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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SOX6
Z-value: 1.02
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Transcription factors associated with SOX6
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SOX6 | hg19_v2_chr11_-_16430399_16430440 | -0.91 | 3.7e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_+_88896819 Show fit | 4.78 |
ENST00000237623.7
ENST00000395080.3 ENST00000508233.1 ENST00000360804.4 |
secreted phosphoprotein 1 |
|
| chr4_+_41614909 Show fit | 3.46 |
ENST00000509454.1
ENST00000396595.3 ENST00000381753.4 |
LIM and calponin homology domains 1 |
|
| chr6_-_64029879 Show fit | 3.35 |
ENST00000370658.5
ENST00000485906.2 ENST00000370657.4 |
lengsin, lens protein with glutamine synthetase domain |
|
| chr9_-_131940526 Show fit | 3.21 |
ENST00000372491.2
|
immediate early response 5-like |
|
| chr17_+_67498538 Show fit | 2.87 |
ENST00000589647.1
|
mitogen-activated protein kinase kinase 6 |
|
| chrX_+_12993202 Show fit | 2.82 |
ENST00000451311.2
ENST00000380636.1 |
thymosin beta 4, X-linked |
|
| chr2_+_27070964 Show fit | 2.66 |
ENST00000288699.6
|
dihydropyrimidinase-like 5 |
|
| chr6_-_127840336 Show fit | 2.58 |
ENST00000525778.1
|
SOGA family member 3 |
|
| chr4_+_41614720 Show fit | 2.55 |
ENST00000509277.1
|
LIM and calponin homology domains 1 |
|
| chr6_-_127840021 Show fit | 2.47 |
ENST00000465909.2
|
SOGA family member 3 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SOX6
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 6.0 | GO:0072709 | cellular response to sorbitol(GO:0072709) |
| 0.0 | 5.1 | GO:0006081 | cellular aldehyde metabolic process(GO:0006081) |
| 1.2 | 4.8 | GO:2000866 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 0.0 | 4.8 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 4.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.2 | 3.8 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
| 0.2 | 3.5 | GO:0070257 | positive regulation of mucus secretion(GO:0070257) |
| 0.4 | 3.4 | GO:1903026 | negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.1 | 3.1 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.1 | 2.7 | GO:0006825 | copper ion transport(GO:0006825) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.6 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.0 | 3.9 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 3.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 3.1 | GO:0071782 | endoplasmic reticulum tubular network(GO:0071782) |
| 0.1 | 2.9 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.1 | 2.6 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.3 | 2.4 | GO:0097129 | cyclin D2-CDK4 complex(GO:0097129) |
| 0.0 | 2.3 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
| 0.1 | 2.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 1.8 | GO:0035861 | site of double-strand break(GO:0035861) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 6.4 | GO:0018479 | benzaldehyde dehydrogenase (NAD+) activity(GO:0018479) |
| 0.1 | 5.2 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 4.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 4.7 | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810) |
| 0.1 | 3.8 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 0.1 | 3.5 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.1 | 3.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.5 | 2.7 | GO:0031849 | olfactory receptor binding(GO:0031849) |
| 0.2 | 2.7 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 2.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 8.4 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 4.9 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 3.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 3.0 | PID SMAD2 3NUCLEAR PATHWAY | Regulation of nuclear SMAD2/3 signaling |
| 0.0 | 2.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.1 | 2.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.5 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 2.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.7 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.0 | 1.3 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.0 | REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION | Genes involved in activated TAK1 mediates p38 MAPK activation |
| 0.0 | 5.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 4.0 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 0.1 | 4.0 | REACTOME METAL ION SLC TRANSPORTERS | Genes involved in Metal ion SLC transporters |
| 0.1 | 2.9 | REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC | Genes involved in Formation of tubulin folding intermediates by CCT/TriC |
| 0.0 | 2.8 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.0 | 2.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 2.2 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 2.0 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |
| 0.1 | 1.9 | REACTOME INTRINSIC PATHWAY | Genes involved in Intrinsic Pathway |