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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TCF7L2
Z-value: 1.62
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Transcription factors associated with TCF7L2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF7L2 | hg19_v2_chr10_+_114710211_114710229 | -0.55 | 1.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_+_101542462 Show fit | 8.50 |
ENST00000370449.4
ENST00000370434.1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
|
| chr11_+_114128522 Show fit | 7.60 |
ENST00000535401.1
|
nicotinamide N-methyltransferase |
|
| chr9_+_97766409 Show fit | 7.60 |
ENST00000425634.2
|
chromosome 9 open reading frame 3 |
|
| chr1_-_153522562 Show fit | 7.59 |
ENST00000368714.1
|
S100 calcium binding protein A4 |
|
| chr5_+_175288631 Show fit | 6.56 |
ENST00000509837.1
|
complexin 2 |
|
| chrX_+_106163626 Show fit | 6.49 |
ENST00000336803.1
|
claudin 2 |
|
| chr8_+_32579271 Show fit | 6.40 |
ENST00000518084.1
|
neuregulin 1 |
|
| chr17_-_63557309 Show fit | 4.79 |
ENST00000580513.1
|
axin 2 |
|
| chr5_-_58335281 Show fit | 4.76 |
ENST00000358923.6
|
phosphodiesterase 4D, cAMP-specific |
|
| chr4_-_139163491 Show fit | 4.48 |
ENST00000280612.5
|
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF7L2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.2 | 12.5 | GO:0061181 | regulation of chondrocyte development(GO:0061181) |
| 1.4 | 12.2 | GO:0021842 | directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842) |
| 0.0 | 11.9 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 2.8 | 8.5 | GO:0050787 | antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787) |
| 0.4 | 7.6 | GO:0034356 | NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356) |
| 2.5 | 7.4 | GO:0090381 | regulation of heart induction(GO:0090381) regulation of heart induction by canonical Wnt signaling pathway(GO:0100012) |
| 0.2 | 7.3 | GO:0060065 | uterus development(GO:0060065) |
| 2.2 | 6.7 | GO:1901202 | negative regulation of extracellular matrix assembly(GO:1901202) |
| 0.2 | 6.6 | GO:0031915 | positive regulation of synaptic plasticity(GO:0031915) |
| 0.2 | 6.5 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.2 | GO:0030673 | axolemma(GO:0030673) |
| 0.5 | 11.8 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 11.6 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 8.7 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.7 | 8.5 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 7.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 7.1 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.0 | 7.0 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.7 | 6.6 | GO:0070033 | synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033) synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554) |
| 0.0 | 5.7 | GO:0031901 | early endosome membrane(GO:0031901) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 12.5 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 1.0 | 12.2 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.4 | 8.5 | GO:0043225 | anion transmembrane-transporting ATPase activity(GO:0043225) |
| 1.9 | 7.6 | GO:0008112 | nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760) |
| 0.3 | 7.6 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.0 | 6.7 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 6.6 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 5.8 | GO:0042826 | histone deacetylase binding(GO:0042826) |
| 0.2 | 4.8 | GO:0031698 | beta-2 adrenergic receptor binding(GO:0031698) |
| 1.5 | 4.5 | GO:0005427 | proton-dependent oligopeptide secondary active transmembrane transporter activity(GO:0005427) secondary active oligopeptide transmembrane transporter activity(GO:0015322) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 12.2 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.3 | 11.3 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 7.3 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 7.1 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 6.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.0 | 4.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 4.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 1.8 | PID EPHRINB REV PATHWAY | Ephrin B reverse signaling |
| 0.0 | 1.7 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 1.2 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.5 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 8.5 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.1 | 7.2 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 6.1 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |
| 0.1 | 5.9 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.1 | 4.8 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.1 | 4.6 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.1 | 3.9 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 2.5 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 1.9 | REACTOME LIGAND GATED ION CHANNEL TRANSPORT | Genes involved in Ligand-gated ion channel transport |