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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SIX1_SIX3_SIX2

Z-value: 0.85

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Transcription factors associated with SIX1_SIX3_SIX2

Gene Symbol Gene ID Gene Info
SIX1
ENSG00000126778.7 SIX homeobox 1
SIX3
ENSG00000138083.3 SIX homeobox 3
SIX2
ENSG00000170577.7 SIX homeobox 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX2hg19_v2_chr2_-_45236540_452365770.642.3e-03Click!
SIX1hg19_v2_chr14_-_61124977_611250370.233.2e-01Click!
SIX3hg19_v2_chr2_+_45168875_45168916-0.155.3e-01Click!

Activity profile of SIX1_SIX3_SIX2 motif

Sorted Z-values of SIX1_SIX3_SIX2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_34654011 3.46 ENST00000531794.1
EHF
ets homologous factor
chr11_-_118135160 2.86 ENST00000438295.2
MPZL2
myelin protein zero-like 2
chr11_-_118134997 2.82 ENST00000278937.2
MPZL2
myelin protein zero-like 2
chr4_+_89514402 1.99 ENST00000426683.1
HERC3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr5_+_125758865 1.92 ENST00000542322.1
ENST00000544396.1
GRAMD3
GRAM domain containing 3
chr5_+_125758813 1.89 ENST00000285689.3
ENST00000515200.1
GRAMD3
GRAM domain containing 3
chrX_+_13587712 1.63 ENST00000361306.1
ENST00000380602.3
EGFL6
EGF-like-domain, multiple 6
chr4_+_89514516 1.59 ENST00000452979.1
HERC3
HECT and RLD domain containing E3 ubiquitin protein ligase 3
chr1_+_160709055 1.50 ENST00000368043.3
ENST00000368042.3
ENST00000458602.2
ENST00000458104.2
SLAMF7
SLAM family member 7
chr1_+_40942887 1.46 ENST00000372706.1
ZFP69
ZFP69 zinc finger protein
chr3_+_42850959 1.45 ENST00000442925.1
ENST00000422265.1
ENST00000497921.1
ENST00000426937.1
ACKR2
KRBOX1
atypical chemokine receptor 2
KRAB box domain containing 1
chr16_-_28550348 1.38 ENST00000324873.6
NUPR1
nuclear protein, transcriptional regulator, 1
chr12_-_15104040 1.36 ENST00000541644.1
ENST00000545895.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr2_-_113594279 1.35 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
IL1B
interleukin 1, beta
chr11_+_71900572 1.34 ENST00000312293.4
FOLR1
folate receptor 1 (adult)
chr1_+_160709029 1.32 ENST00000444090.2
ENST00000441662.2
SLAMF7
SLAM family member 7
chr16_+_58010339 1.30 ENST00000290871.5
ENST00000441824.2
TEPP
testis, prostate and placenta expressed
chr11_+_117947782 1.30 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
TMPRSS4
transmembrane protease, serine 4
chr16_-_28550320 1.30 ENST00000395641.2
NUPR1
nuclear protein, transcriptional regulator, 1
chr1_+_35225339 1.26 ENST00000339480.1
GJB4
gap junction protein, beta 4, 30.3kDa
chr19_-_50836762 1.23 ENST00000474951.1
ENST00000391818.2
KCNC3
potassium voltage-gated channel, Shaw-related subfamily, member 3
chr1_+_152975488 1.22 ENST00000542696.1
SPRR3
small proline-rich protein 3
chr5_+_125759140 1.19 ENST00000543198.1
GRAMD3
GRAM domain containing 3
chr12_-_52845910 1.13 ENST00000252252.3
KRT6B
keratin 6B
chr11_-_59633951 1.13 ENST00000257264.3
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chr6_-_31846744 1.12 ENST00000414427.1
ENST00000229729.6
ENST00000375562.4
SLC44A4
solute carrier family 44, member 4
chr1_+_160709076 1.11 ENST00000359331.4
ENST00000495334.1
SLAMF7
SLAM family member 7
chr11_-_104840093 1.07 ENST00000417440.2
ENST00000444739.2
CASP4
caspase 4, apoptosis-related cysteine peptidase
chr14_+_91709279 1.03 ENST00000554096.1
CTD-2547L24.3
HCG1816139; Uncharacterized protein
chr3_-_111314230 1.02 ENST00000317012.4
ZBED2
zinc finger, BED-type containing 2
chr20_+_44637526 0.97 ENST00000372330.3
MMP9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)
chr10_+_51549498 0.94 ENST00000358559.2
ENST00000298239.6
MSMB
microseminoprotein, beta-
chr3_+_100211412 0.91 ENST00000323523.4
ENST00000403410.1
ENST00000449609.1
TMEM45A
transmembrane protein 45A
chrX_+_56259316 0.89 ENST00000468660.1
KLF8
Kruppel-like factor 8
chr2_-_216240386 0.85 ENST00000438981.1
FN1
fibronectin 1
chr14_-_24729251 0.84 ENST00000559136.1
TGM1
transglutaminase 1
chr19_+_11457175 0.81 ENST00000458408.1
ENST00000586451.1
ENST00000588592.1
CCDC159
coiled-coil domain containing 159
chrX_+_2670066 0.79 ENST00000381174.5
ENST00000419513.2
ENST00000426774.1
XG
Xg blood group
chr11_-_125365435 0.75 ENST00000524435.1
FEZ1
fasciculation and elongation protein zeta 1 (zygin I)
chr16_+_84402098 0.75 ENST00000262429.4
ENST00000416219.2
ATP2C2
ATPase, Ca++ transporting, type 2C, member 2
chr19_+_50015870 0.71 ENST00000599701.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr22_-_43091639 0.69 ENST00000249005.2
ENST00000381278.3
A4GALT
alpha 1,4-galactosyltransferase
chr11_+_117947724 0.66 ENST00000534111.1
TMPRSS4
transmembrane protease, serine 4
chr10_+_48255253 0.65 ENST00000357718.4
ENST00000344416.5
ENST00000456111.2
ENST00000374258.3
ANXA8
AL591684.1
annexin A8
Protein LOC100996760
chr19_-_11039261 0.64 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
YIPF2
Yip1 domain family, member 2
chr17_+_1665345 0.63 ENST00000576406.1
ENST00000571149.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr6_-_150217195 0.62 ENST00000532335.1
RAET1E
retinoic acid early transcript 1E
chr10_-_47173994 0.61 ENST00000414655.2
ENST00000545298.1
ENST00000359178.4
ENST00000358140.4
ENST00000503031.1
ANXA8L1
LINC00842
annexin A8-like 1
long intergenic non-protein coding RNA 842
chr19_-_23578220 0.61 ENST00000595533.1
ENST00000397082.2
ENST00000599743.1
ENST00000300619.7
ZNF91
zinc finger protein 91
chr19_+_50270219 0.60 ENST00000354293.5
ENST00000359032.5
AP2A1
adaptor-related protein complex 2, alpha 1 subunit
chr6_+_28048753 0.60 ENST00000377325.1
ZNF165
zinc finger protein 165
chr7_-_48068643 0.59 ENST00000453192.2
SUN3
Sad1 and UNC84 domain containing 3
chr14_+_91709103 0.59 ENST00000553725.1
CTD-2547L24.3
HCG1816139; Uncharacterized protein
chr19_+_11457232 0.59 ENST00000587531.1
CCDC159
coiled-coil domain containing 159
chr1_+_150245099 0.59 ENST00000369099.3
C1orf54
chromosome 1 open reading frame 54
chr16_+_56642041 0.58 ENST00000245185.5
MT2A
metallothionein 2A
chr12_-_10826612 0.58 ENST00000535345.1
ENST00000542562.1
STYK1
serine/threonine/tyrosine kinase 1
chr3_+_111718036 0.57 ENST00000455401.2
TAGLN3
transgelin 3
chr10_-_33405600 0.57 ENST00000414308.1
RP11-342D11.3
RP11-342D11.3
chr5_-_132073210 0.56 ENST00000378735.1
ENST00000378746.4
KIF3A
kinesin family member 3A
chr22_-_30814469 0.56 ENST00000598426.1
KIAA1658
KIAA1658
chr1_-_149982624 0.55 ENST00000417191.1
ENST00000369135.4
OTUD7B
OTU domain containing 7B
chr9_+_109694914 0.55 ENST00000542028.1
ZNF462
zinc finger protein 462
chr19_+_42055879 0.54 ENST00000407170.2
ENST00000601116.1
ENST00000595395.1
CEACAM21
AC006129.2
carcinoembryonic antigen-related cell adhesion molecule 21
AC006129.2
chr4_+_2794750 0.52 ENST00000452765.2
ENST00000389838.2
SH3BP2
SH3-domain binding protein 2
chr6_-_32160622 0.52 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr6_+_53794780 0.50 ENST00000505762.1
ENST00000511369.1
ENST00000431554.2
MLIP
RP11-411K7.1
muscular LMNA-interacting protein
RP11-411K7.1
chr3_-_196669371 0.50 ENST00000427641.2
ENST00000321256.5
NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr19_+_2867325 0.50 ENST00000307635.2
ENST00000586426.1
ZNF556
zinc finger protein 556
chr14_+_62462541 0.50 ENST00000430451.2
SYT16
synaptotagmin XVI
chr1_-_207119738 0.49 ENST00000356495.4
PIGR
polymeric immunoglobulin receptor
chr1_+_152730499 0.48 ENST00000368773.1
KPRP
keratinocyte proline-rich protein
chr22_-_44258360 0.48 ENST00000330884.4
ENST00000249130.5
SULT4A1
sulfotransferase family 4A, member 1
chr19_-_58446721 0.46 ENST00000396147.1
ENST00000595569.1
ENST00000599852.1
ENST00000425570.3
ENST00000601593.1
ZNF418
zinc finger protein 418
chr2_+_171640291 0.46 ENST00000409885.1
ERICH2
glutamate-rich 2
chr19_+_52996047 0.45 ENST00000601120.1
ZNF578
zinc finger protein 578
chr3_-_196669298 0.45 ENST00000411704.1
ENST00000452404.2
NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr11_+_70244510 0.44 ENST00000346329.3
ENST00000301843.8
ENST00000376561.3
CTTN
cortactin
chr12_-_53901266 0.44 ENST00000609999.1
ENST00000267017.3
NPFF
neuropeptide FF-amide peptide precursor
chr10_+_47746929 0.44 ENST00000340243.6
ENST00000374277.5
ENST00000449464.2
ENST00000538825.1
ENST00000335083.5
ANXA8L2
AL603965.1
annexin A8-like 2
Protein LOC100996760
chr11_-_111794446 0.43 ENST00000527950.1
CRYAB
crystallin, alpha B
chr13_-_46679144 0.43 ENST00000181383.4
CPB2
carboxypeptidase B2 (plasma)
chr18_+_55816546 0.43 ENST00000435432.2
ENST00000357895.5
ENST00000586263.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr3_+_111717600 0.43 ENST00000273368.4
TAGLN3
transgelin 3
chr19_+_16222439 0.43 ENST00000300935.3
RAB8A
RAB8A, member RAS oncogene family
chr19_+_42824511 0.43 ENST00000601644.1
TMEM145
transmembrane protein 145
chr3_-_196669248 0.42 ENST00000447325.1
NCBP2
nuclear cap binding protein subunit 2, 20kDa
chr17_+_6659153 0.42 ENST00000441631.1
ENST00000438512.1
ENST00000346752.4
ENST00000361842.3
XAF1
XIAP associated factor 1
chr3_+_101818088 0.42 ENST00000491959.1
ZPLD1
zona pellucida-like domain containing 1
chr18_+_19192228 0.41 ENST00000300413.5
ENST00000579618.1
ENST00000582475.1
SNRPD1
small nuclear ribonucleoprotein D1 polypeptide 16kDa
chr3_-_74570291 0.40 ENST00000263665.6
CNTN3
contactin 3 (plasmacytoma associated)
chr7_-_48068699 0.40 ENST00000412142.1
ENST00000395572.2
SUN3
Sad1 and UNC84 domain containing 3
chr6_-_35656712 0.39 ENST00000357266.4
ENST00000542713.1
FKBP5
FK506 binding protein 5
chr4_-_153332886 0.39 ENST00000603841.1
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chrX_+_7137475 0.39 ENST00000217961.4
STS
steroid sulfatase (microsomal), isozyme S
chr1_+_15256230 0.38 ENST00000376028.4
ENST00000400798.2
KAZN
kazrin, periplakin interacting protein
chr5_-_142077569 0.38 ENST00000407758.1
ENST00000441680.2
ENST00000419524.2
FGF1
fibroblast growth factor 1 (acidic)
chrX_+_1733876 0.37 ENST00000381241.3
ASMT
acetylserotonin O-methyltransferase
chr16_+_57681338 0.37 ENST00000566187.1
GPR56
G protein-coupled receptor 56
chr7_-_99063769 0.37 ENST00000394186.3
ENST00000359832.4
ENST00000449683.1
ENST00000488775.1
ENST00000523680.1
ENST00000292475.3
ENST00000430982.1
ENST00000555673.1
ENST00000413834.1
ATP5J2
PTCD1
ATP5J2-PTCD1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
pentatricopeptide repeat domain 1
ATP5J2-PTCD1 readthrough
chr1_+_145293371 0.37 ENST00000342960.5
NBPF10
neuroblastoma breakpoint family, member 10
chr7_-_48068671 0.35 ENST00000297325.4
SUN3
Sad1 and UNC84 domain containing 3
chr19_-_15344243 0.35 ENST00000602233.1
EPHX3
epoxide hydrolase 3
chr5_+_81575281 0.34 ENST00000380167.4
ATP6AP1L
ATPase, H+ transporting, lysosomal accessory protein 1-like
chr3_+_197687071 0.34 ENST00000482695.1
ENST00000330198.4
ENST00000419117.1
ENST00000420910.2
ENST00000332636.5
LMLN
leishmanolysin-like (metallopeptidase M8 family)
chr7_+_76751926 0.34 ENST00000285871.4
ENST00000431197.1
CCDC146
coiled-coil domain containing 146
chr11_-_35547151 0.34 ENST00000378878.3
ENST00000529303.1
ENST00000278360.3
PAMR1
peptidase domain containing associated with muscle regeneration 1
chr4_+_71384300 0.33 ENST00000504451.1
AMTN
amelotin
chrX_+_75392771 0.33 ENST00000373358.3
ENST00000373357.3
PBDC1
polysaccharide biosynthesis domain containing 1
chr16_+_29690358 0.33 ENST00000395384.4
ENST00000562473.1
QPRT
quinolinate phosphoribosyltransferase
chr3_+_196669494 0.33 ENST00000602845.1
NCBP2-AS2
NCBP2 antisense RNA 2 (head to head)
chr17_+_1665306 0.33 ENST00000571360.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr1_-_12908578 0.32 ENST00000317869.6
HNRNPCL1
heterogeneous nuclear ribonucleoprotein C-like 1
chr1_-_47082495 0.32 ENST00000545730.1
ENST00000531769.1
ENST00000319928.3
MKNK1
MOB3C
MAP kinase interacting serine/threonine kinase 1
MOB kinase activator 3C
chr20_+_4667094 0.32 ENST00000424424.1
ENST00000457586.1
PRNP
prion protein
chr1_+_174670143 0.32 ENST00000367687.1
ENST00000347255.2
RABGAP1L
RAB GTPase activating protein 1-like
chr1_-_158656488 0.32 ENST00000368147.4
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr11_-_8892900 0.32 ENST00000526155.1
ENST00000524757.1
ENST00000527392.1
ENST00000534665.1
ENST00000525169.1
ENST00000527516.1
ENST00000533471.1
ST5
suppression of tumorigenicity 5
chr17_+_4675175 0.31 ENST00000270560.3
TM4SF5
transmembrane 4 L six family member 5
chr19_+_1026298 0.31 ENST00000263097.4
CNN2
calponin 2
chr19_-_46146946 0.31 ENST00000536630.1
EML2
echinoderm microtubule associated protein like 2
chr19_-_11039188 0.31 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr7_-_141541221 0.31 ENST00000350549.3
ENST00000438520.1
PRSS37
protease, serine, 37
chr11_-_2906979 0.31 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
CDKN1C
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr6_-_138428613 0.31 ENST00000421351.3
PERP
PERP, TP53 apoptosis effector
chr6_+_31802364 0.30 ENST00000375640.3
ENST00000375641.2
C6orf48
chromosome 6 open reading frame 48
chrX_+_1734051 0.30 ENST00000381229.4
ENST00000381233.3
ASMT
acetylserotonin O-methyltransferase
chr19_-_1848451 0.30 ENST00000170168.4
REXO1
REX1, RNA exonuclease 1 homolog (S. cerevisiae)
chr1_+_38022572 0.30 ENST00000541606.1
DNALI1
dynein, axonemal, light intermediate chain 1
chr3_+_111718173 0.30 ENST00000494932.1
TAGLN3
transgelin 3
chr4_+_11470867 0.30 ENST00000515343.1
RP11-281P23.1
RP11-281P23.1
chr19_-_37407172 0.30 ENST00000391711.3
ZNF829
zinc finger protein 829
chr1_+_17531614 0.29 ENST00000375471.4
PADI1
peptidyl arginine deiminase, type I
chr7_+_141490017 0.29 ENST00000247883.4
TAS2R5
taste receptor, type 2, member 5
chr14_-_24740709 0.29 ENST00000399409.3
ENST00000216840.6
RABGGTA
Rab geranylgeranyltransferase, alpha subunit
chr1_-_109618566 0.29 ENST00000338366.5
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr1_-_42800614 0.29 ENST00000372572.1
FOXJ3
forkhead box J3
chr6_-_137365402 0.29 ENST00000541547.1
IL20RA
interleukin 20 receptor, alpha
chr1_+_150245177 0.29 ENST00000369098.3
C1orf54
chromosome 1 open reading frame 54
chr20_+_62694834 0.28 ENST00000415602.1
TCEA2
transcription elongation factor A (SII), 2
chr6_-_35656685 0.28 ENST00000539068.1
ENST00000540787.1
FKBP5
FK506 binding protein 5
chr7_+_95171457 0.28 ENST00000601424.1
AC002451.1
Protein LOC100996577
chr19_+_17420340 0.28 ENST00000359866.4
DDA1
DET1 and DDB1 associated 1
chr17_+_6915902 0.28 ENST00000570898.1
ENST00000552842.1
RNASEK
ribonuclease, RNase K
chr14_-_24911448 0.27 ENST00000555355.1
ENST00000553343.1
ENST00000556523.1
ENST00000556249.1
ENST00000538105.2
ENST00000555225.1
SDR39U1
short chain dehydrogenase/reductase family 39U, member 1
chr17_+_6915798 0.27 ENST00000402093.1
RNASEK
ribonuclease, RNase K
chr16_-_29517141 0.27 ENST00000550665.1
RP11-231C14.4
Uncharacterized protein
chr7_-_92219337 0.27 ENST00000456502.1
ENST00000427372.1
FAM133B
family with sequence similarity 133, member B
chr1_+_196946664 0.26 ENST00000367414.5
CFHR5
complement factor H-related 5
chr1_+_145293114 0.26 ENST00000369338.1
NBPF10
neuroblastoma breakpoint family, member 10
chr2_+_217498105 0.26 ENST00000233809.4
IGFBP2
insulin-like growth factor binding protein 2, 36kDa
chr17_-_59668550 0.26 ENST00000521764.1
NACA2
nascent polypeptide-associated complex alpha subunit 2
chr10_-_103603677 0.25 ENST00000358038.3
KCNIP2
Kv channel interacting protein 2
chr7_-_6865826 0.25 ENST00000538180.1
CCZ1B
CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
chr4_-_156297949 0.25 ENST00000515654.1
MAP9
microtubule-associated protein 9
chr7_+_139026057 0.25 ENST00000541515.3
LUC7L2
LUC7-like 2 (S. cerevisiae)
chr8_+_42195972 0.25 ENST00000532157.1
ENST00000265421.4
ENST00000520008.1
POLB
polymerase (DNA directed), beta
chr3_+_49977440 0.25 ENST00000442092.1
ENST00000266022.4
ENST00000443081.1
RBM6
RNA binding motif protein 6
chr12_-_6756609 0.25 ENST00000229243.2
ACRBP
acrosin binding protein
chr11_-_47788847 0.25 ENST00000263773.5
FNBP4
formin binding protein 4
chr1_+_158149737 0.25 ENST00000368171.3
CD1D
CD1d molecule
chr19_+_1269324 0.25 ENST00000589710.1
ENST00000588230.1
ENST00000413636.2
ENST00000586472.1
ENST00000589686.1
ENST00000444172.2
ENST00000587323.1
ENST00000320936.5
ENST00000587896.1
ENST00000589235.1
ENST00000591659.1
CIRBP
cold inducible RNA binding protein
chr1_+_28562617 0.25 ENST00000497986.1
ENST00000335514.5
ENST00000468425.2
ENST00000465645.1
ATPIF1
ATPase inhibitory factor 1
chr4_-_860950 0.24 ENST00000511980.1
ENST00000510799.1
GAK
cyclin G associated kinase
chr6_-_11779014 0.24 ENST00000229583.5
ADTRP
androgen-dependent TFPI-regulating protein
chr3_+_44754126 0.24 ENST00000449836.1
ENST00000436624.2
ENST00000296091.4
ENST00000411443.1
ZNF502
zinc finger protein 502
chr10_-_43762329 0.24 ENST00000395810.1
RASGEF1A
RasGEF domain family, member 1A
chr7_-_1609591 0.24 ENST00000288607.2
ENST00000404674.3
PSMG3
proteasome (prosome, macropain) assembly chaperone 3
chr13_-_46679185 0.24 ENST00000439329.3
CPB2
carboxypeptidase B2 (plasma)
chr13_+_115047053 0.24 ENST00000375299.3
UPF3A
UPF3 regulator of nonsense transcripts homolog A (yeast)
chr11_+_64323156 0.24 ENST00000377585.3
SLC22A11
solute carrier family 22 (organic anion/urate transporter), member 11
chr16_-_15463926 0.24 ENST00000432570.2
NPIPA5
nuclear pore complex interacting protein family, member A5
chr15_-_43212996 0.24 ENST00000567840.1
TTBK2
tau tubulin kinase 2
chr7_+_158649242 0.24 ENST00000407559.3
WDR60
WD repeat domain 60
chr19_+_17579556 0.23 ENST00000442725.1
SLC27A1
solute carrier family 27 (fatty acid transporter), member 1
chr16_+_57680840 0.23 ENST00000563862.1
ENST00000564722.1
ENST00000569158.1
GPR56
G protein-coupled receptor 56
chr22_-_44258280 0.23 ENST00000540422.1
SULT4A1
sulfotransferase family 4A, member 1
chr15_-_43212836 0.23 ENST00000566931.1
ENST00000564431.1
ENST00000567274.1
TTBK2
tau tubulin kinase 2
chr20_+_44074071 0.23 ENST00000595203.1
AL031663.2
CDNA FLJ26875 fis, clone PRS08969; Uncharacterized protein
chr17_+_76142434 0.23 ENST00000340363.5
ENST00000586999.1
C17orf99
chromosome 17 open reading frame 99
chr7_+_72349920 0.23 ENST00000395270.1
ENST00000446813.1
ENST00000257622.4
POM121
POM121 transmembrane nucleoporin
chr9_+_131644398 0.23 ENST00000372599.3
LRRC8A
leucine rich repeat containing 8 family, member A
chr1_+_207277590 0.23 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr3_-_196230590 0.22 ENST00000318037.3
RNF168
ring finger protein 168, E3 ubiquitin protein ligase
chr15_-_31521567 0.22 ENST00000560812.1
ENST00000559853.1
ENST00000558109.1
RP11-16E12.2
RP11-16E12.2
chr21_+_27011584 0.22 ENST00000400532.1
ENST00000480456.1
ENST00000312957.5
JAM2
junctional adhesion molecule 2
chr3_+_184530173 0.22 ENST00000453056.1
VPS8
vacuolar protein sorting 8 homolog (S. cerevisiae)
chr1_-_159046617 0.21 ENST00000368130.4
AIM2
absent in melanoma 2
chr2_+_208414985 0.21 ENST00000414681.1
CREB1
cAMP responsive element binding protein 1
chr22_+_32455111 0.21 ENST00000543737.1
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1
chr3_+_127771212 0.21 ENST00000243253.3
ENST00000481210.1
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chr18_-_53257027 0.21 ENST00000568740.1
ENST00000564403.2
ENST00000537578.1
TCF4
transcription factor 4
chr17_+_6915730 0.20 ENST00000548577.1
RNASEK
ribonuclease, RNase K
chr10_-_134331695 0.20 ENST00000455414.1
RP11-432J24.5
RP11-432J24.5
chr4_-_140477910 0.20 ENST00000404104.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr1_-_171711387 0.20 ENST00000236192.7
VAMP4
vesicle-associated membrane protein 4
chr3_-_10028366 0.20 ENST00000429759.1
EMC3
ER membrane protein complex subunit 3
chr14_+_104095514 0.20 ENST00000348520.6
ENST00000380038.3
ENST00000389744.4
ENST00000557575.1
ENST00000553286.1
ENST00000347839.6
ENST00000555836.1
ENST00000334553.6
ENST00000246489.7
ENST00000557450.1
ENST00000452929.2
ENST00000554280.1
ENST00000445352.4
KLC1
kinesin light chain 1
chr9_+_131644388 0.20 ENST00000372600.4
LRRC8A
leucine rich repeat containing 8 family, member A
chr1_+_16330723 0.20 ENST00000329454.2
C1orf64
chromosome 1 open reading frame 64

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX1_SIX3_SIX2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0003147 neural crest cell migration involved in heart formation(GO:0003147) anterior neural tube closure(GO:0061713)
0.3 1.4 GO:0046833 snRNA export from nucleus(GO:0006408) positive regulation of RNA export from nucleus(GO:0046833)
0.3 0.8 GO:1904237 regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904235) positive regulation of substrate-dependent cell migration, cell attachment to substrate(GO:1904237)
0.2 0.7 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.2 0.7 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.2 1.1 GO:0032474 otolith morphogenesis(GO:0032474)
0.2 1.4 GO:0071461 cellular response to redox state(GO:0071461)
0.2 1.3 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.2 0.7 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.2 0.6 GO:1900138 negative regulation of phospholipase A2 activity(GO:1900138)
0.2 0.6 GO:0070894 transposon integration(GO:0070893) regulation of transposon integration(GO:0070894) negative regulation of transposon integration(GO:0070895)
0.2 0.6 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.6 GO:0010273 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1 0.4 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
0.1 1.0 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.1 0.8 GO:0043163 cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229)
0.1 0.7 GO:0001575 globoside metabolic process(GO:0001575)
0.1 0.3 GO:0070175 positive regulation of enamel mineralization(GO:0070175)
0.1 0.4 GO:0070253 somatostatin secretion(GO:0070253)
0.1 1.0 GO:0051549 positive regulation of keratinocyte migration(GO:0051549)
0.1 0.3 GO:1990535 neuron projection maintenance(GO:1990535)
0.1 0.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 1.1 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.1 1.2 GO:0042048 olfactory behavior(GO:0042048)
0.1 1.7 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 1.1 GO:0015889 cobalt ion transport(GO:0006824) cobalamin transport(GO:0015889)
0.1 0.2 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
0.1 0.2 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 0.6 GO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.1 0.4 GO:2000638 regulation of SREBP signaling pathway(GO:2000638) negative regulation of SREBP signaling pathway(GO:2000639)
0.1 0.2 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.1 0.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.2 GO:1905224 clathrin-coated pit assembly(GO:1905224)
0.1 0.3 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.1 0.1 GO:0007538 primary sex determination(GO:0007538)
0.1 0.6 GO:0015747 urate transport(GO:0015747)
0.1 0.4 GO:0019236 response to pheromone(GO:0019236)
0.1 0.8 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.0 1.3 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.0 4.3 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.5 GO:0045919 positive regulation of cytolysis(GO:0045919)
0.0 0.1 GO:0072011 glomerular endothelium development(GO:0072011)
0.0 0.2 GO:0044028 DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029)
0.0 0.2 GO:0035617 stress granule disassembly(GO:0035617)
0.0 0.3 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 0.4 GO:0002329 pre-B cell differentiation(GO:0002329)
0.0 0.3 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.4 GO:0030450 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959)
0.0 0.4 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.4 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.3 GO:0072526 pyridine-containing compound catabolic process(GO:0072526)
0.0 0.2 GO:1904925 positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.0 0.6 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.0 0.2 GO:0006620 posttranslational protein targeting to membrane(GO:0006620) pronephric nephron development(GO:0039019)
0.0 0.1 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0 0.2 GO:0003366 cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0 0.2 GO:1904158 axonemal central apparatus assembly(GO:1904158)
0.0 0.2 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.1 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.0 0.4 GO:2000544 cell chemotaxis to fibroblast growth factor(GO:0035766) endothelial cell chemotaxis to fibroblast growth factor(GO:0035768) regulation of cell chemotaxis to fibroblast growth factor(GO:1904847) regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000544)
0.0 0.2 GO:0003068 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.0 0.2 GO:0044789 modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0 0.2 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0 0.3 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.2 GO:0008218 bioluminescence(GO:0008218)
0.0 0.1 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.0 0.3 GO:0071988 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0 0.5 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 1.1 GO:0007398 ectoderm development(GO:0007398)
0.0 0.2 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.3 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 0.2 GO:0060424 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.0 0.2 GO:0032445 fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0 0.2 GO:0070269 pyroptosis(GO:0070269)
0.0 0.2 GO:0001951 intestinal D-glucose absorption(GO:0001951)
0.0 4.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:0061458 reproductive system development(GO:0061458)
0.0 0.1 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.0 0.3 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.0 1.2 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.0 0.3 GO:0002934 desmosome organization(GO:0002934)
0.0 0.4 GO:0007021 tubulin complex assembly(GO:0007021)
0.0 0.2 GO:0070535 histone H2A K63-linked ubiquitination(GO:0070535)
0.0 0.8 GO:0034035 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.2 GO:0019614 catechol-containing compound catabolic process(GO:0019614) catecholamine catabolic process(GO:0042424)
0.0 0.1 GO:0009258 10-formyltetrahydrofolate catabolic process(GO:0009258)
0.0 0.3 GO:0007635 chemosensory behavior(GO:0007635)
0.0 0.8 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.1 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0 0.3 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)
0.0 0.1 GO:1902161 positive regulation of cyclic nucleotide-gated ion channel activity(GO:1902161)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.0 0.1 GO:0097194 execution phase of apoptosis(GO:0097194)
0.0 0.1 GO:0046462 monoacylglycerol metabolic process(GO:0046462) monoacylglycerol catabolic process(GO:0052651)
0.0 1.3 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.0 0.1 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.1 GO:1901297 positive regulation of ephrin receptor signaling pathway(GO:1901189) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.6 GO:0043304 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.0 0.4 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.4 GO:0006706 steroid catabolic process(GO:0006706)
0.0 0.3 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.0 0.1 GO:0009804 coumarin metabolic process(GO:0009804)
0.0 0.3 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.0 0.1 GO:0009730 detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0 0.2 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.0 0.6 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0005846 nuclear cap binding complex(GO:0005846)
0.1 0.6 GO:0016939 kinesin II complex(GO:0016939)
0.1 1.0 GO:0097169 AIM2 inflammasome complex(GO:0097169)
0.1 0.2 GO:0031021 interphase microtubule organizing center(GO:0031021)
0.1 0.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.7 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.1 0.3 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.1 0.4 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.1 0.4 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 1.3 GO:0034992 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.2 GO:0032591 dendritic spine membrane(GO:0032591)
0.0 1.3 GO:0005922 connexon complex(GO:0005922)
0.0 1.0 GO:0043203 axon hillock(GO:0043203)
0.0 0.3 GO:0032437 cuticular plate(GO:0032437)
0.0 0.3 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.0 0.2 GO:0034669 integrin alpha4-beta7 complex(GO:0034669)
0.0 0.6 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 2.4 GO:0001533 cornified envelope(GO:0001533)
0.0 0.1 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.3 GO:0033263 CORVET complex(GO:0033263)
0.0 0.2 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.3 GO:0055028 cortical microtubule(GO:0055028)
0.0 0.1 GO:0005602 complement component C1 complex(GO:0005602)
0.0 0.1 GO:0097441 basilar dendrite(GO:0097441) glial limiting end-foot(GO:0097451)
0.0 2.5 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.4 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.3 GO:0033180 proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
0.0 0.3 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 0.1 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.2 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.0 0.2 GO:0032010 phagolysosome(GO:0032010)
0.0 0.6 GO:0035869 ciliary transition zone(GO:0035869)
0.0 0.3 GO:0072686 mitotic spindle(GO:0072686)
0.0 0.2 GO:0005943 phosphatidylinositol 3-kinase complex, class IA(GO:0005943)
0.0 0.1 GO:0097181 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.0 1.0 GO:0016235 aggresome(GO:0016235)
0.0 0.3 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.2 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 2.8 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.8 GO:0005604 basement membrane(GO:0005604)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0061714 folic acid receptor activity(GO:0061714)
0.1 0.7 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.1 GO:0045118 azole transporter activity(GO:0045118)
0.1 1.4 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.1 0.5 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.1 1.4 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.1 1.4 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 1.1 GO:0031419 cobalamin binding(GO:0031419)
0.1 0.7 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 0.2 GO:0030272 5-formyltetrahydrofolate cyclo-ligase activity(GO:0030272)
0.1 0.3 GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.1 0.2 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.1 0.8 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 0.3 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.1 0.6 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 1.3 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.3 GO:1903135 cupric ion binding(GO:1903135)
0.1 0.2 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160)
0.0 0.4 GO:0050816 phosphothreonine binding(GO:0050816)
0.0 0.3 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.0 0.3 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0004961 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.0 0.2 GO:0004060 arylamine N-acetyltransferase activity(GO:0004060)
0.0 1.1 GO:0050700 CARD domain binding(GO:0050700)
0.0 1.3 GO:0043495 protein anchor(GO:0043495)
0.0 0.6 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 0.4 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 0.6 GO:0046870 cadmium ion binding(GO:0046870)
0.0 0.3 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250) ER retention sequence binding(GO:0046923)
0.0 0.7 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.8 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.1 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0 0.4 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.2 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 0.2 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.0 0.2 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.2 GO:0003696 satellite DNA binding(GO:0003696)
0.0 0.1 GO:1904492 Ac-Asp-Glu binding(GO:1904492) tetrahydrofolyl-poly(glutamate) polymer binding(GO:1904493)
0.0 0.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.0 0.2 GO:1990763 arrestin family protein binding(GO:1990763)
0.0 0.2 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.0 0.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.6 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0 0.1 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.0 0.7 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.1 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.0 0.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 2.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.1 GO:0004766 spermidine synthase activity(GO:0004766)
0.0 0.4 GO:0005522 profilin binding(GO:0005522)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.2 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
0.0 0.3 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.0 0.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.4 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.2 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.1 GO:0030377 urokinase plasminogen activator receptor activity(GO:0030377)
0.0 0.6 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 0.0 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.5 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0043199 sulfate binding(GO:0043199)
0.0 0.1 GO:0016155 formyltetrahydrofolate dehydrogenase activity(GO:0016155)
0.0 0.2 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.2 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.1 GO:0005260 channel-conductance-controlling ATPase activity(GO:0005260)
0.0 0.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.4 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 0.1 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.0 0.4 GO:0035615 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 1.7 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0015245 fatty acid transporter activity(GO:0015245)
0.0 0.3 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.1 GO:0033695 oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0 0.1 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.0 0.4 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
0.0 0.2 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.2 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.0 GO:0004958 prostaglandin F receptor activity(GO:0004958)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.3 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.1 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 2.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.1 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 0.6 PID ARF 3PATHWAY Arf1 pathway
0.0 0.4 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.4 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1 1.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.1 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 1.1 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.6 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 0.9 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.4 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 1.3 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 0.4 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.3 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.2 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 0.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.2 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0 0.4 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 0.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.0 0.3 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.2 REACTOME SPRY REGULATION OF FGF SIGNALING Genes involved in Spry regulation of FGF signaling