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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TCF3_MYOG
Z-value: 1.53
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Transcription factors associated with TCF3_MYOG
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF3 | hg19_v2_chr19_-_1650666_1650744 | 0.84 | 3.0e-06 | Click! |
| MYOG | hg19_v2_chr1_-_203055129_203055164 | -0.30 | 1.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_39258461 Show fit | 14.21 |
ENST00000440582.1
|
keratin associated protein 4-16, pseudogene |
|
| chr4_-_41216492 Show fit | 7.17 |
ENST00000503503.1
ENST00000509446.1 ENST00000503264.1 ENST00000508707.1 ENST00000508593.1 |
amyloid beta (A4) precursor protein-binding, family B, member 2 |
|
| chr12_-_52887034 Show fit | 6.66 |
ENST00000330722.6
|
keratin 6A |
|
| chr8_-_49834299 Show fit | 5.86 |
ENST00000396822.1
|
snail family zinc finger 2 |
|
| chr13_-_20767037 Show fit | 5.61 |
ENST00000382848.4
|
gap junction protein, beta 2, 26kDa |
|
| chr16_+_55522536 Show fit | 5.60 |
ENST00000570283.1
|
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) |
|
| chr8_-_49833978 Show fit | 5.39 |
ENST00000020945.1
|
snail family zinc finger 2 |
|
| chr12_-_52914155 Show fit | 5.34 |
ENST00000549420.1
ENST00000551275.1 ENST00000546577.1 |
keratin 5 |
|
| chr19_+_39687596 Show fit | 5.26 |
ENST00000339852.4
|
non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) |
|
| chr3_-_87039662 Show fit | 5.20 |
ENST00000494229.1
|
vestigial like 3 (Drosophila) |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF3_MYOG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 25.3 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.4 | 15.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.5 | 12.1 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 3.8 | 11.3 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 0.0 | 10.1 | GO:0001764 | neuron migration(GO:0001764) |
| 0.2 | 9.8 | GO:1901998 | toxin transport(GO:1901998) |
| 0.1 | 8.8 | GO:0006446 | regulation of translational initiation(GO:0006446) |
| 0.3 | 8.0 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 0.1 | 7.2 | GO:0003382 | epithelial cell morphogenesis(GO:0003382) |
| 0.7 | 6.9 | GO:1903764 | regulation of potassium ion export across plasma membrane(GO:1903764) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 27.7 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.3 | 24.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 13.2 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 13.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 10.5 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.4 | 10.2 | GO:0097386 | glial cell projection(GO:0097386) |
| 0.3 | 9.1 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.2 | 9.1 | GO:0030057 | desmosome(GO:0030057) |
| 0.3 | 8.2 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 8.2 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 24.5 | GO:0038062 | protein tyrosine kinase collagen receptor activity(GO:0038062) |
| 0.0 | 16.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.1 | 14.2 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 13.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 12.8 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 0.1 | 12.5 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 12.4 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 11.6 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 9.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 9.2 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.0 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.4 | 10.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 9.4 | PID AVB3 OPN PATHWAY | Osteopontin-mediated events |
| 0.1 | 9.3 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.2 | 8.7 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 8.7 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.2 | 8.6 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 8.6 | PID PI3KCI AKT PATHWAY | Class I PI3K signaling events mediated by Akt |
| 0.2 | 8.3 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.1 | 8.0 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.5 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.4 | 11.4 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.1 | 8.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.3 | 8.4 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.1 | 7.9 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 7.6 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 0.1 | 6.3 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 6.1 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.2 | 6.0 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 5.6 | REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS | Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins |