ISMARA results: TBP

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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TBP

Z-value: 5.18

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Transcription factors associated with TBP

Gene Symbol	Gene ID	Gene Info
TBP Ensembl NCBI GeneCards UniProt NextProt	ENSG00000112592.8	TATA-box binding protein

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TBP	hg19_v2_chr6_+_170863421_170863484	-0.56	1.0e-02	Click!

Activity profile of TBP motif

Sorted Z-values of TBP motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_59043166 Show fit	32.19	ENST00000371225.2	TACSTD2 Ensembl NCBI GeneCards UniProt NextProt Show fit	tumor-associated calcium signal transducer 2
chr1_+_153330322 Show fit	31.77	ENST00000368738.3	S100A9 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A9
chr16_+_56659687 Show fit	21.73	ENST00000568293.1 ENST00000330439.6	MT1E Ensembl NCBI GeneCards UniProt NextProt Show fit	metallothionein 1E
chr11_+_18287801 Show fit	20.66	ENST00000532858.1 ENST00000405158.2	SAA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serum amyloid A1
chr13_+_43597269 Show fit	20.02	ENST00000379221.2	DNAJC15 Ensembl NCBI GeneCards UniProt NextProt Show fit	DnaJ (Hsp40) homolog, subfamily C, member 15
chr17_-_39780819 Show fit	19.69	ENST00000311208.8	KRT17 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 17
chr11_+_18287721 Show fit	19.14	ENST00000356524.4	SAA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	serum amyloid A1
chr12_-_52845910 Show fit	18.22	ENST00000252252.3	KRT6B Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 6B
chr17_-_39780634 Show fit	18.14	ENST00000577817.2	KRT17 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 17
chr14_+_75745477 Show fit	18.07	ENST00000303562.4 ENST00000554617.1 ENST00000554212.1 ENST00000535987.1 ENST00000555242.1	FOS Ensembl NCBI GeneCards UniProt NextProt Show fit	FBJ murine osteosarcoma viral oncogene homolog

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TBP

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	49.5	GO:0018149	peptide cross-linking(GO:0018149)
1.7	48.8	GO:0051798	positive regulation of hair follicle development(GO:0051798)
12.1	48.5	GO:0006542	glutamine biosynthetic process(GO:0006542)
2.8	44.5	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
1.0	41.2	GO:0050716	positive regulation of interleukin-1 secretion(GO:0050716)
1.2	40.6	GO:0042744	hydrogen peroxide catabolic process(GO:0042744)
10.8	32.3	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
3.2	32.2	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
2.0	32.0	GO:0043587	tongue morphogenesis(GO:0043587)
0.8	27.1	GO:0071294	cellular response to zinc ion(GO:0071294)

Showing 1 to 10 of 206 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	92.3	GO:0005882	intermediate filament(GO:0005882)
0.9	65.6	GO:0001533	cornified envelope(GO:0001533)
0.5	51.3	GO:0035580	specific granule lumen(GO:0035580)
1.4	47.8	GO:0071682	endocytic vesicle lumen(GO:0071682)
1.5	39.2	GO:0097386	glial cell projection(GO:0097386)
0.6	34.3	GO:0009925	basal plasma membrane(GO:0009925)
0.1	32.4	GO:0034774	secretory granule lumen(GO:0034774)
0.1	19.5	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.2	19.4	GO:0035578	azurophil granule lumen(GO:0035578)
2.0	18.1	GO:0035976	AP1 complex(GO:0035976)

Showing 1 to 10 of 93 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	69.5	GO:0002020	protease binding(GO:0002020)
1.1	58.2	GO:0042056	chemoattractant activity(GO:0042056)
6.5	51.9	GO:0042289	MHC class II protein binding(GO:0042289)
2.0	49.4	GO:0019841	retinol binding(GO:0019841)
12.1	48.5	GO:0016211	glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880)
6.9	48.4	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
4.2	41.8	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	36.3	GO:0005198	structural molecule activity(GO:0005198)
0.2	27.5	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.1	25.8	GO:0030674	protein binding, bridging(GO:0030674)

Showing 1 to 10 of 143 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	88.2	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.4	73.4	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.2	66.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	21.9	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.6	18.1	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.1	12.5	PID IL4 2PATHWAY	IL4-mediated signaling events
0.1	12.2	PID FOXO PATHWAY	FoxO family signaling
0.1	9.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.2	9.6	PID ALK1 PATHWAY	ALK1 signaling events
0.2	9.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans

Showing 1 to 10 of 47 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	41.8	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
1.2	39.8	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.3	31.1	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.7	22.2	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.8	18.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.3	16.8	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.5	15.8	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
0.0	15.5	REACTOME GENERIC TRANSCRIPTION PATHWAY	Genes involved in Generic Transcription Pathway
1.0	15.4	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.2	12.4	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends

Showing 1 to 10 of 62 entries

Results for TBP

Z-value: 5.18

Motif logo

Transcription factors associated with TBP

Activity-expression correlation:

Activity profile of TBP motif

Sorted Z-values of TBP motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TBP

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: