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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for RREB1

Z-value: 2.20

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Transcription factors associated with RREB1

Gene Symbol Gene ID Gene Info
ENSG00000124782.15 ras responsive element binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
RREB1hg19_v2_chr6_+_7107999_71080540.957.3e-11Click!

Activity profile of RREB1 motif

Sorted Z-values of RREB1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_153538292 16.02 ENST00000497140.1
ENST00000368708.3
S100 calcium binding protein A2
chr19_+_35609380 15.74 ENST00000604621.1
FXYD domain containing ion transport regulator 3
chr19_-_51456344 9.56 ENST00000336334.3
ENST00000593428.1
kallikrein-related peptidase 5
chr17_-_39216344 9.43 ENST00000391418.2
keratin associated protein 2-3
chr9_-_21994344 9.03 ENST00000530628.2
ENST00000361570.3
cyclin-dependent kinase inhibitor 2A
chr17_-_39677971 8.90 ENST00000393976.2
keratin 15
chr1_-_153363452 8.39 ENST00000368732.1
ENST00000368733.3
S100 calcium binding protein A8
chr19_-_51456321 8.01 ENST00000391809.2
kallikrein-related peptidase 5
chr9_-_21994597 7.99 ENST00000579755.1
cyclin-dependent kinase inhibitor 2A
chr1_-_17307173 7.30 ENST00000438542.1
ENST00000375535.3
microfibrillar-associated protein 2
chr16_-_4588469 7.18 ENST00000588381.1
ENST00000563332.2
cell death-inducing p53 target 1
chr16_-_4588762 6.71 ENST00000562334.1
ENST00000562579.1
ENST00000567695.1
ENST00000563507.1
cell death-inducing p53 target 1
chr16_+_68771128 6.41 ENST00000261769.5
ENST00000422392.2
cadherin 1, type 1, E-cadherin (epithelial)
chr2_+_234104079 6.08 ENST00000417661.1
inositol polyphosphate-5-phosphatase, 145kDa
chr19_-_51456198 6.04 ENST00000594846.1
kallikrein-related peptidase 5
chr16_-_4588391 5.52 ENST00000586728.1
cell death-inducing p53 target 1
chr1_+_61548374 5.37 ENST00000485903.2
ENST00000371185.2
ENST00000371184.2
nuclear factor I/A
chr8_-_75233563 5.36 ENST00000342232.4
junctophilin 1
chr8_+_26149274 5.26 ENST00000522535.1
protein phosphatase 2, regulatory subunit B, alpha
chr16_-_4588822 5.26 ENST00000564828.1
cell death-inducing p53 target 1
chr2_+_192542879 5.23 ENST00000409510.1
nucleic acid binding protein 1
chr6_+_43112037 4.81 ENST00000473339.1
protein tyrosine kinase 7
chr22_-_44258360 4.69 ENST00000330884.4
ENST00000249130.5
sulfotransferase family 4A, member 1
chr19_-_51471381 4.58 ENST00000594641.1
kallikrein-related peptidase 6
chr10_+_115438920 4.52 ENST00000429617.1
ENST00000369331.4
caspase 7, apoptosis-related cysteine peptidase
chr12_-_95044309 4.36 ENST00000261226.4
transmembrane and coiled-coil domain family 3
chr6_+_7541808 4.28 ENST00000379802.3
desmoplakin
chr6_+_7541845 4.18 ENST00000418664.2
desmoplakin
chr8_+_95653840 4.10 ENST00000520385.1
epithelial splicing regulatory protein 1
chrX_+_102585124 4.09 ENST00000332431.4
ENST00000372666.1
transcription elongation factor A (SII)-like 7
chr18_+_33877654 4.09 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
formin homology 2 domain containing 3
chr1_-_228604328 4.04 ENST00000355586.4
ENST00000366698.2
ENST00000520264.1
ENST00000479800.1
ENST00000295033.3
tripartite motif containing 17
chr2_+_192543153 3.90 ENST00000425611.2
nucleic acid binding protein 1
chr7_-_92465868 3.89 ENST00000424848.2
cyclin-dependent kinase 6
chr2_+_192542850 3.87 ENST00000410026.2
nucleic acid binding protein 1
chr17_+_7788104 3.83 ENST00000380358.4
chromodomain helicase DNA binding protein 3
chr16_+_57679859 3.82 ENST00000569494.1
ENST00000566169.1
G protein-coupled receptor 56
chr2_-_230786378 3.81 ENST00000430954.1
thyroid hormone receptor interactor 12
chr19_-_37406923 3.79 ENST00000520965.1
zinc finger protein 829
chr5_+_150591678 3.67 ENST00000523466.1
GM2 ganglioside activator
chr4_-_87374283 3.66 ENST00000361569.2
mitogen-activated protein kinase 10
chr19_-_19051927 3.65 ENST00000600077.1
homer homolog 3 (Drosophila)
chr13_-_52026730 3.62 ENST00000420668.2
integrator complex subunit 6
chr13_-_74708372 3.49 ENST00000377666.4
Kruppel-like factor 12
chr20_+_1115821 3.49 ENST00000435720.1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr3_+_41241596 3.40 ENST00000450969.1
catenin (cadherin-associated protein), beta 1, 88kDa
chr4_-_56412713 3.32 ENST00000435527.2
clock circadian regulator
chr6_+_149638876 3.28 ENST00000392282.1
TGF-beta activated kinase 1/MAP3K7 binding protein 2
chr16_+_57679945 3.26 ENST00000568157.1
G protein-coupled receptor 56
chr22_+_41487711 3.21 ENST00000263253.7
E1A binding protein p300
chr17_-_6459802 3.20 ENST00000262483.8
PITPNM family member 3
chr3_-_18466026 3.15 ENST00000417717.2
SATB homeobox 1
chr2_+_219745020 3.13 ENST00000258411.3
wingless-type MMTV integration site family, member 10A
chr13_-_52027134 3.10 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
integrator complex subunit 6
chr4_-_77996032 3.10 ENST00000505609.1
cyclin I
chr10_+_13628921 3.09 ENST00000378572.3
pre-mRNA processing factor 18
chr3_+_192958914 3.08 ENST00000264735.2
ENST00000602513.1
HRAS-like suppressor
chr5_+_138629628 3.05 ENST00000508689.1
ENST00000514528.1
matrin 3
chr22_+_38321840 3.04 ENST00000454685.1
MICAL-like 1
chr11_+_128562372 3.03 ENST00000344954.6
Fli-1 proto-oncogene, ETS transcription factor
chr11_-_118789613 3.03 ENST00000532899.1
B-cell CLL/lymphoma 9-like
chr16_+_27325202 2.98 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
interleukin 4 receptor
chr6_-_86352982 2.98 ENST00000369622.3
synaptotagmin binding, cytoplasmic RNA interacting protein
chr4_-_100484825 2.95 ENST00000273962.3
ENST00000514547.1
ENST00000455368.2
tRNA methyltransferase 10 homolog A (S. cerevisiae)
chr12_+_57522692 2.93 ENST00000554174.1
low density lipoprotein receptor-related protein 1
chr12_+_96588279 2.91 ENST00000552142.1
ELK3, ETS-domain protein (SRF accessory protein 2)
chr5_+_138629337 2.86 ENST00000394805.3
ENST00000512876.1
ENST00000513678.1
matrin 3
chr12_+_6554021 2.82 ENST00000266557.3
CD27 molecule
chr11_+_46403194 2.75 ENST00000395569.4
ENST00000395566.4
midkine (neurite growth-promoting factor 2)
chr10_+_127661942 2.72 ENST00000417114.1
ENST00000445510.1
ENST00000368691.1
fibronectin type III and ankyrin repeat domains 1
chr11_+_46403303 2.71 ENST00000407067.1
ENST00000395565.1
midkine (neurite growth-promoting factor 2)
chr17_-_6459768 2.66 ENST00000421306.3
PITPNM family member 3
chr1_-_228604454 2.64 ENST00000456946.2
tripartite motif containing 17
chr11_+_34073269 2.61 ENST00000389645.3
cell cycle associated protein 1
chr3_+_41240925 2.60 ENST00000396183.3
ENST00000349496.5
ENST00000453024.1
catenin (cadherin-associated protein), beta 1, 88kDa
chr1_-_201346761 2.57 ENST00000455702.1
ENST00000422165.1
ENST00000367318.5
ENST00000367320.2
ENST00000438742.1
ENST00000412633.1
ENST00000458432.2
ENST00000421663.2
ENST00000367322.1
ENST00000509001.1
troponin T type 2 (cardiac)
chr5_+_125758865 2.55 ENST00000542322.1
ENST00000544396.1
GRAM domain containing 3
chr2_+_28974531 2.53 ENST00000420282.1
protein phosphatase 1, catalytic subunit, beta isozyme
chr8_-_142011036 2.51 ENST00000520892.1
protein tyrosine kinase 2
chr16_+_57680043 2.51 ENST00000569154.1
G protein-coupled receptor 56
chr5_+_138629389 2.43 ENST00000504045.1
ENST00000504311.1
ENST00000502499.1
matrin 3
chr17_-_4642429 2.41 ENST00000573123.1
chemokine (C-X-C motif) ligand 16
chr12_-_120687948 2.40 ENST00000458477.2
paxillin
chr2_+_54684327 2.38 ENST00000389980.3
spectrin, beta, non-erythrocytic 1
chr11_-_35547151 2.34 ENST00000378878.3
ENST00000529303.1
ENST00000278360.3
peptidase domain containing associated with muscle regeneration 1
chr6_-_86353510 2.32 ENST00000444272.1
synaptotagmin binding, cytoplasmic RNA interacting protein
chr5_+_125758813 2.32 ENST00000285689.3
ENST00000515200.1
GRAM domain containing 3
chr18_+_72166564 2.31 ENST00000583216.1
ENST00000581912.1
ENST00000582589.1
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr5_-_124080203 2.29 ENST00000504926.1
zinc finger protein 608
chr20_+_33462745 2.29 ENST00000488172.1
acyl-CoA synthetase short-chain family member 2
chr5_-_124084493 2.29 ENST00000509799.1
zinc finger protein 608
chr17_+_48611853 2.28 ENST00000507709.1
ENST00000515126.1
ENST00000507467.1
epsin 3
chr13_-_108867846 2.24 ENST00000442234.1
ligase IV, DNA, ATP-dependent
chr8_+_94929969 2.23 ENST00000517764.1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr1_-_113392399 2.23 ENST00000449572.2
ENST00000433505.1
RP11-426L16.8
chr15_+_63481668 2.22 ENST00000321437.4
ENST00000559006.1
ENST00000448330.2
RAB8B, member RAS oncogene family
chr12_-_49351148 2.20 ENST00000398092.4
ENST00000539611.1
ADP-ribosylation factor 3
ADP-ribosylation factor 3
chr12_-_6716569 2.19 ENST00000544040.1
ENST00000545942.1
chromodomain helicase DNA binding protein 4
chr17_-_58499766 2.17 ENST00000588898.1
ubiquitin specific peptidase 32
chr19_-_6720686 2.16 ENST00000245907.6
complement component 3
chr5_-_142065223 2.14 ENST00000378046.1
fibroblast growth factor 1 (acidic)
chr17_-_79817091 2.14 ENST00000570907.1
prolyl 4-hydroxylase, beta polypeptide
chr19_-_19051993 2.14 ENST00000594794.1
ENST00000355887.6
ENST00000392351.3
ENST00000596482.1
homer homolog 3 (Drosophila)
chr9_+_35906176 2.13 ENST00000354323.2
histidine rich carboxyl terminus 1
chr7_+_75932863 2.13 ENST00000429938.1
heat shock 27kDa protein 1
chr19_-_51471362 2.12 ENST00000376853.4
ENST00000424910.2
kallikrein-related peptidase 6
chr6_+_37321823 2.12 ENST00000487950.1
ENST00000469731.1
ring finger protein 8, E3 ubiquitin protein ligase
chr7_-_102213030 2.07 ENST00000511313.1
ENST00000513438.1
ENST00000513506.1
polymerase (RNA) II (DNA directed) polypeptide J3
chr2_+_106468204 2.06 ENST00000425756.1
ENST00000393349.2
NCK adaptor protein 2
chr17_-_76732928 2.06 ENST00000589768.1
cytohesin 1
chr1_+_61548225 2.03 ENST00000371187.3
nuclear factor I/A
chr3_+_140660634 2.02 ENST00000446041.2
ENST00000507429.1
ENST00000324194.6
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr12_-_6716534 2.02 ENST00000544484.1
ENST00000309577.6
ENST00000357008.2
chromodomain helicase DNA binding protein 4
chr2_+_223289208 2.01 ENST00000321276.7
sphingosine-1-phosphate phosphatase 2
chr3_+_140660743 1.98 ENST00000453248.2
solute carrier family 25 (pyrimidine nucleotide carrier ), member 36
chr1_+_43148059 1.97 ENST00000321358.7
ENST00000332220.6
Y box binding protein 1
chr21_-_34915123 1.97 ENST00000438059.1
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
chr12_+_62654119 1.96 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
ubiquitin specific peptidase 15
chr1_+_43148625 1.96 ENST00000436427.1
Y box binding protein 1
chr10_+_13628933 1.95 ENST00000417658.1
ENST00000320054.4
pre-mRNA processing factor 18
chr6_+_168227611 1.95 ENST00000344191.4
ENST00000351017.4
ENST00000392108.3
ENST00000366806.2
ENST00000392112.1
ENST00000400824.4
ENST00000447894.2
ENST00000400822.3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
chr4_-_100485183 1.94 ENST00000394876.2
tRNA methyltransferase 10 homolog A (S. cerevisiae)
chr6_+_7107830 1.93 ENST00000379933.3
ras responsive element binding protein 1
chr6_-_13486369 1.91 ENST00000558378.1
AL583828.1
chr2_-_122247879 1.90 ENST00000545861.1
cytoplasmic linker associated protein 1
chr19_-_57352064 1.90 ENST00000326441.9
ENST00000593695.1
ENST00000599577.1
ENST00000594389.1
ENST00000423103.2
ENST00000598410.1
ENST00000593711.1
ENST00000391708.3
ENST00000221722.5
ENST00000599935.1
paternally expressed 3
zinc finger, imprinted 2
chr17_-_39728303 1.89 ENST00000588431.1
ENST00000246662.4
keratin 9
chr10_+_70091812 1.87 ENST00000265866.7
heterogeneous nuclear ribonucleoprotein H3 (2H9)
chr2_-_67442409 1.86 ENST00000414404.1
ENST00000433133.1
AC078941.1
chr22_-_44258280 1.85 ENST00000540422.1
sulfotransferase family 4A, member 1
chr2_-_85637459 1.84 ENST00000409921.1
capping protein (actin filament), gelsolin-like
chr8_+_144816303 1.83 ENST00000533004.1
FAM83H antisense RNA 1 (head to head)
chr3_-_71632894 1.83 ENST00000493089.1
forkhead box P1
chr3_+_41240986 1.83 ENST00000396185.3
catenin (cadherin-associated protein), beta 1, 88kDa
chr11_+_69455855 1.82 ENST00000227507.2
ENST00000536559.1
cyclin D1
chr11_-_57089671 1.82 ENST00000532437.1
tankyrase 1 binding protein 1, 182kDa
chr17_+_48796905 1.80 ENST00000505658.1
ENST00000393227.2
ENST00000240304.1
ENST00000311571.3
ENST00000505619.1
ENST00000544170.1
ENST00000510984.1
LUC7-like 3 (S. cerevisiae)
chr11_-_129872712 1.80 ENST00000358825.5
ENST00000360871.3
ENST00000528746.1
PR domain containing 10
chr10_+_70091847 1.80 ENST00000441000.2
ENST00000354695.5
heterogeneous nuclear ribonucleoprotein H3 (2H9)
chr4_+_56719782 1.77 ENST00000381295.2
ENST00000346134.7
ENST00000349598.6
exocyst complex component 1
chr19_+_3366547 1.77 ENST00000341919.3
ENST00000590282.1
ENST00000443272.2
nuclear factor I/C (CCAAT-binding transcription factor)
chr3_+_184032919 1.75 ENST00000427845.1
ENST00000342981.4
ENST00000319274.6
eukaryotic translation initiation factor 4 gamma, 1
chr11_+_66886717 1.72 ENST00000398645.2
lysine (K)-specific demethylase 2A
chr8_+_28748099 1.71 ENST00000519047.1
homeobox containing 1
chr1_-_113249734 1.71 ENST00000484054.3
ENST00000369636.2
ENST00000369637.1
ENST00000285735.2
ENST00000369638.2
ras homolog family member C
chr19_-_12405606 1.70 ENST00000356109.5
zinc finger protein 44
chr2_+_48757278 1.70 ENST00000404752.1
ENST00000406226.1
stonin 1
chr1_-_113249678 1.69 ENST00000369633.2
ENST00000425265.2
ENST00000369632.2
ENST00000436685.2
ras homolog family member C
chr7_+_91570165 1.68 ENST00000356239.3
ENST00000359028.2
ENST00000358100.2
A kinase (PRKA) anchor protein 9
chr17_+_35849937 1.62 ENST00000394389.4
dual specificity phosphatase 14
chr17_+_42385927 1.60 ENST00000426726.3
ENST00000590941.1
ENST00000225441.7
RUN domain containing 3A
chr18_-_21242729 1.60 ENST00000585908.2
ankyrin repeat domain 29
chr1_+_46668994 1.58 ENST00000371980.3
leucine rich adaptor protein 1
chr12_+_96588368 1.58 ENST00000547860.1
ELK3, ETS-domain protein (SRF accessory protein 2)
chr15_+_67390920 1.57 ENST00000559092.1
ENST00000560175.1
SMAD family member 3
chr7_-_51384451 1.55 ENST00000441453.1
ENST00000265136.7
ENST00000395542.2
ENST00000395540.2
cordon-bleu WH2 repeat protein
chr11_+_20044375 1.55 ENST00000525322.1
ENST00000530408.1
neuron navigator 2
chr2_-_241836298 1.54 ENST00000414499.1
chromosome 2 open reading frame 54
chr21_-_36259445 1.53 ENST00000399240.1
runt-related transcription factor 1
chr20_+_58179582 1.53 ENST00000371015.1
ENST00000395639.4
phosphatase and actin regulator 3
chr22_-_36357671 1.52 ENST00000408983.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr16_-_3285144 1.52 ENST00000431561.3
ENST00000396870.4
zinc finger protein 200
chr7_-_150721570 1.52 ENST00000377974.2
ENST00000444312.1
ENST00000605938.1
ENST00000605952.1
autophagy related 9B
chr22_-_44894178 1.52 ENST00000341255.3
leucine zipper, down-regulated in cancer 1-like
chr2_-_241836244 1.49 ENST00000454476.2
chromosome 2 open reading frame 54
chr12_-_123849374 1.49 ENST00000602398.1
ENST00000602750.1
strawberry notch homolog 1 (Drosophila)
chr12_+_861717 1.48 ENST00000535572.1
WNK lysine deficient protein kinase 1
chr11_-_85779971 1.47 ENST00000393346.3
phosphatidylinositol binding clathrin assembly protein
chr11_-_35547277 1.46 ENST00000527605.1
peptidase domain containing associated with muscle regeneration 1
chr5_-_133512654 1.46 ENST00000522552.1
S-phase kinase-associated protein 1
chr17_-_66453562 1.46 ENST00000262139.5
ENST00000546360.1
WD repeat domain, phosphoinositide interacting 1
chr5_-_142065612 1.45 ENST00000360966.5
ENST00000411960.1
fibroblast growth factor 1 (acidic)
chr17_-_62658186 1.44 ENST00000262435.9
SMAD specific E3 ubiquitin protein ligase 2
chr11_+_111896320 1.44 ENST00000531306.1
ENST00000537636.1
dihydrolipoamide S-acetyltransferase
chr18_+_72167096 1.44 ENST00000324301.8
CNDP dipeptidase 2 (metallopeptidase M20 family)
chr10_-_71930222 1.44 ENST00000458634.2
ENST00000373239.2
ENST00000373242.2
ENST00000373241.4
SAR1 homolog A (S. cerevisiae)
chr6_-_34664612 1.44 ENST00000374023.3
ENST00000374026.3
chromosome 6 open reading frame 106
chr21_-_47648665 1.43 ENST00000450351.1
ENST00000522411.1
ENST00000356396.4
ENST00000397728.3
ENST00000457828.2
lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
chr17_-_7141490 1.43 ENST00000574236.1
ENST00000572789.1
PHD finger protein 23
chr11_+_46402744 1.41 ENST00000533952.1
midkine (neurite growth-promoting factor 2)
chr12_+_62654155 1.40 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
ubiquitin specific peptidase 15
chr19_-_12405689 1.38 ENST00000355684.5
zinc finger protein 44
chr19_+_10982189 1.38 ENST00000327064.4
ENST00000588947.1
coactivator-associated arginine methyltransferase 1
chr3_+_154797877 1.38 ENST00000462745.1
ENST00000493237.1
membrane metallo-endopeptidase
chr11_-_96239990 1.35 ENST00000511243.2
JRKL antisense RNA 1
chr19_-_18653781 1.34 ENST00000596558.2
ENST00000453489.2
FK506 binding protein 8, 38kDa
chr1_-_21377383 1.34 ENST00000374935.3
eukaryotic translation initiation factor 4 gamma, 3
chr1_+_16083098 1.33 ENST00000496928.2
ENST00000508310.1
filamin binding LIM protein 1
chr20_-_45984401 1.30 ENST00000311275.7
zinc finger, MYND-type containing 8
chr3_-_55521323 1.30 ENST00000264634.4
wingless-type MMTV integration site family, member 5A
chr9_+_132934835 1.28 ENST00000372398.3
neuronal calcium sensor 1
chr1_-_160254913 1.28 ENST00000440949.3
ENST00000368072.5
ENST00000608310.1
ENST00000556710.1
peroxisomal biogenesis factor 19
DDB1 and CUL4 associated factor 8
DDB1- and CUL4-associated factor 8
chr12_+_96588143 1.26 ENST00000228741.3
ENST00000547249.1
ELK3, ETS-domain protein (SRF accessory protein 2)
chr18_-_45456693 1.26 ENST00000587421.1
SMAD family member 2
chr11_+_20044600 1.23 ENST00000311043.8
neuron navigator 2
chr2_-_230786619 1.22 ENST00000389045.3
ENST00000409677.1
thyroid hormone receptor interactor 12
chr11_+_34073195 1.22 ENST00000341394.4
cell cycle associated protein 1
chr19_-_15442701 1.21 ENST00000594841.1
ENST00000601941.1
bromodomain containing 4
chr16_+_1728305 1.21 ENST00000569765.1
hematological and neurological expressed 1-like
chr21_+_34915337 1.21 ENST00000290239.6
ENST00000381692.2
ENST00000300278.4
ENST00000381679.4
SON DNA binding protein

Network of associatons between targets according to the STRING database.

First level regulatory network of RREB1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 23.6 GO:0002225 positive regulation of antimicrobial peptide production(GO:0002225) positive regulation of antimicrobial humoral response(GO:0002760) positive regulation of antibacterial peptide production(GO:0002803)
2.0 7.8 GO:0007403 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
1.7 5.0 GO:0071048 nuclear mRNA surveillance of spliceosomal pre-mRNA splicing(GO:0071030) nuclear retention of unspliced pre-mRNA at the site of transcription(GO:0071048)
1.4 17.0 GO:0035986 senescence-associated heterochromatin focus assembly(GO:0035986)
1.3 4.0 GO:1990519 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
1.2 6.1 GO:0045658 regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
1.1 6.9 GO:0030421 defecation(GO:0030421)
0.8 8.5 GO:0071896 protein localization to adherens junction(GO:0071896)
0.8 3.4 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.8 9.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.8 7.3 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.8 3.2 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.7 2.2 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.7 4.4 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.7 2.2 GO:0001798 positive regulation of type IIa hypersensitivity(GO:0001798) positive regulation of type II hypersensitivity(GO:0002894)
0.6 2.6 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.6 7.9 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.6 2.9 GO:1905167 positive regulation of lysosomal protein catabolic process(GO:1905167)
0.6 6.4 GO:0071680 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.6 2.8 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.5 2.1 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.5 8.4 GO:0032119 sequestering of zinc ion(GO:0032119)
0.5 4.5 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.5 3.0 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.5 1.5 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.5 1.9 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.5 4.2 GO:0072553 terminal button organization(GO:0072553)
0.5 1.4 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.4 3.3 GO:2000323 negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.4 1.7 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.4 6.1 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.4 2.4 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.4 3.9 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
0.4 1.2 GO:0060697 positive regulation of phospholipid catabolic process(GO:0060697)
0.4 1.5 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016)
0.4 2.2 GO:0019541 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.4 5.4 GO:1901509 regulation of endothelial tube morphogenesis(GO:1901509)
0.4 1.4 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
0.4 1.1 GO:0048633 positive regulation of skeletal muscle tissue growth(GO:0048633)
0.3 2.1 GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.3 3.1 GO:0021564 vagus nerve development(GO:0021564)
0.3 2.4 GO:1902962 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.3 6.7 GO:0016540 protein autoprocessing(GO:0016540)
0.3 1.6 GO:0001757 somite specification(GO:0001757)
0.3 3.7 GO:0006689 ganglioside catabolic process(GO:0006689)
0.3 0.9 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.3 2.4 GO:0051661 maintenance of centrosome location(GO:0051661)
0.3 4.0 GO:0007258 JUN phosphorylation(GO:0007258)
0.3 1.4 GO:1901097 negative regulation of autophagosome maturation(GO:1901097)
0.3 4.5 GO:0070141 response to UV-A(GO:0070141)
0.3 2.2 GO:0051461 positive regulation of corticotropin secretion(GO:0051461)
0.3 1.5 GO:0044805 late nucleophagy(GO:0044805)
0.3 1.3 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.3 5.3 GO:0007084 mitotic nuclear envelope reassembly(GO:0007084)
0.2 2.1 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.2 4.5 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.2 24.7 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.2 1.4 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.2 1.1 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.2 1.6 GO:0061767 negative regulation of lung blood pressure(GO:0061767)
0.2 6.7 GO:0016180 snRNA processing(GO:0016180)
0.2 1.1 GO:0009912 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.2 5.8 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.2 2.1 GO:0010265 SCF complex assembly(GO:0010265)
0.2 3.1 GO:0048733 sebaceous gland development(GO:0048733)
0.2 0.8 GO:0045875 negative regulation of sister chromatid cohesion(GO:0045875)
0.2 5.2 GO:0051639 actin filament network formation(GO:0051639)
0.2 4.7 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.2 5.7 GO:0072189 ureter development(GO:0072189)
0.2 4.9 GO:0007172 signal complex assembly(GO:0007172)
0.2 2.0 GO:0006189 brainstem development(GO:0003360) 'de novo' IMP biosynthetic process(GO:0006189)
0.2 1.8 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.2 1.5 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 4.5 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.1 13.2 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 1.7 GO:0002191 cap-dependent translational initiation(GO:0002191)
0.1 3.0 GO:0036010 protein localization to endosome(GO:0036010)
0.1 1.3 GO:1902952 positive regulation of dendritic spine maintenance(GO:1902952) regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.1 2.4 GO:0010818 T cell chemotaxis(GO:0010818)
0.1 5.9 GO:0030488 tRNA methylation(GO:0030488)
0.1 6.5 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1 0.8 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 14.1 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 1.9 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.1 1.5 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.1 0.2 GO:0061056 sclerotome development(GO:0061056)
0.1 5.4 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.1 1.0 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.1 2.4 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.1 1.9 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 3.0 GO:0035855 megakaryocyte development(GO:0035855)
0.1 3.8 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.1 1.5 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 1.6 GO:0031284 positive regulation of guanylate cyclase activity(GO:0031284)
0.1 2.0 GO:0006670 sphingosine metabolic process(GO:0006670)
0.1 1.2 GO:2000580 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
0.1 1.3 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.1 1.2 GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407)
0.1 1.0 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.1 1.8 GO:0051601 exocyst localization(GO:0051601)
0.1 2.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 3.8 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.1 6.9 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 2.9 GO:0010800 positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 0.6 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.1 0.5 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 1.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 6.0 GO:0015914 phospholipid transport(GO:0015914)
0.1 0.6 GO:0035826 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.1 0.4 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
0.1 0.5 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.1 0.6 GO:0055048 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.1 0.6 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.1 6.3 GO:0032508 DNA duplex unwinding(GO:0032508)
0.1 0.3 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.1 0.8 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1 11.1 GO:0031424 keratinization(GO:0031424)
0.1 1.0 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.1 3.3 GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423)
0.0 0.3 GO:0051697 protein delipidation(GO:0051697)
0.0 0.4 GO:0010571 positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0 0.3 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.0 0.5 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.2 GO:0042138 meiotic DNA double-strand break formation(GO:0042138) negative regulation of meiotic cell cycle phase transition(GO:1901994)
0.0 3.6 GO:1901799 negative regulation of proteasomal protein catabolic process(GO:1901799)
0.0 0.4 GO:0008298 intracellular mRNA localization(GO:0008298)
0.0 1.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.5 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 1.1 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.1 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0 5.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 1.0 GO:0007194 negative regulation of adenylate cyclase activity(GO:0007194)
0.0 1.3 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
0.0 7.3 GO:0043542 endothelial cell migration(GO:0043542)
0.0 1.0 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.4 GO:0007512 adult heart development(GO:0007512)
0.0 0.2 GO:0071484 cellular response to light intensity(GO:0071484)
0.0 0.1 GO:0089700 protein kinase D signaling(GO:0089700)
0.0 0.2 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.2 GO:0043249 erythrocyte maturation(GO:0043249)
0.0 0.2 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0 1.4 GO:0006968 cellular defense response(GO:0006968)
0.0 2.2 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0050894 determination of affect(GO:0050894)
0.0 1.1 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 1.0 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.6 GO:0000470 maturation of LSU-rRNA(GO:0000470)
0.0 1.4 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 1.7 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 1.3 GO:0010507 negative regulation of autophagy(GO:0010507)
0.0 4.9 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.6 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.0 0.7 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.2 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0 0.3 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.0 0.9 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.5 GO:0005980 glycogen catabolic process(GO:0005980)
0.0 1.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.3 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.0 0.1 GO:0036159 inner dynein arm assembly(GO:0036159)
0.0 7.3 GO:0010608 posttranscriptional regulation of gene expression(GO:0010608)
0.0 4.0 GO:0016579 protein deubiquitination(GO:0016579)
0.0 0.2 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 23.6 GO:0097209 epidermal lamellar body(GO:0097209)
2.2 24.7 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
1.6 13.0 GO:0070876 SOSS complex(GO:0070876)
1.4 17.0 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
1.3 5.0 GO:0071020 post-spliceosomal complex(GO:0071020)
1.0 7.8 GO:0070369 Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369)
0.9 9.2 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.9 3.7 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.6 2.2 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.5 2.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.5 6.4 GO:0016342 catenin complex(GO:0016342)
0.5 9.6 GO:0005916 fascia adherens(GO:0005916)
0.5 1.9 GO:0031592 centrosomal corona(GO:0031592)
0.4 6.7 GO:0032039 integrator complex(GO:0032039)
0.4 5.4 GO:0030314 junctional membrane complex(GO:0030314)
0.4 1.8 GO:0098592 cytoplasmic side of apical plasma membrane(GO:0098592)
0.4 2.6 GO:1990584 cardiac Troponin complex(GO:1990584)
0.4 2.4 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.4 2.2 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.3 2.4 GO:0032437 cuticular plate(GO:0032437)
0.3 2.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.3 7.4 GO:0030054 cell junction(GO:0030054)
0.2 2.2 GO:0051286 cell tip(GO:0051286)
0.2 2.1 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.2 0.8 GO:0031933 telomeric heterochromatin(GO:0031933)
0.2 3.3 GO:0033391 chromatoid body(GO:0033391)
0.2 7.5 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.2 2.5 GO:0042587 glycogen granule(GO:0042587)
0.2 1.6 GO:0044294 dendritic growth cone(GO:0044294)
0.2 16.0 GO:0034707 chloride channel complex(GO:0034707)
0.1 1.9 GO:0097470 ribbon synapse(GO:0097470)
0.1 3.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1 3.6 GO:0005839 proteasome core complex(GO:0005839)
0.1 0.2 GO:0031379 RNA-directed RNA polymerase complex(GO:0031379)
0.1 3.2 GO:0030014 CCR4-NOT complex(GO:0030014)
0.1 1.8 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 2.8 GO:0005614 interstitial matrix(GO:0005614)
0.1 7.6 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 1.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 4.4 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.1 8.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 4.1 GO:0005865 striated muscle thin filament(GO:0005865)
0.1 1.1 GO:0002116 semaphorin receptor complex(GO:0002116)
0.1 2.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 4.4 GO:0032420 stereocilium(GO:0032420)
0.1 1.8 GO:0071004 U2-type prespliceosome(GO:0071004)
0.1 5.8 GO:0045178 basal part of cell(GO:0045178)
0.1 17.2 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 1.1 GO:0005869 dynactin complex(GO:0005869)
0.1 1.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.1 2.1 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 3.2 GO:0005720 nuclear heterochromatin(GO:0005720)
0.1 0.6 GO:0042788 polysomal ribosome(GO:0042788)
0.1 0.6 GO:0055028 cortical microtubule(GO:0055028)
0.1 1.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.1 1.5 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 1.0 GO:0042588 zymogen granule(GO:0042588)
0.1 2.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.2 GO:0031251 PAN complex(GO:0031251)
0.0 0.6 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 2.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 6.3 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 1.0 GO:0005813 centrosome(GO:0005813)
0.0 1.0 GO:0042641 actomyosin(GO:0042641)
0.0 1.3 GO:0031045 dense core granule(GO:0031045)
0.0 0.7 GO:0060077 inhibitory synapse(GO:0060077)
0.0 1.2 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 2.1 GO:1904115 axon cytoplasm(GO:1904115)
0.0 1.0 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 2.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 4.5 GO:0005903 brush border(GO:0005903)
0.0 1.1 GO:0044298 neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298)
0.0 1.2 GO:0035869 ciliary transition zone(GO:0035869)
0.0 1.9 GO:0005776 autophagosome(GO:0005776)
0.0 0.4 GO:0030008 TRAPP complex(GO:0030008)
0.0 1.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.0 3.2 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 1.9 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.2 GO:0045171 intercellular bridge(GO:0045171)
0.0 5.2 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.0 1.7 GO:0043198 dendritic shaft(GO:0043198)
0.0 3.8 GO:0001650 fibrillar center(GO:0001650)
0.0 0.1 GO:0036156 inner dynein arm(GO:0036156)
0.0 3.6 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.2 GO:0032585 multivesicular body membrane(GO:0032585)
0.0 1.2 GO:0035580 specific granule lumen(GO:0035580)
0.0 1.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.1 GO:0000794 condensed nuclear chromosome(GO:0000794)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.8 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
1.3 4.0 GO:0015218 pyrimidine nucleotide transmembrane transporter activity(GO:0015218)
1.3 3.9 GO:0098770 FBXO family protein binding(GO:0098770)
1.2 8.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
1.0 5.0 GO:0000386 second spliceosomal transesterification activity(GO:0000386)
1.0 2.9 GO:0016964 alpha-2 macroglobulin receptor activity(GO:0016964)
1.0 5.9 GO:0009019 tRNA (guanine-N1-)-methyltransferase activity(GO:0009019)
0.8 6.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.8 3.8 GO:0102008 cytosolic dipeptidase activity(GO:0102008)
0.7 3.0 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.7 2.2 GO:0016418 S-acetyltransferase activity(GO:0016418)
0.7 17.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.7 8.5 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.6 2.3 GO:1990175 EH domain binding(GO:1990175)
0.5 4.8 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.5 2.1 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.5 2.5 GO:0050115 myosin-light-chain-phosphatase activity(GO:0050115)
0.5 2.0 GO:0004637 phosphoribosylamine-glycine ligase activity(GO:0004637) phosphoribosylformylglycinamidine cyclo-ligase activity(GO:0004641) phosphoribosylglycinamide formyltransferase activity(GO:0004644)
0.5 3.4 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.5 3.2 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.5 1.4 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.4 5.9 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.4 7.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.4 1.1 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
0.3 4.0 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.3 1.3 GO:1902379 receptor tyrosine kinase-like orphan receptor binding(GO:0005115) chemoattractant activity involved in axon guidance(GO:1902379)
0.3 2.6 GO:0030172 troponin C binding(GO:0030172)
0.3 2.2 GO:0004741 [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.3 8.2 GO:0032794 GTPase activating protein binding(GO:0032794)
0.3 0.9 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.3 2.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.3 2.9 GO:0071532 ankyrin repeat binding(GO:0071532)
0.3 5.8 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.2 2.1 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.2 6.5 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.2 5.3 GO:0048156 tau protein binding(GO:0048156)
0.2 1.6 GO:0031962 mineralocorticoid receptor binding(GO:0031962)
0.2 2.8 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.2 2.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.2 1.9 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.2 0.8 GO:0015616 DNA translocase activity(GO:0015616)
0.2 3.7 GO:0016004 phospholipase activator activity(GO:0016004)
0.2 1.9 GO:0043515 kinetochore binding(GO:0043515)
0.2 10.5 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.2 15.1 GO:0017080 sodium channel regulator activity(GO:0017080)
0.2 1.6 GO:0010853 cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.2 2.2 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.2 1.2 GO:0050733 RS domain binding(GO:0050733)
0.2 0.9 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.2 2.2 GO:0030911 TPR domain binding(GO:0030911)
0.2 1.5 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.2 1.2 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.1 5.3 GO:0008143 poly(A) binding(GO:0008143)
0.1 0.4 GO:0070984 SET domain binding(GO:0070984)
0.1 1.0 GO:0043813 phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity(GO:0043813)
0.1 3.6 GO:0044548 S100 protein binding(GO:0044548)
0.1 4.5 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.1 0.4 GO:0004139 deoxyribose-phosphate aldolase activity(GO:0004139)
0.1 1.0 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 1.4 GO:0016866 intramolecular transferase activity(GO:0016866)
0.1 2.5 GO:0008432 JUN kinase binding(GO:0008432)
0.1 1.4 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.1 31.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 3.5 GO:0070628 proteasome binding(GO:0070628)
0.1 1.3 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 3.0 GO:0070300 phosphatidic acid binding(GO:0070300)
0.1 0.5 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.1 2.1 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 5.0 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 3.5 GO:0017166 vinculin binding(GO:0017166)
0.1 1.7 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.1 3.3 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 1.1 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.1 2.4 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 2.1 GO:0097602 cullin family protein binding(GO:0097602)
0.1 2.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.1 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1 3.1 GO:0005109 frizzled binding(GO:0005109)
0.1 3.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 2.4 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.1 1.8 GO:0017049 GTP-Rho binding(GO:0017049)
0.1 0.5 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.1 4.1 GO:0050699 WW domain binding(GO:0050699)
0.1 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.1 2.8 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 1.8 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 2.1 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 8.7 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 0.4 GO:0043236 laminin binding(GO:0043236)
0.1 1.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.1 1.0 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.1 1.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 1.4 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.0 1.3 GO:0031005 filamin binding(GO:0031005)
0.0 1.3 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.3 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 1.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.3 GO:0034046 poly(G) binding(GO:0034046)
0.0 1.7 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.0 1.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)
0.0 4.2 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0005112 Notch binding(GO:0005112)
0.0 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.0 0.2 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.0 6.4 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 0.7 GO:0044325 ion channel binding(GO:0044325)
0.0 0.5 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 1.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.8 GO:0043621 protein self-association(GO:0043621)
0.0 0.8 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0 0.6 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 1.4 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 4.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 2.3 GO:0008022 protein C-terminus binding(GO:0008022)
0.0 2.5 GO:0008013 beta-catenin binding(GO:0008013)
0.0 7.2 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 2.4 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.4 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 3.3 GO:0008238 exopeptidase activity(GO:0008238)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.7 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 0.3 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 1.4 GO:0043130 ubiquitin binding(GO:0043130)
0.0 1.4 GO:0046332 SMAD binding(GO:0046332)
0.0 9.7 GO:0003682 chromatin binding(GO:0003682)
0.0 0.2 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0 0.3 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 2.2 GO:0004386 helicase activity(GO:0004386)
0.0 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.2 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 5.3 GO:0003924 GTPase activity(GO:0003924)
0.0 0.5 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 1.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 9.6 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.2 GO:0019865 immunoglobulin binding(GO:0019865)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 17.1 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 10.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.2 3.0 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.2 18.0 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 8.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.2 11.5 PID NECTIN PATHWAY Nectin adhesion pathway
0.2 7.2 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.2 15.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 2.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 4.5 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1 3.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 6.9 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 3.7 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 3.9 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 7.9 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 8.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 6.7 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 2.2 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 8.2 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 2.2 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.1 8.4 PID NOTCH PATHWAY Notch signaling pathway
0.1 4.0 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 2.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 1.0 PID S1P S1P4 PATHWAY S1P4 pathway
0.1 8.0 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 2.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 1.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 1.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.1 2.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 2.9 PID ATM PATHWAY ATM pathway
0.1 2.1 PID PI3KCI PATHWAY Class I PI3K signaling events
0.0 1.8 PID INSULIN PATHWAY Insulin Pathway
0.0 1.2 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 2.5 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.0 1.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.3 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 1.0 PID AR PATHWAY Coregulation of Androgen receptor activity

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 22.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.4 28.4 REACTOME G1 PHASE Genes involved in G1 Phase
0.4 1.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.3 3.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2 4.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2 6.5 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 1.0 REACTOME ADP SIGNALLING THROUGH P2RY12 Genes involved in ADP signalling through P2Y purinoceptor 12
0.2 6.5 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 4.1 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1 2.2 REACTOME INTEGRATION OF PROVIRUS Genes involved in Integration of provirus
0.1 6.0 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.1 2.2 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 5.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.1 1.1 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 5.2 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 8.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 3.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 2.2 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.1 4.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 3.8 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 2.0 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 2.4 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 5.6 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 1.1 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.1 4.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.3 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.8 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 2.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.0 1.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.3 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.0 4.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 3.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.6 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0 5.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.6 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.7 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.2 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.0 4.4 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.0 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 1.3 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes