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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SP3
Z-value: 2.45
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Transcription factors associated with SP3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP3 | hg19_v2_chr2_-_174830430_174830563 | 0.10 | 6.8e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_+_5322561 Show fit | 17.58 |
ENST00000396872.3
ENST00000444741.1 ENST00000297195.4 ENST00000406453.3 |
solute carrier family 29 (equilibrative nucleoside transporter), member 4 |
|
| chr16_+_1203194 Show fit | 14.81 |
ENST00000348261.5
ENST00000358590.4 |
calcium channel, voltage-dependent, T type, alpha 1H subunit |
|
| chr11_+_57227981 Show fit | 14.12 |
ENST00000335099.3
|
reticulon 4 receptor-like 2 |
|
| chr5_-_179780312 Show fit | 12.95 |
ENST00000253778.8
|
glutamine-fructose-6-phosphate transaminase 2 |
|
| chr16_+_2039946 Show fit | 12.56 |
ENST00000248121.2
ENST00000568896.1 |
synaptogyrin 3 |
|
| chr19_+_589893 Show fit | 12.45 |
ENST00000251287.2
|
hyperpolarization activated cyclic nucleotide-gated potassium channel 2 |
|
| chr9_+_139606983 Show fit | 12.31 |
ENST00000371692.4
|
family with sequence similarity 69, member B |
|
| chr2_+_8822113 Show fit | 11.99 |
ENST00000396290.1
ENST00000331129.3 |
inhibitor of DNA binding 2, dominant negative helix-loop-helix protein |
|
| chr21_+_46825032 Show fit | 11.84 |
ENST00000400337.2
|
collagen, type XVIII, alpha 1 |
|
| chr20_-_62130474 Show fit | 11.74 |
ENST00000217182.3
|
eukaryotic translation elongation factor 1 alpha 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 51.7 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.4 | 49.7 | GO:0070126 | mitochondrial translational termination(GO:0070126) |
| 0.4 | 36.9 | GO:0051436 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) |
| 0.5 | 36.7 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 0.9 | 35.1 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 5.8 | 34.7 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 0.8 | 33.0 | GO:0031055 | chromatin remodeling at centromere(GO:0031055) |
| 0.3 | 30.8 | GO:0032981 | NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031) |
| 3.0 | 27.4 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 2.4 | 26.3 | GO:0032226 | positive regulation of synaptic transmission, dopaminergic(GO:0032226) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 152.9 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.2 | 75.5 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.1 | 62.8 | GO:0005740 | mitochondrial envelope(GO:0005740) |
| 0.8 | 59.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.7 | 56.0 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.4 | 54.8 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.3 | 42.2 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 1.3 | 38.9 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 3.8 | 38.1 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) |
| 0.5 | 36.2 | GO:0000313 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 59.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.8 | 44.4 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.2 | 36.8 | GO:0000149 | SNARE binding(GO:0000149) |
| 5.9 | 29.3 | GO:0003947 | (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity(GO:0003947) |
| 2.0 | 28.4 | GO:0031014 | troponin T binding(GO:0031014) |
| 5.5 | 27.5 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
| 0.4 | 24.5 | GO:0003954 | NADH dehydrogenase activity(GO:0003954) |
| 0.7 | 23.5 | GO:0000030 | mannosyltransferase activity(GO:0000030) |
| 1.7 | 22.7 | GO:0008504 | monoamine transmembrane transporter activity(GO:0008504) |
| 1.0 | 21.6 | GO:0003680 | AT DNA binding(GO:0003680) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 50.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 47.4 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.5 | 46.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.5 | 32.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.4 | 24.8 | ST GAQ PATHWAY | G alpha q Pathway |
| 0.1 | 22.3 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 17.8 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.3 | 17.8 | PID HIF2PATHWAY | HIF-2-alpha transcription factor network |
| 1.0 | 15.7 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.6 | 15.5 | SA PROGRAMMED CELL DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 59.8 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.6 | 46.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 0.5 | 40.4 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 0.4 | 37.9 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 1.3 | 37.6 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.5 | 35.3 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.5 | 34.9 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.8 | 33.3 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 1.3 | 31.1 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 0.4 | 30.5 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |