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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TBX21_TBR1

Z-value: 0.31

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Transcription factors associated with TBX21_TBR1

Gene Symbol Gene ID Gene Info
ENSG00000073861.2 T-box transcription factor 21
ENSG00000136535.10 T-box brain transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBR1hg19_v2_chr2_+_162272605_162272753-0.408.1e-02Click!
TBX21hg19_v2_chr17_+_45810594_458106100.321.7e-01Click!

Activity profile of TBX21_TBR1 motif

Sorted Z-values of TBX21_TBR1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr14_+_95078714 1.06 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr1_-_153029980 0.93 ENST00000392653.2
small proline-rich protein 2A
chr17_-_34122596 0.91 ENST00000250144.8
matrix metallopeptidase 28
chr1_+_89829610 0.85 ENST00000370456.4
ENST00000535065.1
guanylate binding protein family, member 6
chr22_-_31688381 0.83 ENST00000487265.2
phosphoinositide-3-kinase interacting protein 1
chr17_-_7493390 0.76 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
SRY (sex determining region Y)-box 15
chr22_-_31688431 0.75 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
phosphoinositide-3-kinase interacting protein 1
chr16_-_79634595 0.74 ENST00000326043.4
ENST00000393350.1
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chrX_+_56259316 0.68 ENST00000468660.1
Kruppel-like factor 8
chr16_+_69139467 0.68 ENST00000569188.1
hyaluronan synthase 3
chr19_+_10381769 0.65 ENST00000423829.2
ENST00000588645.1
intercellular adhesion molecule 1
chr11_+_93754513 0.61 ENST00000315765.9
hephaestin-like 1
chr18_-_59561417 0.60 ENST00000591306.1
ring finger protein 152
chr14_-_65569244 0.60 ENST00000557277.1
ENST00000556892.1
MYC associated factor X
chr12_-_89746173 0.60 ENST00000308385.6
dual specificity phosphatase 6
chr9_-_117853297 0.58 ENST00000542877.1
ENST00000537320.1
ENST00000341037.4
tenascin C
chr2_-_113594279 0.57 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
interleukin 1, beta
chr8_+_120220561 0.56 ENST00000276681.6
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr5_-_39270725 0.52 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr11_-_119599794 0.51 ENST00000264025.3
poliovirus receptor-related 1 (herpesvirus entry mediator C)
chrX_+_99899180 0.51 ENST00000373004.3
sushi-repeat containing protein, X-linked 2
chr14_+_75745477 0.50 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FBJ murine osteosarcoma viral oncogene homolog
chr11_+_120081475 0.48 ENST00000328965.4
OAF homolog (Drosophila)
chr1_+_202995611 0.45 ENST00000367240.2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr7_-_143991230 0.45 ENST00000543357.1
Rho guanine nucleotide exchange factor (GEF) 35
chr21_+_30503282 0.44 ENST00000399925.1
MAP3K7 C-terminal like
chr1_+_38022513 0.44 ENST00000296218.7
dynein, axonemal, light intermediate chain 1
chr4_-_90757364 0.43 ENST00000508895.1
synuclein, alpha (non A4 component of amyloid precursor)
chr4_-_90756769 0.43 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
synuclein, alpha (non A4 component of amyloid precursor)
chr1_+_155099927 0.42 ENST00000368407.3
ephrin-A1
chr1_+_100111580 0.42 ENST00000605497.1
palmdelphin
chr3_-_61237050 0.42 ENST00000476844.1
ENST00000488467.1
ENST00000492590.1
ENST00000468189.1
fragile histidine triad
chr14_+_21510385 0.42 ENST00000298690.4
ribonuclease, RNase A family, 7
chr7_+_144052381 0.42 ENST00000498580.1
ENST00000056217.5
Rho guanine nucleotide exchange factor (GEF) 5
chr22_-_38699003 0.42 ENST00000451964.1
casein kinase 1, epsilon
chr1_+_100111479 0.41 ENST00000263174.4
palmdelphin
chr7_-_143892748 0.41 ENST00000378115.2
Rho guanine nucleotide exchange factor (GEF) 35
chr11_-_16430399 0.40 ENST00000528252.1
SRY (sex determining region Y)-box 6
chr6_+_45390222 0.40 ENST00000359524.5
runt-related transcription factor 2
chr1_+_38022572 0.40 ENST00000541606.1
dynein, axonemal, light intermediate chain 1
chr1_+_28586006 0.39 ENST00000253063.3
sestrin 2
chr6_+_45389893 0.36 ENST00000371432.3
runt-related transcription factor 2
chr6_-_13487784 0.36 ENST00000379287.3
glucose-fructose oxidoreductase domain containing 1
chr12_-_26278030 0.36 ENST00000242728.4
basic helix-loop-helix family, member e41
chr9_+_34990219 0.34 ENST00000541010.1
ENST00000454002.2
ENST00000545841.1
DnaJ (Hsp40) homolog, subfamily B, member 5
chr8_-_101724989 0.34 ENST00000517403.1
poly(A) binding protein, cytoplasmic 1
chr6_-_31620095 0.34 ENST00000424176.1
ENST00000456622.1
BCL2-associated athanogene 6
chr14_+_75746781 0.33 ENST00000555347.1
FBJ murine osteosarcoma viral oncogene homolog
chr17_-_39216344 0.33 ENST00000391418.2
keratin associated protein 2-3
chr9_+_34329493 0.33 ENST00000379158.2
ENST00000346365.4
ENST00000379155.5
nudix (nucleoside diphosphate linked moiety X)-type motif 2
chr12_-_89746264 0.31 ENST00000548755.1
dual specificity phosphatase 6
chr1_+_174843548 0.30 ENST00000478442.1
ENST00000465412.1
RAB GTPase activating protein 1-like
chr11_+_71846764 0.29 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
folate receptor 3 (gamma)
chr1_+_184356188 0.29 ENST00000235307.6
chromosome 1 open reading frame 21
chr21_+_30502806 0.29 ENST00000399928.1
ENST00000399926.1
MAP3K7 C-terminal like
chr10_+_24544249 0.28 ENST00000430453.2
KIAA1217
chr2_+_228678550 0.28 ENST00000409189.3
ENST00000358813.4
chemokine (C-C motif) ligand 20
chr9_+_33750667 0.28 ENST00000457896.1
ENST00000342836.4
ENST00000429677.3
protease, serine, 3
chr6_-_31619697 0.27 ENST00000434444.1
BCL2-associated athanogene 6
chr1_+_182758900 0.27 ENST00000367555.1
ENST00000367554.3
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chr4_-_186732048 0.27 ENST00000448662.2
ENST00000439049.1
ENST00000420158.1
ENST00000431808.1
ENST00000319471.9
sorbin and SH3 domain containing 2
chr3_+_177534653 0.27 ENST00000436078.1
RP11-91K9.1
chr6_-_160166218 0.27 ENST00000537657.1
superoxide dismutase 2, mitochondrial
chr12_+_56473939 0.27 ENST00000450146.2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr1_-_46598371 0.26 ENST00000372006.1
ENST00000425892.1
ENST00000420542.1
ENST00000354242.4
ENST00000340332.6
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
chr5_+_66124590 0.26 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
microtubule associated serine/threonine kinase family member 4
chr20_+_44098385 0.25 ENST00000217425.5
ENST00000339946.3
WAP four-disulfide core domain 2
chr12_+_66582919 0.25 ENST00000545837.1
ENST00000457197.2
interleukin-1 receptor-associated kinase 3
chr6_-_31619892 0.25 ENST00000454165.1
ENST00000428326.1
ENST00000452994.1
BCL2-associated athanogene 6
chr1_+_20915409 0.25 ENST00000375071.3
cytidine deaminase
chr6_-_112194484 0.25 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
FYN oncogene related to SRC, FGR, YES
chr1_+_70687079 0.24 ENST00000395136.2
serine/arginine-rich splicing factor 11
chr1_-_46598284 0.24 ENST00000423209.1
ENST00000262741.5
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
chr1_+_145507587 0.24 ENST00000330165.8
ENST00000369307.3
RNA binding motif protein 8A
chr4_+_124317940 0.24 ENST00000505319.1
ENST00000339241.1
sprouty homolog 1, antagonist of FGF signaling (Drosophila)
chr1_+_39456895 0.24 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
akirin 1
chr4_+_154622652 0.24 ENST00000260010.6
toll-like receptor 2
chr4_+_26322409 0.24 ENST00000514807.1
ENST00000348160.4
ENST00000509158.1
ENST00000355476.3
recombination signal binding protein for immunoglobulin kappa J region
chr3_-_107777208 0.23 ENST00000398258.3
CD47 molecule
chr15_-_41047421 0.23 ENST00000560460.1
ENST00000338376.3
ENST00000560905.1
regulator of microtubule dynamics 3
chr3_-_66551397 0.23 ENST00000383703.3
leucine-rich repeats and immunoglobulin-like domains 1
chr20_+_44098346 0.23 ENST00000372676.3
WAP four-disulfide core domain 2
chr3_-_66551351 0.23 ENST00000273261.3
leucine-rich repeats and immunoglobulin-like domains 1
chr6_-_13487825 0.23 ENST00000603223.1
glucose-fructose oxidoreductase domain containing 1
chr3_+_38035610 0.22 ENST00000465644.1
villin-like
chrX_-_132549506 0.22 ENST00000370828.3
glypican 4
chr6_-_31619742 0.22 ENST00000433828.1
ENST00000456286.1
BCL2-associated athanogene 6
chr6_-_31620149 0.22 ENST00000435080.1
ENST00000375976.4
ENST00000441054.1
BCL2-associated athanogene 6
chr4_+_74735102 0.22 ENST00000395761.3
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr3_+_107243204 0.22 ENST00000456817.1
ENST00000458458.1
bobby sox homolog (Drosophila)
chr1_+_19967014 0.22 ENST00000428975.1
neuroblastoma 1, DAN family BMP antagonist
chr7_-_99766191 0.21 ENST00000423751.1
ENST00000360039.4
galactose-3-O-sulfotransferase 4
chrX_+_69642881 0.21 ENST00000453994.2
ENST00000536730.1
ENST00000538649.1
ENST00000374382.3
glycerophosphodiester phosphodiesterase domain containing 2
chrX_+_102862834 0.21 ENST00000372627.5
ENST00000243286.3
transcription elongation factor A (SII)-like 3
chr11_-_8857248 0.21 ENST00000534248.1
ENST00000530959.1
ENST00000531578.1
ENST00000533225.1
suppression of tumorigenicity 5
chr1_+_144989309 0.21 ENST00000596396.1
Uncharacterized protein
chr5_+_35856951 0.21 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
interleukin 7 receptor
chr14_-_62217779 0.21 ENST00000554254.1
HIF1A antisense RNA 2
chr20_+_1115821 0.21 ENST00000435720.1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr12_-_49351228 0.20 ENST00000541959.1
ENST00000447318.2
ADP-ribosylation factor 3
chr6_+_30848771 0.20 ENST00000503180.1
discoidin domain receptor tyrosine kinase 1
chr9_+_33750515 0.20 ENST00000361005.5
protease, serine, 3
chr1_-_205744205 0.20 ENST00000446390.2
RAB7, member RAS oncogene family-like 1
chrX_+_105412290 0.20 ENST00000357175.2
ENST00000337685.2
melanoma associated antigen (mutated) 1-like 1
chr5_+_150639360 0.20 ENST00000523004.1
GM2 ganglioside activator
chr11_+_129685707 0.19 ENST00000281441.3
transmembrane protein 45B
chr12_+_14572070 0.19 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
activating transcription factor 7 interacting protein
chr6_-_26124138 0.19 ENST00000314332.5
ENST00000396984.1
histone cluster 1, H2bc
chr6_+_30848829 0.19 ENST00000508317.1
discoidin domain receptor tyrosine kinase 1
chr10_+_24498060 0.19 ENST00000376454.3
ENST00000376452.3
KIAA1217
chr11_+_66824276 0.19 ENST00000308831.2
ras homolog family member D
chr19_-_7990991 0.19 ENST00000318978.4
cortexin 1
chr22_+_18560675 0.18 ENST00000329627.7
peroxisomal biogenesis factor 26
chr1_-_6260896 0.18 ENST00000497965.1
ribosomal protein L22
chr1_-_153066998 0.18 ENST00000368750.3
small proline-rich protein 2E
chr3_+_57741957 0.18 ENST00000295951.3
sarcolemma associated protein
chr15_-_43559055 0.18 ENST00000220420.5
ENST00000349114.4
transglutaminase 5
chr11_+_66824346 0.18 ENST00000532559.1
ras homolog family member D
chr19_-_37406923 0.18 ENST00000520965.1
zinc finger protein 829
chr13_+_73629107 0.18 ENST00000539231.1
Kruppel-like factor 5 (intestinal)
chr4_+_100495864 0.17 ENST00000265517.5
ENST00000422897.2
microsomal triglyceride transfer protein
chr9_+_22646189 0.17 ENST00000436786.1
RP11-399D6.2
chr11_+_65266507 0.17 ENST00000544868.1
metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)
chr7_-_87849340 0.17 ENST00000419179.1
ENST00000265729.2
sorcin
chr9_+_124048864 0.17 ENST00000545652.1
gelsolin
chr19_-_39390212 0.16 ENST00000437828.1
sirtuin 2
chr3_-_126373929 0.16 ENST00000523403.1
ENST00000524230.2
thioredoxin reductase 3
chr11_+_111412271 0.16 ENST00000528102.1
layilin
chr19_+_37407212 0.16 ENST00000427117.1
ENST00000587130.1
ENST00000333987.7
ENST00000415168.1
ENST00000444991.1
zinc finger protein 568
chr19_-_10213335 0.16 ENST00000592641.1
ENST00000253109.4
angiopoietin-like 6
chr17_+_26662679 0.16 ENST00000578158.1
tumor necrosis factor, alpha-induced protein 1 (endothelial)
chr12_+_58148842 0.16 ENST00000266643.5
membrane-associated ring finger (C3HC4) 9
chr4_-_74964904 0.16 ENST00000508487.2
chemokine (C-X-C motif) ligand 2
chr12_-_49351303 0.16 ENST00000256682.4
ADP-ribosylation factor 3
chr6_+_116692102 0.16 ENST00000359564.2
dermatan sulfate epimerase
chr11_+_66824303 0.16 ENST00000533360.1
ras homolog family member D
chr1_+_160313165 0.16 ENST00000421914.1
ENST00000535857.1
ENST00000438008.1
nicastrin
chr8_+_75896731 0.16 ENST00000262207.4
cysteine-rich secretory protein LCCL domain containing 1
chr6_+_292051 0.15 ENST00000344450.5
dual specificity phosphatase 22
chr8_+_22857048 0.15 ENST00000251822.6
Rho-related BTB domain containing 2
chr3_+_10857885 0.15 ENST00000254488.2
ENST00000454147.1
solute carrier family 6 (neurotransmitter transporter), member 11
chr3_-_48471454 0.15 ENST00000296440.6
ENST00000448774.2
plexin B1
chr11_+_64950801 0.15 ENST00000526468.1
calpain 1, (mu/I) large subunit
chr1_+_33219592 0.15 ENST00000373481.3
KIAA1522
chr11_+_67195917 0.15 ENST00000524934.1
ENST00000539188.1
ENST00000312629.5
ribosomal protein S6 kinase, 70kDa, polypeptide 2
chr1_-_19229248 0.15 ENST00000375341.3
aldehyde dehydrogenase 4 family, member A1
chr10_+_24497704 0.15 ENST00000376456.4
ENST00000458595.1
KIAA1217
chr1_-_76076793 0.15 ENST00000370859.3
solute carrier family 44, member 5
chr19_-_15529790 0.15 ENST00000596195.1
ENST00000595067.1
ENST00000595465.2
ENST00000397410.5
ENST00000600247.1
A kinase (PRKA) anchor protein 8-like
chr6_+_43149903 0.15 ENST00000252050.4
ENST00000354495.3
ENST00000372647.2
cullin 9
chr14_-_51411194 0.14 ENST00000544180.2
phosphorylase, glycogen, liver
chrX_-_100546314 0.14 ENST00000356784.1
TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
chr19_+_13051206 0.14 ENST00000586760.1
calreticulin
chr12_-_56120838 0.14 ENST00000548160.1
CD63 molecule
chr1_+_160313062 0.14 ENST00000294785.5
ENST00000368063.1
ENST00000437169.1
nicastrin
chr15_+_41913690 0.14 ENST00000563576.1
MGA, MAX dimerization protein
chr2_+_217498105 0.14 ENST00000233809.4
insulin-like growth factor binding protein 2, 36kDa
chr1_+_2036149 0.14 ENST00000482686.1
ENST00000400920.1
ENST00000486681.1
protein kinase C, zeta
chr19_-_44258770 0.14 ENST00000601925.1
ENST00000602222.1
ENST00000599804.1
SMG9 nonsense mediated mRNA decay factor
chr18_-_30050395 0.14 ENST00000269209.6
ENST00000399218.4
GRB2 associated, regulator of MAPK1
chr8_+_144766617 0.14 ENST00000454097.1
ENST00000534303.1
ENST00000529833.1
ENST00000530574.1
ENST00000442058.2
ENST00000358656.4
ENST00000526970.1
ENST00000532158.1
zinc finger protein 707
chr4_+_160188889 0.13 ENST00000264431.4
Rap guanine nucleotide exchange factor (GEF) 2
chr3_+_14058794 0.13 ENST00000424053.1
ENST00000528067.1
ENST00000429201.1
tetra-peptide repeat homeobox-like
chr6_+_32132360 0.13 ENST00000333845.6
ENST00000395512.1
ENST00000432129.1
EGF-like-domain, multiple 8
chr5_+_110407390 0.13 ENST00000344895.3
thymic stromal lymphopoietin
chr20_+_44509857 0.13 ENST00000372523.1
ENST00000372520.1
zinc finger, SWIM-type containing 1
chr1_-_19229014 0.13 ENST00000538839.1
ENST00000290597.5
aldehyde dehydrogenase 4 family, member A1
chr12_+_75874984 0.13 ENST00000550491.1
GLI pathogenesis-related 1
chr1_+_40840320 0.13 ENST00000372708.1
small ArfGAP2
chr17_+_35849937 0.13 ENST00000394389.4
dual specificity phosphatase 14
chr9_+_35829208 0.13 ENST00000439587.2
ENST00000377991.4
transmembrane protein 8B
chr12_-_31479107 0.13 ENST00000542983.1
family with sequence similarity 60, member A
chr6_+_30294612 0.13 ENST00000440271.1
ENST00000396551.3
ENST00000376656.4
ENST00000540416.1
ENST00000428728.1
ENST00000396548.1
ENST00000428404.1
tripartite motif containing 39
chr19_-_44258733 0.13 ENST00000597586.1
ENST00000596714.1
SMG9 nonsense mediated mRNA decay factor
chr1_+_156308403 0.13 ENST00000481479.1
ENST00000368252.1
ENST00000466306.1
ENST00000368251.1
TSSK6 activating co-chaperone
chr1_-_28969517 0.13 ENST00000263974.4
ENST00000373824.4
TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa
chr14_+_85994943 0.13 ENST00000553678.1
Uncharacterized protein
chrX_+_152086373 0.13 ENST00000318529.8
zinc finger protein 185 (LIM domain)
chr1_+_203651937 0.13 ENST00000341360.2
ATPase, Ca++ transporting, plasma membrane 4
chr5_-_49737184 0.13 ENST00000508934.1
ENST00000303221.5
embigin
chr7_-_100026280 0.13 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
zinc finger, CW type with PWWP domain 1
chr5_-_175395283 0.13 ENST00000513482.1
ENST00000265097.4
THO complex 3
chr1_+_201708992 0.13 ENST00000367295.1
neuron navigator 1
chr3_+_171844762 0.13 ENST00000443501.1
fibronectin type III domain containing 3B
chr10_-_126432821 0.12 ENST00000280780.6
family with sequence similarity 53, member B
chr3_-_197024394 0.12 ENST00000434148.1
ENST00000412364.2
ENST00000436682.1
ENST00000456699.2
ENST00000392380.2
discs, large homolog 1 (Drosophila)
chr17_+_25958174 0.12 ENST00000313648.6
ENST00000577392.1
ENST00000584661.1
ENST00000413914.2
lectin, galactoside-binding, soluble, 9
chr22_+_40441456 0.12 ENST00000402203.1
trinucleotide repeat containing 6B
chr19_-_39390350 0.12 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
sirtuin 2
chr11_-_133826852 0.12 ENST00000533871.2
ENST00000321016.8
immunoglobulin superfamily, member 9B
chr2_-_73053126 0.12 ENST00000272427.6
ENST00000410104.1
exocyst complex component 6B
chr1_+_156308245 0.12 ENST00000368253.2
ENST00000470342.1
ENST00000368254.1
TSSK6 activating co-chaperone
chr17_+_7358889 0.12 ENST00000575379.1
cholinergic receptor, nicotinic, beta 1 (muscle)
chr14_-_69619291 0.12 ENST00000554215.1
ENST00000556847.1
DDB1 and CUL4 associated factor 5
chr1_+_10057274 0.12 ENST00000294435.7
retinol binding protein 7, cellular
chr1_+_111682827 0.12 ENST00000357172.4
choline/ethanolamine phosphotransferase 1
chr3_+_50606901 0.12 ENST00000455834.1
HemK methyltransferase family member 1
chr4_+_166300084 0.12 ENST00000402744.4
carboxypeptidase E
chr1_-_21503337 0.12 ENST00000400422.1
ENST00000602326.1
ENST00000411888.1
ENST00000438975.1
eukaryotic translation initiation factor 4 gamma, 3
chr15_+_89922345 0.12 ENST00000558982.1
long intergenic non-protein coding RNA 925

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX21_TBR1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3 0.8 GO:0048627 myoblast development(GO:0048627)
0.2 0.7 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
0.2 0.9 GO:1903284 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) positive regulation of peroxidase activity(GO:2000470)
0.2 0.9 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.1 0.6 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
0.1 1.3 GO:1904327 protein localization to cytosolic proteasome complex(GO:1904327) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.1 0.6 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.1 0.5 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.1 0.4 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.1 0.3 GO:0070446 cellular response to caloric restriction(GO:0061433) negative regulation of oligodendrocyte progenitor proliferation(GO:0070446)
0.1 0.8 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.3 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 0.5 GO:0032474 otolith morphogenesis(GO:0032474)
0.1 0.2 GO:0019858 cytosine metabolic process(GO:0019858)
0.1 0.2 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 0.4 GO:0051673 membrane disruption in other organism(GO:0051673)
0.1 0.6 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.1 0.4 GO:0021778 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1 0.4 GO:0014028 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) notochord formation(GO:0014028)
0.1 0.2 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.1 0.8 GO:0002051 osteoblast fate commitment(GO:0002051)
0.1 0.7 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 0.3 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
0.1 0.3 GO:0003069 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
0.1 0.3 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.2 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.0 0.3 GO:1901295 positive regulation of ephrin receptor signaling pathway(GO:1901189) regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901295) positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:1901297) regulation of canonical Wnt signaling pathway involved in heart development(GO:1905066) positive regulation of canonical Wnt signaling pathway involved in heart development(GO:1905068)
0.0 0.1 GO:1900082 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.0 0.1 GO:0002519 natural killer cell tolerance induction(GO:0002519) positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:2001190)
0.0 0.2 GO:0046391 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)
0.0 0.6 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 1.1 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.1 GO:0002501 peptide antigen assembly with MHC protein complex(GO:0002501)
0.0 0.3 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.0 0.4 GO:2000680 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.0 0.2 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.2 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0 0.3 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.0 0.0 GO:0021767 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373)
0.0 0.1 GO:0072695 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0 0.3 GO:2000623 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0 0.2 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 0.1 GO:0061537 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 0.1 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.0 0.2 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.0 0.4 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.0 0.1 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.0 0.1 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.0 0.2 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.0 0.2 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.0 0.4 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.3 GO:0015884 folic acid transport(GO:0015884)
0.0 0.1 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.2 GO:0006689 ganglioside catabolic process(GO:0006689)
0.0 1.3 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0035521 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0 0.2 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.0 0.2 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.0 0.1 GO:2000481 positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.0 0.0 GO:0002331 pre-B cell allelic exclusion(GO:0002331)
0.0 0.1 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591)
0.0 0.7 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.1 GO:0060268 negative regulation of respiratory burst(GO:0060268)
0.0 0.5 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.0 0.5 GO:0006825 copper ion transport(GO:0006825)
0.0 0.0 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408)
0.0 0.2 GO:0034378 chylomicron assembly(GO:0034378)
0.0 0.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 0.0 GO:0031247 actin rod assembly(GO:0031247)
0.0 0.0 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0 0.1 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.2 GO:0015871 choline transport(GO:0015871)
0.0 0.2 GO:0061669 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.6 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.0 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.1 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.0 0.1 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 0.2 GO:0060056 mammary gland involution(GO:0060056)
0.0 0.1 GO:0043686 co-translational protein modification(GO:0043686)
0.0 0.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0 0.2 GO:0008228 opsonization(GO:0008228)
0.0 0.1 GO:0021603 cranial nerve formation(GO:0021603)
0.0 0.2 GO:0090527 actin filament reorganization(GO:0090527)
0.0 0.2 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 0.1 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0036117 hyaluranon cable(GO:0036117)
0.1 1.3 GO:0072379 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.1 0.9 GO:0035976 AP1 complex(GO:0035976)
0.1 0.2 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.0 0.2 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.4 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.4 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 0.1 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0 0.4 GO:0043219 lateral loop(GO:0043219)
0.0 0.1 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.9 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.2 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.5 GO:0005614 interstitial matrix(GO:0005614)
0.0 0.1 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.0 1.1 GO:0001533 cornified envelope(GO:0001533)
0.0 0.5 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.0 GO:0005668 RNA polymerase transcription factor SL1 complex(GO:0005668)
0.0 0.7 GO:0044665 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
0.0 0.1 GO:0036021 endolysosome lumen(GO:0036021)
0.0 0.1 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.2 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.1 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 0.9 GO:0030286 dynein complex(GO:0030286)
0.0 0.1 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 1.0 GO:1904724 tertiary granule lumen(GO:1904724)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.2 0.9 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.1 0.7 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.3 GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity(GO:0003842)
0.1 0.3 GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.1 0.3 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.5 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.1 0.4 GO:0070728 leucine binding(GO:0070728)
0.1 0.6 GO:0045545 syndecan binding(GO:0045545)
0.1 1.4 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.0 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.1 0.2 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.1 0.2 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.1 0.2 GO:0008184 purine nucleobase binding(GO:0002060) glycogen phosphorylase activity(GO:0008184)
0.1 0.6 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0 0.1 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.0 0.7 GO:0042834 peptidoglycan binding(GO:0042834)
0.0 0.4 GO:0043426 MRF binding(GO:0043426)
0.0 0.3 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.7 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 0.8 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.5 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 0.1 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.0 0.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.0 0.2 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.0 0.1 GO:0048030 disaccharide binding(GO:0048030)
0.0 0.2 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0 0.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.1 GO:0004142 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.0 0.4 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 0.2 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.4 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:1904929 coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway(GO:1904929)
0.0 0.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.2 GO:0016015 morphogen activity(GO:0016015)
0.0 0.2 GO:0005332 gamma-aminobutyric acid:sodium symporter activity(GO:0005332)
0.0 0.3 GO:0000150 recombinase activity(GO:0000150)
0.0 0.7 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.2 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.3 GO:0005542 folic acid binding(GO:0005542)
0.0 1.0 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 0.9 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.3 GO:0008494 translation activator activity(GO:0008494)
0.0 0.2 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.6 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.0 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.0 0.0 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.0 0.1 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.2 GO:0045159 myosin II binding(GO:0045159)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.1 GO:0004447 iodide peroxidase activity(GO:0004447)
0.0 0.1 GO:0031994 insulin-like growth factor I binding(GO:0031994) insulin-like growth factor II binding(GO:0031995)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.3 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 0.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 1.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.2 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.7 PID MYC PATHWAY C-MYC pathway
0.0 0.8 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.0 0.8 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.5 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 0.6 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.9 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.7 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.3 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.8 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 1.7 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.4 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.2 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 0.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation