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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX5

Z-value: 0.74

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Transcription factors associated with SOX5

Gene Symbol Gene ID Gene Info
ENSG00000134532.11 SRY-box transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX5hg19_v2_chr12_-_23737534_237375500.145.4e-01Click!

Activity profile of SOX5 motif

Sorted Z-values of SOX5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_49124230 1.88 ENST00000510283.1
ENST00000510855.1
sperm associated antigen 9
chr7_-_47622156 1.44 ENST00000457718.1
tensin 3
chr13_+_110958124 1.39 ENST00000400163.2
collagen, type IV, alpha 2
chr8_+_26435915 1.24 ENST00000523027.1
dihydropyrimidinase-like 2
chr6_+_105404899 1.21 ENST00000345080.4
lin-28 homolog B (C. elegans)
chr11_-_46848393 1.19 ENST00000526496.1
cytoskeleton associated protein 5
chr4_-_76598544 1.18 ENST00000515457.1
ENST00000357854.3
GTPase activating protein (SH3 domain) binding protein 2
chr4_-_76598326 1.13 ENST00000503660.1
GTPase activating protein (SH3 domain) binding protein 2
chr10_-_14614122 1.06 ENST00000378465.3
ENST00000452706.2
ENST00000378458.2
family with sequence similarity 107, member B
chr2_+_27070964 1.01 ENST00000288699.6
dihydropyrimidinase-like 5
chr10_-_14614095 1.01 ENST00000482277.1
ENST00000378462.1
family with sequence similarity 107, member B
chr2_+_27071045 1.00 ENST00000401478.1
dihydropyrimidinase-like 5
chr3_+_141106458 0.98 ENST00000509883.1
zinc finger and BTB domain containing 38
chr2_-_192711968 0.98 ENST00000304141.4
serum deprivation response
chr10_-_14614311 0.97 ENST00000479731.1
ENST00000468492.1
family with sequence similarity 107, member B
chr6_-_108278456 0.95 ENST00000429168.1
SEC63 homolog (S. cerevisiae)
chr17_-_33448468 0.95 ENST00000591723.1
ENST00000593039.1
ENST00000587405.1
Uncharacterized protein
RAD51 paralog D
chr7_-_131241361 0.94 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
podocalyxin-like
chr18_+_20494078 0.87 ENST00000579124.1
ENST00000577588.1
ENST00000582354.1
ENST00000581819.1
retinoblastoma binding protein 8
chr7_+_111846741 0.85 ENST00000421043.1
ENST00000425229.1
ENST00000450657.1
zinc finger protein 277
chr15_+_91416092 0.83 ENST00000559353.1
furin (paired basic amino acid cleaving enzyme)
chr10_-_14613968 0.83 ENST00000488576.1
ENST00000472095.1
family with sequence similarity 107, member B
chr11_-_115375107 0.82 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
cell adhesion molecule 1
chr12_+_78224667 0.76 ENST00000549464.1
neuron navigator 3
chr10_-_14646388 0.75 ENST00000468747.1
ENST00000378467.4
family with sequence similarity 107, member B
chr7_-_111846435 0.74 ENST00000437633.1
ENST00000428084.1
dedicator of cytokinesis 4
chr4_+_41614720 0.73 ENST00000509277.1
LIM and calponin homology domains 1
chrY_+_15016013 0.73 ENST00000360160.4
ENST00000454054.1
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr1_-_204463829 0.73 ENST00000429009.1
ENST00000415899.1
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr12_+_78359999 0.72 ENST00000550503.1
neuron navigator 3
chr9_+_118916082 0.69 ENST00000328252.3
pregnancy-associated plasma protein A, pappalysin 1
chr7_-_11871815 0.69 ENST00000423059.4
thrombospondin, type I, domain containing 7A
chr15_+_57211318 0.68 ENST00000557947.1
transcription factor 12
chr12_-_121973974 0.68 ENST00000538379.1
ENST00000541318.1
ENST00000541511.1
lysine (K)-specific demethylase 2B
chr3_+_41236325 0.68 ENST00000426215.1
ENST00000405570.1
catenin (cadherin-associated protein), beta 1, 88kDa
chr9_+_129097520 0.67 ENST00000436593.3
multivesicular body subunit 12B
chr1_-_243349684 0.67 ENST00000522895.1
centrosomal protein 170kDa
chr2_-_26205550 0.67 ENST00000405914.1
kinesin family member 3C
chr17_+_40119801 0.66 ENST00000585452.1
2',3'-cyclic nucleotide 3' phosphodiesterase
chr3_+_141105705 0.66 ENST00000513258.1
zinc finger and BTB domain containing 38
chr12_-_498415 0.65 ENST00000535014.1
ENST00000543507.1
ENST00000544760.1
lysine (K)-specific demethylase 5A
chr7_-_47621736 0.65 ENST00000311160.9
tensin 3
chr4_+_41614909 0.65 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
LIM and calponin homology domains 1
chr17_-_4269920 0.64 ENST00000572484.1
ubiquitin-conjugating enzyme E2G 1
chr17_-_46703826 0.64 ENST00000550387.1
ENST00000311177.5
homeobox B9
chr15_+_66994663 0.63 ENST00000457357.2
SMAD family member 6
chr11_-_115127611 0.62 ENST00000545094.1
cell adhesion molecule 1
chr17_-_47786375 0.60 ENST00000511657.1
solute carrier family 35, member B1
chr12_-_102591604 0.59 ENST00000329406.4
pro-melanin-concentrating hormone
chr17_+_67498295 0.58 ENST00000589295.1
mitogen-activated protein kinase kinase 6
chr1_+_164529004 0.58 ENST00000559240.1
ENST00000367897.1
ENST00000540236.1
ENST00000401534.1
pre-B-cell leukemia homeobox 1
chr9_+_82188077 0.58 ENST00000425506.1
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr12_+_27398584 0.57 ENST00000543246.1
serine/threonine kinase 38 like
chr12_+_498545 0.57 ENST00000543504.1
coiled-coil domain containing 77
chr4_-_76598296 0.56 ENST00000395719.3
GTPase activating protein (SH3 domain) binding protein 2
chr9_-_74383302 0.56 ENST00000377066.5
transmembrane protein 2
chr12_+_56360605 0.55 ENST00000553376.1
ENST00000440311.2
ENST00000354056.4
cyclin-dependent kinase 2
chr17_+_67498538 0.55 ENST00000589647.1
mitogen-activated protein kinase kinase 6
chr9_+_129097479 0.55 ENST00000402437.2
multivesicular body subunit 12B
chr12_-_12674032 0.54 ENST00000298573.4
dual specificity phosphatase 16
chr18_+_56532100 0.54 ENST00000588456.1
ENST00000589481.1
ENST00000591049.1
zinc finger protein 532
chr19_+_38397839 0.54 ENST00000222345.6
signal-induced proliferation-associated 1 like 3
chr7_-_83824449 0.53 ENST00000420047.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_+_25469802 0.53 ENST00000330688.4
retinoic acid receptor, beta
chr10_+_35416223 0.52 ENST00000489321.1
ENST00000427847.2
ENST00000345491.3
ENST00000395895.2
ENST00000374728.3
ENST00000487132.1
cAMP responsive element modulator
chr20_+_34679725 0.51 ENST00000432589.1
erythrocyte membrane protein band 4.1-like 1
chr16_+_53469525 0.51 ENST00000544405.2
retinoblastoma-like 2 (p130)
chr7_-_111424506 0.51 ENST00000450156.1
ENST00000494651.2
dedicator of cytokinesis 4
chr15_-_54025300 0.51 ENST00000559418.1
WD repeat domain 72
chr12_+_50479101 0.50 ENST00000551966.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr3_+_141106643 0.50 ENST00000514251.1
zinc finger and BTB domain containing 38
chr3_-_123339343 0.49 ENST00000578202.1
myosin light chain kinase
chr17_+_73539339 0.48 ENST00000581713.1
lethal giant larvae homolog 2 (Drosophila)
chr3_-_123339418 0.46 ENST00000583087.1
myosin light chain kinase
chr9_-_123239632 0.46 ENST00000416449.1
CDK5 regulatory subunit associated protein 2
chr9_-_98268883 0.45 ENST00000551630.1
ENST00000548420.1
patched 1
chr3_+_25469724 0.45 ENST00000437042.2
retinoic acid receptor, beta
chr6_+_126240442 0.45 ENST00000448104.1
ENST00000438495.1
ENST00000444128.1
nuclear receptor coactivator 7
chr15_+_71228826 0.45 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
leucine rich repeat containing 49
chr15_+_66994561 0.45 ENST00000288840.5
SMAD family member 6
chr2_-_164592497 0.44 ENST00000333129.3
ENST00000409634.1
fidgetin
chr7_-_32931623 0.44 ENST00000452926.1
kelch repeat and BTB (POZ) domain containing 2
chr2_-_208030886 0.43 ENST00000426163.1
Kruppel-like factor 7 (ubiquitous)
chr11_+_111808119 0.43 ENST00000531396.1
DIX domain containing 1
chr6_+_30687978 0.43 ENST00000327892.8
ENST00000435534.1
tubulin, beta class I
chrX_+_123094672 0.42 ENST00000354548.5
ENST00000458700.1
stromal antigen 2
chr12_+_498500 0.42 ENST00000540180.1
ENST00000422000.1
ENST00000535052.1
coiled-coil domain containing 77
chr3_-_11685345 0.42 ENST00000430365.2
vestigial like 4 (Drosophila)
chr7_+_134576317 0.42 ENST00000424922.1
ENST00000495522.1
caldesmon 1
chr11_+_110001723 0.42 ENST00000528673.1
zinc finger CCCH-type containing 12C
chr11_-_64647144 0.41 ENST00000359393.2
ENST00000433803.1
ENST00000411683.1
EH-domain containing 1
chr8_-_40755333 0.41 ENST00000297737.6
ENST00000315769.7
zinc finger, matrin-type 4
chr2_-_230787879 0.40 ENST00000435716.1
thyroid hormone receptor interactor 12
chr3_+_112929850 0.40 ENST00000464546.1
BOC cell adhesion associated, oncogene regulated
chr14_-_51027838 0.40 ENST00000555216.1
mitogen-activated protein kinase kinase kinase kinase 5
chr11_-_72852958 0.40 ENST00000458644.2
FCH and double SH3 domains 2
chr12_-_96793142 0.40 ENST00000552262.1
ENST00000551816.1
ENST00000552496.1
cyclin-dependent kinase 17
chr11_-_72852320 0.39 ENST00000422375.1
FCH and double SH3 domains 2
chr12_+_50479109 0.39 ENST00000550477.1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
chr9_-_92051391 0.39 ENST00000420681.2
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chrX_+_135251835 0.39 ENST00000456445.1
four and a half LIM domains 1
chr22_-_36236265 0.38 ENST00000414461.2
ENST00000416721.2
ENST00000449924.2
ENST00000262829.7
ENST00000397305.3
RNA binding protein, fox-1 homolog (C. elegans) 2
chr20_-_18477862 0.38 ENST00000337227.4
retinoblastoma binding protein 9
chrX_+_41192595 0.38 ENST00000399959.2
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr6_+_35996859 0.36 ENST00000472333.1
mitogen-activated protein kinase 14
chr16_+_31085714 0.36 ENST00000300850.5
ENST00000564189.1
ENST00000428260.1
zinc finger protein 646
chr10_+_35415719 0.36 ENST00000474362.1
ENST00000374721.3
cAMP responsive element modulator
chr4_-_53522703 0.36 ENST00000508499.1
ubiquitin specific peptidase 46
chr17_-_4269768 0.35 ENST00000396981.2
ubiquitin-conjugating enzyme E2G 1
chr7_-_111424462 0.35 ENST00000437129.1
dedicator of cytokinesis 4
chr11_+_36397915 0.35 ENST00000526682.1
ENST00000530252.1
proline rich 5 like
chr12_-_52715179 0.35 ENST00000293670.3
keratin 83
chr4_+_170581213 0.35 ENST00000507875.1
chloride channel, voltage-sensitive 3
chr5_+_173316341 0.35 ENST00000520867.1
ENST00000334035.5
cytoplasmic polyadenylation element binding protein 4
chr12_+_49761147 0.34 ENST00000549298.1
spermatogenesis associated, serine-rich 2
chrX_+_135252050 0.34 ENST00000449474.1
ENST00000345434.3
four and a half LIM domains 1
chr11_-_102323740 0.34 ENST00000398136.2
transmembrane protein 123
chr11_-_102323489 0.34 ENST00000361236.3
transmembrane protein 123
chr6_-_152957944 0.33 ENST00000423061.1
spectrin repeat containing, nuclear envelope 1
chr10_+_49514698 0.33 ENST00000432379.1
ENST00000429041.1
ENST00000374189.1
mitogen-activated protein kinase 8
chr1_-_243417762 0.32 ENST00000522191.1
centrosomal protein 170kDa
chr2_-_97536490 0.32 ENST00000449330.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr11_-_13461790 0.32 ENST00000530907.1
BTB (POZ) domain containing 10
chr3_-_135913298 0.32 ENST00000434835.2
male-specific lethal 2 homolog (Drosophila)
chr1_-_86043921 0.31 ENST00000535924.2
dimethylarginine dimethylaminohydrolase 1
chr9_-_130712995 0.31 ENST00000373084.4
family with sequence similarity 102, member A
chr9_-_15510989 0.31 ENST00000380715.1
ENST00000380716.4
ENST00000380738.4
ENST00000380733.4
PC4 and SFRS1 interacting protein 1
chr1_+_164528866 0.31 ENST00000420696.2
pre-B-cell leukemia homeobox 1
chr2_-_145275828 0.30 ENST00000392861.2
ENST00000409211.1
zinc finger E-box binding homeobox 2
chr10_-_104913367 0.30 ENST00000423468.2
5'-nucleotidase, cytosolic II
chr12_+_56360550 0.30 ENST00000266970.4
cyclin-dependent kinase 2
chr7_+_129015671 0.30 ENST00000466993.1
adenosylhomocysteinase-like 2
chr9_-_126030817 0.30 ENST00000348403.5
ENST00000447404.2
ENST00000360998.3
spermatid perinuclear RNA binding protein
chr2_-_26205340 0.29 ENST00000264712.3
kinesin family member 3C
chr1_-_232651312 0.29 ENST00000262861.4
signal-induced proliferation-associated 1 like 2
chr20_+_5987890 0.29 ENST00000378868.4
cardiolipin synthase 1
chr6_-_116381918 0.29 ENST00000606080.1
fyn-related kinase
chr16_-_31085514 0.28 ENST00000300849.4
zinc finger protein 668
chr11_+_19799327 0.28 ENST00000540292.1
neuron navigator 2
chr14_-_92414294 0.28 ENST00000554468.1
fibulin 5
chr2_-_208030295 0.27 ENST00000458272.1
Kruppel-like factor 7 (ubiquitous)
chr4_+_95916947 0.27 ENST00000506363.1
bone morphogenetic protein receptor, type IB
chr3_+_19988736 0.26 ENST00000443878.1
RAB5A, member RAS oncogene family
chr2_+_110656268 0.26 ENST00000553749.1
LIM and senescent cell antigen-like domains 3
chr17_+_33448593 0.26 ENST00000158009.5
fibronectin type III domain containing 8
chr16_-_73093597 0.26 ENST00000397992.5
zinc finger homeobox 3
chr1_-_243418344 0.26 ENST00000366542.1
centrosomal protein 170kDa
chr7_+_106810165 0.25 ENST00000468401.1
ENST00000497535.1
ENST00000485846.1
HMG-box transcription factor 1
chr14_-_22005018 0.25 ENST00000546363.1
spalt-like transcription factor 2
chr1_-_243418621 0.25 ENST00000366544.1
ENST00000366543.1
centrosomal protein 170kDa
chr2_-_55277512 0.25 ENST00000402434.2
reticulon 4
chr1_-_8000872 0.24 ENST00000377507.3
tumor necrosis factor receptor superfamily, member 9
chr6_+_100054606 0.24 ENST00000369215.4
PR domain containing 13
chr9_-_92051354 0.24 ENST00000418828.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
chr11_+_36317830 0.24 ENST00000530639.1
proline rich 5 like
chr4_+_113970772 0.24 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ankyrin 2, neuronal
chr9_+_137218362 0.24 ENST00000481739.1
retinoid X receptor, alpha
chr5_-_38595498 0.24 ENST00000263409.4
leukemia inhibitory factor receptor alpha
chr5_-_138780159 0.24 ENST00000512473.1
ENST00000515581.1
ENST00000515277.1
DnaJ (Hsp40) homolog, subfamily C, member 18
chr10_+_35415851 0.23 ENST00000374726.3
cAMP responsive element modulator
chr1_+_205682497 0.23 ENST00000598338.1
AC119673.1
chr6_+_12290586 0.23 ENST00000379375.5
endothelin 1
chr11_+_16760161 0.23 ENST00000524439.1
ENST00000422258.2
ENST00000528634.1
ENST00000525684.1
chromosome 11 open reading frame 58
chr1_-_243418650 0.22 ENST00000522995.1
centrosomal protein 170kDa
chr3_-_65583561 0.22 ENST00000460329.2
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr10_+_35415978 0.22 ENST00000429130.3
ENST00000469949.2
ENST00000460270.1
cAMP responsive element modulator
chr5_-_39462390 0.21 ENST00000511792.1
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr10_-_116444371 0.21 ENST00000533213.2
ENST00000369252.4
actin binding LIM protein 1
chr3_-_192635943 0.21 ENST00000392452.2
Mab-21 domain containing 2
chr2_-_55277654 0.21 ENST00000337526.6
ENST00000317610.7
ENST00000357732.4
reticulon 4
chr17_+_67498396 0.21 ENST00000588110.1
mitogen-activated protein kinase kinase 6
chr11_+_19798964 0.21 ENST00000527559.2
neuron navigator 2
chr2_-_133427767 0.20 ENST00000397463.2
LY6/PLAUR domain containing 1
chr7_+_135611542 0.20 ENST00000416501.1
AC015987.2
chr1_-_153643442 0.20 ENST00000368681.1
ENST00000361891.4
interleukin enhancer binding factor 2
chr2_-_86422523 0.20 ENST00000442664.2
ENST00000409051.2
ENST00000449247.2
inner membrane protein, mitochondrial
chr18_-_48723690 0.20 ENST00000406189.3
mex-3 RNA binding family member C
chr2_-_208030647 0.20 ENST00000309446.6
Kruppel-like factor 7 (ubiquitous)
chr16_+_3704822 0.19 ENST00000414110.2
deoxyribonuclease I
chr15_+_49715293 0.19 ENST00000267843.4
ENST00000560270.1
fibroblast growth factor 7
chr2_-_160473114 0.19 ENST00000392783.2
bromodomain adjacent to zinc finger domain, 2B
chr1_-_150241341 0.19 ENST00000369109.3
ENST00000414276.2
ENST00000236017.5
APH1A gamma secretase subunit
chr19_-_19626351 0.19 ENST00000585580.3
testis-specific serine kinase 6
chr1_+_165797024 0.18 ENST00000372212.4
uridine-cytidine kinase 2
chrX_-_99891796 0.18 ENST00000373020.4
tetraspanin 6
chrX_+_70503037 0.18 ENST00000535149.1
non-POU domain containing, octamer-binding
chr16_+_20911174 0.18 ENST00000568663.1
LYR motif containing 1
chrX_+_135251783 0.18 ENST00000394153.2
four and a half LIM domains 1
chr17_-_41910505 0.17 ENST00000398389.4
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr7_+_134576151 0.17 ENST00000393118.2
caldesmon 1
chrX_+_123094369 0.17 ENST00000455404.1
ENST00000218089.9
stromal antigen 2
chr17_-_73505961 0.17 ENST00000433559.2
CASK interacting protein 2
chr6_+_122720681 0.17 ENST00000368455.4
ENST00000452194.1
heat shock transcription factor 2
chr5_+_138677515 0.17 ENST00000265192.4
ENST00000511706.1
poly(A) binding protein interacting protein 2
chr13_-_28545276 0.17 ENST00000381020.7
caudal type homeobox 2
chr14_+_77228532 0.16 ENST00000167106.4
ENST00000554237.1
vasohibin 1
chr14_-_92414055 0.16 ENST00000342058.4
fibulin 5
chr8_-_95449155 0.16 ENST00000481490.2
fibrinogen silencer binding protein
chr11_+_111807863 0.16 ENST00000440460.2
DIX domain containing 1
chr17_-_46671323 0.16 ENST00000239151.5
homeobox B5

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.3 0.9 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.3 0.8 GO:0090472 viral protein processing(GO:0019082) regulation of nerve growth factor production(GO:0032903) negative regulation of nerve growth factor production(GO:0032904) dibasic protein processing(GO:0090472)
0.3 1.3 GO:0072709 cellular response to sorbitol(GO:0072709)
0.2 1.4 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 0.9 GO:0001835 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.2 1.9 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 1.6 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.2 0.8 GO:0034721 histone H3-K4 demethylation, trimethyl-H3-K4-specific(GO:0034721)
0.2 1.2 GO:0019075 virus maturation(GO:0019075)
0.2 0.7 GO:1904501 glial cell fate determination(GO:0007403) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of chromatin-mediated maintenance of transcription(GO:1904499) positive regulation of chromatin-mediated maintenance of transcription(GO:1904501) regulation of euchromatin binding(GO:1904793)
0.2 2.9 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.2 0.6 GO:0072334 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
0.1 0.5 GO:0045209 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.1 0.9 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 1.3 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.2 GO:0045994 positive regulation of translational initiation by iron(GO:0045994)
0.1 0.7 GO:0021993 initiation of neural tube closure(GO:0021993)
0.1 0.4 GO:1903045 neural crest cell migration involved in sympathetic nervous system development(GO:1903045)
0.1 0.3 GO:1902595 regulation of DNA replication origin binding(GO:1902595)
0.1 0.9 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 1.0 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 0.6 GO:0010693 negative regulation of alkaline phosphatase activity(GO:0010693) semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.1 0.9 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.1 1.2 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.1 0.5 GO:0010157 response to chlorate(GO:0010157)
0.1 1.0 GO:0003406 retinal pigment epithelium development(GO:0003406)
0.1 0.2 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.1 0.4 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.3 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.1 0.3 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 1.0 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
0.1 0.5 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.1 0.6 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.1 0.4 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.1 0.4 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.0 0.6 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.0 0.2 GO:2001180 negative regulation of interleukin-10 secretion(GO:2001180) negative regulation of interleukin-12 secretion(GO:2001183)
0.0 0.2 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541) positive regulation of fibrinolysis(GO:0051919)
0.0 0.4 GO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0 1.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.2 GO:0006238 CMP salvage(GO:0006238) CMP biosynthetic process(GO:0009224) CMP metabolic process(GO:0046035)
0.0 0.8 GO:0038203 TORC2 signaling(GO:0038203)
0.0 0.1 GO:0035283 rhombomere 3 development(GO:0021569) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0 0.6 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.0 0.2 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.0 0.4 GO:1901314 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.0 0.2 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.0 0.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.3 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0 0.7 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.4 GO:0008343 adult feeding behavior(GO:0008343)
0.0 0.2 GO:0035026 leading edge cell differentiation(GO:0035026)
0.0 0.3 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.2 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0 0.1 GO:1904647 response to rotenone(GO:1904647)
0.0 0.3 GO:0097068 response to thyroxine(GO:0097068) response to L-phenylalanine derivative(GO:1904386)
0.0 0.5 GO:0046600 negative regulation of centriole replication(GO:0046600)
0.0 0.2 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0 0.3 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.0 1.9 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.9 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.5 GO:0070166 enamel mineralization(GO:0070166)
0.0 0.2 GO:2000286 receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0 0.7 GO:0032354 response to follicle-stimulating hormone(GO:0032354)
0.0 0.1 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.0 0.1 GO:0010644 cell communication by electrical coupling(GO:0010644)
0.0 0.2 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.3 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.1 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
0.0 0.4 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0 0.3 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.3 GO:0046085 adenosine metabolic process(GO:0046085)
0.0 0.6 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.0 0.1 GO:0061146 Peyer's patch morphogenesis(GO:0061146)
0.0 1.0 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.0 0.8 GO:2000772 regulation of cellular senescence(GO:2000772)
0.0 1.0 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 0.5 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.4 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0 0.2 GO:0090292 nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0 0.2 GO:1900246 positive regulation of RIG-I signaling pathway(GO:1900246)
0.0 0.9 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.0 0.1 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.3 GO:0021535 cell migration in hindbrain(GO:0021535)
0.0 0.2 GO:1901223 negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0 0.9 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.0 0.3 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 0.1 GO:0035092 sperm chromatin condensation(GO:0035092)
0.0 0.3 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.7 GO:0009214 cyclic nucleotide catabolic process(GO:0009214)
0.0 0.1 GO:0034350 regulation of glial cell apoptotic process(GO:0034350) negative regulation of glial cell apoptotic process(GO:0034351)
0.0 0.5 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0000806 Y chromosome(GO:0000806) cyclin A2-CDK2 complex(GO:0097124) cyclin E1-CDK2 complex(GO:0097134)
0.1 1.3 GO:0005587 collagen type IV trimer(GO:0005587)
0.1 0.9 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.1 0.7 GO:0070369 Scrib-APC-beta-catenin complex(GO:0034750) beta-catenin-TCF7L2 complex(GO:0070369)
0.1 0.9 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.4 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1 1.2 GO:0000813 ESCRT I complex(GO:0000813)
0.1 0.8 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 0.2 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
0.1 0.5 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.5 GO:0061689 tricellular tight junction(GO:0061689)
0.0 0.6 GO:0030478 actin cap(GO:0030478)
0.0 0.7 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 1.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 1.0 GO:0071564 npBAF complex(GO:0071564)
0.0 1.2 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.8 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.1 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 0.3 GO:0072487 MSL complex(GO:0072487)
0.0 0.2 GO:0061617 MICOS complex(GO:0061617)
0.0 0.6 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 1.6 GO:0032420 stereocilium(GO:0032420)
0.0 0.2 GO:0098559 cytoplasmic side of early endosome membrane(GO:0098559)
0.0 0.2 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.2 GO:0042382 paraspeckles(GO:0042382)
0.0 0.1 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.8 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.3 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.0 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 1.0 GO:0097542 ciliary tip(GO:0097542)
0.0 0.5 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0 0.1 GO:1990584 cardiac Troponin complex(GO:1990584)
0.0 1.6 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.3 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 1.6 GO:0005814 centriole(GO:0005814)
0.0 2.1 GO:0072562 blood microparticle(GO:0072562)
0.0 2.4 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0070698 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity(GO:0030617) type I activin receptor binding(GO:0070698)
0.2 1.2 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.2 0.8 GO:0034647 histone demethylase activity (H3-trimethyl-K4 specific)(GO:0034647)
0.2 0.7 GO:0004113 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity(GO:0004113)
0.2 0.6 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
0.1 2.2 GO:0048273 mitogen-activated protein kinase p38 binding(GO:0048273)
0.1 0.3 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 0.3 GO:0043337 cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572) CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity(GO:0043337)
0.1 1.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 0.3 GO:0050146 nucleoside phosphotransferase activity(GO:0050146)
0.1 0.7 GO:0035005 lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 0.5 GO:0005119 smoothened binding(GO:0005119)
0.1 1.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 0.8 GO:0048406 nerve growth factor binding(GO:0048406)
0.1 2.9 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.1 2.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 0.4 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.1 0.2 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.1 0.2 GO:0004923 leukemia inhibitory factor receptor activity(GO:0004923)
0.1 0.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.9 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.1 0.2 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 1.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.0 0.2 GO:0004530 deoxyribonuclease I activity(GO:0004530)
0.0 0.9 GO:0000150 recombinase activity(GO:0000150)
0.0 0.2 GO:0031708 endothelin B receptor binding(GO:0031708)
0.0 0.3 GO:0016403 dimethylargininase activity(GO:0016403)
0.0 0.9 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.6 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.7 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.4 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.7 GO:0070411 I-SMAD binding(GO:0070411)
0.0 0.9 GO:0035173 histone kinase activity(GO:0035173)
0.0 0.9 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.0 0.1 GO:0032038 myosin II heavy chain binding(GO:0032038)
0.0 1.1 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.3 GO:0097100 supercoiled DNA binding(GO:0097100)
0.0 0.7 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.5 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 3.0 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.6 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.1 GO:1903763 gap junction channel activity involved in cell communication by electrical coupling(GO:1903763)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.1 GO:0031013 troponin I binding(GO:0031013)
0.0 0.2 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0 0.1 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.6 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.2 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.0 0.3 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.9 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.9 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 2.6 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 1.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 1.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 0.7 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.9 PID BARD1 PATHWAY BARD1 signaling events
0.0 1.2 PID AURORA A PATHWAY Aurora A signaling
0.0 1.0 NABA COLLAGENS Genes encoding collagen proteins
0.0 1.2 PID BMP PATHWAY BMP receptor signaling
0.0 1.0 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 0.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.7 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 0.1 REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 Genes involved in Autodegradation of the E3 ubiquitin ligase COP1
0.0 0.8 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0 1.7 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.0 2.1 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 1.3 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.0 1.3 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.5 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.0 1.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 2.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 1.1 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 0.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.3 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 0.6 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.6 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 0.5 REACTOME KINESINS Genes involved in Kinesins
0.0 1.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.7 REACTOME MEIOSIS Genes involved in Meiosis