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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SREBF2

Z-value: 0.88

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Transcription factors associated with SREBF2

Gene Symbol Gene ID Gene Info
SREBF2
ENSG00000198911.7 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SREBF2hg19_v2_chr22_+_42229100_42229146-0.417.6e-02Click!

Activity profile of SREBF2 motif

Sorted Z-values of SREBF2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_15168624 3.77 ENST00000312280.3
ENST00000494511.1
ENST00000580584.1
PMP22
peripheral myelin protein 22
chr12_-_53343602 2.97 ENST00000546897.1
ENST00000552551.1
KRT8
keratin 8
chr12_-_53343560 2.81 ENST00000548998.1
KRT8
keratin 8
chr8_+_26435359 2.59 ENST00000311151.5
DPYSL2
dihydropyrimidinase-like 2
chr12_-_53343633 2.58 ENST00000546826.1
KRT8
keratin 8
chr6_+_151561085 2.07 ENST00000402676.2
AKAP12
A kinase (PRKA) anchor protein 12
chr19_-_18392422 1.93 ENST00000252818.3
JUND
jun D proto-oncogene
chr15_+_33010175 1.91 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1
gremlin 1, DAN family BMP antagonist
chr11_+_2923423 1.90 ENST00000312221.5
SLC22A18
solute carrier family 22, member 18
chr19_-_55791058 1.89 ENST00000587959.1
ENST00000585927.1
ENST00000587922.1
ENST00000585698.1
HSPBP1
HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
chr19_-_46285736 1.81 ENST00000291270.4
ENST00000447742.2
ENST00000354227.5
DMPK
dystrophia myotonica-protein kinase
chr11_+_2923499 1.78 ENST00000449793.2
SLC22A18
solute carrier family 22, member 18
chr19_-_46285646 1.76 ENST00000458663.2
DMPK
dystrophia myotonica-protein kinase
chr20_+_33464368 1.67 ENST00000484354.1
ENST00000493805.2
ENST00000473172.1
ACSS2
acyl-CoA synthetase short-chain family member 2
chr11_+_2923619 1.64 ENST00000380574.1
SLC22A18
solute carrier family 22, member 18
chr8_-_17579726 1.50 ENST00000381861.3
MTUS1
microtubule associated tumor suppressor 1
chr8_+_26434578 1.47 ENST00000493789.2
DPYSL2
dihydropyrimidinase-like 2
chr14_+_74960423 1.43 ENST00000556816.1
ENST00000298818.8
ENST00000554924.1
ISCA2
iron-sulfur cluster assembly 2
chr2_-_26205550 1.31 ENST00000405914.1
KIF3C
kinesin family member 3C
chr14_-_35183886 1.22 ENST00000298159.6
CFL2
cofilin 2 (muscle)
chr2_-_26205340 1.12 ENST00000264712.3
KIF3C
kinesin family member 3C
chr4_+_75230853 1.03 ENST00000244869.2
EREG
epiregulin
chr1_+_55505184 0.99 ENST00000302118.5
PCSK9
proprotein convertase subtilisin/kexin type 9
chr16_+_2083265 0.93 ENST00000565855.1
ENST00000566198.1
SLC9A3R2
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr5_+_137774706 0.92 ENST00000378339.2
ENST00000254901.5
ENST00000506158.1
REEP2
receptor accessory protein 2
chr19_-_11308190 0.91 ENST00000586659.1
ENST00000592903.1
ENST00000589359.1
ENST00000588724.1
ENST00000432929.2
KANK2
KN motif and ankyrin repeat domains 2
chr3_-_98620500 0.89 ENST00000326840.6
DCBLD2
discoidin, CUB and LCCL domain containing 2
chr13_+_24844857 0.86 ENST00000409126.1
ENST00000343003.6
SPATA13
spermatogenesis associated 13
chr3_+_160117418 0.85 ENST00000465903.1
ENST00000485645.1
ENST00000360111.2
ENST00000472991.1
ENST00000467468.1
ENST00000469762.1
ENST00000489573.1
ENST00000462787.1
ENST00000490207.1
ENST00000485867.1
SMC4
structural maintenance of chromosomes 4
chr19_+_38664224 0.82 ENST00000601054.1
SIPA1L3
signal-induced proliferation-associated 1 like 3
chr15_-_66858298 0.75 ENST00000537670.1
LCTL
lactase-like
chr2_+_27435734 0.75 ENST00000419744.1
ATRAID
all-trans retinoic acid-induced differentiation factor
chr15_-_73075964 0.71 ENST00000563907.1
ADPGK
ADP-dependent glucokinase
chr17_-_40075197 0.68 ENST00000590770.1
ENST00000590151.1
ACLY
ATP citrate lyase
chr17_-_40075219 0.67 ENST00000537919.1
ENST00000352035.2
ENST00000353196.1
ENST00000393896.2
ACLY
ATP citrate lyase
chr13_+_24844819 0.66 ENST00000399949.2
SPATA13
spermatogenesis associated 13
chr17_+_73257945 0.62 ENST00000579002.1
MRPS7
mitochondrial ribosomal protein S7
chr1_-_155232221 0.57 ENST00000355379.3
SCAMP3
secretory carrier membrane protein 3
chr5_-_139283982 0.56 ENST00000340391.3
NRG2
neuregulin 2
chr19_+_36266417 0.56 ENST00000378944.5
ENST00000007510.4
ARHGAP33
Rho GTPase activating protein 33
chr15_-_73076030 0.53 ENST00000311669.8
ADPGK
ADP-dependent glucokinase
chr11_+_65383227 0.48 ENST00000355703.3
PCNXL3
pecanex-like 3 (Drosophila)
chr5_-_39425068 0.47 ENST00000515700.1
ENST00000339788.6
DAB2
Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
chr5_-_149535421 0.41 ENST00000261799.4
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr17_+_73257742 0.39 ENST00000579761.1
ENST00000245539.6
MRPS7
mitochondrial ribosomal protein S7
chr6_-_32083106 0.39 ENST00000442721.1
TNXB
tenascin XB
chr1_+_231297798 0.38 ENST00000444294.3
TRIM67
tripartite motif containing 67
chr16_+_8736232 0.38 ENST00000562973.1
METTL22
methyltransferase like 22
chr20_+_33464407 0.37 ENST00000253382.5
ACSS2
acyl-CoA synthetase short-chain family member 2
chr9_-_117267717 0.37 ENST00000374057.3
DFNB31
deafness, autosomal recessive 31
chr1_+_206643787 0.35 ENST00000367120.3
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr6_-_42713792 0.33 ENST00000372876.1
TBCC
tubulin folding cofactor C
chr19_+_36266433 0.33 ENST00000314737.5
ARHGAP33
Rho GTPase activating protein 33
chr3_-_171527560 0.32 ENST00000331659.2
PP13439
PP13439
chr18_-_21166841 0.28 ENST00000269228.5
NPC1
Niemann-Pick disease, type C1
chr5_-_149535190 0.28 ENST00000517488.1
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr14_-_74959978 0.28 ENST00000541064.1
NPC2
Niemann-Pick disease, type C2
chr6_-_31926208 0.28 ENST00000454913.1
ENST00000436289.2
NELFE
negative elongation factor complex member E
chr11_+_65480222 0.27 ENST00000534681.1
KAT5
K(lysine) acetyltransferase 5
chr13_+_24844979 0.24 ENST00000454083.1
SPATA13
spermatogenesis associated 13
chr3_-_160117301 0.24 ENST00000326448.7
ENST00000498409.1
ENST00000475677.1
ENST00000478536.1
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr10_-_116444371 0.22 ENST00000533213.2
ENST00000369252.4
ABLIM1
actin binding LIM protein 1
chr2_+_120517717 0.21 ENST00000420482.1
ENST00000488279.2
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr3_-_171528227 0.19 ENST00000356327.5
ENST00000342215.6
ENST00000340989.4
ENST00000351298.4
PLD1
phospholipase D1, phosphatidylcholine-specific
chr2_+_232573222 0.18 ENST00000341369.7
ENST00000409683.1
PTMA
prothymosin, alpha
chrX_-_153236819 0.17 ENST00000354233.3
HCFC1
host cell factor C1 (VP16-accessory protein)
chr9_+_100745615 0.16 ENST00000339399.4
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr17_+_65040678 0.16 ENST00000226021.3
CACNG1
calcium channel, voltage-dependent, gamma subunit 1
chr12_-_91505608 0.14 ENST00000266718.4
LUM
lumican
chr2_-_219925189 0.12 ENST00000295731.6
IHH
indian hedgehog
chr1_-_42384343 0.11 ENST00000372584.1
HIVEP3
human immunodeficiency virus type I enhancer binding protein 3
chr14_-_74959994 0.10 ENST00000238633.2
ENST00000434013.2
NPC2
Niemann-Pick disease, type C2
chr6_-_52860171 0.09 ENST00000370963.4
GSTA4
glutathione S-transferase alpha 4
chr11_+_65479702 0.08 ENST00000530446.1
ENST00000534104.1
ENST00000530605.1
ENST00000528198.1
ENST00000531880.1
ENST00000534650.1
KAT5
K(lysine) acetyltransferase 5
chr1_-_155232047 0.08 ENST00000302631.3
SCAMP3
secretory carrier membrane protein 3
chr1_+_197237352 0.06 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
CRB1
crumbs homolog 1 (Drosophila)
chr11_-_73309228 0.05 ENST00000356467.4
ENST00000064778.4
FAM168A
family with sequence similarity 168, member A
chr16_+_22103828 0.03 ENST00000567131.1
ENST00000568328.1
ENST00000389398.5
ENST00000389397.4
VWA3A
von Willebrand factor A domain containing 3A
chr12_-_48398104 0.03 ENST00000337299.6
ENST00000380518.3
COL2A1
collagen, type II, alpha 1
chr1_+_206643806 0.03 ENST00000537984.1
IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chrX_-_103087136 0.03 ENST00000243298.2
RAB9B
RAB9B, member RAS oncogene family
chr2_+_232573208 0.03 ENST00000409115.3
PTMA
prothymosin, alpha
chr4_+_185909970 0.02 ENST00000505053.1
RP11-386B13.4
RP11-386B13.4
chrX_-_112084043 0.01 ENST00000304758.1
AMOT
angiomotin

Network of associatons between targets according to the STRING database.

First level regulatory network of SREBF2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.3 GO:0046618 drug export(GO:0046618)
0.5 8.4 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.5 1.9 GO:1900154 regulation of bone trabecula formation(GO:1900154) negative regulation of bone trabecula formation(GO:1900155)
0.3 2.0 GO:0019541 acetate biosynthetic process(GO:0019413) acetyl-CoA biosynthetic process from acetate(GO:0019427) propionate metabolic process(GO:0019541) propionate biosynthetic process(GO:0019542)
0.3 1.0 GO:2000646 positive regulation of receptor catabolic process(GO:2000646)
0.3 0.9 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.3 3.6 GO:0014722 regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.2 0.9 GO:0050916 sensory perception of sweet taste(GO:0050916)
0.2 0.7 GO:0060981 cell migration involved in coronary angiogenesis(GO:0060981)
0.2 1.4 GO:0097428 protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1 1.0 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 2.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)
0.1 3.8 GO:0032060 bleb assembly(GO:0032060)
0.1 0.1 GO:0030908 intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.1 1.2 GO:0030043 actin filament fragmentation(GO:0030043)
0.1 0.9 GO:0010032 meiotic chromosome condensation(GO:0010032)
0.1 1.3 GO:0006107 oxaloacetate metabolic process(GO:0006107)
0.1 0.8 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 1.9 GO:0002076 osteoblast development(GO:0002076)
0.0 0.3 GO:0035026 leading edge cell differentiation(GO:0035026)
0.0 2.7 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0 1.0 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.3 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.4 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.2 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.0 1.2 GO:0006735 NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718)
0.0 0.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.3 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 3.1 GO:0030516 regulation of axon extension(GO:0030516)
0.0 0.8 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.0 2.0 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.4 GO:0007252 I-kappaB phosphorylation(GO:0007252)
0.0 0.1 GO:0019046 release from viral latency(GO:0019046)
0.0 1.9 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0009346 citrate lyase complex(GO:0009346)
0.2 1.9 GO:0035976 AP1 complex(GO:0035976)
0.2 8.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 1.0 GO:1990667 PCSK9-AnxA2 complex(GO:1990667)
0.1 3.8 GO:0043218 compact myelin(GO:0043218)
0.1 3.6 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.8 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.9 GO:0000796 condensin complex(GO:0000796)
0.0 0.3 GO:0032021 NELF complex(GO:0032021)
0.0 2.7 GO:0097542 ciliary tip(GO:0097542)
0.0 0.6 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.3 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0 1.0 GO:0000314 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.3 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.8 4.1 GO:0004157 dihydropyrimidinase activity(GO:0004157)
0.4 1.3 GO:0003878 ATP citrate synthase activity(GO:0003878)
0.3 2.0 GO:0003987 acetate-CoA ligase activity(GO:0003987)
0.2 1.0 GO:0070326 very-low-density lipoprotein particle binding(GO:0034189) very-low-density lipoprotein particle receptor binding(GO:0070326)
0.2 1.9 GO:0016015 morphogen activity(GO:0016015)
0.2 0.7 GO:0005019 platelet-derived growth factor beta-receptor activity(GO:0005019)
0.2 0.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.1 2.1 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 8.4 GO:0097110 scaffold protein binding(GO:0097110)
0.1 0.4 GO:0036435 IkappaB kinase activity(GO:0008384) K48-linked polyubiquitin binding(GO:0036435)
0.0 1.9 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.4 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
0.0 3.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 2.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.2 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 1.0 GO:0019843 rRNA binding(GO:0019843)
0.0 1.6 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0 0.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 2.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.6 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 3.8 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.0 1.9 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.9 PID BMP PATHWAY BMP receptor signaling
0.0 1.8 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.7 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 1.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.9 PID AURORA B PATHWAY Aurora B signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.1 2.0 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.1 4.1 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.4 REACTOME KINESINS Genes involved in Kinesins
0.0 1.6 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 0.4 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.0 0.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation