ISMARA results: TFAP2B

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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for TFAP2B

Z-value: 2.66

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Transcription factors associated with TFAP2B

Gene Symbol	Gene ID	Gene Info
TFAP2B Ensembl NCBI GeneCards UniProt NextProt	ENSG00000008196.8	transcription factor AP-2 beta

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TFAP2B	hg19_v2_chr6_+_50786414_50786439	-0.27	2.4e-01	Click!

Activity profile of TFAP2B motif

Sorted Z-values of TFAP2B motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_52914155 Show fit	18.68	ENST00000549420.1 ENST00000551275.1 ENST00000546577.1	KRT5 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 5
chr17_-_39677971 Show fit	11.82	ENST00000393976.2	KRT15 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 15
chr13_-_107187462 Show fit	9.92	ENST00000245323.4	EFNB2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ephrin-B2
chr1_-_153588334 Show fit	9.85	ENST00000476873.1	S100A14 Ensembl NCBI GeneCards UniProt NextProt Show fit	S100 calcium binding protein A14
chr16_+_68679193 Show fit	9.79	ENST00000581171.1	CDH3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cadherin 3, type 1, P-cadherin (placental)
chr16_+_68678892 Show fit	9.77	ENST00000429102.2	CDH3 Ensembl NCBI GeneCards UniProt NextProt Show fit	cadherin 3, type 1, P-cadherin (placental)
chr21_-_28217721 Show fit	9.30	ENST00000284984.3	ADAMTS1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr1_+_152881014 Show fit	9.25	ENST00000368764.3 ENST00000392667.2	IVL Ensembl NCBI GeneCards UniProt NextProt Show fit	involucrin
chr1_+_32042131 Show fit	8.93	ENST00000271064.7 ENST00000537531.1	TINAGL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	tubulointerstitial nephritis antigen-like 1
chr1_+_32042105 Show fit	8.66	ENST00000457433.2 ENST00000441210.2	TINAGL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	tubulointerstitial nephritis antigen-like 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	20.3	GO:0031581	hemidesmosome assembly(GO:0031581)
4.9	19.6	GO:1902910	regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.1	13.9	GO:1903955	positive regulation of protein targeting to mitochondrion(GO:1903955)
1.1	13.1	GO:0035986	senescence-associated heterochromatin focus assembly(GO:0035986)
1.7	12.2	GO:0071461	cellular response to redox state(GO:0071461)
0.0	10.5	GO:0016197	endosomal transport(GO:0016197)
0.5	10.2	GO:0001542	ovulation from ovarian follicle(GO:0001542)
0.3	10.1	GO:0032515	negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1	10.1	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.6	9.9	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)

Showing 1 to 10 of 239 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	17.8	GO:0031225	anchored component of membrane(GO:0031225)
0.2	16.5	GO:0045095	keratin filament(GO:0045095)
0.1	15.7	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	15.6	GO:0031012	extracellular matrix(GO:0031012)
0.1	14.8	GO:0030864	cortical actin cytoskeleton(GO:0030864)
0.1	13.7	GO:0008287	protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
1.1	13.1	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.1	12.1	GO:0001725	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	9.6	GO:0001533	cornified envelope(GO:0001533)
0.0	8.9	GO:0005925	focal adhesion(GO:0005925)

Showing 1 to 10 of 102 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	27.2	GO:0097110	scaffold protein binding(GO:0097110)
0.6	16.7	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.7	15.2	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.7	14.1	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2	13.6	GO:0046875	ephrin receptor binding(GO:0046875)
0.0	13.6	GO:0003779	actin binding(GO:0003779)
0.1	13.2	GO:0004222	metalloendopeptidase activity(GO:0004222)
1.0	12.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.9	11.3	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.2	9.9	GO:0042379	chemokine receptor binding(GO:0042379)

Showing 1 to 10 of 160 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	23.4	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	13.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.5	13.7	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3	11.6	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	10.9	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.2	10.7	PID EPHA FWDPATHWAY	EPHA forward signaling
0.1	10.3	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.0	9.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1	9.3	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2	8.0	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases

Showing 1 to 10 of 48 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	19.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.4	15.0	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.7	14.7	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.2	14.5	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	10.3	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.1	7.9	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	7.9	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	6.6	REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE	Genes involved in Sema4D induced cell migration and growth-cone collapse
0.1	6.6	REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	Genes involved in Integrin alphaIIb beta3 signaling
0.1	5.6	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport

Showing 1 to 10 of 68 entries

Results for TFAP2B

Z-value: 2.66

Motif logo

Transcription factors associated with TFAP2B

Activity-expression correlation:

Activity profile of TFAP2B motif

Sorted Z-values of TFAP2B motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP2B

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: