ISMARA results: STAT1_STAT3

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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for STAT1_STAT3_BCL6

Z-value: 1.77

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Transcription factors associated with STAT1_STAT3_BCL6

Gene Symbol	Gene ID	Gene Info
STAT1 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000115415.14	signal transducer and activator of transcription 1
STAT3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000168610.10	signal transducer and activator of transcription 3
BCL6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000113916.13	BCL6 transcription repressor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
BCL6	hg19_v2_chr3_-_187454281_187454357	-0.91	2.0e-08	Click!
STAT3	hg19_v2_chr17_-_40540586_40540600	0.62	3.6e-03	Click!
STAT1	hg19_v2_chr2_-_191878874_191878976	0.57	8.6e-03	Click!

Activity profile of STAT1_STAT3_BCL6 motif

Sorted Z-values of STAT1_STAT3_BCL6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_+_32582293 Show fit	16.80	ENST00000580907.1 ENST00000225831.4	CCL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	chemokine (C-C motif) ligand 2
chr4_-_155511887 Show fit	13.25	ENST00000302053.3 ENST00000403106.3	FGA Ensembl NCBI GeneCards UniProt NextProt Show fit	fibrinogen alpha chain
chr17_-_46692287 Show fit	8.38	ENST00000239144.4	HOXB8 Ensembl NCBI GeneCards UniProt NextProt Show fit	homeobox B8
chr8_-_27469196 Show fit	8.33	ENST00000546343.1 ENST00000560566.1	CLU Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin
chr2_+_87754989 Show fit	7.86	ENST00000409898.2 ENST00000419680.2 ENST00000414584.1 ENST00000455131.1	LINC00152 Ensembl NCBI GeneCards UniProt NextProt Show fit	long intergenic non-protein coding RNA 152
chr17_-_46691990 Show fit	7.44	ENST00000576562.1	HOXB8 Ensembl NCBI GeneCards UniProt NextProt Show fit	homeobox B8
chr15_-_88799661 Show fit	7.35	ENST00000360948.2 ENST00000357724.2 ENST00000355254.2 ENST00000317501.3	NTRK3 Ensembl NCBI GeneCards UniProt NextProt Show fit	neurotrophic tyrosine kinase, receptor, type 3
chr8_-_27468945 Show fit	7.19	ENST00000405140.3	CLU Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin
chr8_-_27468842 Show fit	7.03	ENST00000523500.1	CLU Ensembl NCBI GeneCards UniProt NextProt Show fit	clusterin
chr17_+_6347761 Show fit	6.62	ENST00000250056.8 ENST00000571373.1 ENST00000570337.2 ENST00000572595.2 ENST00000576056.1	FAM64A Ensembl NCBI GeneCards UniProt NextProt Show fit	family with sequence similarity 64, member A

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT1_STAT3_BCL6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	33.4	GO:1902998	regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.4	19.6	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.6	17.4	GO:0021516	dorsal spinal cord development(GO:0021516)
5.6	16.8	GO:2000502	negative regulation of natural killer cell chemotaxis(GO:2000502)
1.6	10.9	GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway(GO:0038123) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
2.7	10.7	GO:0019056	modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.1	10.7	GO:0006879	cellular iron ion homeostasis(GO:0006879)
0.6	8.9	GO:0098870	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.4	8.6	GO:0002115	store-operated calcium entry(GO:0002115)
0.8	6.4	GO:2000860	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)

Showing 1 to 10 of 279 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	33.3	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.2	30.1	GO:0072562	blood microparticle(GO:0072562)
1.6	22.8	GO:0005577	fibrinogen complex(GO:0005577)
1.2	10.9	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	9.1	GO:0043235	receptor complex(GO:0043235)
0.0	8.1	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	6.6	GO:0005581	collagen trimer(GO:0005581)
0.2	6.4	GO:0043194	axon initial segment(GO:0043194)
1.5	6.1	GO:0071062	rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0	5.9	GO:0016323	basolateral plasma membrane(GO:0016323)

Showing 1 to 10 of 106 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	33.4	GO:0051787	misfolded protein binding(GO:0051787)
0.6	19.1	GO:0048020	CCR chemokine receptor binding(GO:0048020)
1.6	11.2	GO:0016019	peptidoglycan receptor activity(GO:0016019)
0.7	11.0	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.9	10.8	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.5	8.6	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.3	8.6	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2	6.3	GO:0030247	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.6	5.8	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	5.7	GO:0030674	protein binding, bridging(GO:0030674)

Showing 1 to 10 of 183 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	29.7	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.4	22.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.3	22.1	PID IL23 PATHWAY	IL23-mediated signaling events
0.1	11.8	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	8.6	PID SHP2 PATHWAY	SHP2 signaling
0.1	8.5	PID AURORA B PATHWAY	Aurora B signaling
0.1	6.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	6.3	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.2	6.1	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	5.6	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells

Showing 1 to 10 of 47 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	31.9	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	21.8	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.4	17.3	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.2	10.9	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	8.8	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.5	8.6	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	7.0	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	6.9	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.0	6.8	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.3	5.8	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation

Showing 1 to 10 of 74 entries

Results for STAT1_STAT3_BCL6

Z-value: 1.77

Motif logo

Transcription factors associated with STAT1_STAT3_BCL6

Activity-expression correlation:

Activity profile of STAT1_STAT3_BCL6 motif

Sorted Z-values of STAT1_STAT3_BCL6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT1_STAT3_BCL6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: