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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TCF7L1

Z-value: 0.49

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Transcription factors associated with TCF7L1

Gene Symbol Gene ID Gene Info
TCF7L1
ENSG00000152284.4 transcription factor 7 like 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L1hg19_v2_chr2_+_85360499_853605980.869.3e-07Click!

Activity profile of TCF7L1 motif

Sorted Z-values of TCF7L1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_131593364 1.72 ENST00000253754.3
ENST00000379018.3
PDLIM4
PDZ and LIM domain 4
chr3_+_189349162 1.69 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
TP63
tumor protein p63
chr11_-_87908600 1.56 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38
RAB38, member RAS oncogene family
chr15_+_43885252 1.25 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
CKMT1B
creatine kinase, mitochondrial 1B
chr1_-_6479963 1.23 ENST00000377836.4
ENST00000487437.1
ENST00000489730.1
ENST00000377834.4
HES2
hes family bHLH transcription factor 2
chr1_+_68150744 1.22 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr15_+_43985084 1.20 ENST00000434505.1
ENST00000411750.1
CKMT1A
creatine kinase, mitochondrial 1A
chr15_+_43985725 1.13 ENST00000413453.2
CKMT1A
creatine kinase, mitochondrial 1A
chr17_-_39093672 1.11 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr8_-_124553437 1.04 ENST00000517956.1
ENST00000443022.2
FBXO32
F-box protein 32
chr19_+_11071652 0.98 ENST00000344626.4
ENST00000429416.3
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr15_+_41136216 0.94 ENST00000562057.1
ENST00000344051.4
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr15_+_43885799 0.89 ENST00000449946.1
ENST00000417289.1
CKMT1B
creatine kinase, mitochondrial 1B
chr19_+_11071546 0.86 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr1_+_16085244 0.85 ENST00000400773.1
FBLIM1
filamin binding LIM protein 1
chr11_-_94965667 0.83 ENST00000542176.1
ENST00000278499.2
SESN3
sestrin 3
chr8_+_102504979 0.83 ENST00000395927.1
GRHL2
grainyhead-like 2 (Drosophila)
chr15_+_41136734 0.82 ENST00000568580.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr22_-_31688381 0.82 ENST00000487265.2
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr2_+_169923504 0.81 ENST00000357546.2
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr6_-_32145861 0.78 ENST00000336984.6
AGPAT1
1-acylglycerol-3-phosphate O-acyltransferase 1
chr1_+_16085263 0.78 ENST00000483633.2
ENST00000502739.1
ENST00000431771.2
FBLIM1
filamin binding LIM protein 1
chr17_-_46035187 0.78 ENST00000300557.2
PRR15L
proline rich 15-like
chr7_+_90338712 0.76 ENST00000265741.3
ENST00000406263.1
CDK14
cyclin-dependent kinase 14
chr14_+_75746781 0.72 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr2_-_9143786 0.71 ENST00000462696.1
ENST00000305997.3
MBOAT2
membrane bound O-acyltransferase domain containing 2
chr12_+_56324756 0.71 ENST00000331886.5
ENST00000555090.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr22_-_31688431 0.71 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr6_-_11779403 0.66 ENST00000414691.3
ADTRP
androgen-dependent TFPI-regulating protein
chr5_+_102201509 0.66 ENST00000348126.2
ENST00000379787.4
PAM
peptidylglycine alpha-amidating monooxygenase
chr2_+_169923577 0.65 ENST00000432060.2
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr16_+_2820912 0.63 ENST00000570539.1
SRRM2
serine/arginine repetitive matrix 2
chr4_+_78078304 0.63 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
CCNG2
cyclin G2
chr12_+_1738363 0.63 ENST00000397196.2
WNT5B
wingless-type MMTV integration site family, member 5B
chr1_+_59762642 0.61 ENST00000371218.4
ENST00000303721.7
FGGY
FGGY carbohydrate kinase domain containing
chr5_+_102201430 0.60 ENST00000438793.3
ENST00000346918.2
PAM
peptidylglycine alpha-amidating monooxygenase
chr5_-_157002749 0.60 ENST00000517905.1
ENST00000430702.2
ENST00000394020.1
ADAM19
ADAM metallopeptidase domain 19
chr15_+_41136369 0.59 ENST00000563656.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr14_-_23624511 0.59 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr7_+_90339169 0.58 ENST00000436577.2
CDK14
cyclin-dependent kinase 14
chr10_+_11206925 0.58 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2
CUGBP, Elav-like family member 2
chr2_+_228678550 0.57 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr12_+_56324933 0.57 ENST00000549629.1
ENST00000555218.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr1_-_43424500 0.56 ENST00000415851.2
ENST00000426263.3
ENST00000372500.3
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr2_-_208031542 0.56 ENST00000423015.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr5_-_175964366 0.56 ENST00000274811.4
RNF44
ring finger protein 44
chrX_-_32173579 0.56 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
DMD
dystrophin
chr5_+_66300464 0.55 ENST00000436277.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr17_-_7297833 0.52 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr4_-_157892167 0.52 ENST00000541126.1
PDGFC
platelet derived growth factor C
chr5_+_66300446 0.52 ENST00000261569.7
MAST4
microtubule associated serine/threonine kinase family member 4
chr10_-_126107482 0.51 ENST00000368845.5
ENST00000539214.1
OAT
ornithine aminotransferase
chr16_-_4850471 0.50 ENST00000592019.1
ENST00000586153.1
ROGDI
rogdi homolog (Drosophila)
chr7_+_73245193 0.50 ENST00000340958.2
CLDN4
claudin 4
chr16_+_57673348 0.50 ENST00000567915.1
ENST00000564103.1
ENST00000562467.1
GPR56
G protein-coupled receptor 56
chr19_-_11450249 0.49 ENST00000222120.3
RAB3D
RAB3D, member RAS oncogene family
chr1_+_78383813 0.48 ENST00000342754.5
NEXN
nexilin (F actin binding protein)
chrX_-_132091284 0.48 ENST00000370833.2
HS6ST2
heparan sulfate 6-O-sulfotransferase 2
chr6_-_33548006 0.47 ENST00000374467.3
BAK1
BCL2-antagonist/killer 1
chr8_+_55466915 0.46 ENST00000522711.2
RP11-53M11.3
RP11-53M11.3
chr5_-_157002775 0.46 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr17_+_75447326 0.46 ENST00000591088.1
SEPT9
septin 9
chr1_-_115053781 0.45 ENST00000358465.2
ENST00000369543.2
TRIM33
tripartite motif containing 33
chr4_-_146859623 0.45 ENST00000379448.4
ENST00000513320.1
ZNF827
zinc finger protein 827
chr1_+_144339738 0.45 ENST00000538264.1
AL592284.1
Protein LOC642441
chr12_+_56325231 0.44 ENST00000549368.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr10_-_101380121 0.42 ENST00000370495.4
SLC25A28
solute carrier family 25 (mitochondrial iron transporter), member 28
chr10_+_112631547 0.42 ENST00000280154.7
ENST00000393104.2
PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)
chr15_+_52043758 0.42 ENST00000249700.4
ENST00000539962.2
TMOD2
tropomodulin 2 (neuronal)
chr11_-_77184739 0.42 ENST00000524847.1
PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr17_-_7297519 0.41 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr6_-_33547975 0.40 ENST00000442998.2
ENST00000360661.5
BAK1
BCL2-antagonist/killer 1
chr8_-_128231299 0.40 ENST00000500112.1
CCAT1
colon cancer associated transcript 1 (non-protein coding)
chr6_-_128841503 0.39 ENST00000368215.3
ENST00000532331.1
ENST00000368213.5
ENST00000368207.3
ENST00000525459.1
ENST00000368210.3
ENST00000368226.4
ENST00000368227.3
PTPRK
protein tyrosine phosphatase, receptor type, K
chr4_-_140477910 0.39 ENST00000404104.3
SETD7
SET domain containing (lysine methyltransferase) 7
chr3_+_152879985 0.39 ENST00000323534.2
RAP2B
RAP2B, member of RAS oncogene family
chr20_+_36149602 0.38 ENST00000062104.2
ENST00000346199.2
NNAT
neuronatin
chr14_+_101293687 0.38 ENST00000455286.1
MEG3
maternally expressed 3 (non-protein coding)
chr7_-_105926058 0.38 ENST00000417537.1
NAMPT
nicotinamide phosphoribosyltransferase
chr16_-_4852915 0.36 ENST00000322048.7
ROGDI
rogdi homolog (Drosophila)
chr18_+_11751466 0.36 ENST00000535121.1
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr12_-_108154705 0.35 ENST00000547188.1
PRDM4
PR domain containing 4
chr5_+_66124590 0.35 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr5_+_102200948 0.35 ENST00000511477.1
ENST00000506006.1
ENST00000509832.1
PAM
peptidylglycine alpha-amidating monooxygenase
chr9_+_124088860 0.35 ENST00000373806.1
GSN
gelsolin
chr1_+_47799542 0.34 ENST00000471289.2
ENST00000450808.2
CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic
chr8_-_42358742 0.34 ENST00000517366.1
SLC20A2
solute carrier family 20 (phosphate transporter), member 2
chr5_+_43602750 0.34 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT
nicotinamide nucleotide transhydrogenase
chr18_+_11751493 0.33 ENST00000269162.5
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr17_+_42081914 0.33 ENST00000293404.3
ENST00000589767.1
NAGS
N-acetylglutamate synthase
chr2_+_11679963 0.33 ENST00000263834.5
GREB1
growth regulation by estrogen in breast cancer 1
chr4_-_146859787 0.32 ENST00000508784.1
ZNF827
zinc finger protein 827
chr15_+_52043813 0.32 ENST00000435126.2
TMOD2
tropomodulin 2 (neuronal)
chr14_-_35344093 0.32 ENST00000382422.2
BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr1_+_61330931 0.32 ENST00000371191.1
NFIA
nuclear factor I/A
chr5_+_43603229 0.32 ENST00000344920.4
ENST00000512996.2
NNT
nicotinamide nucleotide transhydrogenase
chr3_-_79068138 0.32 ENST00000495273.1
ROBO1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr15_+_41136263 0.31 ENST00000568823.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr4_-_157892498 0.31 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr2_+_234621551 0.31 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr3_-_47823298 0.30 ENST00000254480.5
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr9_+_109685630 0.30 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr1_-_109935819 0.30 ENST00000538502.1
SORT1
sortilin 1
chr3_-_167813132 0.30 ENST00000309027.4
GOLIM4
golgi integral membrane protein 4
chr1_+_93913713 0.30 ENST00000604705.1
ENST00000370253.2
FNBP1L
formin binding protein 1-like
chr4_-_157892055 0.30 ENST00000422544.2
PDGFC
platelet derived growth factor C
chr1_+_151171012 0.29 ENST00000349792.5
ENST00000409426.1
ENST00000441902.2
ENST00000368890.4
ENST00000424999.1
ENST00000368888.4
PIP5K1A
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
chr12_-_133464118 0.29 ENST00000540963.1
CHFR
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
chr1_-_225840747 0.29 ENST00000366843.2
ENST00000366844.3
ENAH
enabled homolog (Drosophila)
chr8_+_120079478 0.29 ENST00000332843.2
COLEC10
collectin sub-family member 10 (C-type lectin)
chr14_+_75230011 0.29 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1
YLP motif containing 1
chr7_+_90338547 0.29 ENST00000446790.1
CDK14
cyclin-dependent kinase 14
chr2_+_17997763 0.28 ENST00000281047.3
MSGN1
mesogenin 1
chr14_-_21516590 0.28 ENST00000555026.1
NDRG2
NDRG family member 2
chr20_+_44509857 0.27 ENST00000372523.1
ENST00000372520.1
ZSWIM1
zinc finger, SWIM-type containing 1
chrX_-_117119243 0.27 ENST00000539496.1
ENST00000469946.1
KLHL13
kelch-like family member 13
chr2_-_208031943 0.26 ENST00000421199.1
ENST00000457962.1
KLF7
Kruppel-like factor 7 (ubiquitous)
chr12_-_109915098 0.26 ENST00000542858.1
ENST00000542262.1
ENST00000424763.2
KCTD10
potassium channel tetramerization domain containing 10
chr5_-_148930960 0.25 ENST00000261798.5
ENST00000377843.2
CSNK1A1
casein kinase 1, alpha 1
chr10_+_11207088 0.24 ENST00000608830.1
CELF2
CUGBP, Elav-like family member 2
chr6_-_11779174 0.24 ENST00000379413.2
ADTRP
androgen-dependent TFPI-regulating protein
chr7_-_148725544 0.23 ENST00000413966.1
PDIA4
protein disulfide isomerase family A, member 4
chr17_+_30813576 0.23 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr13_-_39612176 0.23 ENST00000352251.3
ENST00000350125.3
PROSER1
proline and serine rich 1
chr11_+_69455855 0.22 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr6_+_108881012 0.22 ENST00000343882.6
FOXO3
forkhead box O3
chr6_-_11779840 0.22 ENST00000506810.1
ADTRP
androgen-dependent TFPI-regulating protein
chr19_+_1249869 0.21 ENST00000591446.2
MIDN
midnolin
chr4_-_140544386 0.21 ENST00000561977.1
RP11-308D13.3
RP11-308D13.3
chr13_+_76334498 0.21 ENST00000534657.1
LMO7
LIM domain 7
chr8_+_11660227 0.21 ENST00000443614.2
ENST00000525900.1
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr20_+_45947246 0.21 ENST00000599904.1
AL031666.2
HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
chr4_-_69215467 0.20 ENST00000579690.1
YTHDC1
YTH domain containing 1
chr14_-_23451845 0.20 ENST00000262713.2
AJUBA
ajuba LIM protein
chr15_+_75074915 0.20 ENST00000567123.1
ENST00000569462.1
CSK
c-src tyrosine kinase
chr6_+_12008986 0.19 ENST00000491710.1
HIVEP1
human immunodeficiency virus type I enhancer binding protein 1
chr12_-_49449107 0.19 ENST00000301067.7
KMT2D
lysine (K)-specific methyltransferase 2D
chr2_+_220309379 0.19 ENST00000451076.1
SPEG
SPEG complex locus
chr14_+_39644425 0.19 ENST00000556530.1
PNN
pinin, desmosome associated protein
chr6_+_43968306 0.18 ENST00000442114.2
ENST00000336600.5
ENST00000439969.2
C6orf223
chromosome 6 open reading frame 223
chr16_-_89007491 0.18 ENST00000327483.5
ENST00000564416.1
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr17_-_56065484 0.18 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr19_-_49864746 0.18 ENST00000598810.1
TEAD2
TEA domain family member 2
chr1_-_32801825 0.18 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chr7_+_115850547 0.18 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
TES
testis derived transcript (3 LIM domains)
chr14_+_62331592 0.18 ENST00000554436.1
CTD-2277K2.1
CTD-2277K2.1
chr1_+_82266053 0.17 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2
latrophilin 2
chr10_-_104192405 0.17 ENST00000369937.4
CUEDC2
CUE domain containing 2
chr21_+_30671690 0.17 ENST00000399921.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr12_-_108154925 0.17 ENST00000228437.5
PRDM4
PR domain containing 4
chr8_+_55467072 0.17 ENST00000602362.1
RP11-53M11.3
RP11-53M11.3
chr8_-_145047688 0.16 ENST00000356346.3
PLEC
plectin
chr6_-_27440460 0.16 ENST00000377419.1
ZNF184
zinc finger protein 184
chr3_+_132757215 0.16 ENST00000321871.6
ENST00000393130.3
ENST00000514894.1
ENST00000512662.1
TMEM108
transmembrane protein 108
chr3_+_183353356 0.16 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24
kelch-like family member 24
chr8_+_21777243 0.15 ENST00000521303.1
XPO7
exportin 7
chr7_+_73868439 0.15 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr13_+_98086445 0.15 ENST00000245304.4
RAP2A
RAP2A, member of RAS oncogene family
chr9_+_125795788 0.15 ENST00000373643.5
RABGAP1
RAB GTPase activating protein 1
chr9_-_23826298 0.15 ENST00000380117.1
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr18_+_29769978 0.15 ENST00000269202.6
ENST00000581447.1
MEP1B
meprin A, beta
chr2_-_100721923 0.15 ENST00000356421.2
AFF3
AF4/FMR2 family, member 3
chr1_-_1334685 0.14 ENST00000400809.3
ENST00000408918.4
CCNL2
cyclin L2
chr1_-_116383322 0.14 ENST00000429731.1
NHLH2
nescient helix loop helix 2
chr4_+_170581213 0.14 ENST00000507875.1
CLCN3
chloride channel, voltage-sensitive 3
chr19_-_7990991 0.14 ENST00000318978.4
CTXN1
cortexin 1
chr13_+_76210448 0.14 ENST00000377499.5
LMO7
LIM domain 7
chr8_+_11660120 0.14 ENST00000220584.4
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr1_-_38061522 0.14 ENST00000373062.3
GNL2
guanine nucleotide binding protein-like 2 (nucleolar)
chr1_-_94079648 0.14 ENST00000370247.3
BCAR3
breast cancer anti-estrogen resistance 3
chr16_+_53407383 0.13 ENST00000566383.1
RP11-44F14.2
RP11-44F14.2
chr1_+_43424698 0.13 ENST00000431759.1
SLC2A1-AS1
SLC2A1 antisense RNA 1
chr15_+_65134088 0.13 ENST00000323544.4
ENST00000437723.1
PLEKHO2
AC069368.3
pleckstrin homology domain containing, family O member 2
Uncharacterized protein
chr6_-_27440837 0.13 ENST00000211936.6
ZNF184
zinc finger protein 184
chr10_+_114710425 0.13 ENST00000352065.5
ENST00000369395.1
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr1_+_166808667 0.13 ENST00000537173.1
ENST00000536514.1
ENST00000449930.1
POGK
pogo transposable element with KRAB domain
chr12_-_133464151 0.12 ENST00000315585.7
ENST00000266880.7
ENST00000443047.2
ENST00000432561.2
ENST00000450056.2
CHFR
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
chr3_-_57199397 0.12 ENST00000296318.7
IL17RD
interleukin 17 receptor D
chr8_-_70745575 0.12 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr13_+_76334795 0.12 ENST00000526202.1
ENST00000465261.2
LMO7
LIM domain 7
chr17_-_48072574 0.12 ENST00000434704.2
DLX3
distal-less homeobox 3
chr12_-_31477072 0.11 ENST00000454658.2
FAM60A
family with sequence similarity 60, member A
chr4_-_186877502 0.11 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
SORBS2
sorbin and SH3 domain containing 2
chr10_+_114710516 0.11 ENST00000542695.1
ENST00000346198.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr14_+_59100774 0.11 ENST00000556859.1
ENST00000421793.1
DACT1
dishevelled-binding antagonist of beta-catenin 1
chr12_-_49582837 0.11 ENST00000547939.1
ENST00000546918.1
ENST00000552924.1
TUBA1A
tubulin, alpha 1a
chr7_+_80275953 0.11 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36
CD36 molecule (thrombospondin receptor)
chr7_+_80275752 0.10 ENST00000419819.2
CD36
CD36 molecule (thrombospondin receptor)
chr4_-_69215699 0.10 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr14_-_73493825 0.10 ENST00000318876.5
ENST00000556143.1
ZFYVE1
zinc finger, FYVE domain containing 1
chr3_+_179280668 0.10 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
ACTL6A
actin-like 6A
chr1_-_119869846 0.10 ENST00000457719.1
RP11-418J17.3
RP11-418J17.3
chr13_-_72440901 0.10 ENST00000359684.2
DACH1
dachshund homolog 1 (Drosophila)
chr2_+_47168630 0.10 ENST00000263737.6
TTC7A
tetratricopeptide repeat domain 7A
chr17_+_38337491 0.10 ENST00000538981.1
RAPGEFL1
Rap guanine nucleotide exchange factor (GEF)-like 1
chrX_+_125953746 0.10 ENST00000371125.3
CXorf64
chromosome X open reading frame 64
chr10_+_71562180 0.09 ENST00000517713.1
ENST00000522165.1
ENST00000520133.1
COL13A1
collagen, type XIII, alpha 1
chr6_+_143929307 0.09 ENST00000427704.2
ENST00000305766.6
PHACTR2
phosphatase and actin regulator 2
chr2_-_39348137 0.09 ENST00000426016.1
SOS1
son of sevenless homolog 1 (Drosophila)
chr3_-_160283348 0.09 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.7 GO:0007499 ectoderm and mesoderm interaction(GO:0007499)
0.4 1.8 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.3 1.5 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3 0.9 GO:0002352 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
0.3 1.6 GO:0018032 protein amidation(GO:0018032)
0.2 1.6 GO:1903232 melanosome assembly(GO:1903232)
0.2 0.6 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.1 0.4 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.1 0.4 GO:1904761 negative regulation of myofibroblast differentiation(GO:1904761)
0.1 0.8 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.1 2.3 GO:0006600 creatine metabolic process(GO:0006600)
0.1 1.5 GO:0042904 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.6 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.1 2.7 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 0.5 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.1 0.7 GO:0006740 NADPH regeneration(GO:0006740)
0.1 0.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.2 GO:0021718 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)
0.1 0.7 GO:0001661 conditioned taste aversion(GO:0001661)
0.1 0.2 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
0.1 0.5 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.1 0.3 GO:0006696 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.1 0.3 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.1 0.7 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 0.3 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836)
0.1 0.3 GO:0070980 biphenyl catabolic process(GO:0070980)
0.1 0.4 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.1 1.1 GO:0014877 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 0.6 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.1 1.7 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 0.3 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.8 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 1.1 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.0 0.3 GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0 0.3 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0 0.5 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.0 0.7 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.6 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.0 0.2 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0 1.7 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.3 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) myoblast fate commitment(GO:0048625) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.8 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.0 0.2 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.0 0.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.3 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.4 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.7 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0 0.2 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.4 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.3 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.5 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.3 GO:2000334 blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.0 0.4 GO:0070307 lens fiber cell development(GO:0070307)
0.0 0.1 GO:1903625 negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.0 0.4 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.0 0.2 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.0 0.3 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
0.0 1.1 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.1 GO:1904693 midbrain morphogenesis(GO:1904693)
0.0 0.7 GO:0036152 phosphatidylethanolamine acyl-chain remodeling(GO:0036152)
0.0 0.4 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 0.1 GO:0071895 odontoblast differentiation(GO:0071895)
0.0 0.3 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.6 GO:0015695 organic cation transport(GO:0015695)
0.0 0.5 GO:0061436 establishment of skin barrier(GO:0061436)
0.0 0.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.3 GO:0090360 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0 0.2 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.0 GO:0007387 anterior compartment pattern formation(GO:0007387) posterior compartment specification(GO:0007388)
0.0 0.3 GO:0072189 ureter development(GO:0072189)
0.0 0.1 GO:0001555 oocyte growth(GO:0001555)
0.0 0.1 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
0.0 0.2 GO:0097106 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) postsynaptic density organization(GO:0097106)
0.0 0.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0 0.1 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.3 GO:0007379 segment specification(GO:0007379)
0.0 0.1 GO:0090625 mRNA cleavage involved in gene silencing by siRNA(GO:0090625)
0.0 0.2 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0 0.0 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) positive regulation of corticotropin-releasing hormone secretion(GO:0051466)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0031905 early endosome lumen(GO:0031905)
0.3 1.6 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.3 GO:0008623 CHRAC(GO:0008623)
0.1 2.3 GO:0071564 npBAF complex(GO:0071564)
0.1 0.7 GO:0035976 AP1 complex(GO:0035976)
0.1 0.9 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.6 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.8 GO:0061700 GATOR2 complex(GO:0061700)
0.0 0.2 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.6 GO:0001939 female pronucleus(GO:0001939)
0.0 0.2 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
0.0 0.3 GO:0030478 actin cap(GO:0030478)
0.0 0.5 GO:0042588 zymogen granule(GO:0042588)
0.0 0.5 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 2.1 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 0.7 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.4 GO:0071437 invadopodium(GO:0071437)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding(GO:0036313)
0.4 1.6 GO:0035651 AP-3 adaptor complex binding(GO:0035651)
0.3 1.6 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.2 2.3 GO:0004111 creatine kinase activity(GO:0004111)
0.2 0.7 GO:0016652 NAD(P)+ transhydrogenase activity(GO:0008746) oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor(GO:0016652)
0.2 0.6 GO:0019150 D-ribulokinase activity(GO:0019150)
0.2 0.6 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.5 GO:0017095 heparan sulfate 6-O-sulfotransferase activity(GO:0017095)
0.1 0.4 GO:0047280 nicotinamide phosphoribosyltransferase activity(GO:0047280)
0.1 0.6 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 1.7 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 1.5 GO:0047035 alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.1 1.8 GO:0030957 Tat protein binding(GO:0030957)
0.1 0.3 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.1 0.3 GO:0009041 uridylate kinase activity(GO:0009041)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.3 GO:0052810 1-phosphatidylinositol-5-kinase activity(GO:0052810)
0.1 0.3 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 1.7 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.1 0.3 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 1.5 GO:0031005 filamin binding(GO:0031005)
0.0 0.7 GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity(GO:0047144)
0.0 0.6 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.5 GO:1990226 histone methyltransferase binding(GO:1990226)
0.0 0.8 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0 0.9 GO:0051400 BH domain binding(GO:0051400)
0.0 0.8 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.3 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.2 GO:0002046 opsin binding(GO:0002046)
0.0 0.3 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 1.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.6 GO:0045295 gamma-catenin binding(GO:0045295)
0.0 0.3 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 1.3 GO:0030332 cyclin binding(GO:0030332)
0.0 0.7 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.6 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.3 GO:0045159 myosin II binding(GO:0045159)
0.0 0.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 0.4 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.6 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 0.1 GO:0004382 guanosine-diphosphatase activity(GO:0004382)
0.0 0.5 GO:0008483 transaminase activity(GO:0008483)
0.0 0.7 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 1.1 GO:0070412 R-SMAD binding(GO:0070412)
0.0 0.1 GO:0070097 delta-catenin binding(GO:0070097)
0.0 2.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.3 GO:0005537 mannose binding(GO:0005537)
0.0 0.5 GO:0031489 myosin V binding(GO:0031489)
0.0 0.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.1 GO:0004510 tryptophan 5-monooxygenase activity(GO:0004510)
0.0 0.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0 0.1 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.5 GO:0005109 frizzled binding(GO:0005109)
0.0 0.1 GO:0050436 microfibril binding(GO:0050436)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 0.9 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 2.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0 1.2 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 0.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 0.2 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.0 0.5 PID S1P S1P2 PATHWAY S1P2 pathway
0.0 1.8 PID P73PATHWAY p73 transcription factor network
0.0 0.6 PID AVB3 OPN PATHWAY Osteopontin-mediated events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.6 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.0 1.7 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.0 0.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.8 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 0.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 0.7 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.0 0.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.6 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 4.3 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 0.8 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.5 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules