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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for VAX1_GSX2
Z-value: 0.98
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Transcription factors associated with VAX1_GSX2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| VAX1 | hg19_v2_chr10_-_118897806_118897817 | 0.89 | 1.2e-07 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr14_+_67831576 Show fit | 2.94 |
ENST00000555876.1
|
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa |
|
| chr4_+_88896819 Show fit | 2.37 |
ENST00000237623.7
ENST00000395080.3 ENST00000508233.1 ENST00000360804.4 |
secreted phosphoprotein 1 |
|
| chr10_-_5046042 Show fit | 2.02 |
ENST00000421196.3
ENST00000455190.1 |
aldo-keto reductase family 1, member C2 |
|
| chr15_+_62853562 Show fit | 2.02 |
ENST00000561311.1
|
talin 2 |
|
| chr12_-_15815626 Show fit | 1.96 |
ENST00000540613.1
|
epidermal growth factor receptor pathway substrate 8 |
|
| chr10_+_6779326 Show fit | 1.96 |
ENST00000417112.1
|
RP11-554I8.2 |
|
| chr3_+_149191723 Show fit | 1.93 |
ENST00000305354.4
|
transmembrane 4 L six family member 4 |
|
| chr17_+_73539339 Show fit | 1.86 |
ENST00000581713.1
|
lethal giant larvae homolog 2 (Drosophila) |
|
| chr1_-_197115818 Show fit | 1.80 |
ENST00000367409.4
ENST00000294732.7 |
asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
|
| chr2_-_188419078 Show fit | 1.72 |
ENST00000437725.1
ENST00000409676.1 ENST00000339091.4 ENST00000420747.1 |
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
Network of associatons between targets according to the STRING database.
First level regulatory network of VAX1_GSX2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 3.3 | GO:0009753 | response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395) |
| 0.0 | 3.2 | GO:0009301 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.0 | 3.0 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.7 | 2.9 | GO:1990737 | response to manganese-induced endoplasmic reticulum stress(GO:1990737) |
| 0.1 | 2.9 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.6 | 2.4 | GO:2000866 | positive regulation of estrogen secretion(GO:2000863) positive regulation of estradiol secretion(GO:2000866) |
| 0.1 | 2.4 | GO:0046085 | adenosine metabolic process(GO:0046085) |
| 0.1 | 2.4 | GO:0071447 | cellular response to hydroperoxide(GO:0071447) |
| 0.1 | 2.1 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.2 | 2.0 | GO:0070358 | actin polymerization-dependent cell motility(GO:0070358) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 3.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 1.0 | 2.9 | GO:0043614 | multi-eIF complex(GO:0043614) translation preinitiation complex(GO:0070993) glial limiting end-foot(GO:0097451) |
| 0.1 | 2.8 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 2.6 | GO:0000792 | heterochromatin(GO:0000792) |
| 0.2 | 1.9 | GO:0033063 | Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063) |
| 0.0 | 1.9 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.1 | 1.8 | GO:0072687 | meiotic spindle(GO:0072687) |
| 0.0 | 1.8 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.1 | 1.7 | GO:0070938 | contractile ring(GO:0070938) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.5 | 3.3 | GO:0018636 | phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) |
| 0.1 | 3.0 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 2.9 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.1 | 2.6 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 2.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 2.5 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.5 | 2.4 | GO:0008665 | 2'-phosphotransferase activity(GO:0008665) |
| 0.0 | 2.3 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 2.2 | GO:0019905 | syntaxin binding(GO:0019905) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 2.4 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.0 | 2.3 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
| 0.0 | 2.1 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.0 | 2.0 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 0.0 | 1.9 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.7 | PID SYNDECAN 4 PATHWAY | Syndecan-4-mediated signaling events |
| 0.0 | 1.3 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.0 | 1.1 | ST INTEGRIN SIGNALING PATHWAY | Integrin Signaling Pathway |
| 0.0 | 1.0 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.4 | REACTOME PERK REGULATED GENE EXPRESSION | Genes involved in PERK regulated gene expression |
| 0.0 | 3.2 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 0.0 | 2.7 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.6 | REACTOME RECYCLING OF BILE ACIDS AND SALTS | Genes involved in Recycling of bile acids and salts |
| 0.0 | 2.4 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.1 | 2.3 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 0.0 | 1.8 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |
| 0.0 | 1.7 | REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE | Genes involved in Formation of Fibrin Clot (Clotting Cascade) |
| 0.0 | 1.6 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 1.2 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |