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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SIX4

Z-value: 0.53

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Transcription factors associated with SIX4

Gene Symbol Gene ID Gene Info
ENSG00000100625.8 SIX homeobox 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SIX4hg19_v2_chr14_-_61190754_611908520.272.5e-01Click!

Activity profile of SIX4 motif

Sorted Z-values of SIX4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_117947782 2.05 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
transmembrane protease, serine 4
chr12_+_8975061 1.62 ENST00000299698.7
alpha-2-macroglobulin-like 1
chr17_-_39684550 1.39 ENST00000455635.1
ENST00000361566.3
keratin 19
chr14_+_21510385 1.36 ENST00000298690.4
ribonuclease, RNase A family, 7
chr8_+_144798429 1.26 ENST00000338033.4
ENST00000395107.4
ENST00000395108.2
mitogen-activated protein kinase 15
chr11_+_117947724 1.21 ENST00000534111.1
transmembrane protease, serine 4
chr2_+_85811525 1.09 ENST00000306384.4
vesicle-associated membrane protein 5
chr20_-_45530365 1.04 ENST00000414085.1
RP11-323C15.2
chr3_-_69249863 0.98 ENST00000478263.1
ENST00000462512.1
FERM domain containing 4B
chr12_-_4488872 0.69 ENST00000237837.1
fibroblast growth factor 23
chr19_+_13134772 0.57 ENST00000587760.1
ENST00000585575.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr11_-_96076334 0.56 ENST00000524717.1
mastermind-like 2 (Drosophila)
chr1_-_109849612 0.54 ENST00000357155.1
myosin binding protein H-like
chr1_-_207119738 0.52 ENST00000356495.4
polymeric immunoglobulin receptor
chr1_+_38022572 0.51 ENST00000541606.1
dynein, axonemal, light intermediate chain 1
chr7_-_99063769 0.51 ENST00000394186.3
ENST00000359832.4
ENST00000449683.1
ENST00000488775.1
ENST00000523680.1
ENST00000292475.3
ENST00000430982.1
ENST00000555673.1
ENST00000413834.1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
pentatricopeptide repeat domain 1
ATP5J2-PTCD1 readthrough
chr19_+_13135386 0.44 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr3_-_183967296 0.44 ENST00000455059.1
ENST00000445626.2
ALG3, alpha-1,3- mannosyltransferase
chr1_+_116915855 0.42 ENST00000295598.5
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr6_+_53794780 0.41 ENST00000505762.1
ENST00000511369.1
ENST00000431554.2
muscular LMNA-interacting protein
RP11-411K7.1
chr7_+_69064300 0.40 ENST00000342771.4
autism susceptibility candidate 2
chr19_+_19174795 0.38 ENST00000318596.7
solute carrier family 25, member 42
chr1_-_42800860 0.36 ENST00000445886.1
ENST00000361346.1
ENST00000361776.1
forkhead box J3
chr8_-_6115044 0.35 ENST00000519555.1
RP11-124B13.1
chr11_+_117049854 0.34 ENST00000278951.7
SID1 transmembrane family, member 2
chr11_+_117049910 0.34 ENST00000431081.2
ENST00000524842.1
SID1 transmembrane family, member 2
chr11_-_2906979 0.34 ENST00000380725.1
ENST00000313407.6
ENST00000430149.2
ENST00000440480.2
ENST00000414822.3
cyclin-dependent kinase inhibitor 1C (p57, Kip2)
chr6_+_41040678 0.33 ENST00000341376.6
ENST00000353205.5
nuclear transcription factor Y, alpha
chr10_+_7860460 0.33 ENST00000344293.5
TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
chr1_-_42800614 0.32 ENST00000372572.1
forkhead box J3
chr14_-_67981916 0.32 ENST00000357461.2
transmembrane protein 229B
chr1_-_42801540 0.30 ENST00000372573.1
forkhead box J3
chr1_-_32264356 0.30 ENST00000452755.2
SPOC domain containing 1
chr1_+_17559776 0.29 ENST00000537499.1
ENST00000413717.2
ENST00000536552.1
peptidyl arginine deiminase, type I
chr11_-_35547572 0.29 ENST00000378880.2
peptidase domain containing associated with muscle regeneration 1
chr1_-_38061522 0.29 ENST00000373062.3
guanine nucleotide binding protein-like 2 (nucleolar)
chr19_+_50270219 0.29 ENST00000354293.5
ENST00000359032.5
adaptor-related protein complex 2, alpha 1 subunit
chr1_+_35734562 0.29 ENST00000314607.6
ENST00000373297.2
zinc finger, MYM-type 4
chr4_+_11470867 0.27 ENST00000515343.1
RP11-281P23.1
chr6_-_41040268 0.27 ENST00000373154.2
ENST00000244558.9
ENST00000464633.1
ENST00000424266.2
ENST00000479950.1
ENST00000482515.1
O-acyl-ADP-ribose deacylase 1
chr3_-_183966717 0.27 ENST00000446569.1
ENST00000418734.2
ENST00000397676.3
ALG3, alpha-1,3- mannosyltransferase
chr19_+_11466167 0.26 ENST00000591608.1
Lipid phosphate phosphatase-related protein type 2
chrX_+_54466829 0.26 ENST00000375151.4
TSR2, 20S rRNA accumulation, homolog (S. cerevisiae)
chr11_+_117049445 0.26 ENST00000324225.4
ENST00000532960.1
SID1 transmembrane family, member 2
chr20_-_52687059 0.25 ENST00000371435.2
ENST00000395961.3
breast carcinoma amplified sequence 1
chr10_-_131762105 0.23 ENST00000368648.3
ENST00000355311.5
early B-cell factor 3
chr6_-_41040195 0.21 ENST00000463088.1
ENST00000469104.1
ENST00000486443.1
O-acyl-ADP-ribose deacylase 1
chr16_+_640201 0.20 ENST00000563109.1
RAB40C, member RAS oncogene family
chr4_-_2420335 0.19 ENST00000503000.1
zinc finger, FYVE domain containing 28
chr11_-_130184470 0.18 ENST00000357899.4
ENST00000397753.1
zinc finger and BTB domain containing 44
chr10_+_102759045 0.18 ENST00000370220.1
leucine zipper, putative tumor suppressor 2
chr12_-_10282742 0.17 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
C-type lectin domain family 7, member A
chr5_+_78365577 0.17 ENST00000518666.1
ENST00000521567.1
betaine--homocysteine S-methyltransferase 2
chr11_+_2415061 0.17 ENST00000481687.1
CD81 molecule
chr11_-_130184555 0.16 ENST00000525842.1
zinc finger and BTB domain containing 44
chr1_-_78148324 0.16 ENST00000370801.3
ENST00000433749.1
zinc finger, ZZ-type containing 3
chr5_-_78365437 0.14 ENST00000380311.4
ENST00000540686.1
ENST00000255189.3
dimethylglycine dehydrogenase
chr7_-_38969150 0.14 ENST00000418457.2
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr7_+_97361218 0.14 ENST00000319273.5
tachykinin, precursor 1
chr1_-_32264250 0.13 ENST00000528579.1
SPOC domain containing 1
chr5_+_78365536 0.13 ENST00000255192.3
betaine--homocysteine S-methyltransferase 2
chr1_+_161123536 0.13 ENST00000368003.5
ubiquitin-fold modifier conjugating enzyme 1
chr20_-_43150601 0.12 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
serine incorporator 3
chr10_+_26505179 0.12 ENST00000376261.3
glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
chr13_+_33160553 0.12 ENST00000315596.10
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chrX_+_41583408 0.11 ENST00000302548.4
G protein-coupled receptor 82
chr20_+_57875457 0.11 ENST00000337938.2
ENST00000311585.7
ENST00000371028.2
endothelin 3
chr11_+_125462690 0.11 ENST00000392708.4
ENST00000529196.1
ENST00000531491.1
STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
chr11_+_34073269 0.11 ENST00000389645.3
cell cycle associated protein 1
chr7_-_111428957 0.10 ENST00000417165.1
dedicator of cytokinesis 4
chr1_+_226250379 0.10 ENST00000366815.3
ENST00000366814.3
H3 histone, family 3A
chr4_+_90823130 0.10 ENST00000508372.1
multimerin 1
chr1_+_149239529 0.10 ENST00000457216.2
RP11-403I13.4
chr10_+_50507232 0.10 ENST00000374144.3
chromosome 10 open reading frame 71
chr20_-_4055812 0.09 ENST00000379526.1
Uncharacterized protein
chr19_+_11466062 0.08 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
Lipid phosphate phosphatase-related protein type 2
chr5_-_175788758 0.08 ENST00000510164.1
ENST00000533553.1
ENST00000504688.1
ENST00000393725.2
ENST00000503082.1
ENST00000506983.1
KIAA1191
chr4_+_2420659 0.07 ENST00000382849.2
RP11-503N18.1
chr2_-_113999260 0.07 ENST00000468980.2
paired box 8
chr1_-_114414316 0.07 ENST00000528414.1
ENST00000538253.1
ENST00000460620.1
ENST00000420377.2
ENST00000525799.1
ENST00000359785.5
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
chr17_+_15635561 0.07 ENST00000584301.1
ENST00000580596.1
ENST00000464963.1
ENST00000437605.2
ENST00000579428.1
TBC1 domain family, member 26
chr17_-_18547731 0.06 ENST00000575220.1
ENST00000405044.1
ENST00000572213.1
ENST00000573652.1
TBC1 domain family, member 28
chr6_+_1080164 0.06 ENST00000314040.1
Uncharacterized protein; cDNA FLJ34594 fis, clone KIDNE2009109
chr17_-_61523622 0.06 ENST00000448884.2
ENST00000582297.1
ENST00000582034.1
ENST00000578072.1
ENST00000360793.3
cytochrome b561
chr2_-_180427304 0.06 ENST00000336917.5
zinc finger protein 385B
chrX_-_152160740 0.06 ENST00000361887.5
ENST00000439251.1
ENST00000452693.1
paraneoplastic Ma antigen family member 5
chr12_+_4829507 0.06 ENST00000252318.2
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 8 (GalNAc-T8)
chr14_-_67981870 0.05 ENST00000555994.1
transmembrane protein 229B
chrX_+_56100757 0.05 ENST00000433279.1
Uncharacterized protein
chr7_+_97361388 0.05 ENST00000350485.4
ENST00000346867.4
tachykinin, precursor 1
chr1_-_231473578 0.05 ENST00000360394.2
ENST00000366645.1
exocyst complex component 8
chr22_-_39268308 0.05 ENST00000407418.3
chromobox homolog 6
chr1_-_173176452 0.04 ENST00000281834.3
tumor necrosis factor (ligand) superfamily, member 4
chr12_-_10282836 0.04 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
C-type lectin domain family 7, member A
chr2_-_61244308 0.04 ENST00000407787.1
ENST00000398658.2
pseudouridylate synthase 10
chr3_-_122712079 0.04 ENST00000393583.2
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
chr3_+_183967409 0.04 ENST00000324557.4
ENST00000402825.3
endothelin converting enzyme 2
chr14_-_94984181 0.04 ENST00000341228.2
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
chr2_+_101223490 0.03 ENST00000414647.1
ENST00000424342.1
AC068538.4
chr1_-_152196669 0.03 ENST00000368801.2
hornerin
chr4_-_170897045 0.03 ENST00000508313.1
RP11-205M3.3
chr10_+_88414298 0.03 ENST00000372071.2
opsin 4
chr12_+_30948865 0.03 ENST00000547804.1
long intergenic non-protein coding RNA 941
chr3_+_107602030 0.03 ENST00000494231.1
long intergenic non-protein coding RNA 636
chr11_+_46958248 0.02 ENST00000536126.1
ENST00000278460.7
ENST00000378618.2
ENST00000395460.2
ENST00000378615.3
ENST00000543718.1
chromosome 11 open reading frame 49
chr11_+_33279850 0.02 ENST00000531504.1
ENST00000456517.1
homeodomain interacting protein kinase 3
chr5_+_149569520 0.02 ENST00000230671.2
ENST00000524041.1
solute carrier family 6 (neurotransmitter transporter), member 7
chr3_+_72200408 0.02 ENST00000473713.1
long intergenic non-protein coding RNA 870
chr8_+_95907993 0.02 ENST00000523378.1
NADH dehydrogenase (ubiquinone) complex I, assembly factor 6
chr7_+_2687173 0.02 ENST00000403167.1
tweety family member 3
chr10_+_88414338 0.02 ENST00000241891.5
ENST00000443292.1
opsin 4
chr8_+_132916318 0.02 ENST00000254624.5
ENST00000522709.1
EFR3 homolog A (S. cerevisiae)
chr14_-_106692191 0.02 ENST00000390607.2
immunoglobulin heavy variable 3-21
chr19_+_13135439 0.01 ENST00000586873.1
nuclear factor I/X (CCAAT-binding transcription factor)

Network of associatons between targets according to the STRING database.

First level regulatory network of SIX4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0051673 membrane disruption in other organism(GO:0051673)
0.2 0.7 GO:0010980 regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980) vitamin D catabolic process(GO:0042369)
0.1 0.4 GO:0035349 coenzyme A transport(GO:0015880) coenzyme A transmembrane transport(GO:0035349) adenosine 3',5'-bisphosphate transmembrane transport(GO:0071106) AMP transport(GO:0080121)
0.1 0.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1 0.3 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1 0.2 GO:2000854 positive regulation of corticosterone secretion(GO:2000854)
0.1 0.9 GO:0033227 dsRNA transport(GO:0033227)
0.1 0.3 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.1 0.5 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.0 0.1 GO:0006579 amino-acid betaine catabolic process(GO:0006579)
0.0 1.3 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.0 0.4 GO:0031944 negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.0 0.6 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.0 0.5 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.0 0.3 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.0 0.2 GO:0043128 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
0.0 0.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.1 GO:0060623 pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.0 0.3 GO:0071267 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.0 0.1 GO:2000612 thyroid-stimulating hormone secretion(GO:0070460) regulation of thyroid-stimulating hormone secretion(GO:2000612)
0.0 0.1 GO:0006540 glutamate decarboxylation to succinate(GO:0006540)
0.0 1.4 GO:0060706 cell differentiation involved in embryonic placenta development(GO:0060706)
0.0 0.0 GO:2000569 T-helper 2 cell activation(GO:0035712) regulation of T-helper 2 cell activation(GO:2000569) positive regulation of T-helper 2 cell activation(GO:2000570)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.1 GO:0014826 vein smooth muscle contraction(GO:0014826)
0.0 0.1 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 1.0 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 0.1 GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.0 1.1 GO:0043001 Golgi to plasma membrane protein transport(GO:0043001)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 0.1 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.2 GO:0009756 carbohydrate mediated signaling(GO:0009756)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:1990357 terminal web(GO:1990357)
0.0 0.3 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.5 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.3 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.5 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.1 GO:0033263 CORVET complex(GO:0033263)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 1.1 GO:0031201 SNARE complex(GO:0031201)
0.0 0.0 GO:0036457 keratohyalin granule(GO:0036457)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.2 0.9 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1 0.7 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.4 GO:0080122 coenzyme A transmembrane transporter activity(GO:0015228) adenosine 3',5'-bisphosphate transmembrane transporter activity(GO:0071077) AMP transmembrane transporter activity(GO:0080122)
0.1 0.3 GO:0047150 betaine-homocysteine S-methyltransferase activity(GO:0047150)
0.1 1.4 GO:0042834 peptidoglycan binding(GO:0042834)
0.1 0.3 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.1 0.5 GO:0019763 immunoglobulin receptor activity(GO:0019763)
0.0 1.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.1 GO:0046997 oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997)
0.0 3.3 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.5 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.5 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.0 0.4 GO:1990239 steroid hormone binding(GO:1990239)
0.0 1.1 GO:0005484 SNAP receptor activity(GO:0005484)
0.0 0.2 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0 0.1 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.0 0.3 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0 1.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.1 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.0 1.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.0 0.6 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.7 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling