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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for TP73
Z-value: 1.28
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Transcription factors associated with TP73
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TP73 | hg19_v2_chr1_+_3598871_3598930 | 0.23 | 3.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TP73
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 10.7 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.3 | 8.4 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 1.9 | 7.7 | GO:0001808 | negative regulation of type IV hypersensitivity(GO:0001808) |
| 1.2 | 4.9 | GO:2001287 | negative regulation of caveolin-mediated endocytosis(GO:2001287) |
| 0.1 | 2.7 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.4 | 2.1 | GO:1900106 | hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106) |
| 0.1 | 2.1 | GO:0035878 | nail development(GO:0035878) |
| 0.0 | 2.1 | GO:0048477 | oogenesis(GO:0048477) |
| 0.2 | 2.0 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 0.0 | 1.8 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 10.7 | GO:0035976 | AP1 complex(GO:0035976) |
| 1.0 | 4.9 | GO:0044393 | microspike(GO:0044393) |
| 0.7 | 2.1 | GO:0036117 | hyaluranon cable(GO:0036117) |
| 0.0 | 2.0 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 1.9 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.0 | 1.6 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 1.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 1.4 | GO:0032590 | dendrite membrane(GO:0032590) |
| 0.1 | 1.3 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 1.2 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 10.8 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 8.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.3 | 7.7 | GO:0042015 | interleukin-20 binding(GO:0042015) |
| 0.1 | 4.9 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.0 | 2.7 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 2.5 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.0 | 2.2 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.4 | 2.1 | GO:0050501 | hyaluronan synthase activity(GO:0050501) |
| 0.1 | 2.1 | GO:0038132 | neuregulin binding(GO:0038132) |
| 0.0 | 2.1 | GO:0005496 | steroid binding(GO:0005496) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 10.7 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 2.9 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 2.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.4 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.9 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.0 | 0.4 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 10.0 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 2.1 | REACTOME HYALURONAN UPTAKE AND DEGRADATION | Genes involved in Hyaluronan uptake and degradation |
| 0.1 | 1.9 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.0 | 1.9 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.0 | 1.6 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 1.4 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.0 | 1.3 | REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES | Genes involved in Cross-presentation of soluble exogenous antigens (endosomes) |
| 0.1 | 1.2 | REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS | Genes involved in Bile salt and organic anion SLC transporters |
| 0.0 | 1.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.0 | 1.0 | REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS | Genes involved in Purine ribonucleoside monophosphate biosynthesis |