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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for SRF

Z-value: 1.79

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Transcription factors associated with SRF

Gene Symbol Gene ID Gene Info
SRF
ENSG00000112658.6 serum response factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
SRFhg19_v2_chr6_+_43139037_431390940.371.1e-01Click!

Activity profile of SRF motif

Sorted Z-values of SRF motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_137801160 50.38 ENST00000239938.4
EGR1
early growth response 1
chr18_+_61143994 8.10 ENST00000382771.4
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr14_+_75745477 6.90 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr19_+_16177826 6.22 ENST00000589897.1
TPM4
tropomyosin 4
chr12_+_4382917 5.96 ENST00000261254.3
CCND2
cyclin D2
chr2_-_161056762 4.85 ENST00000428609.2
ENST00000409967.2
ITGB6
integrin, beta 6
chr2_-_161056802 4.63 ENST00000283249.2
ENST00000409872.1
ITGB6
integrin, beta 6
chr19_+_45971246 4.61 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
FOSB
FBJ murine osteosarcoma viral oncogene homolog B
chr3_-_99594948 4.20 ENST00000471562.1
ENST00000495625.2
FILIP1L
filamin A interacting protein 1-like
chr1_-_89531041 3.64 ENST00000370473.4
GBP1
guanylate binding protein 1, interferon-inducible
chr3_-_99595037 3.49 ENST00000383694.2
FILIP1L
filamin A interacting protein 1-like
chr5_+_150404904 3.48 ENST00000521632.1
GPX3
glutathione peroxidase 3 (plasma)
chr12_-_15104040 3.47 ENST00000541644.1
ENST00000545895.1
ARHGDIB
Rho GDP dissociation inhibitor (GDI) beta
chr17_+_30089454 3.26 ENST00000577970.1
RP11-805L22.3
RP11-805L22.3
chr10_-_64576105 3.26 ENST00000242480.3
ENST00000411732.1
EGR2
early growth response 2
chr20_+_35169885 3.11 ENST00000279022.2
ENST00000346786.2
MYL9
myosin, light chain 9, regulatory
chr12_-_50616122 3.03 ENST00000552823.1
ENST00000552909.1
LIMA1
LIM domain and actin binding 1
chr8_+_97597148 2.96 ENST00000521590.1
SDC2
syndecan 2
chr14_-_94443105 2.86 ENST00000555019.1
ASB2
ankyrin repeat and SOCS box containing 2
chr12_-_50616382 2.84 ENST00000552783.1
LIMA1
LIM domain and actin binding 1
chr4_+_87928140 2.77 ENST00000307808.6
AFF1
AF4/FMR2 family, member 1
chr3_-_121379739 2.70 ENST00000428394.2
ENST00000314583.3
HCLS1
hematopoietic cell-specific Lyn substrate 1
chr1_-_91487806 2.51 ENST00000361321.5
ZNF644
zinc finger protein 644
chr11_-_65667884 2.28 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOSL1
FOS-like antigen 1
chr19_+_13135386 2.22 ENST00000360105.4
ENST00000588228.1
ENST00000591028.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr19_+_1026298 2.13 ENST00000263097.4
CNN2
calponin 2
chr15_+_96873921 2.13 ENST00000394166.3
NR2F2
nuclear receptor subfamily 2, group F, member 2
chr5_+_66254698 2.04 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr17_+_50939459 2.04 ENST00000412360.1
AC102948.2
Uncharacterized protein
chr11_-_65667997 2.02 ENST00000312562.2
ENST00000534222.1
FOSL1
FOS-like antigen 1
chr5_-_142000883 1.98 ENST00000359370.6
FGF1
fibroblast growth factor 1 (acidic)
chr19_+_57901208 1.92 ENST00000366197.5
ENST00000596282.1
ENST00000597400.1
ENST00000598895.1
ENST00000336128.7
ENST00000596617.1
ZNF548
AC003002.6
zinc finger protein 548
Uncharacterized protein
chr9_+_124088860 1.82 ENST00000373806.1
GSN
gelsolin
chr4_-_87028478 1.80 ENST00000515400.1
ENST00000395157.3
MAPK10
mitogen-activated protein kinase 10
chr4_+_87928353 1.79 ENST00000511722.1
AFF1
AF4/FMR2 family, member 1
chr1_-_91487770 1.77 ENST00000337393.5
ZNF644
zinc finger protein 644
chr1_+_16085244 1.72 ENST00000400773.1
FBLIM1
filamin binding LIM protein 1
chr7_+_143078652 1.67 ENST00000354434.4
ENST00000449423.2
ZYX
zyxin
chr9_+_92219919 1.67 ENST00000252506.6
ENST00000375769.1
GADD45G
growth arrest and DNA-damage-inducible, gamma
chr22_+_38004723 1.64 ENST00000381756.5
GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr22_+_38004832 1.63 ENST00000405147.3
ENST00000429218.1
ENST00000325180.8
ENST00000337437.4
GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr19_+_1026566 1.62 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
CNN2
calponin 2
chr22_+_38004473 1.55 ENST00000414350.3
ENST00000343632.4
GGA1
golgi-associated, gamma adaptin ear containing, ARF binding protein 1
chr19_+_13134772 1.55 ENST00000587760.1
ENST00000585575.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr4_+_87928413 1.52 ENST00000544085.1
AFF1
AF4/FMR2 family, member 1
chr9_+_131644781 1.49 ENST00000259324.5
LRRC8A
leucine rich repeat containing 8 family, member A
chr12_+_75874580 1.48 ENST00000456650.3
GLIPR1
GLI pathogenesis-related 1
chr19_-_15344243 1.36 ENST00000602233.1
EPHX3
epoxide hydrolase 3
chr3_-_71294304 1.29 ENST00000498215.1
FOXP1
forkhead box P1
chr5_-_124080203 1.27 ENST00000504926.1
ZNF608
zinc finger protein 608
chr13_-_46742630 1.24 ENST00000416500.1
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr19_-_15343773 1.20 ENST00000435261.1
ENST00000594042.1
EPHX3
epoxide hydrolase 3
chr6_+_43139037 1.17 ENST00000265354.4
SRF
serum response factor (c-fos serum response element-binding transcription factor)
chr19_+_54372877 1.17 ENST00000414489.1
MYADM
myeloid-associated differentiation marker
chr1_+_16085263 1.12 ENST00000483633.2
ENST00000502739.1
ENST00000431771.2
FBLIM1
filamin binding LIM protein 1
chr15_+_74218787 1.11 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr8_-_22550815 1.06 ENST00000317216.2
EGR3
early growth response 3
chr2_-_31030277 1.06 ENST00000534090.2
ENST00000295055.8
CAPN13
calpain 13
chr19_-_36247910 1.06 ENST00000587965.1
ENST00000004982.3
HSPB6
heat shock protein, alpha-crystallin-related, B6
chr8_+_125954281 1.05 ENST00000510897.2
ENST00000533286.1
LINC00964
long intergenic non-protein coding RNA 964
chr1_-_89591749 1.02 ENST00000370466.3
GBP2
guanylate binding protein 2, interferon-inducible
chr22_-_36784035 1.02 ENST00000216181.5
MYH9
myosin, heavy chain 9, non-muscle
chr4_+_189321881 1.01 ENST00000512839.1
ENST00000513313.1
LINC01060
long intergenic non-protein coding RNA 1060
chr17_-_4890919 0.99 ENST00000572543.1
ENST00000381311.5
ENST00000348066.3
ENST00000358183.4
CAMTA2
calmodulin binding transcription activator 2
chrX_+_22056165 0.96 ENST00000535894.1
PHEX
phosphate regulating endopeptidase homolog, X-linked
chr5_+_40679584 0.89 ENST00000302472.3
PTGER4
prostaglandin E receptor 4 (subtype EP4)
chr13_+_27825706 0.88 ENST00000272274.4
ENST00000319826.4
ENST00000326092.4
RPL21
ribosomal protein L21
chr11_-_71823715 0.85 ENST00000545944.1
ENST00000502597.2
ANAPC15
anaphase promoting complex subunit 15
chr12_+_75874460 0.84 ENST00000266659.3
GLIPR1
GLI pathogenesis-related 1
chr4_+_186064395 0.82 ENST00000281456.6
SLC25A4
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
chr17_-_27949911 0.81 ENST00000492276.2
ENST00000345068.5
ENST00000584602.1
CORO6
coronin 6
chr18_+_54318616 0.79 ENST00000254442.3
WDR7
WD repeat domain 7
chr19_+_52102540 0.77 ENST00000601315.1
AC018755.17
AC018755.17
chr19_+_54372639 0.72 ENST00000391769.2
MYADM
myeloid-associated differentiation marker
chr19_-_35166604 0.71 ENST00000601241.1
SCGB2B2
secretoglobin, family 2B, member 2
chr7_-_5570229 0.69 ENST00000331789.5
ACTB
actin, beta
chr18_+_54318566 0.66 ENST00000589935.1
ENST00000357574.3
WDR7
WD repeat domain 7
chr5_-_179050660 0.66 ENST00000519056.1
ENST00000506721.1
ENST00000503105.1
ENST00000504348.1
ENST00000508103.1
ENST00000510431.1
ENST00000515158.1
ENST00000393432.4
ENST00000442819.2
HNRNPH1
heterogeneous nuclear ribonucleoprotein H1 (H)
chr18_-_54318353 0.65 ENST00000590954.1
ENST00000540155.1
TXNL1
thioredoxin-like 1
chr9_+_140772226 0.64 ENST00000277551.2
ENST00000371372.1
ENST00000277549.5
ENST00000371363.1
ENST00000371357.1
ENST00000371355.4
CACNA1B
calcium channel, voltage-dependent, N type, alpha 1B subunit
chr11_-_2162468 0.61 ENST00000434045.2
IGF2
insulin-like growth factor 2 (somatomedin A)
chr12_-_6772303 0.60 ENST00000396807.4
ENST00000446105.2
ENST00000341550.4
ING4
inhibitor of growth family, member 4
chr7_+_88388628 0.60 ENST00000333190.4
ZNF804B
zinc finger protein 804B
chr2_+_101179152 0.60 ENST00000264254.6
PDCL3
phosducin-like 3
chr16_+_30077098 0.59 ENST00000395240.3
ENST00000566846.1
ALDOA
aldolase A, fructose-bisphosphate
chr11_+_12108410 0.56 ENST00000527997.1
RP13-631K18.5
RP13-631K18.5
chr5_-_176923846 0.55 ENST00000506537.1
PDLIM7
PDZ and LIM domain 7 (enigma)
chr6_-_159466136 0.54 ENST00000367066.3
ENST00000326965.6
TAGAP
T-cell activation RhoGTPase activating protein
chr12_+_59989791 0.54 ENST00000552432.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr6_-_159466042 0.54 ENST00000338313.5
TAGAP
T-cell activation RhoGTPase activating protein
chr4_+_81118647 0.54 ENST00000415738.2
PRDM8
PR domain containing 8
chr5_+_96077888 0.52 ENST00000509259.1
ENST00000503828.1
CAST
calpastatin
chr8_+_38244638 0.51 ENST00000526356.1
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr1_+_167599330 0.51 ENST00000367854.3
ENST00000361496.3
RCSD1
RCSD domain containing 1
chr11_-_2162162 0.51 ENST00000381389.1
IGF2
insulin-like growth factor 2 (somatomedin A)
chr9_-_35691017 0.51 ENST00000378292.3
TPM2
tropomyosin 2 (beta)
chr17_+_3379284 0.50 ENST00000263080.2
ASPA
aspartoacylase
chr22_+_45714361 0.47 ENST00000452238.1
FAM118A
family with sequence similarity 118, member A
chr2_-_96811170 0.47 ENST00000288943.4
DUSP2
dual specificity phosphatase 2
chr11_-_71823796 0.46 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
ANAPC15
anaphase promoting complex subunit 15
chr1_+_28099683 0.46 ENST00000373943.4
STX12
syntaxin 12
chr4_-_10118469 0.46 ENST00000499869.2
WDR1
WD repeat domain 1
chr1_+_206858328 0.45 ENST00000367103.3
MAPKAPK2
mitogen-activated protein kinase-activated protein kinase 2
chr1_-_208084729 0.44 ENST00000310833.7
ENST00000356522.4
CD34
CD34 molecule
chr7_-_559853 0.43 ENST00000405692.2
PDGFA
platelet-derived growth factor alpha polypeptide
chr4_-_109087445 0.42 ENST00000512172.1
LEF1
lymphoid enhancer-binding factor 1
chr17_-_4871085 0.42 ENST00000575142.1
ENST00000206020.3
SPAG7
sperm associated antigen 7
chr22_+_45714672 0.42 ENST00000424557.1
FAM118A
family with sequence similarity 118, member A
chr12_+_59989918 0.41 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr8_-_101965146 0.41 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr5_-_111093167 0.41 ENST00000446294.2
ENST00000419114.2
NREP
neuronal regeneration related protein
chr2_-_112237835 0.41 ENST00000442293.1
ENST00000439494.1
MIR4435-1HG
MIR4435-1 host gene (non-protein coding)
chr20_-_62258394 0.41 ENST00000370077.1
GMEB2
glucocorticoid modulatory element binding protein 2
chr12_-_125398850 0.40 ENST00000535859.1
ENST00000546271.1
ENST00000540700.1
ENST00000546120.1
UBC
ubiquitin C
chr4_-_109087872 0.40 ENST00000510624.1
LEF1
lymphoid enhancer-binding factor 1
chr4_-_10118573 0.37 ENST00000382452.2
ENST00000382451.2
WDR1
WD repeat domain 1
chr1_+_47881744 0.36 ENST00000335071.2
FOXE3
forkhead box E3
chr10_-_29923893 0.35 ENST00000355867.4
SVIL
supervillin
chr3_+_63953415 0.34 ENST00000484332.1
ATXN7
ataxin 7
chr4_-_54930790 0.34 ENST00000263921.3
CHIC2
cysteine-rich hydrophobic domain 2
chr11_-_71823266 0.34 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
ANAPC15
anaphase promoting complex subunit 15
chr13_+_42614176 0.33 ENST00000540693.1
DGKH
diacylglycerol kinase, eta
chr4_-_109087906 0.32 ENST00000515500.1
LEF1
lymphoid enhancer-binding factor 1
chr7_+_114055052 0.31 ENST00000462331.1
ENST00000408937.3
ENST00000403559.4
ENST00000350908.4
ENST00000393498.2
ENST00000393495.3
ENST00000378237.3
ENST00000393489.3
FOXP2
forkhead box P2
chr8_-_22550691 0.30 ENST00000519492.1
EGR3
early growth response 3
chr16_+_66413128 0.30 ENST00000563425.2
CDH5
cadherin 5, type 2 (vascular endothelium)
chr12_+_62654119 0.29 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
USP15
ubiquitin specific peptidase 15
chr16_+_30077055 0.29 ENST00000564595.2
ENST00000569798.1
ALDOA
aldolase A, fructose-bisphosphate
chr9_-_79520989 0.29 ENST00000376713.3
ENST00000376718.3
ENST00000428286.1
PRUNE2
prune homolog 2 (Drosophila)
chr13_+_27825446 0.29 ENST00000311549.6
RPL21
ribosomal protein L21
chr7_+_143078379 0.28 ENST00000449630.1
ENST00000457235.1
ZYX
zyxin
chr12_-_6772249 0.28 ENST00000467678.1
ENST00000493873.1
ENST00000423703.2
ENST00000412586.2
ENST00000444704.2
ING4
inhibitor of growth family, member 4
chr1_+_167599532 0.27 ENST00000537350.1
RCSD1
RCSD domain containing 1
chr16_+_56965960 0.27 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr1_-_208084387 0.26 ENST00000537704.1
CD34
CD34 molecule
chr1_+_11994715 0.26 ENST00000449038.1
ENST00000376369.3
ENST00000429000.2
ENST00000196061.4
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr7_+_149416439 0.26 ENST00000497895.1
KRBA1
KRAB-A domain containing 1
chr5_-_169816638 0.24 ENST00000521859.1
ENST00000274629.4
KCNMB1
potassium large conductance calcium-activated channel, subfamily M, beta member 1
chr19_-_47975417 0.24 ENST00000236877.6
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr2_-_106054952 0.24 ENST00000336660.5
ENST00000393352.3
ENST00000607522.1
FHL2
four and a half LIM domains 2
chr22_-_36850991 0.24 ENST00000442579.1
RP5-1119A7.14
RP5-1119A7.14
chr12_-_11548496 0.22 ENST00000389362.4
ENST00000565533.1
ENST00000546254.1
PRB2
PRB1
proline-rich protein BstNI subfamily 2
proline-rich protein BstNI subfamily 1
chr8_-_125827922 0.21 ENST00000533516.1
RP11-1082L8.4
RP11-1082L8.4
chr22_-_50216853 0.18 ENST00000342989.5
ENST00000542442.1
BRD1
bromodomain containing 1
chr10_-_90712520 0.18 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chrX_+_101502170 0.18 ENST00000372757.1
NXF2
nuclear RNA export factor 2
chrX_-_11284095 0.18 ENST00000303025.6
ENST00000534860.1
ARHGAP6
Rho GTPase activating protein 6
chr22_-_36357671 0.17 ENST00000408983.2
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr10_-_16859442 0.17 ENST00000602389.1
ENST00000345264.5
RSU1
Ras suppressor protein 1
chr10_-_16859361 0.17 ENST00000377921.3
RSU1
Ras suppressor protein 1
chr1_-_152332480 0.17 ENST00000388718.5
FLG2
filaggrin family member 2
chr17_-_4890649 0.16 ENST00000361571.5
CAMTA2
calmodulin binding transcription activator 2
chr17_-_55911970 0.16 ENST00000581805.1
ENST00000580960.1
RP11-60A24.3
RP11-60A24.3
chr19_-_45826125 0.15 ENST00000221476.3
CKM
creatine kinase, muscle
chrX_-_101694853 0.14 ENST00000372749.1
NXF2B
nuclear RNA export factor 2B
chr19_-_47975106 0.13 ENST00000539381.1
ENST00000594353.1
ENST00000542837.1
SLC8A2
solute carrier family 8 (sodium/calcium exchanger), member 2
chr19_+_13135439 0.13 ENST00000586873.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr6_-_16761678 0.12 ENST00000244769.4
ENST00000436367.1
ATXN1
ataxin 1
chr2_-_161264385 0.11 ENST00000409972.1
RBMS1
RNA binding motif, single stranded interacting protein 1
chr7_-_44180884 0.11 ENST00000458240.1
ENST00000223364.3
MYL7
myosin, light chain 7, regulatory
chr19_+_57901326 0.11 ENST00000596400.1
AC003002.6
Uncharacterized protein
chr2_-_73520667 0.08 ENST00000545030.1
ENST00000436467.2
EGR4
early growth response 4
chrX_-_103499602 0.08 ENST00000372588.4
ESX1
ESX homeobox 1
chr2_-_106015527 0.07 ENST00000344213.4
ENST00000358129.4
FHL2
four and a half LIM domains 2
chr6_-_99797522 0.07 ENST00000389677.5
FAXC
failed axon connections homolog (Drosophila)
chr16_+_4666475 0.06 ENST00000591895.1
MGRN1
mahogunin ring finger 1, E3 ubiquitin protein ligase
chr3_+_187930719 0.06 ENST00000312675.4
LPP
LIM domain containing preferred translocation partner in lipoma
chr2_-_208031943 0.06 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr19_+_35861831 0.05 ENST00000454971.1
GPR42
G protein-coupled receptor 42 (gene/pseudogene)
chr14_-_94443065 0.05 ENST00000555287.1
ASB2
ankyrin repeat and SOCS box containing 2
chr8_+_1993152 0.05 ENST00000262113.4
MYOM2
myomesin 2
chr8_+_1993173 0.05 ENST00000523438.1
MYOM2
myomesin 2
chr10_+_96162242 0.03 ENST00000225235.4
TBC1D12
TBC1 domain family, member 12
chr8_-_101965559 0.02 ENST00000353245.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr1_+_219347186 0.01 ENST00000366928.5
LYPLAL1
lysophospholipase-like 1
chr12_+_62654155 0.01 ENST00000312635.6
ENST00000393654.3
ENST00000549237.1
USP15
ubiquitin specific peptidase 15
chr2_+_56179262 0.01 ENST00000606639.1
RP11-481J13.1
RP11-481J13.1
chr6_-_123958051 0.00 ENST00000546248.1
TRDN
triadin

Network of associatons between targets according to the STRING database.

First level regulatory network of SRF

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
16.8 50.4 GO:0050720 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720)
1.1 3.3 GO:0021571 rhombomere 3 development(GO:0021569) rhombomere 5 development(GO:0021571) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.9 9.5 GO:0038044 transforming growth factor-beta secretion(GO:0038044)
0.8 6.9 GO:0001661 conditioned taste aversion(GO:0001661)
0.7 4.3 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.5 4.3 GO:0007296 vitellogenesis(GO:0007296)
0.5 2.1 GO:0009956 radial pattern formation(GO:0009956)
0.5 3.5 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.5 3.5 GO:0071461 cellular response to redox state(GO:0071461)
0.4 3.0 GO:0008218 bioluminescence(GO:0008218)
0.4 2.8 GO:1903921 protein processing in phagocytic vesicle(GO:1900756) regulation of protein processing in phagocytic vesicle(GO:1903921) positive regulation of protein processing in phagocytic vesicle(GO:1903923)
0.4 1.2 GO:0061145 bronchus cartilage development(GO:0060532) lung smooth muscle development(GO:0061145)
0.3 0.9 GO:2000417 negative regulation of eosinophil migration(GO:2000417)
0.3 1.1 GO:0018277 protein deamination(GO:0018277)
0.2 3.8 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.2 6.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.2 1.3 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.2 1.5 GO:0002329 pre-B cell differentiation(GO:0002329)
0.2 1.7 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.2 0.8 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.2 0.9 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.2 0.5 GO:0006533 aspartate catabolic process(GO:0006533)
0.2 2.0 GO:0035768 cell chemotaxis to fibroblast growth factor(GO:0035766) endothelial cell chemotaxis to fibroblast growth factor(GO:0035768) regulation of cell chemotaxis to fibroblast growth factor(GO:1904847) regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000544)
0.2 4.6 GO:0051412 response to corticosterone(GO:0051412)
0.2 1.0 GO:1904383 response to sodium phosphate(GO:1904383)
0.1 2.8 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.6 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.1 8.1 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.1 0.8 GO:0015853 adenine transport(GO:0015853)
0.1 1.4 GO:0045586 regulation of gamma-delta T cell differentiation(GO:0045586)
0.1 1.8 GO:0007258 JUN phosphorylation(GO:0007258)
0.1 0.2 GO:1903413 cellular response to bile acid(GO:1903413)
0.1 1.0 GO:0006848 pyruvate transport(GO:0006848) pyruvate transmembrane transport(GO:1901475)
0.1 1.1 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.1 0.4 GO:0061073 ciliary body morphogenesis(GO:0061073)
0.1 0.3 GO:0098582 innate vocalization behavior(GO:0098582)
0.1 0.3 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.1 0.4 GO:0060684 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512) epithelial-mesenchymal cell signaling(GO:0060684)
0.1 4.8 GO:1901998 toxin transport(GO:1901998)
0.1 5.9 GO:0031529 ruffle organization(GO:0031529)
0.1 1.6 GO:1903504 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.1 1.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.1 0.3 GO:0046947 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.1 1.4 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 0.9 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.8 GO:0071474 cellular hyperosmotic response(GO:0071474)
0.0 0.2 GO:0072008 glomerular mesangial cell differentiation(GO:0072008)
0.0 0.3 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0 1.1 GO:0014898 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898)
0.0 3.1 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)
0.0 0.5 GO:0044351 macropinocytosis(GO:0044351)
0.0 2.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.5 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0 0.2 GO:0055011 atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.0 3.0 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.0 0.3 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0 1.1 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0 0.5 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.3 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.2 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 1.2 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.4 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 2.1 GO:0030038 contractile actin filament bundle assembly(GO:0030038) stress fiber assembly(GO:0043149)
0.0 0.1 GO:0002074 extraocular skeletal muscle development(GO:0002074)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 9.5 GO:0034685 integrin alphav-beta6 complex(GO:0034685)
0.8 6.9 GO:0035976 AP1 complex(GO:0035976)
0.7 6.0 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.3 2.9 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.3 6.2 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.2 1.0 GO:0097513 myosin II filament(GO:0097513)
0.1 1.8 GO:0030478 actin cap(GO:0030478)
0.1 13.1 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 6.1 GO:0008023 transcription elongation factor complex(GO:0008023)
0.1 1.1 GO:1990907 beta-catenin-TCF complex(GO:1990907)
0.1 4.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 0.3 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.0 1.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0042643 actomyosin, actin portion(GO:0042643)
0.0 0.2 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.0 4.3 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.7 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.7 GO:0046930 pore complex(GO:0046930)
0.0 0.6 GO:0000502 proteasome complex(GO:0000502)
0.0 3.4 GO:0005796 Golgi lumen(GO:0005796)
0.0 3.1 GO:0005667 transcription factor complex(GO:0005667)
0.0 0.3 GO:0036449 microtubule minus-end(GO:0036449)
0.0 2.3 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 2.0 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.7 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.2 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 1.0 GO:0005884 actin filament(GO:0005884)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
10.1 50.4 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.3 3.5 GO:0005094 Rho GDP-dissociation inhibitor activity(GO:0005094)
0.2 1.0 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.2 1.2 GO:0010736 serum response element binding(GO:0010736)
0.2 4.8 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 0.8 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
0.2 3.5 GO:0008430 selenium binding(GO:0008430)
0.2 1.8 GO:0045159 myosin II binding(GO:0045159)
0.2 0.5 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
0.2 1.8 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.1 2.5 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.6 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1 10.2 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.9 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.1 5.9 GO:0003785 actin monomer binding(GO:0003785)
0.1 2.8 GO:0031005 filamin binding(GO:0031005)
0.1 0.3 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.1 9.5 GO:0001618 virus receptor activity(GO:0001618)
0.1 0.9 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 1.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.1 2.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.3 GO:0033823 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.1 5.0 GO:0003700 transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.1 1.1 GO:0030284 estrogen receptor activity(GO:0030284)
0.1 8.1 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 3.6 GO:0030507 spectrin binding(GO:0030507)
0.1 0.7 GO:0043199 sulfate binding(GO:0043199)
0.1 0.5 GO:0004046 aminoacylase activity(GO:0004046)
0.0 0.5 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0 2.1 GO:0001972 retinoic acid binding(GO:0001972)
0.0 0.6 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.0 5.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.1 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 1.1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.7 GO:0050998 Tat protein binding(GO:0030957) nitric-oxide synthase binding(GO:0050998)
0.0 0.6 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 1.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.0 0.4 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.5 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.8 GO:0008266 poly(U) RNA binding(GO:0008266)
0.0 1.8 GO:0050681 androgen receptor binding(GO:0050681)
0.0 2.7 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.0 0.1 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.3 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 1.0 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 5.1 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 50.4 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.3 6.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.2 9.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 11.4 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 6.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 4.3 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 3.0 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 1.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 3.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 5.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.8 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.0 2.7 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.0 2.0 PID FGF PATHWAY FGF signaling pathway
0.0 3.6 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 2.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 1.9 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.8 PID CMYB PATHWAY C-MYB transcription factor network
0.0 0.2 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.2 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 0.5 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 0.3 PID S1P S1P2 PATHWAY S1P2 pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 51.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.3 8.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 2.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 3.0 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 4.1 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1 0.9 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.1 3.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 6.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 4.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 3.6 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 1.0 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 7.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 5.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.5 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 4.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.5 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 0.9 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 0.7 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.0 0.8 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.0 0.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell