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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for RUNX1_RUNX2
Z-value: 1.55
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Transcription factors associated with RUNX1_RUNX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| RUNX1 | hg19_v2_chr21_-_36421535_36421610 | -0.96 | 2.2e-11 | Click! |
| RUNX2 | hg19_v2_chr6_+_45296048_45296106 | -0.90 | 6.4e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of RUNX1_RUNX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 16.7 | GO:1901750 | leukotriene D4 metabolic process(GO:1901748) leukotriene D4 biosynthetic process(GO:1901750) |
| 0.7 | 14.5 | GO:1990573 | potassium ion import across plasma membrane(GO:1990573) |
| 0.1 | 12.1 | GO:0002223 | stimulatory C-type lectin receptor signaling pathway(GO:0002223) |
| 3.2 | 9.6 | GO:2000502 | negative regulation of natural killer cell chemotaxis(GO:2000502) |
| 0.1 | 9.6 | GO:0050999 | regulation of nitric-oxide synthase activity(GO:0050999) |
| 0.4 | 9.2 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.9 | 8.3 | GO:0046618 | drug export(GO:0046618) |
| 0.7 | 8.0 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 1.8 | 7.2 | GO:2000866 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 0.9 | 7.2 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 37.4 | GO:0005615 | extracellular space(GO:0005615) |
| 0.6 | 15.5 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.2 | 12.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.1 | 10.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 10.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 10.0 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.8 | 7.8 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.1 | 6.9 | GO:0005844 | polysome(GO:0005844) |
| 0.4 | 6.5 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 6.3 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 16.7 | GO:0036374 | glutathione hydrolase activity(GO:0036374) |
| 0.7 | 15.5 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.4 | 11.6 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.3 | 11.5 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 1.4 | 8.4 | GO:0015307 | drug:proton antiporter activity(GO:0015307) |
| 1.6 | 8.2 | GO:0003947 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947) |
| 0.1 | 8.0 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 7.8 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 1.0 | 7.2 | GO:0008955 | peptidoglycan glycosyltransferase activity(GO:0008955) |
| 0.1 | 6.6 | GO:0005245 | voltage-gated calcium channel activity(GO:0005245) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 15.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 10.5 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 9.5 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 8.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 6.1 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 5.2 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.1 | 5.0 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 5.0 | PID INTEGRIN3 PATHWAY | Beta3 integrin cell surface interactions |
| 0.1 | 4.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 4.3 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 14.2 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.3 | 11.4 | REACTOME ACTIVATION OF GENES BY ATF4 | Genes involved in Activation of Genes by ATF4 |
| 0.3 | 10.6 | REACTOME ENOS ACTIVATION AND REGULATION | Genes involved in eNOS activation and regulation |
| 0.1 | 8.6 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.4 | 8.5 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 0.2 | 7.9 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.3 | 7.8 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 7.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.2 | 7.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 7.2 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |