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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for THRB

Z-value: 0.58

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.13 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24536222_24536249-0.852.4e-06Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_45307817 2.30 ENST00000020926.3
SYT13
synaptotagmin XIII
chr14_+_32414059 2.22 ENST00000553330.1
RP11-187E13.1
Uncharacterized protein
chr17_-_73840415 1.45 ENST00000592386.1
ENST00000412096.2
ENST00000586147.1
UNC13D
unc-13 homolog D (C. elegans)
chr11_+_71934962 1.36 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr10_+_62538248 1.36 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr12_+_54378923 1.22 ENST00000303460.4
HOXC10
homeobox C10
chr10_+_60145155 1.16 ENST00000373895.3
TFAM
transcription factor A, mitochondrial
chr10_+_62538089 1.15 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr20_+_388791 1.01 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr1_+_32712815 1.01 ENST00000373582.3
FAM167B
family with sequence similarity 167, member B
chr17_-_73840774 0.98 ENST00000207549.4
UNC13D
unc-13 homolog D (C. elegans)
chr1_+_77997785 0.98 ENST00000478255.1
AK5
adenylate kinase 5
chr13_+_27844464 0.96 ENST00000241463.4
RASL11A
RAS-like, family 11, member A
chr17_-_73840614 0.95 ENST00000586108.1
UNC13D
unc-13 homolog D (C. elegans)
chr8_-_100905925 0.94 ENST00000518171.1
COX6C
cytochrome c oxidase subunit VIc
chr12_+_54378849 0.80 ENST00000515593.1
HOXC10
homeobox C10
chr8_-_131028782 0.72 ENST00000519020.1
FAM49B
family with sequence similarity 49, member B
chr17_-_73839792 0.70 ENST00000590762.1
UNC13D
unc-13 homolog D (C. elegans)
chr20_+_37434329 0.69 ENST00000299824.1
ENST00000373331.2
PPP1R16B
protein phosphatase 1, regulatory subunit 16B
chr20_+_388679 0.67 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr11_-_64014379 0.62 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr12_-_21810765 0.56 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr17_+_7533439 0.56 ENST00000441599.2
ENST00000380450.4
ENST00000416273.3
ENST00000575903.1
ENST00000576830.1
ENST00000571153.1
ENST00000575618.1
ENST00000576152.1
SHBG
sex hormone-binding globulin
chr12_-_21810726 0.54 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr1_-_207224307 0.48 ENST00000315927.4
YOD1
YOD1 deubiquitinase
chr17_+_1646130 0.47 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr8_-_124037890 0.42 ENST00000519018.1
ENST00000523036.1
DERL1
derlin 1
chr9_-_139268068 0.38 ENST00000371734.3
ENST00000371732.5
ENST00000315908.7
CARD9
caspase recruitment domain family, member 9
chr10_+_35456444 0.37 ENST00000361599.4
CREM
cAMP responsive element modulator
chr15_-_35838348 0.36 ENST00000561411.1
ENST00000256538.4
ENST00000440392.2
DPH6
diphthamine biosynthesis 6
chr20_+_3024266 0.33 ENST00000245983.2
ENST00000359100.2
ENST00000359987.1
GNRH2
gonadotropin-releasing hormone 2
chr14_+_75761099 0.33 ENST00000561000.1
ENST00000558575.1
RP11-293M10.5
RP11-293M10.5
chr11_+_46366799 0.33 ENST00000532868.2
DGKZ
diacylglycerol kinase, zeta
chr16_+_8736232 0.32 ENST00000562973.1
METTL22
methyltransferase like 22
chr1_-_154164534 0.29 ENST00000271850.7
ENST00000368530.2
TPM3
tropomyosin 3
chr11_+_46366918 0.28 ENST00000528615.1
ENST00000395574.3
DGKZ
diacylglycerol kinase, zeta
chr4_+_114214125 0.27 ENST00000509550.1
ANK2
ankyrin 2, neuronal
chr11_+_57310114 0.26 ENST00000527972.1
ENST00000399154.2
SMTNL1
smoothelin-like 1
chr8_-_100905850 0.25 ENST00000520271.1
ENST00000522940.1
ENST00000523016.1
ENST00000517682.2
ENST00000297564.2
COX6C
cytochrome c oxidase subunit VIc
chr10_+_123970670 0.24 ENST00000496913.2
TACC2
transforming, acidic coiled-coil containing protein 2
chr2_+_200472779 0.24 ENST00000427045.1
ENST00000419243.1
AC093590.1
AC093590.1
chr11_-_47400062 0.21 ENST00000533030.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr8_+_19674651 0.21 ENST00000397977.3
INTS10
integrator complex subunit 10
chr11_+_73498898 0.20 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chr2_-_9563319 0.20 ENST00000497105.1
ENST00000360635.3
ENST00000359712.3
ITGB1BP1
integrin beta 1 binding protein 1
chr11_-_47399942 0.18 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_47400078 0.17 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_+_73498973 0.17 ENST00000537007.1
MRPL48
mitochondrial ribosomal protein L48
chr11_-_47400032 0.13 ENST00000533968.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chrX_+_101854096 0.13 ENST00000246174.2
ENST00000537008.1
ENST00000541409.1
ARMCX5
armadillo repeat containing, X-linked 5
chr11_+_5617976 0.08 ENST00000445329.1
TRIM6
tripartite motif containing 6
chr11_+_5617858 0.06 ENST00000380097.3
TRIM6
tripartite motif containing 6
chr7_+_102937869 0.06 ENST00000249269.4
ENST00000428154.1
ENST00000420236.2
PMPCB
peptidase (mitochondrial processing) beta
chr8_+_28174649 0.04 ENST00000301908.3
PNOC
prepronociceptin
chr2_-_9563469 0.03 ENST00000484735.1
ENST00000456913.2
ITGB1BP1
integrin beta 1 binding protein 1
chr6_+_77484663 0.03 ENST00000607287.1
RP11-354K4.2
RP11-354K4.2
chr5_+_131746575 0.03 ENST00000337752.2
ENST00000378947.3
ENST00000407797.1
C5orf56
chromosome 5 open reading frame 56
chr2_-_73869508 0.00 ENST00000272425.3
NAT8
N-acetyltransferase 8 (GCN5-related, putative)

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.1 GO:0002432 granuloma formation(GO:0002432)
0.4 2.5 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.3 1.0 GO:0006173 dADP biosynthetic process(GO:0006173)
0.3 1.2 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.2 0.7 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.2 1.7 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.1 0.7 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.1 2.0 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 0.5 GO:1990167 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.1 0.7 GO:2000568 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.1 0.4 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
0.1 0.5 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 0.3 GO:0036371 protein localization to T-tubule(GO:0036371)
0.0 1.1 GO:0006089 lactate metabolic process(GO:0006089)
0.0 1.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.4 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0 1.4 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.4 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 2.3 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 1.0 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.6 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.0 0.1 GO:0010994 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.3 1.7 GO:0071797 LUBAC complex(GO:0071797)
0.2 4.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 2.0 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.1 0.4 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
0.0 0.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.3 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.2 GO:0032039 integrator complex(GO:0032039)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.1 0.5 GO:1904455 ubiquitin-specific protease activity involved in negative regulation of ERAD pathway(GO:1904455)
0.1 0.7 GO:0023030 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.1 1.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 2.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 1.4 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 0.6 GO:0005497 androgen binding(GO:0005497)
0.1 0.7 GO:0051525 NFAT protein binding(GO:0051525)
0.0 1.0 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 1.0 GO:0015002 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.6 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 2.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 4.1 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0050700 CARD domain binding(GO:0050700)
0.0 0.4 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.0 0.0 GO:0001515 opioid peptide activity(GO:0001515)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 1.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.6 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.3 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 1.1 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 1.4 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.0 1.0 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0 1.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport