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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SMAD2

Z-value: 0.44

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Transcription factors associated with SMAD2

Gene Symbol Gene ID Gene Info
SMAD2
ENSG00000175387.11 SMAD family member 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD2hg19_v2_chr18_-_45456693_454567330.292.2e-01Click!

Activity profile of SMAD2 motif

Sorted Z-values of SMAD2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_228028829 0.59 ENST00000396625.3
ENST00000329662.7
COL4A4
collagen, type IV, alpha 4
chr18_+_20715416 0.49 ENST00000580153.1
CABLES1
Cdk5 and Abl enzyme substrate 1
chr20_+_43343476 0.44 ENST00000372868.2
WISP2
WNT1 inducible signaling pathway protein 2
chr20_+_43343886 0.43 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr5_+_175298573 0.38 ENST00000512824.1
CPLX2
complexin 2
chr19_-_3551043 0.38 ENST00000589995.1
MFSD12
major facilitator superfamily domain containing 12
chr19_-_46105411 0.37 ENST00000323040.4
ENST00000544371.1
GPR4
OPA3
G protein-coupled receptor 4
optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr1_-_44497118 0.35 ENST00000537678.1
ENST00000466926.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr19_+_50148087 0.34 ENST00000601038.1
ENST00000595242.1
SCAF1
SR-related CTD-associated factor 1
chr1_-_44482979 0.33 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr21_-_47706098 0.33 ENST00000426537.1
MCM3AP
minichromosome maintenance complex component 3 associated protein
chr20_+_43343517 0.32 ENST00000372865.4
WISP2
WNT1 inducible signaling pathway protein 2
chr12_-_120241187 0.31 ENST00000392520.2
CIT
citron (rho-interacting, serine/threonine kinase 21)
chr11_-_118789613 0.31 ENST00000532899.1
BCL9L
B-cell CLL/lymphoma 9-like
chr7_-_155601766 0.30 ENST00000430104.1
SHH
sonic hedgehog
chr17_-_15165825 0.29 ENST00000426385.3
PMP22
peripheral myelin protein 22
chr15_-_88799384 0.26 ENST00000540489.2
ENST00000557856.1
ENST00000558676.1
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr5_+_140345820 0.24 ENST00000289269.5
PCDHAC2
protocadherin alpha subfamily C, 2
chr8_-_142377367 0.23 ENST00000377741.3
GPR20
G protein-coupled receptor 20
chr15_-_88799661 0.22 ENST00000360948.2
ENST00000357724.2
ENST00000355254.2
ENST00000317501.3
NTRK3
neurotrophic tyrosine kinase, receptor, type 3
chr16_-_17564738 0.22 ENST00000261381.6
XYLT1
xylosyltransferase I
chr7_+_150758642 0.21 ENST00000488420.1
SLC4A2
solute carrier family 4 (anion exchanger), member 2
chr8_+_144373550 0.21 ENST00000330143.3
ENST00000521537.1
ENST00000518432.1
ENST00000520333.1
ZNF696
zinc finger protein 696
chr17_-_58469591 0.21 ENST00000589335.1
USP32
ubiquitin specific peptidase 32
chr12_-_47473557 0.20 ENST00000321382.3
AMIGO2
adhesion molecule with Ig-like domain 2
chr16_+_31483374 0.20 ENST00000394863.3
TGFB1I1
transforming growth factor beta 1 induced transcript 1
chr12_+_47473369 0.20 ENST00000546455.1
PCED1B
PC-esterase domain containing 1B
chr2_-_72375167 0.20 ENST00000001146.2
CYP26B1
cytochrome P450, family 26, subfamily B, polypeptide 1
chr19_+_49128209 0.20 ENST00000599748.1
ENST00000443164.1
ENST00000599029.1
SPHK2
sphingosine kinase 2
chr20_+_34680620 0.19 ENST00000430276.1
ENST00000373950.2
ENST00000452261.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr17_+_3627185 0.19 ENST00000325418.4
GSG2
germ cell associated 2 (haspin)
chr17_-_7297833 0.18 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr5_-_151066514 0.18 ENST00000538026.1
ENST00000522348.1
ENST00000521569.1
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr2_+_74881398 0.18 ENST00000339773.5
ENST00000434486.1
SEMA4F
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F
chrX_+_48660565 0.18 ENST00000413163.2
ENST00000441703.1
ENST00000426196.1
HDAC6
histone deacetylase 6
chr19_-_46272462 0.17 ENST00000317578.6
SIX5
SIX homeobox 5
chr12_-_47473642 0.17 ENST00000266581.4
AMIGO2
adhesion molecule with Ig-like domain 2
chr17_-_15165854 0.17 ENST00000395936.1
ENST00000395938.2
PMP22
peripheral myelin protein 22
chr16_-_425205 0.17 ENST00000448854.1
TMEM8A
transmembrane protein 8A
chr12_-_47473425 0.16 ENST00000550413.1
AMIGO2
adhesion molecule with Ig-like domain 2
chr16_+_30406423 0.16 ENST00000524644.1
ZNF48
zinc finger protein 48
chr17_+_40440094 0.16 ENST00000546010.2
STAT5A
signal transducer and activator of transcription 5A
chr17_+_36508826 0.16 ENST00000580660.1
SOCS7
suppressor of cytokine signaling 7
chr22_+_45072925 0.16 ENST00000006251.7
PRR5
proline rich 5 (renal)
chr15_-_82338460 0.16 ENST00000558133.1
ENST00000329713.4
MEX3B
mex-3 RNA binding family member B
chr5_+_133861339 0.16 ENST00000282605.4
ENST00000361895.2
ENST00000402835.1
PHF15
jade family PHD finger 2
chr6_-_31612808 0.16 ENST00000438149.1
BAG6
BCL2-associated athanogene 6
chr20_-_56284816 0.16 ENST00000395819.3
ENST00000341744.3
PMEPA1
prostate transmembrane protein, androgen induced 1
chr19_+_56186557 0.15 ENST00000270460.6
EPN1
epsin 1
chr22_-_43567750 0.15 ENST00000494035.1
TTLL12
tubulin tyrosine ligase-like family, member 12
chr3_-_195603566 0.15 ENST00000424563.1
ENST00000411741.1
TNK2
tyrosine kinase, non-receptor, 2
chr3_+_111393659 0.15 ENST00000477665.1
PLCXD2
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr6_+_30853002 0.15 ENST00000421124.2
ENST00000512725.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr22_-_37823468 0.15 ENST00000402918.2
ELFN2
extracellular leucine-rich repeat and fibronectin type III domain containing 2
chr9_+_101867387 0.15 ENST00000374990.2
ENST00000552516.1
TGFBR1
transforming growth factor, beta receptor 1
chr12_-_6798025 0.14 ENST00000542351.1
ENST00000538829.1
ZNF384
zinc finger protein 384
chr19_+_10527449 0.14 ENST00000592685.1
ENST00000380702.2
PDE4A
phosphodiesterase 4A, cAMP-specific
chr6_+_30689401 0.14 ENST00000396389.1
ENST00000396384.1
TUBB
tubulin, beta class I
chr14_+_31343747 0.13 ENST00000216361.4
ENST00000396618.3
ENST00000475087.1
COCH
cochlin
chr4_-_103749179 0.13 ENST00000502690.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr2_+_154728426 0.13 ENST00000392825.3
ENST00000434213.1
GALNT13
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13)
chr11_-_75379479 0.13 ENST00000434603.2
MAP6
microtubule-associated protein 6
chr3_+_88108381 0.13 ENST00000473136.1
RP11-159G9.5
Uncharacterized protein
chr3_+_194406603 0.13 ENST00000329759.4
FAM43A
family with sequence similarity 43, member A
chr22_+_45072958 0.13 ENST00000403581.1
PRR5
proline rich 5 (renal)
chr9_+_101867359 0.12 ENST00000374994.4
TGFBR1
transforming growth factor, beta receptor 1
chr8_-_117886732 0.12 ENST00000517485.1
RAD21
RAD21 homolog (S. pombe)
chr19_+_11466062 0.12 ENST00000251473.5
ENST00000591329.1
ENST00000586380.1
DKFZP761J1410
Lipid phosphate phosphatase-related protein type 2
chr12_+_93965609 0.12 ENST00000549887.1
ENST00000551556.1
SOCS2
suppressor of cytokine signaling 2
chr19_+_50094866 0.12 ENST00000418929.2
PRR12
proline rich 12
chr14_-_68159152 0.12 ENST00000554035.1
RDH11
retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
chr12_+_68042517 0.12 ENST00000393555.3
DYRK2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr9_+_133569108 0.12 ENST00000372358.5
ENST00000546165.1
ENST00000372352.3
ENST00000372351.3
ENST00000372350.3
ENST00000495699.2
EXOSC2
exosome component 2
chr11_+_2923423 0.12 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr11_-_3859089 0.12 ENST00000396979.1
RHOG
ras homolog family member G
chr11_-_107729504 0.11 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr12_-_108991778 0.11 ENST00000549447.1
TMEM119
transmembrane protein 119
chr6_-_152489484 0.11 ENST00000354674.4
ENST00000539504.1
SYNE1
spectrin repeat containing, nuclear envelope 1
chr19_+_56186606 0.11 ENST00000085079.7
EPN1
epsin 1
chr3_+_9834179 0.11 ENST00000498623.2
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr17_+_7792101 0.11 ENST00000358181.4
ENST00000330494.7
CHD3
chromodomain helicase DNA binding protein 3
chr7_+_143080063 0.11 ENST00000446634.1
ZYX
zyxin
chr11_-_107729287 0.11 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr11_+_64808675 0.10 ENST00000529996.1
SAC3D1
SAC3 domain containing 1
chr22_+_37956479 0.10 ENST00000430687.1
CDC42EP1
CDC42 effector protein (Rho GTPase binding) 1
chr11_-_65150103 0.10 ENST00000294187.6
ENST00000398802.1
ENST00000360662.3
ENST00000377152.2
ENST00000530936.1
SLC25A45
solute carrier family 25, member 45
chr3_+_50316458 0.10 ENST00000316436.3
LSMEM2
leucine-rich single-pass membrane protein 2
chr17_-_3571934 0.10 ENST00000225525.3
TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr21_+_47401650 0.10 ENST00000361866.3
COL6A1
collagen, type VI, alpha 1
chr3_-_88108212 0.10 ENST00000482016.1
CGGBP1
CGG triplet repeat binding protein 1
chr4_-_140477353 0.10 ENST00000406354.1
ENST00000506866.2
SETD7
SET domain containing (lysine methyltransferase) 7
chr17_-_40761375 0.10 ENST00000543197.1
ENST00000309428.5
FAM134C
family with sequence similarity 134, member C
chr11_-_65149422 0.10 ENST00000526432.1
ENST00000527174.1
SLC25A45
solute carrier family 25, member 45
chr4_-_102268708 0.10 ENST00000525819.1
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr19_-_55580838 0.10 ENST00000396247.3
ENST00000586945.1
ENST00000587026.1
RDH13
retinol dehydrogenase 13 (all-trans/9-cis)
chr6_+_143771934 0.09 ENST00000367592.1
PEX3
peroxisomal biogenesis factor 3
chr15_+_75498739 0.09 ENST00000565074.1
C15orf39
chromosome 15 open reading frame 39
chr12_-_57472522 0.09 ENST00000379391.3
ENST00000300128.4
TMEM194A
transmembrane protein 194A
chr5_+_14143728 0.09 ENST00000344204.4
ENST00000537187.1
TRIO
trio Rho guanine nucleotide exchange factor
chr1_+_16693578 0.09 ENST00000401088.4
ENST00000471507.1
ENST00000401089.3
ENST00000375590.3
ENST00000492354.1
SZRD1
SUZ RNA binding domain containing 1
chr11_-_117166201 0.09 ENST00000510915.1
BACE1
beta-site APP-cleaving enzyme 1
chr17_-_1389419 0.09 ENST00000575158.1
MYO1C
myosin IC
chr10_+_102821551 0.09 ENST00000370200.5
KAZALD1
Kazal-type serine peptidase inhibitor domain 1
chr20_+_35974532 0.09 ENST00000373578.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr1_-_149908217 0.08 ENST00000369140.3
MTMR11
myotubularin related protein 11
chr3_+_40547483 0.08 ENST00000420891.1
ENST00000314529.6
ENST00000418905.1
ZNF620
zinc finger protein 620
chr3_-_49761337 0.08 ENST00000535833.1
ENST00000308388.6
ENST00000480687.1
ENST00000308375.6
AMIGO3
GMPPB
adhesion molecule with Ig-like domain 3
GDP-mannose pyrophosphorylase B
chr16_+_2286726 0.08 ENST00000382437.4
ENST00000569184.1
DNASE1L2
deoxyribonuclease I-like 2
chr16_+_58059470 0.08 ENST00000219271.3
MMP15
matrix metallopeptidase 15 (membrane-inserted)
chr17_-_46178741 0.08 ENST00000581003.1
ENST00000225603.4
CBX1
chromobox homolog 1
chr8_-_91657740 0.08 ENST00000422900.1
TMEM64
transmembrane protein 64
chrX_+_48660107 0.07 ENST00000376643.2
HDAC6
histone deacetylase 6
chr12_-_120554534 0.07 ENST00000538903.1
ENST00000534951.1
RAB35
RAB35, member RAS oncogene family
chr17_-_58469687 0.07 ENST00000590133.1
USP32
ubiquitin specific peptidase 32
chr16_-_54320675 0.07 ENST00000329734.3
IRX3
iroquois homeobox 3
chr11_-_107590383 0.07 ENST00000525934.1
ENST00000531293.1
SLN
sarcolipin
chr12_+_104982622 0.07 ENST00000549016.1
CHST11
carbohydrate (chondroitin 4) sulfotransferase 11
chr8_-_130587237 0.07 ENST00000520048.1
CCDC26
coiled-coil domain containing 26
chr4_-_103749205 0.07 ENST00000508249.1
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr1_-_935491 0.07 ENST00000304952.6
HES4
hes family bHLH transcription factor 4
chr12_-_120663792 0.07 ENST00000546532.1
ENST00000548912.1
PXN
paxillin
chr19_-_49522727 0.06 ENST00000600007.1
CTB-60B18.10
CTB-60B18.10
chr7_+_149416439 0.06 ENST00000497895.1
KRBA1
KRAB-A domain containing 1
chr10_-_102045882 0.06 ENST00000579542.1
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr3_-_71179699 0.06 ENST00000497355.1
FOXP1
forkhead box P1
chr6_-_27841289 0.06 ENST00000355981.2
HIST1H4L
histone cluster 1, H4l
chr8_-_95907423 0.06 ENST00000396133.3
ENST00000308108.4
CCNE2
cyclin E2
chr3_-_71179988 0.06 ENST00000491238.1
FOXP1
forkhead box P1
chr1_-_149908710 0.06 ENST00000439741.2
ENST00000361405.6
ENST00000406732.3
MTMR11
myotubularin related protein 11
chr6_+_147525541 0.06 ENST00000367481.3
ENST00000546097.1
STXBP5
syntaxin binding protein 5 (tomosyn)
chr7_+_69064566 0.06 ENST00000403018.2
AUTS2
autism susceptibility candidate 2
chr12_+_67663056 0.06 ENST00000545606.1
CAND1
cullin-associated and neddylation-dissociated 1
chr2_-_74667612 0.06 ENST00000305557.5
ENST00000233330.6
RTKN
rhotekin
chrX_-_154688276 0.06 ENST00000369445.2
F8A3
coagulation factor VIII-associated 3
chr1_-_153508460 0.06 ENST00000462776.2
S100A6
S100 calcium binding protein A6
chr6_+_32132360 0.06 ENST00000333845.6
ENST00000395512.1
ENST00000432129.1
EGFL8
EGF-like-domain, multiple 8
chr5_-_150521192 0.06 ENST00000523714.1
ENST00000521749.1
ANXA6
annexin A6
chr22_+_22676808 0.06 ENST00000390290.2
IGLV1-51
immunoglobulin lambda variable 1-51
chr3_+_130569429 0.06 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
ATP2C1
ATPase, Ca++ transporting, type 2C, member 1
chr11_+_75273101 0.06 ENST00000533603.1
ENST00000358171.3
ENST00000526242.1
SERPINH1
serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
chr12_+_68042495 0.06 ENST00000344096.3
DYRK2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr7_-_10979750 0.06 ENST00000339600.5
NDUFA4
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa
chr5_-_172755056 0.05 ENST00000520648.1
STC2
stanniocalcin 2
chr17_+_40761660 0.05 ENST00000251413.3
ENST00000591509.1
TUBG1
tubulin, gamma 1
chr4_-_39640513 0.05 ENST00000511809.1
ENST00000505729.1
SMIM14
small integral membrane protein 14
chr10_+_102729249 0.05 ENST00000519649.1
ENST00000518124.1
SEMA4G
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
chrX_+_38420783 0.05 ENST00000422612.2
ENST00000286824.6
ENST00000545599.1
TSPAN7
tetraspanin 7
chr16_-_67997947 0.05 ENST00000537830.2
SLC12A4
solute carrier family 12 (potassium/chloride transporter), member 4
chr4_+_102268904 0.05 ENST00000527564.1
ENST00000529296.1
AP001816.1
Uncharacterized protein
chr17_-_7297519 0.05 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr9_+_140145713 0.05 ENST00000388931.3
ENST00000412566.1
C9orf173
chromosome 9 open reading frame 173
chr7_-_559853 0.05 ENST00000405692.2
PDGFA
platelet-derived growth factor alpha polypeptide
chr12_+_1800179 0.05 ENST00000357103.4
ADIPOR2
adiponectin receptor 2
chr16_-_87417351 0.05 ENST00000311635.7
FBXO31
F-box protein 31
chr18_+_13217965 0.05 ENST00000587905.1
LDLRAD4
low density lipoprotein receptor class A domain containing 4
chr10_-_102046417 0.05 ENST00000370372.2
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr13_-_80915059 0.05 ENST00000377104.3
SPRY2
sprouty homolog 2 (Drosophila)
chr19_-_6501778 0.05 ENST00000596291.1
TUBB4A
tubulin, beta 4A class IVa
chr11_+_7597639 0.05 ENST00000533792.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr5_+_140762268 0.05 ENST00000518325.1
PCDHGA7
protocadherin gamma subfamily A, 7
chr4_-_114682719 0.04 ENST00000394522.3
CAMK2D
calcium/calmodulin-dependent protein kinase II delta
chr4_-_84030996 0.04 ENST00000411416.2
PLAC8
placenta-specific 8
chr17_-_60142609 0.04 ENST00000397786.2
MED13
mediator complex subunit 13
chr11_-_75380165 0.04 ENST00000304771.3
MAP6
microtubule-associated protein 6
chr12_+_53443680 0.04 ENST00000314250.6
ENST00000451358.1
TENC1
tensin like C1 domain containing phosphatase (tensin 2)
chr7_-_130080818 0.04 ENST00000343969.5
ENST00000541543.1
ENST00000489512.1
CEP41
centrosomal protein 41kDa
chr20_+_30598231 0.04 ENST00000300415.8
ENST00000262659.8
CCM2L
cerebral cavernous malformation 2-like
chr19_-_14224969 0.04 ENST00000589994.1
PRKACA
protein kinase, cAMP-dependent, catalytic, alpha
chr11_+_71238313 0.04 ENST00000398536.4
KRTAP5-7
keratin associated protein 5-7
chr12_+_110338323 0.04 ENST00000312777.5
ENST00000536408.2
TCHP
trichoplein, keratin filament binding
chrX_-_30595959 0.03 ENST00000378962.3
CXorf21
chromosome X open reading frame 21
chr1_+_44412577 0.03 ENST00000372343.3
IPO13
importin 13
chr11_-_74204742 0.03 ENST00000310109.4
LIPT2
lipoyl(octanoyl) transferase 2 (putative)
chrX_-_47489244 0.03 ENST00000469388.1
ENST00000396992.3
ENST00000377005.2
CFP
complement factor properdin
chr7_+_99905325 0.03 ENST00000332397.6
ENST00000437326.2
SPDYE3
speedy/RINGO cell cycle regulator family member E3
chr8_+_11561660 0.03 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA4
GATA binding protein 4
chr9_-_28670283 0.03 ENST00000379992.2
LINGO2
leucine rich repeat and Ig domain containing 2
chr14_+_70078303 0.03 ENST00000342745.4
KIAA0247
KIAA0247
chr11_-_22647350 0.03 ENST00000327470.3
FANCF
Fanconi anemia, complementation group F
chr1_+_156163880 0.03 ENST00000359511.4
ENST00000423538.2
SLC25A44
solute carrier family 25, member 44
chr17_+_30593195 0.03 ENST00000431505.2
ENST00000269051.4
ENST00000538145.1
RHBDL3
rhomboid, veinlet-like 3 (Drosophila)
chr16_+_53164956 0.03 ENST00000563410.1
CHD9
chromodomain helicase DNA binding protein 9
chrX_+_48660287 0.03 ENST00000444343.2
ENST00000376610.2
ENST00000334136.5
ENST00000376619.2
HDAC6
histone deacetylase 6
chr18_+_3448455 0.03 ENST00000549780.1
TGIF1
TGFB-induced factor homeobox 1
chr5_+_139493665 0.03 ENST00000331327.3
PURA
purine-rich element binding protein A
chrX_-_99987088 0.03 ENST00000372981.1
ENST00000263033.5
SYTL4
synaptotagmin-like 4
chr15_+_45879964 0.02 ENST00000565409.1
ENST00000564765.1
BLOC1S6
biogenesis of lysosomal organelles complex-1, subunit 6, pallidin
chr19_-_14606900 0.02 ENST00000393029.3
ENST00000393028.1
ENST00000393033.4
ENST00000345425.2
ENST00000586027.1
ENST00000591349.1
ENST00000587210.1
GIPC1
GIPC PDZ domain containing family, member 1
chr16_-_56459354 0.02 ENST00000290649.5
AMFR
autocrine motility factor receptor, E3 ubiquitin protein ligase
chr12_-_53207842 0.02 ENST00000458244.2
KRT4
keratin 4
chr5_-_74062867 0.02 ENST00000509097.1
GFM2
G elongation factor, mitochondrial 2
chr21_-_38639813 0.02 ENST00000309117.6
ENST00000398998.1
DSCR3
Down syndrome critical region gene 3
chr12_-_108991812 0.02 ENST00000392806.3
ENST00000547567.1
TMEM119
transmembrane protein 119
chr12_-_71003568 0.02 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB
protein tyrosine phosphatase, receptor type, B
chr12_+_122516626 0.02 ENST00000319080.7
MLXIP
MLX interacting protein
chr6_+_4087664 0.02 ENST00000430835.2
C6orf201
chromosome 6 open reading frame 201
chr2_-_17981462 0.02 ENST00000402989.1
ENST00000428868.1
SMC6
structural maintenance of chromosomes 6
chr9_-_140513231 0.02 ENST00000371417.3
C9orf37
chromosome 9 open reading frame 37
chr22_+_31518938 0.02 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr7_-_130080977 0.01 ENST00000223208.5
CEP41
centrosomal protein 41kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.1 0.5 GO:0048687 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.1 0.3 GO:0060738 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908) positive regulation of immature T cell proliferation in thymus(GO:0033092) right lung development(GO:0060458) primary prostatic bud elongation(GO:0060516) epithelial-mesenchymal signaling involved in prostate gland development(GO:0060738)
0.1 0.3 GO:0070843 misfolded protein transport(GO:0070843) polyubiquitinated protein transport(GO:0070844) polyubiquitinated misfolded protein transport(GO:0070845) Hsp90 deacetylation(GO:0070846)
0.1 0.2 GO:0035981 tongue muscle cell differentiation(GO:0035981) positive regulation of skeletal muscle fiber differentiation(GO:1902811) regulation of tongue muscle cell differentiation(GO:2001035) positive regulation of tongue muscle cell differentiation(GO:2001037)
0.1 0.2 GO:0072356 chromosome passenger complex localization to kinetochore(GO:0072356)
0.1 0.3 GO:1905073 occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.0 0.2 GO:0006669 sphinganine-1-phosphate biosynthetic process(GO:0006669)
0.0 0.2 GO:1902723 negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0 0.4 GO:0072144 glomerular mesangial cell development(GO:0072144)
0.0 0.1 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.0 0.2 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.0 0.2 GO:0000255 allantoin metabolic process(GO:0000255)
0.0 0.6 GO:0032836 glomerular basement membrane development(GO:0032836)
0.0 0.2 GO:0000066 mitochondrial ornithine transport(GO:0000066)
0.0 0.1 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.0 0.0 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.0 0.1 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0 0.1 GO:1901877 regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877)
0.0 0.1 GO:0033037 polysaccharide localization(GO:0033037)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
0.0 0.1 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.0 0.1 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.0 0.1 GO:0003335 corneocyte development(GO:0003335)
0.0 0.0 GO:0090271 positive regulation of fibroblast growth factor production(GO:0090271)
0.0 0.2 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0 0.1 GO:0072086 specification of loop of Henle identity(GO:0072086)
0.0 0.2 GO:1904327 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.0 0.5 GO:0032060 bleb assembly(GO:0032060)
0.0 0.3 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.1 GO:0098582 innate vocalization behavior(GO:0098582)
0.0 0.1 GO:0032185 septin cytoskeleton organization(GO:0032185)
0.0 0.1 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 0.4 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.1 GO:0046618 drug export(GO:0046618)
0.0 0.1 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.2 GO:0010991 negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.1 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.0 0.1 GO:0009644 response to high light intensity(GO:0009644)
0.0 0.2 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.4 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0 0.2 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.0 0.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.1 GO:0070931 Golgi-associated vesicle lumen(GO:0070931)
0.0 0.1 GO:0045160 myosin I complex(GO:0045160)
0.0 0.1 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
0.0 0.2 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.1 GO:0000798 nuclear cohesin complex(GO:0000798)
0.0 0.5 GO:0043218 compact myelin(GO:0043218)
0.0 0.3 GO:0031932 TORC2 complex(GO:0031932)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.2 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.0 0.3 GO:0042903 tubulin deacetylase activity(GO:0042903)
0.0 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.5 GO:0005030 neurotrophin receptor activity(GO:0005030)
0.0 1.3 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.2 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.2 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.0 0.3 GO:0005114 transforming growth factor beta receptor activity, type I(GO:0005025) type II transforming growth factor beta receptor binding(GO:0005114)
0.0 0.2 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.0 0.2 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0008798 beta-aspartyl-peptidase activity(GO:0008798)
0.0 0.1 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.0 0.0 GO:0097003 adipokinetic hormone receptor activity(GO:0097003)
0.0 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0050659 N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity(GO:0050659)
0.0 0.1 GO:0070568 guanylyltransferase activity(GO:0070568)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters