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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX21

Z-value: 0.39

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Transcription factors associated with SOX21

Gene Symbol Gene ID Gene Info
SOX21
ENSG00000125285.4 SRY-box transcription factor 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX21hg19_v2_chr13_-_95364389_953643890.311.9e-01Click!

Activity profile of SOX21 motif

Sorted Z-values of SOX21 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_+_5005445 1.66 ENST00000380872.4
AKR1C1
aldo-keto reductase family 1, member C1
chr7_-_107968999 1.49 ENST00000456431.1
NRCAM
neuronal cell adhesion molecule
chr11_+_114168085 1.25 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chr20_+_43343886 1.04 ENST00000190983.4
WISP2
WNT1 inducible signaling pathway protein 2
chr7_-_86849883 0.99 ENST00000433078.1
TMEM243
transmembrane protein 243, mitochondrial
chr8_-_19459993 0.90 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr12_+_123011776 0.77 ENST00000450485.2
ENST00000333479.7
KNTC1
kinetochore associated 1
chr7_-_86849836 0.75 ENST00000455575.1
TMEM243
transmembrane protein 243, mitochondrial
chr7_-_107968921 0.74 ENST00000442580.1
NRCAM
neuronal cell adhesion molecule
chr8_-_142377367 0.73 ENST00000377741.3
GPR20
G protein-coupled receptor 20
chr1_+_199996733 0.65 ENST00000236914.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr2_+_217363559 0.61 ENST00000600880.1
ENST00000446558.1
RPL37A
ribosomal protein L37a
chrY_+_14813160 0.61 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr1_+_221051699 0.60 ENST00000366903.6
HLX
H2.0-like homeobox
chr3_-_155524049 0.57 ENST00000534941.1
ENST00000340171.2
C3orf33
chromosome 3 open reading frame 33
chr12_+_20522179 0.56 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr3_+_37035263 0.53 ENST00000458205.2
ENST00000539477.1
MLH1
mutL homolog 1
chr3_+_37035289 0.52 ENST00000455445.2
ENST00000441265.1
ENST00000435176.1
ENST00000429117.1
ENST00000536378.1
MLH1
mutL homolog 1
chrX_-_55208866 0.51 ENST00000545075.1
MTRNR2L10
MT-RNR2-like 10
chr19_+_42381337 0.49 ENST00000597454.1
ENST00000444740.2
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr15_-_80263506 0.49 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr7_-_37382683 0.46 ENST00000455879.1
ELMO1
engulfment and cell motility 1
chr14_-_92588013 0.45 ENST00000553514.1
ENST00000605997.1
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr17_-_18266660 0.44 ENST00000582653.1
ENST00000352886.6
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr22_-_40929812 0.43 ENST00000422851.1
MKL1
megakaryoblastic leukemia (translocation) 1
chr11_-_8285405 0.32 ENST00000335790.3
ENST00000534484.1
LMO1
LIM domain only 1 (rhombotin 1)
chr19_+_42381173 0.32 ENST00000221972.3
CD79A
CD79a molecule, immunoglobulin-associated alpha
chr3_-_37034702 0.31 ENST00000322716.5
EPM2AIP1
EPM2A (laforin) interacting protein 1
chr3_-_45957534 0.30 ENST00000536047.1
LZTFL1
leucine zipper transcription factor-like 1
chr3_-_45957088 0.30 ENST00000539217.1
LZTFL1
leucine zipper transcription factor-like 1
chr7_-_37026108 0.29 ENST00000396045.3
ELMO1
engulfment and cell motility 1
chr21_+_30672433 0.29 ENST00000451655.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr17_+_66245341 0.27 ENST00000577985.1
AMZ2
archaelysin family metallopeptidase 2
chr7_-_73133959 0.26 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
STX1A
syntaxin 1A (brain)
chr14_+_20215587 0.25 ENST00000331723.1
OR4Q3
olfactory receptor, family 4, subfamily Q, member 3
chr4_-_39034542 0.25 ENST00000344606.6
TMEM156
transmembrane protein 156
chr5_-_95158644 0.23 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr14_+_101361107 0.23 ENST00000553584.1
ENST00000554852.1
MEG8
maternally expressed 8 (non-protein coding)
chr9_-_104249400 0.22 ENST00000374848.3
TMEM246
transmembrane protein 246
chr5_-_95158375 0.22 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr4_-_83931862 0.22 ENST00000506560.1
ENST00000442461.2
ENST00000446851.2
ENST00000340417.3
LIN54
lin-54 homolog (C. elegans)
chr9_-_70465758 0.22 ENST00000489273.1
CBWD5
COBW domain containing 5
chr3_+_37034823 0.21 ENST00000231790.2
ENST00000456676.2
MLH1
mutL homolog 1
chr8_+_101170563 0.21 ENST00000520508.1
ENST00000388798.2
SPAG1
sperm associated antigen 1
chr10_-_17243579 0.21 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
TRDMT1
tRNA aspartic acid methyltransferase 1
chr8_-_146078376 0.20 ENST00000533270.1
ENST00000305103.3
ENST00000402718.3
COMMD5
COMM domain containing 5
chr7_+_7196565 0.20 ENST00000429911.1
C1GALT1
core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1
chr22_+_39353527 0.20 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr15_+_58702742 0.20 ENST00000356113.6
ENST00000414170.3
LIPC
lipase, hepatic
chr12_-_10588539 0.19 ENST00000381902.2
ENST00000381901.1
ENST00000539033.1
KLRC2
NKG2-E
killer cell lectin-like receptor subfamily C, member 2
Uncharacterized protein
chr1_-_169455169 0.19 ENST00000367804.4
ENST00000236137.5
SLC19A2
solute carrier family 19 (thiamine transporter), member 2
chr11_-_62474803 0.18 ENST00000533982.1
ENST00000360796.5
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr16_-_15982440 0.16 ENST00000575938.1
ENST00000573396.1
ENST00000573968.1
ENST00000575744.1
ENST00000573429.1
ENST00000255759.6
ENST00000575073.1
FOPNL
FGFR1OP N-terminal like
chr2_+_102759199 0.15 ENST00000409288.1
ENST00000410023.1
IL1R1
interleukin 1 receptor, type I
chr5_-_55529115 0.15 ENST00000513241.2
ENST00000341048.4
ANKRD55
ankyrin repeat domain 55
chr14_-_92588246 0.15 ENST00000329559.3
NDUFB1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa
chr8_-_50466973 0.13 ENST00000520800.1
RP11-738G5.2
Uncharacterized protein
chr12_+_101673872 0.13 ENST00000261637.4
UTP20
UTP20, small subunit (SSU) processome component, homolog (yeast)
chr1_+_146714291 0.12 ENST00000431239.1
ENST00000369259.3
ENST00000369258.4
ENST00000361293.5
CHD1L
chromodomain helicase DNA binding protein 1-like
chr4_-_69083720 0.12 ENST00000432593.3
TMPRSS11BNL
TMPRSS11B N-terminal like
chr3_+_38537960 0.11 ENST00000453767.1
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr6_-_121655593 0.11 ENST00000398212.2
TBC1D32
TBC1 domain family, member 32
chrX_-_138724677 0.10 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
MCF2
MCF.2 cell line derived transforming sequence
chr3_+_38537763 0.09 ENST00000287675.5
ENST00000358249.2
ENST00000422077.2
EXOG
endo/exonuclease (5'-3'), endonuclease G-like
chr1_-_217250231 0.09 ENST00000493748.1
ENST00000463665.1
ESRRG
estrogen-related receptor gamma
chr3_-_164875850 0.09 ENST00000472120.1
RP11-747D18.1
RP11-747D18.1
chr17_+_60457914 0.09 ENST00000305286.3
ENST00000520404.1
ENST00000518576.1
EFCAB3
EF-hand calcium binding domain 3
chr3_+_141103634 0.08 ENST00000507722.1
ZBTB38
zinc finger and BTB domain containing 38
chr11_-_57479673 0.08 ENST00000337672.2
ENST00000431606.2
MED19
mediator complex subunit 19
chrY_+_16634483 0.08 ENST00000382872.1
NLGN4Y
neuroligin 4, Y-linked
chr2_+_3705785 0.08 ENST00000252505.3
ALLC
allantoicase
chr7_-_14942944 0.07 ENST00000403951.2
DGKB
diacylglycerol kinase, beta 90kDa
chr18_+_43319467 0.07 ENST00000591541.1
SLC14A1
solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
chr19_-_45737469 0.07 ENST00000413988.1
EXOC3L2
exocyst complex component 3-like 2
chr10_-_18944123 0.06 ENST00000606425.1
RP11-139J15.7
Uncharacterized protein
chr1_-_151148492 0.06 ENST00000295314.4
TMOD4
tropomodulin 4 (muscle)
chr14_+_22600515 0.06 ENST00000390456.3
TRAV8-7
T cell receptor alpha variable 8-7 (non-functional)
chr12_+_1099675 0.06 ENST00000545318.2
ERC1
ELKS/RAB6-interacting/CAST family member 1
chr12_-_1058849 0.06 ENST00000358495.3
RAD52
RAD52 homolog (S. cerevisiae)
chr6_+_131894284 0.05 ENST00000368087.3
ENST00000356962.2
ARG1
arginase 1
chr14_+_50291993 0.05 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr4_-_177190364 0.05 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chrX_-_131353461 0.04 ENST00000370874.1
RAP2C
RAP2C, member of RAS oncogene family
chr9_-_14910990 0.04 ENST00000380881.4
ENST00000422223.2
FREM1
FRAS1 related extracellular matrix 1
chr19_+_16308659 0.04 ENST00000590263.1
ENST00000590756.1
ENST00000541844.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr8_-_143961236 0.04 ENST00000377675.3
ENST00000517471.1
ENST00000292427.4
CYP11B1
cytochrome P450, family 11, subfamily B, polypeptide 1
chr18_+_28923589 0.03 ENST00000462981.2
DSG1
desmoglein 1
chr8_+_67687413 0.03 ENST00000521960.1
ENST00000522398.1
ENST00000522629.1
ENST00000520976.1
ENST00000396596.1
SGK3
serum/glucocorticoid regulated kinase family, member 3
chr3_+_155838337 0.03 ENST00000490337.1
ENST00000389636.5
KCNAB1
potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr8_-_94029882 0.02 ENST00000520686.1
TRIQK
triple QxxK/R motif containing
chr12_+_58087738 0.02 ENST00000552285.1
OS9
osteosarcoma amplified 9, endoplasmic reticulum lectin
chr1_-_75100539 0.02 ENST00000420661.2
C1orf173
chromosome 1 open reading frame 173
chr12_+_69742121 0.02 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
LYZ
lysozyme
chr14_+_60712463 0.02 ENST00000325642.3
ENST00000529574.1
PPM1A
protein phosphatase, Mg2+/Mn2+ dependent, 1A
chr14_-_95922526 0.01 ENST00000554873.1
SYNE3
spectrin repeat containing, nuclear envelope family member 3
chrX_+_52927576 0.01 ENST00000416841.2
FAM156B
family with sequence similarity 156, member B
chr4_+_81951957 0.01 ENST00000282701.2
BMP3
bone morphogenetic protein 3
chr7_+_120702819 0.01 ENST00000423795.1
CPED1
cadherin-like and PC-esterase domain containing 1
chr8_-_66750978 0.01 ENST00000523253.1
PDE7A
phosphodiesterase 7A
chr5_+_140579162 0.01 ENST00000536699.1
ENST00000354757.3
PCDHB11
protocadherin beta 11
chr19_+_16308711 0.01 ENST00000429941.2
ENST00000444449.2
ENST00000589822.1
AP1M1
adaptor-related protein complex 1, mu 1 subunit
chr7_+_34697973 0.00 ENST00000381539.3
NPSR1
neuropeptide S receptor 1
chrX_+_65384052 0.00 ENST00000336279.5
ENST00000458621.1
HEPH
hephaestin
chrX_+_36053908 0.00 ENST00000378660.2
CHDC2
calponin homology domain containing 2

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0043060 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
0.2 1.7 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.2 0.6 GO:1903568 negative regulation of protein localization to cilium(GO:1903565) regulation of protein localization to ciliary membrane(GO:1903567) negative regulation of protein localization to ciliary membrane(GO:1903568)
0.1 2.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 0.9 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.4 GO:1904481 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.1 0.3 GO:0046013 regulation of T cell homeostatic proliferation(GO:0046013)
0.1 0.7 GO:0061113 pancreas morphogenesis(GO:0061113)
0.1 0.6 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.3 GO:0010701 positive regulation of norepinephrine secretion(GO:0010701)
0.1 1.2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.1 0.3 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117)
0.1 0.2 GO:0016267 O-glycan processing, core 1(GO:0016267)
0.0 0.1 GO:0034471 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.0 0.4 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.0 0.2 GO:0071934 thiamine transmembrane transport(GO:0071934)
0.0 0.2 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.3 GO:2000467 positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0 0.8 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.0 0.2 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.0 0.1 GO:0043605 cellular amide catabolic process(GO:0043605)
0.0 0.7 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.0 0.5 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 0.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
0.0 0.5 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.8 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.1 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0005715 late recombination nodule(GO:0005715)
0.2 0.8 GO:1990423 RZZ complex(GO:1990423)
0.1 0.8 GO:0019815 B cell receptor complex(GO:0019815)
0.1 2.2 GO:0043194 axon initial segment(GO:0043194)
0.1 0.3 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.8 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.9 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.1 GO:0030688 preribosome, small subunit precursor(GO:0030688)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0047718 androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
0.3 1.2 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.2 0.6 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 1.3 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 0.9 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 0.4 GO:0070905 serine binding(GO:0070905)
0.1 2.2 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1 0.2 GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity(GO:0016263)
0.0 0.2 GO:0015403 thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 0.2 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 0.2 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.2 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.5 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.0 1.0 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.5 GO:0051400 BH domain binding(GO:0051400)
0.0 0.2 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.0 0.5 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.3 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.0 0.3 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 0.6 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.1 GO:0050682 AF-2 domain binding(GO:0050682)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.2 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.9 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.3 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 0.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.8 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.3 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.0 0.7 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.7 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0 0.5 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates