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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for SPIB
Z-value: 1.63
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Transcription factors associated with SPIB
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPIB | hg19_v2_chr19_+_50922187_50922215 | -0.45 | 4.5e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_15114492 Show fit | 6.65 |
ENST00000541546.1
|
Rho GDP dissociation inhibitor (GDI) beta |
|
| chr2_+_113885138 Show fit | 6.33 |
ENST00000409930.3
|
interleukin 1 receptor antagonist |
|
| chr2_+_233925064 Show fit | 6.02 |
ENST00000359570.5
ENST00000538935.1 |
inositol polyphosphate-5-phosphatase, 145kDa |
|
| chr9_-_21995300 Show fit | 5.90 |
ENST00000498628.2
|
cyclin-dependent kinase inhibitor 2A |
|
| chr17_-_39093672 Show fit | 5.88 |
ENST00000209718.3
ENST00000436344.3 ENST00000485751.1 |
keratin 23 (histone deacetylase inducible) |
|
| chr12_-_15114191 Show fit | 5.85 |
ENST00000541380.1
|
Rho GDP dissociation inhibitor (GDI) beta |
|
| chr12_-_15114603 Show fit | 5.59 |
ENST00000228945.4
|
Rho GDP dissociation inhibitor (GDI) beta |
|
| chr22_-_37640277 Show fit | 5.42 |
ENST00000401529.3
ENST00000249071.6 |
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
|
| chr22_-_37640456 Show fit | 4.93 |
ENST00000405484.1
ENST00000441619.1 ENST00000406508.1 |
ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) |
|
| chr3_-_121379739 Show fit | 4.44 |
ENST00000428394.2
ENST00000314583.3 |
hematopoietic cell-specific Lyn substrate 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIB
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 21.7 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 0.9 | 10.6 | GO:0048298 | positive regulation of isotype switching to IgA isotypes(GO:0048298) |
| 0.9 | 10.4 | GO:0060753 | regulation of mast cell chemotaxis(GO:0060753) |
| 0.6 | 7.0 | GO:0035986 | senescence-associated heterochromatin focus assembly(GO:0035986) |
| 0.0 | 6.9 | GO:0006903 | vesicle targeting(GO:0006903) |
| 1.3 | 6.6 | GO:0045659 | regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 0.7 | 6.3 | GO:2000660 | negative regulation of interleukin-1-mediated signaling pathway(GO:2000660) |
| 0.4 | 6.2 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 6.0 | GO:0070268 | cornification(GO:0070268) |
| 0.3 | 5.7 | GO:0016540 | protein autoprocessing(GO:0016540) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 11.0 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.6 | 7.0 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.0 | 5.8 | GO:0005770 | late endosome(GO:0005770) |
| 0.0 | 5.6 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 5.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 5.0 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 4.8 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 4.7 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.1 | 4.5 | GO:1990124 | messenger ribonucleoprotein complex(GO:1990124) |
| 0.6 | 4.4 | GO:0019815 | B cell receptor complex(GO:0019815) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 21.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.2 | 9.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 8.7 | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) |
| 0.0 | 8.6 | GO:0019887 | protein kinase regulator activity(GO:0019887) |
| 0.3 | 7.0 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.8 | 6.6 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.2 | 6.5 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.2 | 6.4 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 2.1 | 6.3 | GO:0005150 | interleukin-1, Type I receptor binding(GO:0005150) |
| 0.6 | 6.2 | GO:0004111 | creatine kinase activity(GO:0004111) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.8 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.2 | 9.4 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 8.7 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.3 | 7.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 6.8 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.1 | 6.5 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 6.5 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 6.3 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 5.9 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.1 | 5.0 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 24.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.1 | 16.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 14.7 | REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS | Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements |
| 0.2 | 9.4 | REACTOME REGULATION OF SIGNALING BY CBL | Genes involved in Regulation of signaling by CBL |
| 0.2 | 8.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 6.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.1 | 6.0 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.1 | 4.2 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.3 | 4.1 | REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE | Genes involved in Regulation of Insulin Secretion by Acetylcholine |
| 0.1 | 3.5 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |