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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SOX10_SOX15
Z-value: 1.69
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Transcription factors associated with SOX10_SOX15
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX15 | hg19_v2_chr17_-_7493390_7493488 | -0.81 | 1.3e-05 | Click! |
| SOX10 | hg19_v2_chr22_-_38380543_38380569 | 0.23 | 3.3e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr6_-_127840336 Show fit | 6.99 |
ENST00000525778.1
|
SOGA family member 3 |
|
| chr2_+_27070964 Show fit | 6.49 |
ENST00000288699.6
|
dihydropyrimidinase-like 5 |
|
| chr2_+_27071045 Show fit | 5.89 |
ENST00000401478.1
|
dihydropyrimidinase-like 5 |
|
| chr4_+_41614909 Show fit | 5.59 |
ENST00000509454.1
ENST00000396595.3 ENST00000381753.4 |
LIM and calponin homology domains 1 |
|
| chr6_-_127840021 Show fit | 5.18 |
ENST00000465909.2
|
SOGA family member 3 |
|
| chr4_+_41614720 Show fit | 4.47 |
ENST00000509277.1
|
LIM and calponin homology domains 1 |
|
| chr6_-_64029879 Show fit | 4.40 |
ENST00000370658.5
ENST00000485906.2 ENST00000370657.4 |
lengsin, lens protein with glutamine synthetase domain |
|
| chr15_-_88799948 Show fit | 4.24 |
ENST00000394480.2
|
neurotrophic tyrosine kinase, receptor, type 3 |
|
| chr6_-_127840453 Show fit | 4.08 |
ENST00000556132.1
|
SOGA family member 3 |
|
| chrX_+_12993202 Show fit | 3.91 |
ENST00000451311.2
ENST00000380636.1 |
thymosin beta 4, X-linked |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX10_SOX15
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 18.3 | GO:0010506 | regulation of autophagy(GO:0010506) |
| 2.4 | 9.5 | GO:0048687 | modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026) |
| 0.0 | 9.1 | GO:0007411 | axon guidance(GO:0007411) |
| 0.5 | 8.0 | GO:1901898 | negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898) |
| 0.3 | 6.2 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.6 | 4.7 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.5 | 4.4 | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377) |
| 0.2 | 4.1 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 0.2 | 4.1 | GO:0070933 | histone H4 deacetylation(GO:0070933) |
| 0.1 | 3.8 | GO:0060065 | uterus development(GO:0060065) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 7.5 | GO:0036464 | cytoplasmic ribonucleoprotein granule(GO:0036464) |
| 0.2 | 6.2 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 6.2 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.2 | 5.8 | GO:0000930 | gamma-tubulin complex(GO:0000930) |
| 0.0 | 4.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 4.1 | GO:0035861 | site of double-strand break(GO:0035861) |
| 0.4 | 4.0 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.2 | 3.7 | GO:0000815 | ESCRT III complex(GO:0000815) |
| 0.0 | 3.6 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 13.2 | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810) |
| 0.6 | 9.5 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
| 0.2 | 8.9 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.1 | 8.6 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 7.4 | GO:0004386 | helicase activity(GO:0004386) |
| 1.2 | 5.8 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.2 | 5.5 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.1 | 5.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.2 | 4.4 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.2 | 4.1 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.0 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.2 | 6.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.3 | 6.6 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 5.5 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 5.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.1 | 3.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.1 | 3.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.0 | 3.4 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 2.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.1 | 2.7 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.5 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 8.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 6.0 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.0 | 4.6 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 4.4 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 3.7 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.1 | 3.3 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 3.3 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.0 | 2.9 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 0.0 | 2.5 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |