ISMARA results: SP1

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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SP1

Z-value: 3.42

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Transcription factors associated with SP1

Gene Symbol	Gene ID	Gene Info
SP1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000185591.5	Sp1 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
SP1	hg19_v2_chr12_+_53773944_53773993	0.76	1.0e-04	Click!

Activity profile of SP1 motif

Sorted Z-values of SP1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_+_50192457 Show fit	20.21	ENST00000414301.1 ENST00000450338.1	SEMA3F Ensembl NCBI GeneCards UniProt NextProt Show fit	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr14_+_94640633 Show fit	16.87	ENST00000304338.3	PPP4R4 Ensembl NCBI GeneCards UniProt NextProt Show fit	protein phosphatase 4, regulatory subunit 4
chr3_+_50192499 Show fit	16.13	ENST00000413852.1	SEMA3F Ensembl NCBI GeneCards UniProt NextProt Show fit	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr3_+_50192537 Show fit	15.97	ENST00000002829.3	SEMA3F Ensembl NCBI GeneCards UniProt NextProt Show fit	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr5_-_141257954 Show fit	14.75	ENST00000456271.1 ENST00000394536.3 ENST00000503492.1 ENST00000287008.3	PCDH1 Ensembl NCBI GeneCards UniProt NextProt Show fit	protocadherin 1
chr19_-_51504852 Show fit	14.57	ENST00000391806.2 ENST00000347619.4 ENST00000291726.7 ENST00000320838.5	KLK8 Ensembl NCBI GeneCards UniProt NextProt Show fit	kallikrein-related peptidase 8
chr2_+_14772810 Show fit	14.55	ENST00000295092.2 ENST00000331243.4	FAM84A Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 84, member A
chr7_-_143892748 Show fit	14.01	ENST00000378115.2	ARHGEF35 Ensembl NCBI GeneCards UniProt NextProt Show fit	Rho guanine nucleotide exchange factor (GEF) 35
chr6_+_41606176 Show fit	13.92	ENST00000441667.1 ENST00000230321.6 ENST00000373050.4 ENST00000446650.1 ENST00000435476.1	MDFI Ensembl NCBI GeneCards UniProt NextProt Show fit	MyoD family inhibitor
chr5_+_131593364 Show fit	13.92	ENST00000253754.3 ENST00000379018.3	PDLIM4 Ensembl NCBI GeneCards UniProt NextProt Show fit	PDZ and LIM domain 4

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of SP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.3	59.9	GO:0035290	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.3	49.8	GO:0043484	regulation of RNA splicing(GO:0043484)
1.5	42.5	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.6	41.0	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.3	38.7	GO:0070268	cornification(GO:0070268)
1.5	37.9	GO:0007252	I-kappaB phosphorylation(GO:0007252)
1.6	36.3	GO:0071481	cellular response to X-ray(GO:0071481)
2.3	33.9	GO:0010668	ectodermal cell differentiation(GO:0010668)
0.3	33.2	GO:0030032	lamellipodium assembly(GO:0030032)
2.2	33.0	GO:0002191	cap-dependent translational initiation(GO:0002191)

Showing 1 to 10 of 1,365 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	86.0	GO:0016605	PML body(GO:0016605)
0.2	84.4	GO:0016607	nuclear speck(GO:0016607)
0.7	84.0	GO:0017053	transcriptional repressor complex(GO:0017053)
0.3	77.3	GO:0019897	extrinsic component of plasma membrane(GO:0019897)
0.5	66.8	GO:0032432	actin filament bundle(GO:0032432)
0.8	53.6	GO:1903293	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.4	52.2	GO:0072686	mitotic spindle(GO:0072686)
0.2	51.9	GO:0005681	spliceosomal complex(GO:0005681)
0.7	49.0	GO:0002102	podosome(GO:0002102)
1.8	48.5	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)

Showing 1 to 10 of 475 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	341.4	GO:0045296	cadherin binding(GO:0045296)
0.4	110.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.4	67.9	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.4	66.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	62.8	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3	61.4	GO:0017124	SH3 domain binding(GO:0017124)
0.6	52.9	GO:0019003	GDP binding(GO:0019003)
2.1	51.2	GO:0045499	chemorepellent activity(GO:0045499)
0.2	44.9	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
0.8	43.9	GO:0042162	telomeric DNA binding(GO:0042162)

Showing 1 to 10 of 772 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.1	98.8	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.7	84.1	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.9	79.7	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
1.2	77.8	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
1.2	68.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.5	67.3	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.9	63.7	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.6	54.1	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.2	51.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	51.6	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors

Showing 1 to 10 of 114 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	58.8	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
1.0	50.7	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
2.0	47.2	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3	43.6	REACTOME MRNA SPLICING	Genes involved in mRNA Splicing
0.4	41.9	REACTOME O LINKED GLYCOSYLATION OF MUCINS	Genes involved in O-linked glycosylation of mucins
0.6	40.9	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
1.6	40.8	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.1	36.8	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	35.0	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
1.1	34.8	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling

Showing 1 to 10 of 183 entries

Results for SP1

Z-value: 3.42

Motif logo

Transcription factors associated with SP1

Activity-expression correlation:

Activity profile of SP1 motif

Sorted Z-values of SP1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of SP1

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: