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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for UBP1

Z-value: 0.32

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Transcription factors associated with UBP1

Gene Symbol Gene ID Gene Info
UBP1
ENSG00000153560.7 upstream binding protein 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
UBP1hg19_v2_chr3_-_33481835_33481905-0.292.1e-01Click!

Activity profile of UBP1 motif

Sorted Z-values of UBP1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_41136734 0.86 ENST00000568580.1
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr2_+_17721920 0.85 ENST00000295156.4
VSNL1
visinin-like 1
chrX_+_115567767 0.80 ENST00000371900.4
SLC6A14
solute carrier family 6 (amino acid transporter), member 14
chrX_+_13587712 0.79 ENST00000361306.1
ENST00000380602.3
EGFL6
EGF-like-domain, multiple 6
chr11_-_102668879 0.76 ENST00000315274.6
MMP1
matrix metallopeptidase 1 (interstitial collagenase)
chr17_+_74381343 0.61 ENST00000392496.3
SPHK1
sphingosine kinase 1
chr2_+_17721937 0.58 ENST00000451533.1
VSNL1
visinin-like 1
chr6_-_47009996 0.57 ENST00000371243.2
GPR110
G protein-coupled receptor 110
chr19_-_58459039 0.44 ENST00000282308.3
ENST00000598928.1
ZNF256
zinc finger protein 256
chr12_-_8815215 0.44 ENST00000544889.1
ENST00000543369.1
MFAP5
microfibrillar associated protein 5
chr3_+_111718036 0.42 ENST00000455401.2
TAGLN3
transgelin 3
chr12_-_8815299 0.40 ENST00000535336.1
MFAP5
microfibrillar associated protein 5
chr2_+_228678550 0.40 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr9_+_112852477 0.37 ENST00000480388.1
AKAP2
A kinase (PRKA) anchor protein 2
chr14_+_75988768 0.37 ENST00000286639.6
BATF
basic leucine zipper transcription factor, ATF-like
chr12_+_101188547 0.33 ENST00000546991.1
ENST00000392979.3
ANO4
anoctamin 4
chr9_+_109685630 0.27 ENST00000451160.2
RP11-508N12.4
Uncharacterized protein
chr11_+_128761220 0.27 ENST00000529694.1
KCNJ5
potassium inwardly-rectifying channel, subfamily J, member 5
chr19_-_51538148 0.26 ENST00000319590.4
ENST00000250351.4
KLK12
kallikrein-related peptidase 12
chr10_-_75676400 0.26 ENST00000412307.2
C10orf55
chromosome 10 open reading frame 55
chr19_-_11039261 0.25 ENST00000590329.1
ENST00000587943.1
ENST00000585858.1
ENST00000586748.1
ENST00000586575.1
ENST00000253031.2
YIPF2
Yip1 domain family, member 2
chr1_-_151826173 0.25 ENST00000368817.5
THEM5
thioesterase superfamily member 5
chrX_+_74493896 0.24 ENST00000373383.4
ENST00000373379.1
UPRT
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae)
chr1_+_12042015 0.23 ENST00000412236.1
MFN2
mitofusin 2
chr11_-_134123142 0.22 ENST00000392595.2
ENST00000341541.3
ENST00000352327.5
ENST00000392594.3
THYN1
thymocyte nuclear protein 1
chr4_-_100815525 0.22 ENST00000226522.8
ENST00000499666.2
LAMTOR3
late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
chr3_+_111718173 0.22 ENST00000494932.1
TAGLN3
transgelin 3
chr5_+_122847908 0.19 ENST00000511130.2
ENST00000512718.3
CSNK1G3
casein kinase 1, gamma 3
chr4_-_57524061 0.18 ENST00000508121.1
HOPX
HOP homeobox
chr7_+_142829162 0.18 ENST00000291009.3
PIP
prolactin-induced protein
chr3_+_29323043 0.17 ENST00000452462.1
ENST00000456853.1
RBMS3
RNA binding motif, single stranded interacting protein 3
chr19_+_49661079 0.17 ENST00000355712.5
TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr1_-_144995002 0.16 ENST00000369356.4
PDE4DIP
phosphodiesterase 4D interacting protein
chr8_+_28747884 0.16 ENST00000287701.10
ENST00000444075.1
ENST00000403668.2
ENST00000519662.1
ENST00000558662.1
ENST00000523613.1
ENST00000560599.1
ENST00000397358.3
HMBOX1
homeobox containing 1
chr9_+_15422702 0.16 ENST00000380821.3
ENST00000421710.1
SNAPC3
small nuclear RNA activating complex, polypeptide 3, 50kDa
chr4_-_159080806 0.16 ENST00000590648.1
FAM198B
family with sequence similarity 198, member B
chr19_-_11039188 0.15 ENST00000588347.1
YIPF2
Yip1 domain family, member 2
chr2_+_113033164 0.13 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr2_+_162087577 0.13 ENST00000439442.1
TANK
TRAF family member-associated NFKB activator
chr15_-_42343388 0.13 ENST00000399518.3
PLA2G4E
phospholipase A2, group IVE
chr1_+_63989004 0.13 ENST00000371088.4
EFCAB7
EF-hand calcium binding domain 7
chr2_-_163175133 0.13 ENST00000421365.2
ENST00000263642.2
IFIH1
interferon induced with helicase C domain 1
chr5_-_111093759 0.13 ENST00000509979.1
ENST00000513100.1
ENST00000508161.1
ENST00000455559.2
NREP
neuronal regeneration related protein
chr1_-_144995074 0.12 ENST00000534536.1
PDE4DIP
phosphodiesterase 4D interacting protein
chr19_-_49864746 0.12 ENST00000598810.1
TEAD2
TEA domain family member 2
chr5_-_111093717 0.12 ENST00000507032.2
NREP
neuronal regeneration related protein
chr15_-_77712429 0.10 ENST00000564328.1
ENST00000558305.1
PEAK1
pseudopodium-enriched atypical kinase 1
chr17_-_48450534 0.10 ENST00000503633.1
ENST00000442592.3
ENST00000225969.4
MRPL27
mitochondrial ribosomal protein L27
chr1_+_155108294 0.09 ENST00000303343.8
ENST00000368404.4
ENST00000368401.5
SLC50A1
solute carrier family 50 (sugar efflux transporter), member 1
chr9_-_14322319 0.09 ENST00000606230.1
NFIB
nuclear factor I/B
chr7_+_142498725 0.09 ENST00000466254.1
TRBC2
T cell receptor beta constant 2
chr12_+_57984943 0.09 ENST00000422156.3
PIP4K2C
phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
chr7_+_132937820 0.09 ENST00000393161.2
ENST00000253861.4
EXOC4
exocyst complex component 4
chr11_-_11374904 0.08 ENST00000528848.2
CSNK2A3
casein kinase 2, alpha 3 polypeptide
chr1_+_48688357 0.08 ENST00000533824.1
ENST00000438567.2
ENST00000236495.5
ENST00000420136.2
SLC5A9
solute carrier family 5 (sodium/sugar cotransporter), member 9
chr6_-_154567984 0.08 ENST00000517438.1
IPCEF1
interaction protein for cytohesin exchange factors 1
chr2_-_170550842 0.07 ENST00000421028.1
CCDC173
coiled-coil domain containing 173
chr5_+_95998070 0.07 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
CAST
calpastatin
chrX_+_24167828 0.07 ENST00000379188.3
ENST00000419690.1
ENST00000379177.1
ENST00000304543.5
ZFX
zinc finger protein, X-linked
chr4_-_47839966 0.06 ENST00000273857.4
ENST00000505909.1
ENST00000502252.1
CORIN
corin, serine peptidase
chr19_-_59066327 0.06 ENST00000596708.1
ENST00000601220.1
ENST00000597848.1
CHMP2A
charged multivesicular body protein 2A
chr7_+_101460882 0.06 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr8_-_28747717 0.05 ENST00000416984.2
INTS9
integrator complex subunit 9
chr9_-_35685452 0.05 ENST00000607559.1
TPM2
tropomyosin 2 (beta)
chr11_+_10326612 0.05 ENST00000534464.1
ENST00000530439.1
ENST00000524948.1
ENST00000528655.1
ENST00000526492.1
ENST00000525063.1
ADM
adrenomedullin
chr1_-_150669604 0.04 ENST00000427665.1
ENST00000540514.1
GOLPH3L
golgi phosphoprotein 3-like
chr8_-_66474884 0.04 ENST00000520902.1
CTD-3025N20.2
CTD-3025N20.2
chr4_+_156587853 0.04 ENST00000506455.1
ENST00000511108.1
GUCY1A3
guanylate cyclase 1, soluble, alpha 3
chr19_-_8070474 0.04 ENST00000407627.2
ENST00000593807.1
ELAVL1
ELAV like RNA binding protein 1
chr4_-_168155730 0.03 ENST00000502330.1
ENST00000357154.3
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr13_-_23949671 0.03 ENST00000402364.1
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr3_-_56502375 0.03 ENST00000288221.6
ERC2
ELKS/RAB6-interacting/CAST family member 2
chr1_-_182369751 0.03 ENST00000367565.1
TEDDM1
transmembrane epididymal protein 1
chr7_+_150706010 0.02 ENST00000475017.1
NOS3
nitric oxide synthase 3 (endothelial cell)
chr2_+_166430619 0.02 ENST00000409420.1
CSRNP3
cysteine-serine-rich nuclear protein 3
chr1_-_152332480 0.02 ENST00000388718.5
FLG2
filaggrin family member 2
chr19_+_49660997 0.02 ENST00000598691.1
ENST00000252826.5
TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr11_-_56238014 0.01 ENST00000312240.2
OR5M3
olfactory receptor, family 5, subfamily M, member 3
chr15_+_34638066 0.01 ENST00000333756.4
NUTM1
NUT midline carcinoma, family member 1
chr12_+_100041527 0.01 ENST00000324341.1
FAM71C
family with sequence similarity 71, member C
chr11_-_113345995 0.01 ENST00000355319.2
ENST00000542616.1
DRD2
dopamine receptor D2
chr15_-_101835110 0.01 ENST00000560496.1
SNRPA1
small nuclear ribonucleoprotein polypeptide A'
chr15_-_77712477 0.00 ENST00000560626.2
PEAK1
pseudopodium-enriched atypical kinase 1
chr22_+_38071615 0.00 ENST00000215909.5
LGALS1
lectin, galactoside-binding, soluble, 1
chr1_-_185126037 0.00 ENST00000367506.5
ENST00000367504.3
TRMT1L
tRNA methyltransferase 1 homolog (S. cerevisiae)-like
chr5_+_127039075 0.00 ENST00000514853.2
CTC-228N24.1
CTC-228N24.1
chr4_-_168155169 0.00 ENST00000534949.1
ENST00000535728.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr10_-_27443294 0.00 ENST00000396296.3
ENST00000375972.3
ENST00000376016.3
ENST00000491542.2
YME1L1
YME1-like 1 ATPase
chr4_-_168155700 0.00 ENST00000357545.4
ENST00000512648.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr15_+_81475047 0.00 ENST00000559388.1
IL16
interleukin 16
chr4_+_156588115 0.00 ENST00000455639.2
GUCY1A3
guanylate cyclase 1, soluble, alpha 3

Network of associatons between targets according to the STRING database.

First level regulatory network of UBP1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0046521 sphingoid catabolic process(GO:0046521)
0.1 0.4 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.0 0.2 GO:1904199 positive regulation of regulation of vascular smooth muscle cell membrane depolarization(GO:1904199) regulation of vascular smooth muscle cell membrane depolarization(GO:1990736)
0.0 0.3 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
0.0 0.9 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0 0.1 GO:0034344 type III interferon production(GO:0034343) regulation of type III interferon production(GO:0034344)
0.0 0.1 GO:1901656 glycoside transport(GO:1901656)
0.0 0.3 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.0 1.4 GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0035774)
0.0 0.2 GO:0035965 cardiolipin acyl-chain remodeling(GO:0035965)
0.0 0.1 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.0 0.8 GO:0032461 positive regulation of protein oligomerization(GO:0032461)
0.0 0.1 GO:2000158 positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0 0.2 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.0 0.8 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:1903722 regulation of centriole elongation(GO:1903722)
0.0 0.4 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 0.2 GO:0006222 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.1 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.0 0.2 GO:0071986 Ragulator complex(GO:0071986)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.1 0.6 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 0.3 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.0 0.8 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.0 0.1 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0 0.2 GO:0004849 uridine kinase activity(GO:0004849)
0.0 0.2 GO:0019864 IgG binding(GO:0019864)
0.0 0.1 GO:0035800 deubiquitinase activator activity(GO:0035800)
0.0 0.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.0 0.3 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.0 0.2 GO:0003964 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.8 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis