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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SOX13_SOX12
Z-value: 1.96
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Transcription factors associated with SOX13_SOX12
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX12 | hg19_v2_chr20_+_306221_306239 | -0.97 | 2.8e-12 | Click! |
| SOX13 | hg19_v2_chr1_+_204042723_204042784 | 0.41 | 7.2e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX13_SOX12
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 24.3 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 1.9 | 13.4 | GO:0038172 | interleukin-33-mediated signaling pathway(GO:0038172) |
| 0.3 | 11.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 3.7 | 11.0 | GO:1902173 | negative regulation of keratinocyte apoptotic process(GO:1902173) |
| 0.6 | 11.0 | GO:0098789 | pre-mRNA cleavage required for polyadenylation(GO:0098789) |
| 0.9 | 9.7 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.2 | 9.6 | GO:0097435 | fibril organization(GO:0097435) |
| 0.6 | 9.1 | GO:0032119 | sequestering of zinc ion(GO:0032119) |
| 0.1 | 8.1 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.4 | 7.1 | GO:0008090 | retrograde axonal transport(GO:0008090) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 22.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 20.6 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 12.3 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.5 | 11.9 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 11.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 11.2 | GO:0005747 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.4 | 11.0 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.4 | 9.5 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.0 | 8.3 | GO:0034774 | secretory granule lumen(GO:0034774) |
| 0.0 | 7.4 | GO:0055037 | recycling endosome(GO:0055037) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 17.0 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 4.5 | 13.4 | GO:0002113 | interleukin-33 binding(GO:0002113) |
| 0.1 | 12.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.7 | 10.3 | GO:0004022 | alcohol dehydrogenase (NAD) activity(GO:0004022) |
| 0.3 | 9.6 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 1.3 | 9.1 | GO:0035662 | Toll-like receptor 4 binding(GO:0035662) |
| 0.1 | 8.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 8.9 | GO:0008201 | heparin binding(GO:0008201) |
| 0.1 | 8.1 | GO:0008137 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 15.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.2 | 15.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 12.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 10.1 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.2 | 9.6 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 9.4 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 7.1 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.3 | 6.6 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 5.2 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.3 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 7.1 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.0 | 4.7 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 4.6 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.0 | 4.3 | REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL | Genes involved in Cell surface interactions at the vascular wall |
| 0.0 | 4.0 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.1 | 3.9 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.2 | 3.7 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.2 | 3.3 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 3.2 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |