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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SMAD3

Z-value: 1.21

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Transcription factors associated with SMAD3

Gene Symbol Gene ID Gene Info
SMAD3
ENSG00000166949.11 SMAD family member 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SMAD3hg19_v2_chr15_+_67420441_674206060.651.9e-03Click!

Activity profile of SMAD3 motif

Sorted Z-values of SMAD3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_26189304 2.71 ENST00000340756.2
HIST1H4D
histone cluster 1, H4d
chr6_-_26027480 2.36 ENST00000377364.3
HIST1H4B
histone cluster 1, H4b
chr6_+_27114861 2.08 ENST00000377459.1
HIST1H2AH
histone cluster 1, H2ah
chr6_+_26273144 1.99 ENST00000377733.2
HIST1H2BI
histone cluster 1, H2bi
chr6_+_27782788 1.83 ENST00000359465.4
HIST1H2BM
histone cluster 1, H2bm
chr6_-_27782548 1.72 ENST00000333151.3
HIST1H2AJ
histone cluster 1, H2aj
chr6_+_27775899 1.71 ENST00000358739.3
HIST1H2AI
histone cluster 1, H2ai
chr11_-_61101247 1.65 ENST00000543627.1
DDB1
damage-specific DNA binding protein 1, 127kDa
chr11_+_33563821 1.61 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L
KIAA1549-like
chr11_-_107729504 1.34 ENST00000265836.7
SLC35F2
solute carrier family 35, member F2
chr16_+_14280742 1.26 ENST00000341243.5
MKL2
MKL/myocardin-like 2
chr6_-_27775694 1.24 ENST00000377401.2
HIST1H2BL
histone cluster 1, H2bl
chr11_-_107729287 1.22 ENST00000375682.4
SLC35F2
solute carrier family 35, member F2
chr6_-_27860956 1.21 ENST00000359611.2
HIST1H2AM
histone cluster 1, H2am
chr8_+_38586068 1.14 ENST00000443286.2
ENST00000520340.1
ENST00000518415.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr11_+_57531292 1.08 ENST00000524579.1
CTNND1
catenin (cadherin-associated protein), delta 1
chr6_-_26033796 1.07 ENST00000259791.2
HIST1H2AB
histone cluster 1, H2ab
chr8_+_22250334 1.06 ENST00000520832.1
SLC39A14
solute carrier family 39 (zinc transporter), member 14
chrX_-_62571220 1.04 ENST00000374884.2
SPIN4
spindlin family, member 4
chr20_-_6103666 1.04 ENST00000536936.1
FERMT1
fermitin family member 1
chr2_-_208031943 0.97 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr1_+_209602771 0.97 ENST00000440276.1
MIR205HG
MIR205 host gene (non-protein coding)
chrX_-_62571187 0.96 ENST00000335144.3
SPIN4
spindlin family, member 4
chr11_-_71781096 0.94 ENST00000535087.1
ENST00000535838.1
NUMA1
nuclear mitotic apparatus protein 1
chr3_+_141103634 0.91 ENST00000507722.1
ZBTB38
zinc finger and BTB domain containing 38
chr6_-_41888843 0.90 ENST00000434077.1
ENST00000409312.1
MED20
mediator complex subunit 20
chr13_-_60738003 0.89 ENST00000400330.1
ENST00000400324.4
DIAPH3
diaphanous-related formin 3
chr1_-_156399184 0.88 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
C1orf61
chromosome 1 open reading frame 61
chr6_+_27100811 0.88 ENST00000359193.2
HIST1H2AG
histone cluster 1, H2ag
chr6_-_26124138 0.87 ENST00000314332.5
ENST00000396984.1
HIST1H2BC
histone cluster 1, H2bc
chr16_+_30773610 0.86 ENST00000566811.1
RNF40
ring finger protein 40, E3 ubiquitin protein ligase
chr17_-_982198 0.85 ENST00000571945.1
ENST00000536794.2
ABR
active BCR-related
chr6_-_27100529 0.84 ENST00000607124.1
ENST00000339812.2
ENST00000541790.1
HIST1H2BJ
histone cluster 1, H2bj
chr17_-_39942322 0.81 ENST00000449889.1
ENST00000465293.1
JUP
junction plakoglobin
chr18_+_43753500 0.80 ENST00000587591.1
ENST00000588730.1
C18orf25
chromosome 18 open reading frame 25
chr22_-_41677625 0.80 ENST00000452543.1
ENST00000418067.1
RANGAP1
Ran GTPase activating protein 1
chr6_+_27861190 0.79 ENST00000303806.4
HIST1H2BO
histone cluster 1, H2bo
chr5_-_41870621 0.77 ENST00000196371.5
OXCT1
3-oxoacid CoA transferase 1
chrX_-_48328631 0.76 ENST00000429543.1
ENST00000317669.5
SLC38A5
solute carrier family 38, member 5
chr11_+_33563618 0.75 ENST00000526400.1
KIAA1549L
KIAA1549-like
chr11_+_35222629 0.74 ENST00000526553.1
CD44
CD44 molecule (Indian blood group)
chr10_-_24911746 0.70 ENST00000320481.6
ARHGAP21
Rho GTPase activating protein 21
chr15_-_43785274 0.70 ENST00000413546.1
TP53BP1
tumor protein p53 binding protein 1
chr1_-_21113765 0.69 ENST00000438032.1
ENST00000424732.1
ENST00000437575.1
HP1BP3
heterochromatin protein 1, binding protein 3
chr6_-_26216872 0.67 ENST00000244601.3
HIST1H2BG
histone cluster 1, H2bg
chr19_-_11688500 0.66 ENST00000433365.2
ACP5
acid phosphatase 5, tartrate resistant
chr5_-_127674883 0.64 ENST00000507835.1
FBN2
fibrillin 2
chrX_-_48328551 0.64 ENST00000376876.3
SLC38A5
solute carrier family 38, member 5
chr8_+_38585704 0.62 ENST00000519416.1
ENST00000520615.1
TACC1
transforming, acidic coiled-coil containing protein 1
chr12_+_65563329 0.61 ENST00000308330.2
LEMD3
LEM domain containing 3
chr1_-_44482979 0.61 ENST00000360584.2
ENST00000357730.2
ENST00000528803.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr7_-_55620433 0.60 ENST00000418904.1
VOPP1
vesicular, overexpressed in cancer, prosurvival protein 1
chr8_+_128747661 0.59 ENST00000259523.6
MYC
v-myc avian myelocytomatosis viral oncogene homolog
chr1_+_200863949 0.59 ENST00000413687.2
C1orf106
chromosome 1 open reading frame 106
chr12_-_110906027 0.58 ENST00000537466.2
ENST00000550974.1
ENST00000228827.3
GPN3
GPN-loop GTPase 3
chr16_+_14280564 0.56 ENST00000572567.1
MKL2
MKL/myocardin-like 2
chr1_+_193091080 0.54 ENST00000367435.3
CDC73
cell division cycle 73
chr11_+_124824000 0.54 ENST00000529051.1
ENST00000344762.5
CCDC15
coiled-coil domain containing 15
chr11_-_12031273 0.53 ENST00000525493.1
DKK3
dickkopf WNT signaling pathway inhibitor 3
chrX_-_46618490 0.52 ENST00000328306.4
SLC9A7
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
chr11_-_107729887 0.52 ENST00000525815.1
SLC35F2
solute carrier family 35, member F2
chr2_-_128784846 0.52 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
SAP130
Sin3A-associated protein, 130kDa
chr18_+_43753974 0.51 ENST00000282059.6
ENST00000321319.6
C18orf25
chromosome 18 open reading frame 25
chr12_+_119616447 0.49 ENST00000281938.2
HSPB8
heat shock 22kDa protein 8
chr6_+_27791862 0.49 ENST00000355057.1
HIST1H4J
histone cluster 1, H4j
chr12_+_67663056 0.48 ENST00000545606.1
CAND1
cullin-associated and neddylation-dissociated 1
chr6_+_30850862 0.48 ENST00000504651.1
ENST00000512694.1
ENST00000515233.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr15_-_26874230 0.48 ENST00000400188.3
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr11_+_34938119 0.47 ENST00000227868.4
ENST00000430469.2
ENST00000533262.1
PDHX
pyruvate dehydrogenase complex, component X
chr1_-_8877692 0.47 ENST00000400908.2
RERE
arginine-glutamic acid dipeptide (RE) repeats
chr1_-_9189144 0.46 ENST00000414642.2
GPR157
G protein-coupled receptor 157
chr12_+_96588143 0.45 ENST00000228741.3
ENST00000547249.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr6_+_26124373 0.45 ENST00000377791.2
ENST00000602637.1
HIST1H2AC
histone cluster 1, H2ac
chr20_-_43280325 0.45 ENST00000537820.1
ADA
adenosine deaminase
chr11_+_35211511 0.43 ENST00000524922.1
CD44
CD44 molecule (Indian blood group)
chr12_+_26111823 0.42 ENST00000381352.3
ENST00000535907.1
ENST00000405154.2
RASSF8
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
chr6_-_41888814 0.42 ENST00000409060.1
ENST00000265350.4
MED20
mediator complex subunit 20
chr20_+_55926566 0.42 ENST00000411894.1
ENST00000429339.1
RAE1
ribonucleic acid export 1
chr3_-_14220068 0.42 ENST00000449060.2
ENST00000511155.1
XPC
xeroderma pigmentosum, complementation group C
chr5_+_140566 0.42 ENST00000502646.1
PLEKHG4B
pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
chr14_+_53196872 0.41 ENST00000442123.2
ENST00000354586.4
STYX
serine/threonine/tyrosine interacting protein
chr1_+_39796810 0.41 ENST00000289893.4
MACF1
microtubule-actin crosslinking factor 1
chr17_+_30813576 0.40 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr19_-_37958086 0.40 ENST00000592490.1
ENST00000392149.2
ZNF569
zinc finger protein 569
chr1_+_90287480 0.39 ENST00000394593.3
LRRC8D
leucine rich repeat containing 8 family, member D
chr3_+_149531607 0.38 ENST00000468648.1
ENST00000459632.1
RNF13
ring finger protein 13
chr3_+_69811858 0.37 ENST00000433517.1
MITF
microphthalmia-associated transcription factor
chr6_-_27841289 0.37 ENST00000355981.2
HIST1H4L
histone cluster 1, H4l
chr6_-_26285737 0.37 ENST00000377727.1
ENST00000289352.1
HIST1H4H
histone cluster 1, H4h
chr16_-_11723066 0.37 ENST00000576036.1
LITAF
lipopolysaccharide-induced TNF factor
chr19_+_34850385 0.36 ENST00000587521.2
ENST00000587384.1
ENST00000592277.1
GPI
glucose-6-phosphate isomerase
chr6_-_27806117 0.36 ENST00000330180.2
HIST1H2AK
histone cluster 1, H2ak
chr19_-_11688447 0.36 ENST00000590420.1
ACP5
acid phosphatase 5, tartrate resistant
chr6_+_26204825 0.35 ENST00000360441.4
HIST1H4E
histone cluster 1, H4e
chr10_-_102046417 0.35 ENST00000370372.2
BLOC1S2
biogenesis of lysosomal organelles complex-1, subunit 2
chr19_+_42724423 0.35 ENST00000301215.3
ENST00000597945.1
ZNF526
zinc finger protein 526
chr18_+_55862873 0.35 ENST00000588494.1
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr20_+_55926625 0.34 ENST00000452119.1
RAE1
ribonucleic acid export 1
chr15_-_83316711 0.34 ENST00000568128.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr6_-_52441713 0.34 ENST00000182527.3
TRAM2
translocation associated membrane protein 2
chr12_-_323689 0.33 ENST00000428720.1
SLC6A12
solute carrier family 6 (neurotransmitter transporter), member 12
chr22_+_20877924 0.33 ENST00000445189.1
MED15
mediator complex subunit 15
chr20_+_55926274 0.32 ENST00000371242.2
ENST00000527947.1
RAE1
ribonucleic acid export 1
chr1_+_202385953 0.32 ENST00000466968.1
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr14_+_96858454 0.31 ENST00000555570.1
AK7
adenylate kinase 7
chr16_-_15180257 0.31 ENST00000540462.1
RRN3
RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
chr1_+_205682497 0.30 ENST00000598338.1
AC119673.1
AC119673.1
chr20_-_43280361 0.30 ENST00000372874.4
ADA
adenosine deaminase
chr1_+_52682052 0.30 ENST00000371591.1
ZFYVE9
zinc finger, FYVE domain containing 9
chr16_-_58328923 0.29 ENST00000567164.1
ENST00000219301.4
ENST00000569727.1
PRSS54
protease, serine, 54
chr6_+_30850697 0.29 ENST00000509639.1
ENST00000412274.2
ENST00000507901.1
ENST00000507046.1
ENST00000437124.2
ENST00000454612.2
ENST00000396342.2
DDR1
discoidin domain receptor tyrosine kinase 1
chr3_+_12838161 0.28 ENST00000456430.2
CAND2
cullin-associated and neddylation-dissociated 2 (putative)
chr10_-_105437909 0.28 ENST00000540321.1
SH3PXD2A
SH3 and PX domains 2A
chr2_+_99797636 0.27 ENST00000409145.1
MRPL30
mitochondrial ribosomal protein L30
chr6_-_133119668 0.26 ENST00000275227.4
ENST00000538764.1
SLC18B1
solute carrier family 18, subfamily B, member 1
chr19_-_11688951 0.26 ENST00000589792.1
ACP5
acid phosphatase 5, tartrate resistant
chr16_+_30773636 0.25 ENST00000402121.3
ENST00000565995.1
ENST00000563683.1
ENST00000357890.5
ENST00000565931.1
RNF40
ring finger protein 40, E3 ubiquitin protein ligase
chr6_+_12008986 0.25 ENST00000491710.1
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chr5_+_122181279 0.25 ENST00000395451.4
ENST00000506996.1
SNX24
sorting nexin 24
chr9_+_72658490 0.25 ENST00000377182.4
MAMDC2
MAM domain containing 2
chr16_-_58328870 0.25 ENST00000543437.1
PRSS54
protease, serine, 54
chr6_+_30851205 0.25 ENST00000515881.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr1_-_160832642 0.25 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr12_+_110906169 0.24 ENST00000377673.5
FAM216A
family with sequence similarity 216, member A
chr15_-_83315874 0.23 ENST00000569257.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr20_-_30311703 0.23 ENST00000450273.1
ENST00000456404.1
ENST00000420488.1
ENST00000439267.1
BCL2L1
BCL2-like 1
chr18_+_55862622 0.23 ENST00000456173.2
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr5_+_167913450 0.23 ENST00000231572.3
ENST00000538719.1
RARS
arginyl-tRNA synthetase
chr16_-_3350614 0.22 ENST00000268674.2
TIGD7
tigger transposable element derived 7
chr9_+_37486005 0.22 ENST00000377792.3
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr17_-_26733604 0.22 ENST00000584426.1
ENST00000584995.1
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr15_-_43785303 0.22 ENST00000382039.3
ENST00000450115.2
ENST00000382044.4
TP53BP1
tumor protein p53 binding protein 1
chr21_-_46086844 0.21 ENST00000360770.3
KRTAP12-2
keratin associated protein 12-2
chr1_+_149804218 0.21 ENST00000610125.1
HIST2H4A
histone cluster 2, H4a
chr11_+_46383121 0.21 ENST00000454345.1
DGKZ
diacylglycerol kinase, zeta
chr9_+_37485932 0.21 ENST00000377798.4
ENST00000442009.2
POLR1E
polymerase (RNA) I polypeptide E, 53kDa
chr1_-_159684371 0.20 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr5_+_52776228 0.20 ENST00000256759.3
FST
follistatin
chr5_-_68628543 0.20 ENST00000396496.2
ENST00000511257.1
ENST00000383374.2
CCDC125
coiled-coil domain containing 125
chr11_+_116700614 0.19 ENST00000375345.1
APOC3
apolipoprotein C-III
chr11_+_116700600 0.19 ENST00000227667.3
APOC3
apolipoprotein C-III
chr8_+_10530133 0.18 ENST00000304519.5
C8orf74
chromosome 8 open reading frame 74
chr5_+_55147205 0.18 ENST00000396836.2
ENST00000396834.1
ENST00000447346.2
ENST00000359040.5
IL31RA
interleukin 31 receptor A
chr17_-_34195862 0.18 ENST00000592980.1
ENST00000587626.1
C17orf66
chromosome 17 open reading frame 66
chr17_+_78193443 0.18 ENST00000577155.1
SLC26A11
solute carrier family 26 (anion exchanger), member 11
chr1_+_59762310 0.18 ENST00000582567.1
ENST00000413489.1
FGGY
FGGY carbohydrate kinase domain containing
chr2_+_75061108 0.18 ENST00000290573.2
HK2
hexokinase 2
chr4_-_39033963 0.17 ENST00000381938.3
TMEM156
transmembrane protein 156
chr7_+_133261209 0.17 ENST00000545148.1
EXOC4
exocyst complex component 4
chr22_+_41956767 0.17 ENST00000306149.7
CSDC2
cold shock domain containing C2, RNA binding
chr16_-_11036300 0.16 ENST00000331808.4
DEXI
Dexi homolog (mouse)
chr20_-_60795296 0.15 ENST00000340177.5
HRH3
histamine receptor H3
chr17_+_12859080 0.15 ENST00000583608.1
ARHGAP44
Rho GTPase activating protein 44
chr5_-_79950775 0.15 ENST00000439211.2
DHFR
dihydrofolate reductase
chr20_-_23030296 0.15 ENST00000377103.2
THBD
thrombomodulin
chr1_-_11042094 0.15 ENST00000377004.4
ENST00000377008.4
C1orf127
chromosome 1 open reading frame 127
chr1_+_59762642 0.15 ENST00000371218.4
ENST00000303721.7
FGGY
FGGY carbohydrate kinase domain containing
chr16_+_25228242 0.14 ENST00000219660.5
AQP8
aquaporin 8
chr15_+_63796779 0.14 ENST00000561442.1
ENST00000560070.1
ENST00000540797.1
ENST00000380324.3
ENST00000268049.7
ENST00000536001.1
ENST00000539772.1
USP3
ubiquitin specific peptidase 3
chr17_+_36452989 0.14 ENST00000312513.5
ENST00000582535.1
MRPL45
mitochondrial ribosomal protein L45
chr19_-_55691614 0.13 ENST00000592470.1
ENST00000354308.3
SYT5
synaptotagmin V
chr1_-_9129895 0.13 ENST00000473209.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr15_-_83316087 0.12 ENST00000568757.1
CPEB1
cytoplasmic polyadenylation element binding protein 1
chr20_+_58251716 0.12 ENST00000355648.4
PHACTR3
phosphatase and actin regulator 3
chr11_+_60869867 0.11 ENST00000347785.3
CD5
CD5 molecule
chr5_+_140625147 0.11 ENST00000231173.3
PCDHB15
protocadherin beta 15
chr10_+_129796390 0.11 ENST00000455661.1
PTPRE
protein tyrosine phosphatase, receptor type, E
chr5_+_79950463 0.10 ENST00000265081.6
MSH3
mutS homolog 3
chr20_+_44036620 0.10 ENST00000372710.3
DBNDD2
dysbindin (dystrobrevin binding protein 1) domain containing 2
chr19_+_51728316 0.09 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
CD33
CD33 molecule
chr17_-_34195889 0.09 ENST00000311880.2
C17orf66
chromosome 17 open reading frame 66
chr15_+_22736246 0.09 ENST00000316397.3
GOLGA6L1
golgin A6 family-like 1
chr20_+_55926583 0.09 ENST00000395840.2
RAE1
ribonucleic acid export 1
chr5_-_132362226 0.09 ENST00000509437.1
ENST00000355372.2
ENST00000513541.1
ENST00000509008.1
ENST00000513848.1
ENST00000504170.1
ENST00000324170.3
ZCCHC10
zinc finger, CCHC domain containing 10
chr3_+_51741072 0.09 ENST00000395052.3
GRM2
glutamate receptor, metabotropic 2
chr15_+_68117872 0.08 ENST00000380035.2
ENST00000389002.1
SKOR1
SKI family transcriptional corepressor 1
chr19_+_41594377 0.08 ENST00000330436.3
CYP2A13
cytochrome P450, family 2, subfamily A, polypeptide 13
chr16_+_618837 0.08 ENST00000409439.2
PIGQ
phosphatidylinositol glycan anchor biosynthesis, class Q
chr1_+_207039154 0.08 ENST00000367096.3
ENST00000391930.2
IL20
interleukin 20
chr11_-_3147835 0.08 ENST00000525498.1
OSBPL5
oxysterol binding protein-like 5
chr15_+_63889552 0.07 ENST00000360587.2
FBXL22
F-box and leucine-rich repeat protein 22
chr19_-_55691377 0.07 ENST00000589172.1
SYT5
synaptotagmin V
chr1_-_160832490 0.07 ENST00000322302.7
ENST00000368033.3
CD244
CD244 molecule, natural killer cell receptor 2B4
chr17_+_38121772 0.07 ENST00000577447.1
GSDMA
gasdermin A
chr6_+_116937636 0.06 ENST00000368581.4
ENST00000229554.5
ENST00000368580.4
RSPH4A
radial spoke head 4 homolog A (Chlamydomonas)
chr1_-_9129631 0.06 ENST00000377414.3
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr9_+_136399929 0.06 ENST00000393060.1
ADAMTSL2
ADAMTS-like 2
chr4_+_2813946 0.06 ENST00000442312.2
SH3BP2
SH3-domain binding protein 2
chr16_+_30484054 0.06 ENST00000564118.1
ENST00000454514.2
ENST00000433423.2
ITGAL
integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)
chr16_-_58328884 0.06 ENST00000569079.1
PRSS54
protease, serine, 54
chr15_+_63889577 0.06 ENST00000534939.1
ENST00000539570.3
FBXL22
F-box and leucine-rich repeat protein 22
chr15_+_22736484 0.06 ENST00000560659.2
GOLGA6L1
golgin A6 family-like 1
chrX_-_153523462 0.06 ENST00000361930.3
ENST00000369926.1
TEX28
testis expressed 28
chr6_+_139349817 0.05 ENST00000367660.3
ABRACL
ABRA C-terminal like
chr2_+_96991033 0.05 ENST00000420176.1
ENST00000536814.1
ENST00000439118.2
ITPRIPL1
inositol 1,4,5-trisphosphate receptor interacting protein-like 1
chr9_-_14910990 0.05 ENST00000380881.4
ENST00000422223.2
FREM1
FRAS1 related extracellular matrix 1
chr3_+_190105909 0.04 ENST00000456423.1
CLDN16
claudin 16
chr4_+_2814011 0.04 ENST00000502260.1
ENST00000435136.2
SH3BP2
SH3-domain binding protein 2
chr6_+_27806319 0.04 ENST00000606613.1
ENST00000396980.3
HIST1H2BN
histone cluster 1, H2bn
chr15_+_81591757 0.03 ENST00000558332.1
IL16
interleukin 16

Network of associatons between targets according to the STRING database.

First level regulatory network of SMAD3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.2 0.7 GO:0046103 adenosine catabolic process(GO:0006154) inosine biosynthetic process(GO:0046103)
0.2 0.6 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.2 0.8 GO:1904117 response to vasopressin(GO:1904116) cellular response to vasopressin(GO:1904117)
0.2 0.5 GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex(GO:0034402)
0.2 1.0 GO:0048817 negative regulation of hair follicle maturation(GO:0048817)
0.2 1.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.6 GO:0090095 regulation of metanephric cap mesenchymal cell proliferation(GO:0090095) positive regulation of metanephric cap mesenchymal cell proliferation(GO:0090096)
0.1 0.6 GO:0044376 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.1 0.4 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 1.2 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.4 GO:2000910 negative regulation of cholesterol import(GO:0060621) negative regulation of sterol import(GO:2000910)
0.1 0.8 GO:0071603 endothelial cell-cell adhesion(GO:0071603)
0.1 1.1 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.1 0.4 GO:0001189 RNA polymerase I transcriptional preinitiation complex assembly(GO:0001188) RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript(GO:0001189)
0.1 0.8 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.1 0.3 GO:0071661 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
0.1 0.3 GO:0001180 transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.1 0.7 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.8 GO:0046952 ketone body catabolic process(GO:0046952)
0.1 0.9 GO:1902365 regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.1 1.4 GO:0015816 glycine transport(GO:0015816)
0.1 0.4 GO:0034334 adherens junction maintenance(GO:0034334)
0.1 1.2 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1 0.6 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.5 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.1 0.8 GO:0010265 SCF complex assembly(GO:0010265)
0.1 0.4 GO:0019242 methylglyoxal biosynthetic process(GO:0019242)
0.1 1.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.1 0.5 GO:1902612 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.1 0.9 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.1 0.4 GO:0045204 MAPK export from nucleus(GO:0045204)
0.1 0.6 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.1 0.8 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 1.1 GO:1903874 ferrous iron transport(GO:0015684) ferrous iron transmembrane transport(GO:1903874)
0.1 1.0 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.5 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0 5.9 GO:0006342 chromatin silencing(GO:0006342)
0.0 0.3 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0 0.2 GO:0046452 dihydrofolate metabolic process(GO:0046452)
0.0 0.2 GO:0006420 arginyl-tRNA aminoacylation(GO:0006420)
0.0 0.6 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 0.2 GO:0051958 methotrexate transport(GO:0051958)
0.0 0.2 GO:0014050 negative regulation of glutamate secretion(GO:0014050)
0.0 4.6 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.2 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.2 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 1.1 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.0 0.2 GO:1901526 negative regulation of mitochondrial membrane permeability(GO:0035795) positive regulation of macromitophagy(GO:1901526) positive regulation of mitophagy in response to mitochondrial depolarization(GO:1904925)
0.0 0.5 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.4 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.5 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.4 GO:0060155 platelet dense granule organization(GO:0060155)
0.0 0.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.3 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.3 GO:0060019 radial glial cell differentiation(GO:0060019)
0.0 1.5 GO:0051145 smooth muscle cell differentiation(GO:0051145)
0.0 0.3 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.0 0.2 GO:0048341 paraxial mesoderm formation(GO:0048341)
0.0 0.1 GO:0009804 coumarin metabolic process(GO:0009804)
0.0 0.2 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0051918 negative regulation of fibrinolysis(GO:0051918)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
0.2 0.8 GO:0071665 gamma-catenin-TCF7L2 complex(GO:0071665)
0.2 11.7 GO:0000786 nucleosome(GO:0000786)
0.2 1.7 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.1 1.2 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 1.1 GO:0033503 HULC complex(GO:0033503)
0.1 0.4 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.9 GO:0055028 cortical microtubule(GO:0055028)
0.1 0.4 GO:0071942 XPC complex(GO:0071942)
0.1 0.4 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 0.5 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
0.0 0.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 1.2 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.2 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.1 GO:0032302 MutSbeta complex(GO:0032302)
0.0 0.4 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559) cytoplasmic side of late endosome membrane(GO:0098560)
0.0 1.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0005915 zonula adherens(GO:0005915)
0.0 0.6 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:0001534 radial spoke(GO:0001534)
0.0 0.6 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.6 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 1.0 GO:0031941 filamentous actin(GO:0031941)
0.0 0.5 GO:0070822 Sin3-type complex(GO:0070822)
0.0 0.4 GO:0031083 BLOC-1 complex(GO:0031083)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0005199 structural constituent of cell wall(GO:0005199)
0.2 0.8 GO:0008260 3-oxoacid CoA-transferase activity(GO:0008260)
0.2 0.6 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.1 0.4 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.5 GO:0000404 heteroduplex DNA loop binding(GO:0000404)
0.1 0.9 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 1.4 GO:0015187 glycine transmembrane transporter activity(GO:0015187)
0.1 0.5 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.3 GO:0019150 D-ribulokinase activity(GO:0019150)
0.1 0.3 GO:0001181 transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.1 0.4 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.1 0.5 GO:0008267 poly-glutamine tract binding(GO:0008267)
0.1 1.1 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.1 0.4 GO:0004347 glucose-6-phosphate isomerase activity(GO:0004347)
0.1 0.6 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 1.3 GO:0008199 ferric iron binding(GO:0008199)
0.1 1.0 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 1.7 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.5 GO:0034603 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0 0.7 GO:0004000 adenosine deaminase activity(GO:0004000)
0.0 0.9 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.3 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.0 0.2 GO:0033265 choline binding(GO:0033265)
0.0 0.5 GO:0022851 GABA-gated chloride ion channel activity(GO:0022851)
0.0 0.2 GO:0004814 arginine-tRNA ligase activity(GO:0004814)
0.0 0.2 GO:0015350 methotrexate transporter activity(GO:0015350)
0.0 0.6 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.5 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.0 0.1 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.0 1.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 1.8 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
0.0 0.2 GO:0051870 methotrexate binding(GO:0051870)
0.0 1.8 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.1 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.2 GO:0019158 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0 0.8 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.4 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.0 0.2 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.2 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 9.7 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.2 GO:0004969 histamine receptor activity(GO:0004969)
0.0 1.0 GO:0070888 E-box binding(GO:0070888)
0.0 0.1 GO:0004127 cytidylate kinase activity(GO:0004127)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)
0.0 0.7 GO:0031491 nucleosome binding(GO:0031491)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 1.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 1.9 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.0 2.0 PID AURORA A PATHWAY Aurora A signaling
0.0 0.8 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.9 PID ATM PATHWAY ATM pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 17.7 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.1 2.1 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.1 1.2 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 0.9 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.9 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.7 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 1.4 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.5 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 1.2 REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.5 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.0 1.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.4 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.2 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.0 1.7 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.4 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling