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 NABA COLLAGENS Genes encoding collagen proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)