Project
SARS-CoV-2 Analysis Results (GEO series: GSE147507)
Navigation
Downloads
Results for TP63
Z-value: 4.12
Motif logo
Transcription factors associated with TP63
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP63 | hg19_v2_chr3_+_189507460_189507471 | 0.99 | 3.0e-19 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr12_-_52887034 Show fit | 33.95 |
ENST00000330722.6
|
keratin 6A |
|
| chr15_+_101417919 Show fit | 32.36 |
ENST00000561338.1
|
aldehyde dehydrogenase 1 family, member A3 |
|
| chr12_-_15114603 Show fit | 31.19 |
ENST00000228945.4
|
Rho GDP dissociation inhibitor (GDI) beta |
|
| chr1_-_153588334 Show fit | 27.55 |
ENST00000476873.1
|
S100 calcium binding protein A14 |
|
| chr3_+_122044084 Show fit | 25.18 |
ENST00000264474.3
ENST00000479204.1 |
cystatin A (stefin A) |
|
| chr18_+_61143994 Show fit | 24.91 |
ENST00000382771.4
|
serpin peptidase inhibitor, clade B (ovalbumin), member 5 |
|
| chr1_+_86889769 Show fit | 23.95 |
ENST00000370565.4
|
chloride channel accessory 2 |
|
| chr2_+_208104497 Show fit | 23.50 |
ENST00000430494.1
|
AC007879.7 |
|
| chr12_-_15114492 Show fit | 22.18 |
ENST00000541546.1
|
Rho GDP dissociation inhibitor (GDI) beta |
|
| chr1_-_26197744 Show fit | 21.61 |
ENST00000374296.3
|
progestin and adipoQ receptor family member VII |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP63
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 12.1 | 84.4 | GO:0071461 | cellular response to redox state(GO:0071461) |
| 1.1 | 72.7 | GO:0032732 | positive regulation of interleukin-1 production(GO:0032732) |
| 1.0 | 46.3 | GO:0060512 | prostate gland morphogenesis(GO:0060512) |
| 1.6 | 37.9 | GO:0090179 | planar cell polarity pathway involved in neural tube closure(GO:0090179) |
| 8.5 | 33.9 | GO:0051710 | cytolysis by symbiont of host cells(GO:0001897) regulation of cytolysis in other organism(GO:0051710) |
| 8.3 | 33.0 | GO:0001808 | negative regulation of type IV hypersensitivity(GO:0001808) |
| 1.3 | 32.7 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 8.1 | 32.4 | GO:0060166 | olfactory pit development(GO:0060166) |
| 1.1 | 27.6 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
| 3.3 | 26.1 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 109.3 | GO:0070062 | extracellular exosome(GO:0070062) |
| 0.1 | 61.6 | GO:0016604 | nuclear body(GO:0016604) |
| 0.6 | 54.3 | GO:0045095 | keratin filament(GO:0045095) |
| 1.0 | 34.5 | GO:0071682 | endocytic vesicle lumen(GO:0071682) |
| 0.0 | 26.9 | GO:0045177 | apical part of cell(GO:0045177) |
| 0.4 | 23.9 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.3 | 21.3 | GO:0001533 | cornified envelope(GO:0001533) |
| 2.6 | 18.1 | GO:0072558 | NLRP1 inflammasome complex(GO:0072558) protease inhibitor complex(GO:0097179) |
| 0.1 | 17.2 | GO:0030175 | filopodium(GO:0030175) |
| 0.2 | 16.9 | GO:0015030 | Cajal body(GO:0015030) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.0 | 84.4 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.6 | 82.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.3 | 61.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.2 | 48.8 | GO:0001078 | transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078) |
| 0.1 | 48.1 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.6 | 34.5 | GO:0042056 | chemoattractant activity(GO:0042056) |
| 5.5 | 33.0 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 2.0 | 32.4 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.5 | 27.6 | GO:0042379 | chemokine receptor binding(GO:0042379) |
| 1.5 | 26.1 | GO:0008199 | ferric iron binding(GO:0008199) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 103.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.5 | 55.4 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.8 | 34.5 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 20.8 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.5 | 18.1 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.2 | 17.6 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.8 | 16.3 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.1 | 14.0 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.6 | 13.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 11.7 | PID TRAIL PATHWAY | TRAIL signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 86.9 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.2 | 39.8 | REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING | Genes involved in Advanced glycosylation endproduct receptor signaling |
| 0.3 | 26.1 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |
| 1.1 | 18.1 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.6 | 16.3 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.5 | 14.7 | REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS | Genes involved in Facilitative Na+-independent glucose transporters |
| 0.1 | 14.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.6 | 13.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.2 | 10.0 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 9.1 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |