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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for STAT4

Z-value: 0.96

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Transcription factors associated with STAT4

Gene Symbol Gene ID Gene Info
STAT4
ENSG00000138378.13 signal transducer and activator of transcription 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
STAT4hg19_v2_chr2_-_192016316_1920163250.614.4e-03Click!

Activity profile of STAT4 motif

Sorted Z-values of STAT4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_61143994 6.23 ENST00000382771.4
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr11_-_119999611 5.24 ENST00000529044.1
TRIM29
tripartite motif containing 29
chr11_-_119999539 5.24 ENST00000541857.1
TRIM29
tripartite motif containing 29
chr18_+_61144160 5.06 ENST00000489441.1
ENST00000424602.1
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr22_-_38349552 3.79 ENST00000422191.1
ENST00000249079.2
ENST00000418863.1
ENST00000403305.1
ENST00000403026.1
C22orf23
chromosome 22 open reading frame 23
chr2_+_113885138 3.66 ENST00000409930.3
IL1RN
interleukin 1 receptor antagonist
chr5_-_151066514 3.43 ENST00000538026.1
ENST00000522348.1
ENST00000521569.1
SPARC
secreted protein, acidic, cysteine-rich (osteonectin)
chr11_+_12302492 3.04 ENST00000533534.1
MICALCL
MICAL C-terminal like
chr5_-_39274617 2.65 ENST00000510188.1
FYB
FYN binding protein
chr6_-_56716686 2.58 ENST00000520645.1
DST
dystonin
chr6_+_36646435 2.54 ENST00000244741.5
ENST00000405375.1
ENST00000373711.2
CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
chr11_+_123986069 2.33 ENST00000456829.2
ENST00000361352.5
ENST00000449321.1
ENST00000392748.1
ENST00000360334.4
ENST00000392744.4
VWA5A
von Willebrand factor A domain containing 5A
chr19_+_56905024 2.30 ENST00000591172.1
ENST00000589888.1
ENST00000587979.1
ENST00000585659.1
ENST00000593109.1
ZNF582-AS1
ZNF582 antisense RNA 1 (head to head)
chr12_-_15082050 2.15 ENST00000540097.1
ERP27
endoplasmic reticulum protein 27
chr7_-_41740181 2.14 ENST00000442711.1
INHBA
inhibin, beta A
chr17_+_1666108 2.08 ENST00000570731.1
SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr3_-_50649192 2.06 ENST00000443053.2
ENST00000348721.3
CISH
cytokine inducible SH2-containing protein
chr3_+_50649302 2.04 ENST00000446044.1
MAPKAPK3
mitogen-activated protein kinase-activated protein kinase 3
chr1_+_68150744 1.98 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr2_+_210444748 1.90 ENST00000392194.1
MAP2
microtubule-associated protein 2
chr12_+_56324756 1.88 ENST00000331886.5
ENST00000555090.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr19_-_56904799 1.77 ENST00000589895.1
ENST00000589143.1
ENST00000301310.4
ENST00000586929.1
ZNF582
zinc finger protein 582
chr13_-_26795840 1.72 ENST00000381570.3
ENST00000399762.2
ENST00000346166.3
RNF6
ring finger protein (C3H2C3 type) 6
chr4_-_140477353 1.55 ENST00000406354.1
ENST00000506866.2
SETD7
SET domain containing (lysine methyltransferase) 7
chr1_+_16085263 1.47 ENST00000483633.2
ENST00000502739.1
ENST00000431771.2
FBLIM1
filamin binding LIM protein 1
chr12_+_56324933 1.44 ENST00000549629.1
ENST00000555218.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr12_+_14518598 1.42 ENST00000261168.4
ENST00000538511.1
ENST00000545723.1
ENST00000543189.1
ENST00000536444.1
ATF7IP
activating transcription factor 7 interacting protein
chr1_-_161337662 1.40 ENST00000367974.1
C1orf192
chromosome 1 open reading frame 192
chr10_+_106028923 1.24 ENST00000338595.2
GSTO2
glutathione S-transferase omega 2
chr19_+_10197463 1.23 ENST00000590378.1
ENST00000397881.3
C19orf66
chromosome 19 open reading frame 66
chr3_-_71114066 1.22 ENST00000485326.2
FOXP1
forkhead box P1
chr5_+_131409476 1.20 ENST00000296871.2
CSF2
colony stimulating factor 2 (granulocyte-macrophage)
chr7_-_38969150 1.18 ENST00000418457.2
VPS41
vacuolar protein sorting 41 homolog (S. cerevisiae)
chr5_+_140753444 1.13 ENST00000517434.1
PCDHGA6
protocadherin gamma subfamily A, 6
chr3_-_183735731 1.13 ENST00000334444.6
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr11_-_46113756 1.11 ENST00000531959.1
PHF21A
PHD finger protein 21A
chr13_-_41240717 1.10 ENST00000379561.5
FOXO1
forkhead box O1
chr14_-_21270561 1.09 ENST00000412779.2
RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr19_-_44952635 1.08 ENST00000592308.1
ENST00000588931.1
ENST00000291187.4
ZNF229
zinc finger protein 229
chr2_+_171785824 1.05 ENST00000452526.2
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr10_+_81065975 1.02 ENST00000446377.2
ZMIZ1
zinc finger, MIZ-type containing 1
chr3_-_183735651 0.98 ENST00000427120.2
ENST00000392579.2
ENST00000382494.2
ENST00000446941.2
ABCC5
ATP-binding cassette, sub-family C (CFTR/MRP), member 5
chr3_+_45429998 0.97 ENST00000265537.3
ENST00000415258.1
ENST00000431023.1
ENST00000414984.1
LARS2
leucyl-tRNA synthetase 2, mitochondrial
chr4_-_140477910 0.96 ENST00000404104.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr14_-_100841794 0.95 ENST00000556295.1
ENST00000554820.1
WARS
tryptophanyl-tRNA synthetase
chr1_-_144364246 0.93 ENST00000540273.1
PPIAL4B
peptidylprolyl isomerase A (cyclophilin A)-like 4B
chr1_+_9242221 0.90 ENST00000412639.2
RP3-510D11.2
RP3-510D11.2
chr13_-_45915221 0.90 ENST00000309246.5
ENST00000379060.4
ENST00000379055.1
ENST00000527226.1
ENST00000379056.1
TPT1
tumor protein, translationally-controlled 1
chr3_+_45430105 0.88 ENST00000430399.1
LARS2
leucyl-tRNA synthetase 2, mitochondrial
chr1_-_9811600 0.87 ENST00000435891.1
CLSTN1
calsyntenin 1
chr1_+_149553003 0.85 ENST00000369222.3
PPIAL4C
peptidylprolyl isomerase A (cyclophilin A)-like 4C
chr19_-_44405623 0.84 ENST00000591815.1
RP11-15A1.3
RP11-15A1.3
chr8_-_42358742 0.84 ENST00000517366.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr1_-_144994840 0.81 ENST00000369351.3
ENST00000369349.3
PDE4DIP
phosphodiesterase 4D interacting protein
chr3_-_187455680 0.80 ENST00000438077.1
BCL6
B-cell CLL/lymphoma 6
chr1_-_144994909 0.79 ENST00000369347.4
ENST00000369354.3
PDE4DIP
phosphodiesterase 4D interacting protein
chr14_+_55034599 0.78 ENST00000392067.3
ENST00000357634.3
SAMD4A
sterile alpha motif domain containing 4A
chr4_-_76957214 0.78 ENST00000306621.3
CXCL11
chemokine (C-X-C motif) ligand 11
chr5_-_121413974 0.77 ENST00000231004.4
LOX
lysyl oxidase
chr11_+_33563821 0.77 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L
KIAA1549-like
chr2_+_68961934 0.76 ENST00000409202.3
ARHGAP25
Rho GTPase activating protein 25
chr4_-_68995571 0.75 ENST00000356291.2
TMPRSS11F
transmembrane protease, serine 11F
chr3_+_38179969 0.75 ENST00000396334.3
ENST00000417037.2
ENST00000424893.1
ENST00000495303.1
ENST00000443433.2
ENST00000421516.1
MYD88
myeloid differentiation primary response 88
chr17_+_7358889 0.74 ENST00000575379.1
CHRNB1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr7_-_82792215 0.74 ENST00000333891.9
ENST00000423517.2
PCLO
piccolo presynaptic cytomatrix protein
chr9_+_72658490 0.73 ENST00000377182.4
MAMDC2
MAM domain containing 2
chr4_-_87770416 0.72 ENST00000273905.6
SLC10A6
solute carrier family 10 (sodium/bile acid cotransporter), member 6
chr12_-_49245916 0.71 ENST00000552512.1
ENST00000551468.1
DDX23
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr22_-_31536480 0.70 ENST00000215885.3
PLA2G3
phospholipase A2, group III
chr20_-_18774614 0.70 ENST00000412553.1
LINC00652
long intergenic non-protein coding RNA 652
chr19_-_44405941 0.70 ENST00000587128.1
RP11-15A1.3
RP11-15A1.3
chr2_+_68961905 0.69 ENST00000295381.3
ARHGAP25
Rho GTPase activating protein 25
chrX_+_107288280 0.69 ENST00000458383.1
VSIG1
V-set and immunoglobulin domain containing 1
chr11_+_33563618 0.68 ENST00000526400.1
KIAA1549L
KIAA1549-like
chr5_-_111092873 0.66 ENST00000509025.1
ENST00000515855.1
NREP
neuronal regeneration related protein
chr6_+_143447322 0.66 ENST00000458219.1
AIG1
androgen-induced 1
chr2_+_68962014 0.65 ENST00000467265.1
ARHGAP25
Rho GTPase activating protein 25
chr14_-_21490417 0.65 ENST00000556366.1
NDRG2
NDRG family member 2
chr1_-_33502528 0.65 ENST00000354858.6
AK2
adenylate kinase 2
chr6_+_35995552 0.65 ENST00000468133.1
MAPK14
mitogen-activated protein kinase 14
chr2_-_214017151 0.63 ENST00000452786.1
IKZF2
IKAROS family zinc finger 2 (Helios)
chr1_+_10534944 0.63 ENST00000356607.4
ENST00000538836.1
ENST00000491661.2
PEX14
peroxisomal biogenesis factor 14
chr1_+_155146318 0.63 ENST00000368385.4
ENST00000545012.1
ENST00000392451.2
ENST00000368383.3
ENST00000368382.1
ENST00000334634.4
TRIM46
tripartite motif containing 46
chr10_-_95241951 0.61 ENST00000358334.5
ENST00000359263.4
ENST00000371488.3
MYOF
myoferlin
chr11_+_128563652 0.57 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr14_-_21490958 0.57 ENST00000554104.1
NDRG2
NDRG family member 2
chr1_-_33502441 0.57 ENST00000548033.1
ENST00000487289.1
ENST00000373449.2
ENST00000480134.1
ENST00000467905.1
AK2
adenylate kinase 2
chr16_-_67260901 0.56 ENST00000341546.3
ENST00000409509.1
ENST00000433915.1
ENST00000454102.2
LRRC29
AC040160.1
leucine rich repeat containing 29
Uncharacterized protein; cDNA FLJ57407, weakly similar to Mus musculus leucine rich repeat containing 29 (Lrrc29), mRNA
chr2_-_160473114 0.55 ENST00000392783.2
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr20_+_39657454 0.55 ENST00000361337.2
TOP1
topoisomerase (DNA) I
chr1_-_28384598 0.55 ENST00000373864.1
EYA3
eyes absent homolog 3 (Drosophila)
chr13_+_100153665 0.54 ENST00000376387.4
TM9SF2
transmembrane 9 superfamily member 2
chr1_-_161279749 0.54 ENST00000533357.1
ENST00000360451.6
ENST00000336559.4
MPZ
myelin protein zero
chr14_-_21490653 0.50 ENST00000449431.2
NDRG2
NDRG family member 2
chr1_-_205391178 0.50 ENST00000367153.4
ENST00000367151.2
ENST00000391936.2
ENST00000367149.3
LEMD1
LEM domain containing 1
chr11_+_20044375 0.49 ENST00000525322.1
ENST00000530408.1
NAV2
neuron navigator 2
chr5_-_127674883 0.49 ENST00000507835.1
FBN2
fibrillin 2
chr2_-_160472952 0.49 ENST00000541068.2
ENST00000355831.2
ENST00000343439.5
ENST00000392782.1
BAZ2B
bromodomain adjacent to zinc finger domain, 2B
chr11_+_20044096 0.48 ENST00000533917.1
NAV2
neuron navigator 2
chrX_-_137793826 0.47 ENST00000315930.6
FGF13
fibroblast growth factor 13
chr2_-_75796837 0.47 ENST00000233712.1
EVA1A
eva-1 homolog A (C. elegans)
chr19_+_44617511 0.46 ENST00000262894.6
ENST00000588926.1
ENST00000592780.1
ZNF225
zinc finger protein 225
chr11_-_133715394 0.45 ENST00000299140.3
ENST00000532889.1
SPATA19
spermatogenesis associated 19
chr6_+_108977520 0.45 ENST00000540898.1
FOXO3
forkhead box O3
chr5_+_34685805 0.45 ENST00000508315.1
RAI14
retinoic acid induced 14
chr8_-_114449112 0.44 ENST00000455883.2
ENST00000352409.3
ENST00000297405.5
CSMD3
CUB and Sushi multiple domains 3
chr2_-_171627269 0.44 ENST00000442456.1
AC007405.4
AC007405.4
chr5_+_667759 0.43 ENST00000594226.1
AC026740.1
Uncharacterized protein
chr12_+_56435637 0.43 ENST00000356464.5
ENST00000552361.1
RPS26
ribosomal protein S26
chr6_+_46761118 0.42 ENST00000230588.4
MEP1A
meprin A, alpha (PABA peptide hydrolase)
chrX_+_107288239 0.42 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr3_+_15468862 0.42 ENST00000396842.2
EAF1
ELL associated factor 1
chr10_-_62060232 0.42 ENST00000503925.1
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_+_95831529 0.42 ENST00000295210.6
ENST00000453539.2
ZNF2
zinc finger protein 2
chr5_-_64777733 0.40 ENST00000381055.3
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr19_-_54663473 0.39 ENST00000222224.3
LENG1
leukocyte receptor cluster (LRC) member 1
chr16_+_58283814 0.39 ENST00000443128.2
ENST00000219299.4
CCDC113
coiled-coil domain containing 113
chr20_+_42136308 0.39 ENST00000434666.1
ENST00000427442.2
ENST00000439769.1
ENST00000418998.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr5_+_73109339 0.37 ENST00000296799.4
ARHGEF28
Rho guanine nucleotide exchange factor (GEF) 28
chr6_+_139349903 0.37 ENST00000461027.1
ABRACL
ABRA C-terminal like
chr6_-_136610911 0.36 ENST00000530767.1
ENST00000527759.1
ENST00000527536.1
ENST00000529826.1
ENST00000531224.1
ENST00000353331.4
BCLAF1
BCL2-associated transcription factor 1
chr6_+_32407619 0.36 ENST00000395388.2
ENST00000374982.5
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr10_-_126847276 0.36 ENST00000531469.1
CTBP2
C-terminal binding protein 2
chr19_+_50145328 0.36 ENST00000360565.3
SCAF1
SR-related CTD-associated factor 1
chr16_+_85932760 0.35 ENST00000565552.1
IRF8
interferon regulatory factor 8
chr10_-_95242044 0.34 ENST00000371501.4
ENST00000371502.4
ENST00000371489.1
MYOF
myoferlin
chrX_+_114874727 0.34 ENST00000543070.1
PLS3
plastin 3
chr2_-_197675000 0.33 ENST00000342506.2
C2orf66
chromosome 2 open reading frame 66
chr8_-_120685608 0.33 ENST00000427067.2
ENPP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr3_+_122296465 0.33 ENST00000483793.1
PARP15
poly (ADP-ribose) polymerase family, member 15
chr1_+_202431859 0.32 ENST00000391959.3
ENST00000367270.4
PPP1R12B
protein phosphatase 1, regulatory subunit 12B
chr5_+_137203465 0.32 ENST00000239926.4
MYOT
myotilin
chr1_+_149754227 0.32 ENST00000444948.1
ENST00000369168.4
FCGR1A
Fc fragment of IgG, high affinity Ia, receptor (CD64)
chr19_-_44331332 0.31 ENST00000602179.1
LYPD5
LY6/PLAUR domain containing 5
chr3_+_171561127 0.31 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr2_+_231921574 0.31 ENST00000308696.6
ENST00000373635.4
ENST00000440838.1
ENST00000409643.1
PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr14_-_21924209 0.31 ENST00000557364.1
CHD8
chromodomain helicase DNA binding protein 8
chr1_-_120935894 0.30 ENST00000369383.4
ENST00000369384.4
FCGR1B
Fc fragment of IgG, high affinity Ib, receptor (CD64)
chr1_+_182584314 0.30 ENST00000566297.1
RP11-317P15.4
RP11-317P15.4
chr14_-_36645674 0.30 ENST00000556013.2
PTCSC3
papillary thyroid carcinoma susceptibility candidate 3 (non-protein coding)
chr6_-_32152064 0.30 ENST00000375076.4
ENST00000375070.3
AGER
advanced glycosylation end product-specific receptor
chr12_+_27396901 0.30 ENST00000541191.1
ENST00000389032.3
STK38L
serine/threonine kinase 38 like
chr17_-_3417062 0.29 ENST00000570318.1
ENST00000541913.1
SPATA22
spermatogenesis associated 22
chr3_+_187871060 0.28 ENST00000448637.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr19_-_4902877 0.27 ENST00000381781.2
ARRDC5
arrestin domain containing 5
chr1_+_17906970 0.27 ENST00000375415.1
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chrX_+_107288197 0.27 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr11_-_64490634 0.26 ENST00000377559.3
ENST00000265459.6
NRXN2
neurexin 2
chr3_+_122399697 0.26 ENST00000494811.1
PARP14
poly (ADP-ribose) polymerase family, member 14
chr18_+_6729725 0.26 ENST00000400091.2
ENST00000583410.1
ENST00000584387.1
ARHGAP28
Rho GTPase activating protein 28
chr5_+_179921344 0.25 ENST00000261951.4
CNOT6
CCR4-NOT transcription complex, subunit 6
chr3_-_126327398 0.25 ENST00000383572.2
TXNRD3NB
thioredoxin reductase 3 neighbor
chr12_+_100750846 0.25 ENST00000323346.5
SLC17A8
solute carrier family 17 (vesicular glutamate transporter), member 8
chr16_+_24549014 0.25 ENST00000564314.1
ENST00000567686.1
RBBP6
retinoblastoma binding protein 6
chr3_+_5020801 0.25 ENST00000256495.3
BHLHE40
basic helix-loop-helix family, member e40
chr10_+_102790980 0.25 ENST00000393459.1
ENST00000224807.5
SFXN3
sideroflexin 3
chr3_-_196242233 0.24 ENST00000397537.2
SMCO1
single-pass membrane protein with coiled-coil domains 1
chr19_-_39881777 0.24 ENST00000595564.1
ENST00000221265.3
PAF1
Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
chr2_-_37193606 0.24 ENST00000379213.2
ENST00000263918.4
STRN
striatin, calmodulin binding protein
chr5_-_111093167 0.24 ENST00000446294.2
ENST00000419114.2
NREP
neuronal regeneration related protein
chr5_+_137203541 0.24 ENST00000421631.2
MYOT
myotilin
chr12_+_133656995 0.24 ENST00000356456.5
ZNF140
zinc finger protein 140
chr5_-_111093340 0.24 ENST00000508870.1
NREP
neuronal regeneration related protein
chr5_-_111093081 0.23 ENST00000453526.2
ENST00000509427.1
NREP
neuronal regeneration related protein
chr16_-_67260691 0.22 ENST00000447579.1
ENST00000393992.1
ENST00000424285.1
LRRC29
leucine rich repeat containing 29
chr18_+_6729698 0.22 ENST00000383472.4
ARHGAP28
Rho GTPase activating protein 28
chr11_+_6411670 0.22 ENST00000530395.1
ENST00000527275.1
SMPD1
sphingomyelin phosphodiesterase 1, acid lysosomal
chrX_+_100646190 0.21 ENST00000471855.1
RPL36A
ribosomal protein L36a
chr7_-_115670792 0.21 ENST00000265440.7
ENST00000393485.1
TFEC
transcription factor EC
chr14_-_100841670 0.21 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr1_-_1208851 0.20 ENST00000488418.1
UBE2J2
ubiquitin-conjugating enzyme E2, J2
chr19_+_44331555 0.20 ENST00000590950.1
ZNF283
zinc finger protein 283
chr15_-_60690932 0.20 ENST00000559818.1
ANXA2
annexin A2
chr19_+_50529329 0.20 ENST00000599155.1
ZNF473
zinc finger protein 473
chr15_+_45021183 0.20 ENST00000559390.1
TRIM69
tripartite motif containing 69
chr5_+_137203557 0.20 ENST00000515645.1
MYOT
myotilin
chr2_-_29297127 0.19 ENST00000331664.5
C2orf71
chromosome 2 open reading frame 71
chr14_-_20881579 0.19 ENST00000556935.1
ENST00000262715.5
ENST00000556549.1
TEP1
telomerase-associated protein 1
chr12_-_49245936 0.19 ENST00000308025.3
DDX23
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23
chr14_+_24630465 0.19 ENST00000557894.1
ENST00000559284.1
ENST00000560275.1
IRF9
interferon regulatory factor 9
chr11_+_64059464 0.19 ENST00000394525.2
KCNK4
potassium channel, subfamily K, member 4
chr10_+_17794251 0.18 ENST00000377495.1
ENST00000338221.5
TMEM236
transmembrane protein 236
chr15_-_100882191 0.18 ENST00000268070.4
ADAMTS17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr10_-_103578182 0.17 ENST00000439817.1
MGEA5
meningioma expressed antigen 5 (hyaluronidase)
chr11_-_118436707 0.17 ENST00000264020.2
ENST00000264021.3
IFT46
intraflagellar transport 46 homolog (Chlamydomonas)
chr3_+_159570722 0.17 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr1_-_226065330 0.17 ENST00000436966.1
TMEM63A
transmembrane protein 63A
chr5_+_127039075 0.17 ENST00000514853.2
CTC-228N24.1
CTC-228N24.1
chr10_-_104179682 0.17 ENST00000406432.1
PSD
pleckstrin and Sec7 domain containing
chr7_-_115670804 0.17 ENST00000320239.7
TFEC
transcription factor EC
chr4_+_158141843 0.16 ENST00000509417.1
ENST00000296526.7
GRIA2
glutamate receptor, ionotropic, AMPA 2
chr6_-_117150198 0.16 ENST00000310357.3
ENST00000368549.3
ENST00000530250.1
GPRC6A
G protein-coupled receptor, family C, group 6, member A
chr5_+_36606700 0.16 ENST00000416645.2
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_+_15469058 0.16 ENST00000432764.2
EAF1
ELL associated factor 1
chr20_-_49308048 0.16 ENST00000327979.2
FAM65C
family with sequence similarity 65, member C
chr1_+_214163033 0.16 ENST00000607425.1
PROX1
prospero homeobox 1
chr22_+_24551765 0.15 ENST00000337989.7
CABIN1
calcineurin binding protein 1
chr14_+_35591020 0.15 ENST00000603611.1
KIAA0391
KIAA0391
chr9_+_100069933 0.15 ENST00000529487.1
CCDC180
coiled-coil domain containing 180
chr6_-_45544507 0.14 ENST00000563807.1
RP1-166H4.2
RP1-166H4.2

Network of associatons between targets according to the STRING database.

First level regulatory network of STAT4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.6 1.9 GO:0032747 positive regulation of interleukin-23 production(GO:0032747)
0.6 1.9 GO:0006429 leucyl-tRNA aminoacylation(GO:0006429)
0.6 3.4 GO:0033591 response to L-ascorbic acid(GO:0033591)
0.4 1.7 GO:0044314 protein K27-linked ubiquitination(GO:0044314)
0.4 2.5 GO:0060574 intestinal epithelial cell maturation(GO:0060574)
0.4 3.7 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.3 2.1 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.3 1.2 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.2 1.2 GO:0006172 ADP biosynthetic process(GO:0006172)
0.2 0.9 GO:0000354 cis assembly of pre-catalytic spliceosome(GO:0000354)
0.2 0.6 GO:0016561 protein import into peroxisome matrix, translocation(GO:0016561)
0.2 1.2 GO:0032625 interleukin-21 production(GO:0032625) interleukin-21 secretion(GO:0072619)
0.2 0.8 GO:0032764 negative regulation of mast cell cytokine production(GO:0032764) negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 11.3 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.2 1.1 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter(GO:0035947)
0.2 1.0 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.2 2.5 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.2 2.6 GO:0008090 retrograde axonal transport(GO:0008090)
0.2 0.8 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.1 0.4 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 1.0 GO:0007296 vitellogenesis(GO:0007296)
0.1 2.0 GO:0044351 macropinocytosis(GO:0044351)
0.1 0.5 GO:1904425 negative regulation of GTP binding(GO:1904425)
0.1 1.0 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) vagus nerve development(GO:0021564)
0.1 2.1 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
0.1 0.3 GO:1904604 regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904596) negative regulation of connective tissue replacement involved in inflammatory response wound healing(GO:1904597) regulation of advanced glycation end-product receptor activity(GO:1904603) negative regulation of advanced glycation end-product receptor activity(GO:1904604) negative regulation of connective tissue replacement(GO:1905204)
0.1 1.8 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 0.3 GO:0000711 meiotic DNA repair synthesis(GO:0000711)
0.1 1.2 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.1 0.4 GO:0002503 peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.1 2.0 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 0.5 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.1 2.4 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 1.5 GO:0033623 regulation of integrin activation(GO:0033623)
0.1 0.7 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 0.8 GO:0043950 positive regulation of cAMP-mediated signaling(GO:0043950)
0.1 0.4 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.9 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.7 GO:0035095 behavioral response to nicotine(GO:0035095)
0.1 0.8 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 1.4 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.1 2.7 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 0.2 GO:0061114 hepatocyte cell migration(GO:0002194) otic placode formation(GO:0043049) optic placode formation involved in camera-type eye formation(GO:0046619) branching involved in pancreas morphogenesis(GO:0061114) acinar cell differentiation(GO:0090425) positive regulation of forebrain neuron differentiation(GO:2000979)
0.0 1.4 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 8.1 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.0 0.6 GO:0099612 protein localization to axon(GO:0099612)
0.0 0.2 GO:0071469 detection of mechanical stimulus involved in sensory perception of touch(GO:0050976) cellular response to alkaline pH(GO:0071469)
0.0 0.8 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 0.5 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.3 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.4 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.5 GO:0040016 embryonic cleavage(GO:0040016)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.3 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.3 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.3 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.0 0.1 GO:0071284 cellular response to lead ion(GO:0071284)
0.0 0.3 GO:0097116 gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0 0.5 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 1.0 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.2 GO:0023021 termination of signal transduction(GO:0023021)
0.0 0.1 GO:0034334 adherens junction maintenance(GO:0034334)
0.0 0.5 GO:0098743 cell aggregation(GO:0098743)
0.0 0.2 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.3 GO:2000394 positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0 0.6 GO:0035855 megakaryocyte development(GO:0035855)
0.0 0.1 GO:0061364 negative regulation of negative chemotaxis(GO:0050925) apoptotic process involved in luteolysis(GO:0061364)
0.0 1.9 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.2 GO:0044130 negative regulation of growth of symbiont in host(GO:0044130)
0.0 0.2 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.1 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.0 0.2 GO:0070777 gamma-aminobutyric acid biosynthetic process(GO:0009449) D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0 0.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0 0.3 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0 1.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 0.3 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.7 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.2 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.0 0.8 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.1 GO:0034201 response to oleic acid(GO:0034201)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0070557 PCNA-p21 complex(GO:0070557)
0.7 2.1 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.4 2.6 GO:0031673 H zone(GO:0031673)
0.2 1.9 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
0.2 0.6 GO:0032783 ELL-EAF complex(GO:0032783)
0.2 0.5 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1 0.9 GO:0045298 tubulin complex(GO:0045298)
0.1 0.3 GO:0097441 basilar dendrite(GO:0097441)
0.1 1.2 GO:0033263 CORVET complex(GO:0033263)
0.1 0.6 GO:1990769 proximal neuron projection(GO:1990769)
0.1 3.4 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 0.3 GO:0034515 proteasome storage granule(GO:0034515)
0.1 2.1 GO:0043203 axon hillock(GO:0043203)
0.1 10.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.3 GO:0098843 postsynaptic endocytic zone(GO:0098843)
0.0 1.0 GO:0005614 interstitial matrix(GO:0005614)
0.0 1.1 GO:0005682 U5 snRNP(GO:0005682)
0.0 0.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.0 0.3 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.4 GO:0097470 ribbon synapse(GO:0097470)
0.0 0.1 GO:0002081 outer acrosomal membrane(GO:0002081)
0.0 0.7 GO:0042629 mast cell granule(GO:0042629)
0.0 0.5 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.2 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.0 0.4 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0043194 axon initial segment(GO:0043194)
0.0 1.1 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.4 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 2.9 GO:0001650 fibrillar center(GO:0001650)
0.0 0.1 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.4 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.7 GO:0048786 presynaptic active zone(GO:0048786)
0.0 1.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0005150 interleukin-1, Type I receptor binding(GO:0005150)
0.8 2.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.6 1.9 GO:0004823 leucine-tRNA ligase activity(GO:0004823)
0.4 2.1 GO:0070699 type II activin receptor binding(GO:0070699)
0.2 10.4 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2 1.2 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.2 0.8 GO:0048248 CXCR3 chemokine receptor binding(GO:0048248)
0.2 1.0 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.2 1.1 GO:0004522 ribonuclease A activity(GO:0004522)
0.1 0.4 GO:0032093 SAM domain binding(GO:0032093)
0.1 0.7 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.1 0.3 GO:1904599 advanced glycation end-product binding(GO:1904599)
0.1 1.9 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.1 0.8 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.1 2.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 5.9 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.1 0.8 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 11.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 2.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.1 0.3 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.1 0.2 GO:0098782 mechanically-gated potassium channel activity(GO:0098782)
0.1 1.2 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 1.9 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.6 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 0.5 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.1 0.5 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 1.5 GO:0031005 filamin binding(GO:0031005)
0.0 0.4 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0 0.1 GO:0001226 RNA polymerase II transcription corepressor binding(GO:0001226)
0.0 3.7 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.8 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848) acetylcholine binding(GO:0042166)
0.0 1.1 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 2.5 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 0.2 GO:0043426 MRF binding(GO:0043426)
0.0 2.3 GO:0050681 androgen receptor binding(GO:0050681)
0.0 0.4 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 0.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.1 GO:0005477 pyruvate secondary active transmembrane transporter activity(GO:0005477)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.3 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.7 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.2 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 0.3 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 1.1 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0 0.1 GO:0008310 single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0 0.8 GO:0030371 translation repressor activity(GO:0030371)
0.0 0.3 GO:0015172 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 0.4 GO:0001221 transcription cofactor binding(GO:0001221)
0.0 0.1 GO:0005166 neurotrophin p75 receptor binding(GO:0005166)
0.0 2.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 0.3 GO:0070403 NAD+ binding(GO:0070403)
0.0 0.7 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 0.3 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 1.0 GO:0033558 histone deacetylase activity(GO:0004407) protein deacetylase activity(GO:0033558)
0.0 2.0 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.2 GO:0005522 profilin binding(GO:0005522)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 17.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.2 2.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.1 4.4 PID IL1 PATHWAY IL1-mediated signaling events
0.0 2.8 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.0 3.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 2.1 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 2.5 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 1.9 PID LKB1 PATHWAY LKB1 signaling events
0.0 3.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 0.2 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 0.8 PID FOXO PATHWAY FoxO family signaling
0.0 0.8 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.0 0.2 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.4 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 0.9 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.0 0.9 PID PLK1 PATHWAY PLK1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 2.5 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 2.7 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 1.9 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.1 2.7 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.1 1.9 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.1 4.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 1.6 REACTOME PIP3 ACTIVATES AKT SIGNALING Genes involved in PIP3 activates AKT signaling
0.0 2.1 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 1.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 1.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 1.2 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.2 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 0.9 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.0 0.3 REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.0 0.2 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 1.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation