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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SP4_PML
Z-value: 4.21
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Transcription factors associated with SP4_PML
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SP4 | hg19_v2_chr7_+_21467642_21467671 | 0.71 | 4.8e-04 | Click! |
| PML | hg19_v2_chr15_+_74287118_74287144 | -0.53 | 1.6e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SP4_PML
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 81.9 | GO:0007052 | mitotic spindle organization(GO:0007052) |
| 0.7 | 41.1 | GO:0060119 | inner ear receptor cell development(GO:0060119) |
| 0.7 | 34.7 | GO:1900026 | positive regulation of substrate adhesion-dependent cell spreading(GO:1900026) |
| 0.7 | 34.0 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 1.4 | 32.7 | GO:1903830 | magnesium ion transmembrane transport(GO:1903830) |
| 0.5 | 28.3 | GO:0035329 | hippo signaling(GO:0035329) |
| 2.2 | 26.3 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 1.1 | 25.6 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.5 | 25.4 | GO:0051225 | spindle assembly(GO:0051225) |
| 3.5 | 24.3 | GO:2000567 | memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 218.4 | GO:0005829 | cytosol(GO:0005829) |
| 0.7 | 61.4 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.4 | 61.0 | GO:0000922 | spindle pole(GO:0000922) |
| 0.5 | 57.7 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 55.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.3 | 52.9 | GO:0005884 | actin filament(GO:0005884) |
| 0.2 | 44.8 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.1 | 42.8 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 1.0 | 38.6 | GO:0097431 | mitotic spindle pole(GO:0097431) |
| 0.3 | 38.0 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 126.8 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.3 | 92.8 | GO:0042393 | histone binding(GO:0042393) |
| 0.1 | 92.5 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.4 | 85.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 72.8 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 1.2 | 50.7 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.2 | 44.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.3 | 36.7 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.2 | 34.3 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.4 | 34.1 | GO:0019003 | GDP binding(GO:0019003) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 71.4 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.9 | 68.9 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.9 | 64.0 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.6 | 57.5 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.6 | 53.4 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.4 | 52.1 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 47.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.0 | 47.5 | PID RETINOIC ACID PATHWAY | Retinoic acid receptors-mediated signaling |
| 0.7 | 44.6 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.5 | 42.4 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 109.3 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.2 | 62.2 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.6 | 52.1 | REACTOME TRIGLYCERIDE BIOSYNTHESIS | Genes involved in Triglyceride Biosynthesis |
| 1.4 | 46.1 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.9 | 45.5 | REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING | Genes involved in Downregulation of TGF-beta receptor signaling |
| 0.1 | 42.7 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 42.6 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.7 | 35.3 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.4 | 35.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.9 | 34.4 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |