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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX1

Z-value: 0.40

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Transcription factors associated with SOX1

Gene Symbol Gene ID Gene Info
SOX1
ENSG00000182968.3 SRY-box transcription factor 1

Activity profile of SOX1 motif

Sorted Z-values of SOX1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_16916624 0.84 ENST00000513882.1
MYO10
myosin X
chr6_+_149539767 0.59 ENST00000606202.1
ENST00000536230.1
ENST00000445901.1
TAB2
RP1-111D6.3
TGF-beta activated kinase 1/MAP3K7 binding protein 2
RP1-111D6.3
chr7_+_36450169 0.52 ENST00000428612.1
ANLN
anillin, actin binding protein
chr3_+_127770455 0.49 ENST00000464451.1
SEC61A1
Sec61 alpha 1 subunit (S. cerevisiae)
chrX_+_114874727 0.48 ENST00000543070.1
PLS3
plastin 3
chr2_+_11864458 0.47 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
LPIN1
lipin 1
chr3_-_33686925 0.47 ENST00000485378.2
ENST00000313350.6
ENST00000487200.1
CLASP2
cytoplasmic linker associated protein 2
chr17_+_80816395 0.43 ENST00000576160.2
ENST00000571712.1
TBCD
tubulin folding cofactor D
chr15_+_57540230 0.41 ENST00000559703.1
TCF12
transcription factor 12
chr7_-_105029812 0.41 ENST00000482897.1
SRPK2
SRSF protein kinase 2
chr17_+_75316336 0.41 ENST00000591934.1
SEPT9
septin 9
chr2_-_96926313 0.39 ENST00000435268.1
TMEM127
transmembrane protein 127
chr10_-_92681033 0.36 ENST00000371697.3
ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr3_+_158362299 0.34 ENST00000478576.1
ENST00000264263.5
ENST00000464732.1
GFM1
G elongation factor, mitochondrial 1
chr5_+_135383008 0.33 ENST00000508767.1
ENST00000604555.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chr3_+_136676707 0.30 ENST00000329582.4
IL20RB
interleukin 20 receptor beta
chr9_-_13165457 0.30 ENST00000542239.1
ENST00000538841.1
ENST00000433359.2
MPDZ
multiple PDZ domain protein
chr15_+_42565393 0.28 ENST00000561871.1
GANC
glucosidase, alpha; neutral C
chr17_+_75181292 0.28 ENST00000431431.2
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr8_-_134501873 0.26 ENST00000523634.1
ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr1_-_200379129 0.25 ENST00000367353.1
ZNF281
zinc finger protein 281
chr4_-_74486347 0.25 ENST00000342081.3
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr3_+_136676851 0.25 ENST00000309741.5
IL20RB
interleukin 20 receptor beta
chr8_-_134501937 0.25 ENST00000519924.1
ST3GAL1
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
chr1_+_46805832 0.24 ENST00000474844.1
NSUN4
NOP2/Sun domain family, member 4
chr4_-_74486109 0.24 ENST00000395777.2
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr10_-_73976884 0.24 ENST00000317126.4
ENST00000545550.1
ASCC1
activating signal cointegrator 1 complex subunit 1
chr11_+_125496619 0.24 ENST00000532669.1
ENST00000278916.3
CHEK1
checkpoint kinase 1
chr16_-_18937072 0.23 ENST00000569122.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr14_-_89878369 0.21 ENST00000553840.1
ENST00000556916.1
FOXN3
forkhead box N3
chr4_-_74486217 0.20 ENST00000335049.5
ENST00000307439.5
RASSF6
Ras association (RalGDS/AF-6) domain family member 6
chr13_-_22178284 0.20 ENST00000468222.2
ENST00000382374.4
MICU2
mitochondrial calcium uptake 2
chr11_+_125496400 0.20 ENST00000524737.1
CHEK1
checkpoint kinase 1
chr1_-_200379104 0.19 ENST00000367352.3
ZNF281
zinc finger protein 281
chr14_+_62164340 0.19 ENST00000557538.1
ENST00000539097.1
HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
chr3_-_16524357 0.19 ENST00000432519.1
RFTN1
raftlin, lipid raft linker 1
chr9_-_85882145 0.18 ENST00000328788.1
FRMD3
FERM domain containing 3
chr12_+_75874460 0.17 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr3_-_171489085 0.15 ENST00000418087.1
PLD1
phospholipase D1, phosphatidylcholine-specific
chr16_-_11876408 0.15 ENST00000396516.2
ZC3H7A
zinc finger CCCH-type containing 7A
chr3_-_44519131 0.15 ENST00000425708.2
ENST00000396077.2
ZNF445
zinc finger protein 445
chr6_+_148593425 0.15 ENST00000367469.1
SASH1
SAM and SH3 domain containing 1
chr3_-_185655795 0.15 ENST00000342294.4
ENST00000382191.4
ENST00000453386.2
TRA2B
transformer 2 beta homolog (Drosophila)
chr10_-_73976025 0.15 ENST00000342444.4
ENST00000533958.1
ENST00000527593.1
ENST00000394915.3
ENST00000530461.1
ENST00000317168.6
ENST00000524829.1
ASCC1
activating signal cointegrator 1 complex subunit 1
chr1_-_43638168 0.15 ENST00000431635.2
EBNA1BP2
EBNA1 binding protein 2
chr9_-_104249400 0.15 ENST00000374848.3
TMEM246
transmembrane protein 246
chr12_+_100594557 0.14 ENST00000546902.1
ENST00000552376.1
ENST00000551617.1
ACTR6
ARP6 actin-related protein 6 homolog (yeast)
chr1_+_206516200 0.14 ENST00000295713.5
SRGAP2
SLIT-ROBO Rho GTPase activating protein 2
chr9_-_2844058 0.14 ENST00000397885.2
KIAA0020
KIAA0020
chr6_-_138866823 0.13 ENST00000342260.5
NHSL1
NHS-like 1
chrX_-_57021943 0.12 ENST00000374919.3
SPIN3
spindlin family, member 3
chr19_-_10491130 0.12 ENST00000530829.1
ENST00000529370.1
TYK2
tyrosine kinase 2
chr1_-_19578003 0.11 ENST00000375199.3
ENST00000375208.3
ENST00000356068.2
ENST00000477853.1
EMC1
ER membrane protein complex subunit 1
chr14_+_20811722 0.11 ENST00000429687.3
PARP2
poly (ADP-ribose) polymerase 2
chr19_+_21324827 0.10 ENST00000600692.1
ENST00000599296.1
ENST00000594425.1
ENST00000311048.7
ZNF431
zinc finger protein 431
chr4_-_170924888 0.10 ENST00000502832.1
ENST00000393704.3
MFAP3L
microfibrillar-associated protein 3-like
chr4_+_154622652 0.10 ENST00000260010.6
TLR2
toll-like receptor 2
chr11_+_125496124 0.09 ENST00000533778.2
ENST00000534070.1
CHEK1
checkpoint kinase 1
chr11_+_102980126 0.09 ENST00000375735.2
DYNC2H1
dynein, cytoplasmic 2, heavy chain 1
chr20_-_49575058 0.09 ENST00000371584.4
ENST00000371583.5
ENST00000413082.1
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr5_-_173043591 0.09 ENST00000285908.5
ENST00000480951.1
ENST00000311086.4
BOD1
biorientation of chromosomes in cell division 1
chr3_-_126327398 0.09 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr1_+_184020830 0.08 ENST00000533373.1
ENST00000423085.2
TSEN15
TSEN15 tRNA splicing endonuclease subunit
chr20_-_49575081 0.08 ENST00000371588.5
ENST00000371582.4
DPM1
dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
chr1_+_184020811 0.08 ENST00000361641.1
TSEN15
TSEN15 tRNA splicing endonuclease subunit
chr5_+_158654712 0.08 ENST00000520323.1
CTB-11I22.2
CTB-11I22.2
chr17_-_38821373 0.08 ENST00000394052.3
KRT222
keratin 222
chr9_-_123638633 0.07 ENST00000456291.1
PHF19
PHD finger protein 19
chr14_+_38033252 0.07 ENST00000554829.1
RP11-356O9.1
RP11-356O9.1
chrX_+_11129388 0.07 ENST00000321143.4
ENST00000380763.3
ENST00000380762.4
HCCS
holocytochrome c synthase
chr11_-_78052923 0.07 ENST00000340149.2
GAB2
GRB2-associated binding protein 2
chr1_+_24646263 0.07 ENST00000524724.1
GRHL3
grainyhead-like 3 (Drosophila)
chr4_+_26585538 0.06 ENST00000264866.4
TBC1D19
TBC1 domain family, member 19
chr1_+_152975488 0.06 ENST00000542696.1
SPRR3
small proline-rich protein 3
chr2_+_171034646 0.06 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr6_+_28249299 0.06 ENST00000405948.2
PGBD1
piggyBac transposable element derived 1
chr1_+_65613340 0.06 ENST00000546702.1
AK4
adenylate kinase 4
chr11_-_57177586 0.05 ENST00000529411.1
RP11-872D17.8
Uncharacterized protein
chr11_-_111649074 0.05 ENST00000534218.1
RP11-108O10.2
RP11-108O10.2
chr1_+_152957707 0.05 ENST00000368762.1
SPRR1A
small proline-rich protein 1A
chr10_+_47894572 0.04 ENST00000355876.5
FAM21B
family with sequence similarity 21, member B
chr20_-_14318248 0.04 ENST00000378053.3
ENST00000341420.4
FLRT3
fibronectin leucine rich transmembrane protein 3
chr16_-_1538765 0.04 ENST00000447419.2
ENST00000440447.2
PTX4
pentraxin 4, long
chr6_+_32685782 0.04 ENST00000448198.1
ENST00000585372.1
XXbac-BPG254F23.7
XXbac-BPG254F23.7
chr10_-_43892668 0.04 ENST00000544000.1
HNRNPF
heterogeneous nuclear ribonucleoprotein F
chr6_+_27833034 0.04 ENST00000357320.2
HIST1H2AL
histone cluster 1, H2al
chr2_-_14541060 0.04 ENST00000418420.1
ENST00000417751.1
LINC00276
long intergenic non-protein coding RNA 276
chr4_+_156680153 0.04 ENST00000502959.1
ENST00000505764.1
ENST00000507146.1
ENST00000264424.8
ENST00000503520.1
GUCY1B3
guanylate cyclase 1, soluble, beta 3
chr22_+_32149927 0.03 ENST00000437411.1
ENST00000535622.1
ENST00000536766.1
ENST00000400242.3
ENST00000266091.3
ENST00000400249.2
ENST00000400246.1
ENST00000382105.2
DEPDC5
DEP domain containing 5
chr17_+_19186292 0.03 ENST00000395626.1
ENST00000571254.1
EPN2
epsin 2
chr6_+_28249332 0.03 ENST00000259883.3
PGBD1
piggyBac transposable element derived 1
chr17_+_33448593 0.03 ENST00000158009.5
FNDC8
fibronectin type III domain containing 8
chr3_-_58613323 0.03 ENST00000474531.1
ENST00000465970.1
FAM107A
family with sequence similarity 107, member A
chr1_+_240255166 0.03 ENST00000319653.9
FMN2
formin 2
chr19_+_17830051 0.02 ENST00000594625.1
ENST00000324096.4
ENST00000600186.1
ENST00000597735.1
MAP1S
microtubule-associated protein 1S
chr11_-_6790286 0.02 ENST00000338569.2
OR2AG2
olfactory receptor, family 2, subfamily AG, member 2
chr11_-_47400032 0.02 ENST00000533968.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr17_-_15519008 0.02 ENST00000261644.8
CDRT1
CMT1A duplicated region transcript 1
chr5_-_54988559 0.02 ENST00000502247.1
SLC38A9
solute carrier family 38, member 9
chr4_-_142134031 0.02 ENST00000420921.2
RNF150
ring finger protein 150
chr12_+_93096619 0.02 ENST00000397833.3
C12orf74
chromosome 12 open reading frame 74
chrX_+_129040122 0.02 ENST00000394422.3
ENST00000371051.5
UTP14A
UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
chr12_+_55248289 0.02 ENST00000308796.6
MUCL1
mucin-like 1
chr12_+_7456880 0.01 ENST00000399422.4
ACSM4
acyl-CoA synthetase medium-chain family member 4
chr17_+_74729060 0.01 ENST00000587459.1
RP11-318A15.7
Uncharacterized protein
chr3_-_55539287 0.01 ENST00000472238.1
RP11-875H7.5
RP11-875H7.5
chr19_+_35842445 0.01 ENST00000246553.2
FFAR1
free fatty acid receptor 1
chr11_-_47399942 0.01 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr20_+_49575342 0.01 ENST00000244051.1
MOCS3
molybdenum cofactor synthesis 3
chr1_-_86848760 0.01 ENST00000460698.2
ODF2L
outer dense fiber of sperm tails 2-like
chr11_+_29181503 0.00 ENST00000530960.1
RP11-466I1.1
RP11-466I1.1
chr12_-_110434096 0.00 ENST00000320063.9
ENST00000457474.2
ENST00000547815.1
ENST00000361006.5
GIT2
G protein-coupled receptor kinase interacting ArfGAP 2
chr8_-_99955042 0.00 ENST00000519420.1
STK3
serine/threonine kinase 3
chr10_-_75401500 0.00 ENST00000359322.4
MYOZ1
myozenin 1
chr22_+_20692438 0.00 ENST00000434783.3
FAM230A
family with sequence similarity 230, member A
chr10_-_96829246 0.00 ENST00000371270.3
ENST00000535898.1
ENST00000539050.1
CYP2C8
cytochrome P450, family 2, subfamily C, polypeptide 8
chr8_-_110620284 0.00 ENST00000529690.1
SYBU
syntabulin (syntaxin-interacting)
chr8_+_80209929 0.00 ENST00000519983.1
RP11-1114I9.1
RP11-1114I9.1

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0000921 septin ring assembly(GO:0000921) septin ring organization(GO:0031106)
0.1 0.5 GO:0001808 negative regulation of type IV hypersensitivity(GO:0001808)
0.1 0.5 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.1 0.5 GO:0039019 pronephric nephron development(GO:0039019)
0.1 0.4 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.2 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.1 0.5 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.4 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.2 GO:0051541 neural fold elevation formation(GO:0021502) elastin metabolic process(GO:0051541) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) positive regulation of chemokine-mediated signaling pathway(GO:0070101)
0.0 0.1 GO:0021816 lamellipodium assembly involved in ameboidal cell migration(GO:0003363) extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration(GO:0021816)
0.0 0.1 GO:0032289 central nervous system myelin formation(GO:0032289)
0.0 0.3 GO:0000023 maltose metabolic process(GO:0000023)
0.0 0.5 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.1 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
0.0 0.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.0 0.2 GO:0019348 dolichol metabolic process(GO:0019348)
0.0 0.4 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
0.0 0.3 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 0.5 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 0.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.5 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.4 GO:0010172 embryonic body morphogenesis(GO:0010172)
0.0 0.2 GO:0002457 T cell antigen processing and presentation(GO:0002457)
0.0 0.4 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0 0.4 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.2 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0 0.8 GO:0032433 filopodium tip(GO:0032433)
0.0 0.2 GO:1990246 uniplex complex(GO:1990246)
0.0 0.5 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.1 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0 0.3 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.4 GO:0031105 septin complex(GO:0031105)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1 0.5 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.5 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.1 0.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.1 0.8 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 0.2 GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383)
0.0 0.3 GO:0039552 RIG-I binding(GO:0039552)
0.0 0.2 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0 0.3 GO:0032450 alpha-1,4-glucosidase activity(GO:0004558) maltose alpha-glucosidase activity(GO:0032450)
0.0 0.1 GO:1990404 protein ADP-ribosylase activity(GO:1990404)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.5 GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.6 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.4 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0071723 lipopolysaccharide receptor activity(GO:0001875) lipopeptide binding(GO:0071723)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.6 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0 0.5 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.5 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.4 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.0 0.2 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis