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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Z-value: 7.40
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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000065978.13 | Y-box binding protein 1 | |
| ENSG00000170345.5 | Fos proto-oncogene, AP-1 transcription factor subunit | |
| ENSG00000066136.15 | nuclear transcription factor Y subunit gamma | |
| ENSG00000001167.10 | nuclear transcription factor Y subunit alpha | |
| ENSG00000120837.3 | nuclear transcription factor Y subunit beta | |
| ENSG00000115816.9 | CCAAT enhancer binding protein zeta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFYB | hg19_v2_chr12_-_104531945_104531996 | 0.87 | 4.9e-07 | Click! |
| NFYC | hg19_v2_chr1_+_41157361_41157416 | 0.82 | 1.0e-05 | Click! |
| CEBPZ | hg19_v2_chr2_-_37458749_37458856 | 0.81 | 1.4e-05 | Click! |
| FOS | hg19_v2_chr14_+_75746340_75746373 | -0.81 | 1.5e-05 | Click! |
| YBX1 | hg19_v2_chr1_+_43148625_43148710 | -0.65 | 1.8e-03 | Click! |
| NFYA | hg19_v2_chr6_+_41040678_41040722 | 0.08 | 7.4e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.2 | 87.5 | GO:0061641 | CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641) |
| 2.7 | 54.9 | GO:0051988 | regulation of attachment of spindle microtubules to kinetochore(GO:0051988) |
| 0.7 | 53.6 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 0.8 | 43.4 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 0.6 | 42.4 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 4.7 | 37.9 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 1.4 | 36.6 | GO:0000920 | cell separation after cytokinesis(GO:0000920) |
| 5.8 | 34.9 | GO:0016321 | female meiosis chromosome segregation(GO:0016321) |
| 2.1 | 34.0 | GO:0045842 | positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101) |
| 0.8 | 33.5 | GO:0006270 | DNA replication initiation(GO:0006270) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 87.0 | GO:0000776 | kinetochore(GO:0000776) |
| 2.1 | 85.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.8 | 69.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 10.4 | 62.7 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 0.4 | 59.1 | GO:0000922 | spindle pole(GO:0000922) |
| 0.1 | 58.4 | GO:0005635 | nuclear envelope(GO:0005635) |
| 0.6 | 57.0 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.8 | 53.2 | GO:0000786 | nucleosome(GO:0000786) |
| 8.6 | 43.0 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 5.0 | 39.7 | GO:0032133 | chromosome passenger complex(GO:0032133) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 84.3 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 9.8 | 68.8 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 0.2 | 68.5 | GO:0042393 | histone binding(GO:0042393) |
| 0.4 | 64.5 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.1 | 49.4 | GO:0015631 | tubulin binding(GO:0015631) |
| 0.8 | 49.2 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.5 | 33.8 | GO:0097472 | cyclin-dependent protein kinase activity(GO:0097472) |
| 0.5 | 32.8 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 3.6 | 32.7 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 9.6 | 28.7 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 238.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.8 | 142.2 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 1.4 | 101.6 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.6 | 42.4 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.3 | 31.4 | PID E2F PATHWAY | E2F transcription factor network |
| 1.4 | 30.1 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
| 0.4 | 24.9 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.3 | 23.9 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.5 | 23.0 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.3 | 21.6 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 184.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 2.5 | 91.1 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 1.3 | 63.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 2.6 | 63.3 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 3.6 | 61.9 | REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION | Genes involved in E2F-enabled inhibition of pre-replication complex formation |
| 0.7 | 59.4 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 1.6 | 59.3 | REACTOME FANCONI ANEMIA PATHWAY | Genes involved in Fanconi Anemia pathway |
| 0.5 | 49.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.6 | 48.6 | REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21 | Genes involved in SCF(Skp2)-mediated degradation of p27/p21 |
| 2.6 | 46.5 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |