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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SOX7

Z-value: 0.58

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Transcription factors associated with SOX7

Gene Symbol Gene ID Gene Info
SOX7
ENSG00000171056.6 SRY-box transcription factor 7
SOX7
ENSG00000258724.1 SRY-box transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SOX7hg19_v2_chr8_-_10588010_10588030-0.843.3e-06Click!

Activity profile of SOX7 motif

Sorted Z-values of SOX7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_58027138 2.56 ENST00000341156.4
B4GALNT1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr10_+_5005445 2.51 ENST00000380872.4
AKR1C1
aldo-keto reductase family 1, member C1
chr10_-_5046042 2.19 ENST00000421196.3
ENST00000455190.1
AKR1C2
aldo-keto reductase family 1, member C2
chr2_-_190445499 1.66 ENST00000261024.2
SLC40A1
solute carrier family 40 (iron-regulated transporter), member 1
chr8_-_19459993 1.60 ENST00000454498.2
ENST00000520003.1
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr12_-_90049828 1.40 ENST00000261173.2
ENST00000348959.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr1_+_199996733 1.40 ENST00000236914.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr12_-_90049878 1.16 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chrY_+_14813160 1.13 ENST00000338981.3
USP9Y
ubiquitin specific peptidase 9, Y-linked
chr12_-_57443886 1.01 ENST00000300119.3
MYO1A
myosin IA
chr1_+_10509971 0.95 ENST00000320498.4
CORT
cortistatin
chr5_-_95158644 0.84 ENST00000237858.6
GLRX
glutaredoxin (thioltransferase)
chr1_+_156698743 0.82 ENST00000524343.1
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr11_+_7618413 0.81 ENST00000528883.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr9_-_70465758 0.74 ENST00000489273.1
CBWD5
COBW domain containing 5
chr5_-_95158375 0.71 ENST00000512469.2
ENST00000379979.4
ENST00000505427.1
ENST00000508780.1
GLRX
glutaredoxin (thioltransferase)
chr11_-_62474803 0.70 ENST00000533982.1
ENST00000360796.5
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr1_+_156698708 0.67 ENST00000519086.1
RRNAD1
ribosomal RNA adenine dimethylase domain containing 1
chr12_+_64173583 0.65 ENST00000261234.6
TMEM5
transmembrane protein 5
chr16_-_279405 0.62 ENST00000430864.1
ENST00000293872.8
ENST00000337351.4
ENST00000397783.1
LUC7L
LUC7-like (S. cerevisiae)
chr8_-_102803163 0.62 ENST00000523645.1
ENST00000520346.1
ENST00000220931.6
ENST00000522448.1
ENST00000522951.1
ENST00000522252.1
ENST00000519098.1
NCALD
neurocalcin delta
chr19_-_5784610 0.61 ENST00000390672.2
ENST00000419421.2
PRR22
proline rich 22
chr16_+_28303804 0.55 ENST00000341901.4
SBK1
SH3 domain binding kinase 1
chr2_-_68547019 0.54 ENST00000409862.1
CNRIP1
cannabinoid receptor interacting protein 1
chr15_+_75639372 0.51 ENST00000566313.1
ENST00000568059.1
ENST00000568881.1
NEIL1
nei endonuclease VIII-like 1 (E. coli)
chr2_+_179317994 0.51 ENST00000375129.4
DFNB59
deafness, autosomal recessive 59
chr3_-_123411191 0.50 ENST00000354792.5
ENST00000508240.1
MYLK
myosin light chain kinase
chr16_-_28303360 0.49 ENST00000501520.1
RP11-57A19.2
RP11-57A19.2
chr15_+_66585950 0.49 ENST00000525109.1
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr8_+_77593448 0.43 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr17_-_66951382 0.39 ENST00000586539.1
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr12_-_123728548 0.38 ENST00000545406.1
MPHOSPH9
M-phase phosphoprotein 9
chr1_+_223101757 0.37 ENST00000284476.6
DISP1
dispatched homolog 1 (Drosophila)
chr9_-_37592561 0.35 ENST00000544379.1
ENST00000377773.5
ENST00000401811.3
ENST00000321301.6
TOMM5
translocase of outer mitochondrial membrane 5 homolog (yeast)
chr14_+_101361107 0.31 ENST00000553584.1
ENST00000554852.1
MEG8
maternally expressed 8 (non-protein coding)
chr17_-_66951474 0.26 ENST00000269080.2
ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr17_-_56082455 0.26 ENST00000578794.1
RP11-159D12.5
Uncharacterized protein
chr21_-_15918618 0.24 ENST00000400564.1
ENST00000400566.1
SAMSN1
SAM domain, SH3 domain and nuclear localization signals 1
chr6_-_111804905 0.24 ENST00000358835.3
ENST00000435970.1
REV3L
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr2_-_152118276 0.23 ENST00000409092.1
RBM43
RNA binding motif protein 43
chr5_+_161494770 0.23 ENST00000414552.2
ENST00000361925.4
GABRG2
gamma-aminobutyric acid (GABA) A receptor, gamma 2
chrX_+_69353284 0.22 ENST00000342206.6
ENST00000356413.4
IGBP1
immunoglobulin (CD79A) binding protein 1
chr6_-_86303833 0.20 ENST00000505648.1
SNX14
sorting nexin 14
chr4_-_177190364 0.19 ENST00000296525.3
ASB5
ankyrin repeat and SOCS box containing 5
chr17_-_28661065 0.19 ENST00000328886.4
ENST00000538566.2
TMIGD1
transmembrane and immunoglobulin domain containing 1
chr12_-_57328187 0.18 ENST00000293502.1
SDR9C7
short chain dehydrogenase/reductase family 9C, member 7
chr19_-_38916802 0.18 ENST00000587738.1
RASGRP4
RAS guanyl releasing protein 4
chr2_-_166930131 0.18 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A
sodium channel, voltage-gated, type I, alpha subunit
chr16_-_21442874 0.17 ENST00000534903.1
NPIPB3
nuclear pore complex interacting protein family, member B3
chr10_-_17243579 0.16 ENST00000525762.1
ENST00000412821.3
ENST00000351358.4
ENST00000377766.5
ENST00000358282.7
ENST00000488990.1
ENST00000377799.3
TRDMT1
tRNA aspartic acid methyltransferase 1
chr17_-_39623681 0.16 ENST00000225899.3
KRT32
keratin 32
chr21_+_34144411 0.16 ENST00000382375.4
ENST00000453404.1
ENST00000382378.1
ENST00000477513.1
C21orf49
chromosome 21 open reading frame 49
chr6_-_46048116 0.15 ENST00000185206.6
CLIC5
chloride intracellular channel 5
chr2_+_3705785 0.15 ENST00000252505.3
ALLC
allantoicase
chr5_-_176778803 0.14 ENST00000303127.7
LMAN2
lectin, mannose-binding 2
chr6_+_168434678 0.13 ENST00000496008.1
KIF25
kinesin family member 25
chr6_+_150690133 0.12 ENST00000392255.3
ENST00000500320.3
IYD
iodotyrosine deiodinase
chr6_+_80129989 0.12 ENST00000429444.1
RP1-232L24.3
RP1-232L24.3
chr19_-_38916822 0.11 ENST00000586305.1
RASGRP4
RAS guanyl releasing protein 4
chr5_+_175511859 0.11 ENST00000503724.2
ENST00000253490.4
FAM153B
family with sequence similarity 153, member B
chr6_+_131894284 0.11 ENST00000368087.3
ENST00000356962.2
ARG1
arginase 1
chr11_+_3011093 0.11 ENST00000332881.2
AC131971.1
HCG1782999; PRO0943; Uncharacterized protein
chr16_+_22518495 0.11 ENST00000541154.1
NPIPB5
nuclear pore complex interacting protein family, member B5
chr14_+_50291993 0.10 ENST00000595378.1
AL627171.2
HCG1786899; PRO2610; Uncharacterized protein
chr17_+_80858418 0.10 ENST00000574422.1
TBCD
tubulin folding cofactor D
chr8_+_12803176 0.09 ENST00000524591.2
KIAA1456
KIAA1456
chr12_-_39734783 0.08 ENST00000552961.1
KIF21A
kinesin family member 21A
chr6_+_29555683 0.08 ENST00000383640.2
OR2H2
olfactory receptor, family 2, subfamily H, member 2
chr6_+_150690028 0.08 ENST00000229447.5
ENST00000344419.3
IYD
iodotyrosine deiodinase
chr1_+_100598742 0.07 ENST00000370139.1
TRMT13
tRNA methyltransferase 13 homolog (S. cerevisiae)
chr4_-_39034542 0.07 ENST00000344606.6
TMEM156
transmembrane protein 156
chr3_-_122694215 0.07 ENST00000449546.1
SEMA5B
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
chr6_+_150690089 0.07 ENST00000392256.2
IYD
iodotyrosine deiodinase
chr19_+_37837218 0.07 ENST00000591134.1
HKR1
HKR1, GLI-Kruppel zinc finger family member
chr1_+_158901329 0.04 ENST00000368140.1
ENST00000368138.3
ENST00000392254.2
ENST00000392252.3
ENST00000368135.4
PYHIN1
pyrin and HIN domain family, member 1
chr14_-_31856397 0.04 ENST00000538864.2
ENST00000550366.1
HEATR5A
HEAT repeat containing 5A
chr15_+_59439899 0.03 ENST00000599727.1
C15ORF31
C15ORF31
chr15_+_63414760 0.03 ENST00000557972.1
LACTB
lactamase, beta
chr9_+_105757590 0.03 ENST00000374798.3
ENST00000487798.1
CYLC2
cylicin, basic protein of sperm head cytoskeleton 2

Network of associatons between targets according to the STRING database.

First level regulatory network of SOX7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 4.7 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.6 1.7 GO:1903988 spleen trabecula formation(GO:0060345) iron cation export(GO:1903414) ferrous iron export(GO:1903988)
0.3 2.6 GO:1990034 cellular response to corticosterone stimulus(GO:0071386) calcium ion export from cell(GO:1990034)
0.2 2.6 GO:0030259 lipid glycosylation(GO:0030259)
0.2 1.4 GO:0061113 pancreas morphogenesis(GO:0061113)
0.2 1.6 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.1 0.5 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1 1.5 GO:0031167 rRNA methylation(GO:0031167)
0.1 1.6 GO:0045838 positive regulation of membrane potential(GO:0045838)
0.0 1.0 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.0 0.1 GO:0046603 negative regulation of mitotic centrosome separation(GO:0046603)
0.0 0.7 GO:0035269 protein O-linked mannosylation(GO:0035269)
0.0 0.7 GO:0042908 xenobiotic transport(GO:0042908)
0.0 0.2 GO:0043605 cellular amide catabolic process(GO:0043605)
0.0 0.5 GO:0032074 negative regulation of nuclease activity(GO:0032074)
0.0 1.0 GO:0030033 microvillus assembly(GO:0030033)
0.0 0.1 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467)
0.0 0.7 GO:0034389 lipid particle organization(GO:0034389)
0.0 0.3 GO:0006570 tyrosine metabolic process(GO:0006570)
0.0 0.5 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 0.4 GO:0060539 diaphragm development(GO:0060539)
0.0 0.2 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.2 GO:0071420 cellular response to histamine(GO:0071420)
0.0 0.6 GO:0006376 mRNA splice site selection(GO:0006376)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0071821 FANCM-MHF complex(GO:0071821)
0.1 2.6 GO:0032591 dendritic spine membrane(GO:0032591)
0.1 4.2 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.6 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.0 0.4 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.5 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 0.5 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 1.0 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.2 GO:0032590 dendrite membrane(GO:0032590)
0.0 0.0 GO:0033011 perinuclear theca(GO:0033011)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.7 GO:0047086 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086)
0.6 1.7 GO:0097689 iron channel activity(GO:0097689)
0.5 2.6 GO:0003947 (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947)
0.2 1.5 GO:0000179 rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2 1.6 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.1 1.6 GO:0015038 glutathione disulfide oxidoreductase activity(GO:0015038)
0.1 0.6 GO:0050733 RS domain binding(GO:0050733)
0.1 2.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.7 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.5 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.0 0.3 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 1.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0016428 tRNA (cytosine-5-)-methyltransferase activity(GO:0016428)
0.0 1.1 GO:0070410 co-SMAD binding(GO:0070410)
0.0 0.2 GO:0008503 benzodiazepine receptor activity(GO:0008503)
0.0 0.4 GO:0015197 peptide transporter activity(GO:0015197)
0.0 0.5 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.0 0.3 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0 0.6 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 1.4 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.1 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.6 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 1.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.7 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.4 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.6 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 0.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.3 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones