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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SIX5_SMARCC2_HCFC1
Z-value: 1.35
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Transcription factors associated with SIX5_SMARCC2_HCFC1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000177045.6 | SIX homeobox 5 | |
| ENSG00000139613.7 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 2 | |
| ENSG00000172534.9 | host cell factor C1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SIX5 | hg19_v2_chr19_-_46272462_46272562 | 0.78 | 4.4e-05 | Click! |
| HCFC1 | hg19_v2_chrX_-_153236819_153236978 | 0.77 | 6.9e-05 | Click! |
| SMARCC2 | hg19_v2_chr12_-_56583332_56583369 | 0.12 | 6.0e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr19_-_47551836 Show fit | 3.65 |
ENST00000253047.6
|
transmembrane protein 160 |
|
| chr19_-_51014345 Show fit | 3.38 |
ENST00000391815.3
ENST00000594350.1 ENST00000601423.1 |
Josephin domain containing 2 |
|
| chr19_-_51014460 Show fit | 3.00 |
ENST00000595669.1
|
Josephin domain containing 2 |
|
| chr19_-_51014588 Show fit | 2.94 |
ENST00000598418.1
|
Josephin domain containing 2 |
|
| chr19_+_51152702 Show fit | 2.81 |
ENST00000425202.1
|
chromosome 19 open reading frame 81 |
|
| chr1_-_247095236 Show fit | 2.41 |
ENST00000478568.1
|
AT hook containing transcription factor 1 |
|
| chr2_+_38893047 Show fit | 2.35 |
ENST00000272252.5
|
galactose mutarotase (aldose 1-epimerase) |
|
| chr19_-_51611623 Show fit | 2.33 |
ENST00000421832.2
|
cytosolic thiouridylase subunit 1 |
|
| chr19_+_50169081 Show fit | 2.28 |
ENST00000246784.3
|
BCL2-like 12 (proline rich) |
|
| chr2_+_38893208 Show fit | 2.28 |
ENST00000410063.1
|
galactose mutarotase (aldose 1-epimerase) |
Network of associatons between targets according to the STRING database.
First level regulatory network of SIX5_SMARCC2_HCFC1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 8.0 | GO:0016579 | protein deubiquitination(GO:0016579) |
| 0.3 | 6.2 | GO:1990001 | inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001) |
| 1.2 | 4.6 | GO:0033499 | galactose catabolic process via UDP-galactose(GO:0033499) |
| 0.0 | 4.0 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 0.2 | 3.0 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.2 | 3.0 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.1 | 2.9 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 2.9 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.7 | 2.8 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 0.1 | 2.6 | GO:0007220 | Notch receptor processing(GO:0007220) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.5 | GO:0000922 | spindle pole(GO:0000922) |
| 0.2 | 3.4 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.0 | 3.3 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 2.9 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.3 | 2.6 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 0.2 | 2.6 | GO:0070765 | gamma-secretase complex(GO:0070765) |
| 0.0 | 2.5 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.1 | 2.4 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.7 | 2.2 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.0 | 2.2 | GO:0042645 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.8 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.0 | 5.3 | GO:0002039 | p53 binding(GO:0002039) |
| 0.2 | 4.6 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.7 | 3.0 | GO:0047860 | diiodophenylpyruvate reductase activity(GO:0047860) |
| 0.2 | 2.6 | GO:0097322 | 7SK snRNA binding(GO:0097322) |
| 0.8 | 2.5 | GO:0051908 | double-stranded DNA 5'-3' exodeoxyribonuclease activity(GO:0051908) |
| 0.2 | 2.3 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.2 | 2.2 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 2.2 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.7 | 2.1 | GO:0008309 | double-stranded DNA exodeoxyribonuclease activity(GO:0008309) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 3.0 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.1 | 2.6 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 2.5 | PID BARD1 PATHWAY | BARD1 signaling events |
| 0.0 | 2.2 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.0 | 2.1 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.0 | 1.8 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.4 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.1 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 0.1 | 4.5 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.0 | 3.5 | REACTOME CDK MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6 | Genes involved in CDK-mediated phosphorylation and removal of Cdc6 |
| 0.1 | 3.4 | REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS | Genes involved in NRIF signals cell death from the nucleus |
| 0.1 | 3.3 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.0 | 3.2 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.1 | 2.2 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.1 | 2.2 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 2.1 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 0.1 | 2.0 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |