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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZBTB3

Z-value: 0.45

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Transcription factors associated with ZBTB3

Gene Symbol Gene ID Gene Info
ZBTB3
ENSG00000185670.7 zinc finger and BTB domain containing 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZBTB3hg19_v2_chr11_-_62521614_625216600.106.6e-01Click!

Activity profile of ZBTB3 motif

Sorted Z-values of ZBTB3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_52887034 4.03 ENST00000330722.6
KRT6A
keratin 6A
chr17_-_5487768 2.20 ENST00000269280.4
ENST00000345221.3
ENST00000262467.5
NLRP1
NLR family, pyrin domain containing 1
chr4_-_15939963 1.94 ENST00000259988.2
FGFBP1
fibroblast growth factor binding protein 1
chr6_+_30851205 1.16 ENST00000515881.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr6_+_30850697 0.84 ENST00000509639.1
ENST00000412274.2
ENST00000507901.1
ENST00000507046.1
ENST00000437124.2
ENST00000454612.2
ENST00000396342.2
DDR1
discoidin domain receptor tyrosine kinase 1
chrX_+_23801280 0.80 ENST00000379251.3
ENST00000379253.3
ENST00000379254.1
ENST00000379270.4
SAT1
spermidine/spermine N1-acetyltransferase 1
chr6_+_30850862 0.71 ENST00000504651.1
ENST00000512694.1
ENST00000515233.1
DDR1
discoidin domain receptor tyrosine kinase 1
chr8_+_144821557 0.69 ENST00000534398.1
FAM83H-AS1
FAM83H antisense RNA 1 (head to head)
chr19_+_16187085 0.62 ENST00000300933.4
TPM4
tropomyosin 4
chr19_-_49496557 0.57 ENST00000323798.3
ENST00000541188.1
ENST00000544287.1
ENST00000540532.1
ENST00000263276.6
GYS1
glycogen synthase 1 (muscle)
chr19_-_2042065 0.55 ENST00000591588.1
ENST00000591142.1
MKNK2
MAP kinase interacting serine/threonine kinase 2
chr18_-_33709268 0.54 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr3_-_149688971 0.53 ENST00000498307.1
ENST00000489155.1
PFN2
profilin 2
chr3_-_49131473 0.52 ENST00000430979.1
ENST00000357496.2
ENST00000437939.1
QRICH1
glutamine-rich 1
chr12_-_10022735 0.49 ENST00000228438.2
CLEC2B
C-type lectin domain family 2, member B
chr1_+_12040238 0.47 ENST00000444836.1
ENST00000235329.5
MFN2
mitofusin 2
chr4_+_166300084 0.41 ENST00000402744.4
CPE
carboxypeptidase E
chr6_-_46138676 0.41 ENST00000371383.2
ENST00000230565.3
ENPP5
ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)
chr3_-_49131614 0.40 ENST00000450685.1
QRICH1
glutamine-rich 1
chr6_+_31939608 0.40 ENST00000375331.2
ENST00000375333.2
STK19
serine/threonine kinase 19
chr19_+_52848659 0.39 ENST00000327920.8
ZNF610
zinc finger protein 610
chr18_+_32073253 0.38 ENST00000283365.9
ENST00000596745.1
ENST00000315456.6
DTNA
dystrobrevin, alpha
chr12_+_123949053 0.36 ENST00000350887.5
SNRNP35
small nuclear ribonucleoprotein 35kDa (U11/U12)
chr18_+_42260059 0.36 ENST00000426838.4
SETBP1
SET binding protein 1
chr3_-_49131013 0.35 ENST00000424300.1
QRICH1
glutamine-rich 1
chr6_-_41122063 0.35 ENST00000426005.2
ENST00000437044.2
ENST00000373127.4
TREML1
triggering receptor expressed on myeloid cells-like 1
chr11_-_130786400 0.34 ENST00000265909.4
SNX19
sorting nexin 19
chr3_-_195163803 0.34 ENST00000326793.6
ACAP2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr3_+_139063372 0.33 ENST00000478464.1
MRPS22
mitochondrial ribosomal protein S22
chr11_-_67980744 0.32 ENST00000401547.2
ENST00000453170.1
ENST00000304363.4
SUV420H1
suppressor of variegation 4-20 homolog 1 (Drosophila)
chr9_+_72002837 0.32 ENST00000377216.3
FAM189A2
family with sequence similarity 189, member A2
chr3_+_139062838 0.30 ENST00000310776.4
ENST00000465056.1
ENST00000465373.1
MRPS22
mitochondrial ribosomal protein S22
chr11_-_82782952 0.30 ENST00000534141.1
RAB30
RAB30, member RAS oncogene family
chr7_+_134576317 0.30 ENST00000424922.1
ENST00000495522.1
CALD1
caldesmon 1
chr3_-_49131788 0.29 ENST00000395443.2
ENST00000411682.1
QRICH1
glutamine-rich 1
chr9_-_34637718 0.26 ENST00000378892.1
ENST00000277010.4
SIGMAR1
sigma non-opioid intracellular receptor 1
chr5_-_115177247 0.26 ENST00000500945.2
ATG12
autophagy related 12
chr11_-_82782861 0.26 ENST00000524635.1
ENST00000526205.1
ENST00000527633.1
ENST00000533486.1
ENST00000533276.2
RAB30
RAB30, member RAS oncogene family
chr19_-_6670128 0.26 ENST00000245912.3
TNFSF14
tumor necrosis factor (ligand) superfamily, member 14
chr11_+_64692143 0.23 ENST00000164133.2
ENST00000532850.1
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr17_+_46018872 0.23 ENST00000583599.1
ENST00000434554.2
ENST00000225573.4
ENST00000544840.1
ENST00000534893.1
PNPO
pyridoxamine 5'-phosphate oxidase
chr15_+_64428529 0.23 ENST00000560861.1
SNX1
sorting nexin 1
chrX_+_134166333 0.22 ENST00000257013.7
FAM127A
family with sequence similarity 127, member A
chr3_-_149688502 0.22 ENST00000481767.1
ENST00000475518.1
PFN2
profilin 2
chr11_+_67007518 0.22 ENST00000530342.1
ENST00000308783.5
KDM2A
lysine (K)-specific demethylase 2A
chr10_-_73533255 0.21 ENST00000394957.3
C10orf54
chromosome 10 open reading frame 54
chr4_-_17783135 0.21 ENST00000265018.3
FAM184B
family with sequence similarity 184, member B
chr1_+_211433275 0.21 ENST00000367005.4
RCOR3
REST corepressor 3
chr9_+_140500126 0.20 ENST00000431925.2
ENST00000419386.1
ARRDC1
arrestin domain containing 1
chr3_-_149688655 0.20 ENST00000461930.1
ENST00000423691.2
ENST00000490975.1
ENST00000461868.1
ENST00000452853.2
PFN2
profilin 2
chr11_-_130786333 0.19 ENST00000533214.1
ENST00000528555.1
ENST00000530356.1
ENST00000539184.1
SNX19
sorting nexin 19
chr5_+_75379224 0.18 ENST00000322285.7
SV2C
synaptic vesicle glycoprotein 2C
chr5_-_149669612 0.18 ENST00000510347.1
CAMK2A
calcium/calmodulin-dependent protein kinase II alpha
chr6_+_12958137 0.17 ENST00000457702.2
ENST00000379345.2
PHACTR1
phosphatase and actin regulator 1
chr12_-_62586543 0.17 ENST00000416284.3
FAM19A2
family with sequence similarity 19 (chemokine (C-C motif)-like), member A2
chr1_+_110036728 0.16 ENST00000369868.3
ENST00000430195.2
CYB561D1
cytochrome b561 family, member D1
chr9_+_74526384 0.16 ENST00000334731.2
ENST00000377031.3
C9orf85
chromosome 9 open reading frame 85
chr8_+_38261880 0.15 ENST00000527175.1
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr12_+_8185288 0.15 ENST00000162391.3
FOXJ2
forkhead box J2
chr5_-_74807418 0.15 ENST00000405807.4
ENST00000261415.7
COL4A3BP
collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
chr14_-_90085458 0.14 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
FOXN3
forkhead box N3
chr6_-_31939734 0.14 ENST00000375356.3
DXO
decapping exoribonuclease
chrX_+_11776278 0.14 ENST00000312196.4
ENST00000337339.2
MSL3
male-specific lethal 3 homolog (Drosophila)
chr1_+_155146318 0.14 ENST00000368385.4
ENST00000545012.1
ENST00000392451.2
ENST00000368383.3
ENST00000368382.1
ENST00000334634.4
TRIM46
tripartite motif containing 46
chr1_-_111148969 0.14 ENST00000316361.4
KCNA2
potassium voltage-gated channel, shaker-related subfamily, member 2
chr3_-_195163584 0.14 ENST00000439666.1
ACAP2
ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
chr7_+_23719749 0.14 ENST00000409192.3
ENST00000344962.4
ENST00000409653.1
ENST00000409994.3
FAM221A
family with sequence similarity 221, member A
chr5_+_75378997 0.14 ENST00000502798.2
SV2C
synaptic vesicle glycoprotein 2C
chr17_+_7531281 0.14 ENST00000575729.1
ENST00000340624.5
SHBG
sex hormone-binding globulin
chr5_+_74807886 0.13 ENST00000514296.1
POLK
polymerase (DNA directed) kappa
chr1_+_154229547 0.13 ENST00000428595.1
UBAP2L
ubiquitin associated protein 2-like
chr7_-_127225620 0.13 ENST00000321407.2
GCC1
GRIP and coiled-coil domain containing 1
chr6_-_31940065 0.13 ENST00000375349.3
ENST00000337523.5
DXO
decapping exoribonuclease
chrX_+_152224766 0.12 ENST00000370265.4
ENST00000447306.1
PNMA3
paraneoplastic Ma antigen 3
chr21_+_45209394 0.12 ENST00000497547.1
RRP1
ribosomal RNA processing 1
chr7_+_134576151 0.11 ENST00000393118.2
CALD1
caldesmon 1
chr1_-_32801825 0.11 ENST00000329421.7
MARCKSL1
MARCKS-like 1
chrX_+_118708517 0.11 ENST00000346330.3
UBE2A
ubiquitin-conjugating enzyme E2A
chr12_+_27619743 0.11 ENST00000298876.4
ENST00000416383.1
SMCO2
single-pass membrane protein with coiled-coil domains 2
chr1_+_110036699 0.10 ENST00000496961.1
ENST00000533024.1
ENST00000310611.4
ENST00000527072.1
ENST00000420578.2
ENST00000528785.1
CYB561D1
cytochrome b561 family, member D1
chr21_-_48024986 0.09 ENST00000291700.4
ENST00000367071.4
S100B
S100 calcium binding protein B
chr1_+_210001309 0.08 ENST00000491415.2
DIEXF
digestive organ expansion factor homolog (zebrafish)
chr2_+_88824161 0.07 ENST00000303254.3
TEX37
testis expressed 37
chr9_+_74526532 0.07 ENST00000486911.2
C9orf85
chromosome 9 open reading frame 85
chr7_-_38394118 0.07 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr5_+_112074029 0.06 ENST00000512211.2
APC
adenomatous polyposis coli
chrX_-_154563889 0.06 ENST00000369449.2
ENST00000321926.4
CLIC2
chloride intracellular channel 2
chr16_+_53164833 0.06 ENST00000564845.1
CHD9
chromodomain helicase DNA binding protein 9
chr1_-_236046872 0.06 ENST00000536965.1
LYST
lysosomal trafficking regulator
chr17_+_75123947 0.06 ENST00000586429.1
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr4_-_73935409 0.06 ENST00000507544.2
ENST00000295890.4
COX18
COX18 cytochrome C oxidase assembly factor
chr16_+_24266874 0.05 ENST00000005284.3
CACNG3
calcium channel, voltage-dependent, gamma subunit 3
chr17_+_61554829 0.05 ENST00000582627.1
ACE
angiotensin I converting enzyme
chr17_+_75542997 0.05 ENST00000592651.1
ENST00000590398.1
RP11-13K12.1
RP11-13K12.1
chr16_+_89787393 0.05 ENST00000289816.5
ENST00000568064.1
ZNF276
zinc finger protein 276
chr1_+_65210772 0.04 ENST00000371072.4
ENST00000294428.3
RAVER2
ribonucleoprotein, PTB-binding 2
chr1_+_160160346 0.04 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_+_28285973 0.03 ENST00000373884.5
XKR8
XK, Kell blood group complex subunit-related family, member 8
chr2_-_40679148 0.03 ENST00000417271.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr1_-_166136187 0.02 ENST00000338353.3
FAM78B
family with sequence similarity 78, member B
chr3_-_39322728 0.02 ENST00000541347.1
ENST00000412814.1
CX3CR1
chemokine (C-X3-C motif) receptor 1
chr7_-_38403077 0.02 ENST00000426402.2
TRGV2
T cell receptor gamma variable 2
chr19_-_45657028 0.01 ENST00000429338.1
ENST00000589776.1
NKPD1
NTPase, KAP family P-loop domain containing 1
chr9_+_125132803 0.01 ENST00000540753.1
PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr6_+_42141029 0.01 ENST00000372958.1
GUCA1A
guanylate cyclase activator 1A (retina)
chr1_-_169555709 0.01 ENST00000546081.1
F5
coagulation factor V (proaccelerin, labile factor)
chr5_+_115177178 0.01 ENST00000316788.7
AP3S1
adaptor-related protein complex 3, sigma 1 subunit
chr4_+_159236462 0.01 ENST00000460056.2
RXFP1
relaxin/insulin-like family peptide receptor 1
chr12_-_114843889 0.01 ENST00000405440.2
TBX5
T-box 5
chr2_-_154335300 0.00 ENST00000325926.3
RPRM
reprimo, TP53 dependent G2 arrest mediator candidate

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 GO:0051710 cytolysis by symbiont of host cells(GO:0001897) regulation of cytolysis in other organism(GO:0051710)
0.7 2.2 GO:1904784 NLRP1 inflammasome complex assembly(GO:1904784)
0.2 1.9 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 2.7 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.4 GO:0030070 insulin processing(GO:0030070)
0.1 0.5 GO:1990502 dense core granule maturation(GO:1990502)
0.1 0.4 GO:0032918 polyamine acetylation(GO:0032917) spermidine acetylation(GO:0032918)
0.1 0.9 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.1 0.2 GO:0042823 pyridoxal phosphate biosynthetic process(GO:0042823)
0.1 0.3 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.1 0.2 GO:0035621 ER to Golgi ceramide transport(GO:0035621)
0.0 0.5 GO:0061734 parkin-mediated mitophagy in response to mitochondrial depolarization(GO:0061734)
0.0 0.2 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.0 0.5 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.3 GO:0038003 opioid receptor signaling pathway(GO:0038003)
0.0 0.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.0 0.1 GO:0061484 hematopoietic stem cell homeostasis(GO:0061484)
0.0 0.5 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.0 0.5 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.3 GO:0071028 nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.0 GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion(GO:0014809)
0.0 0.2 GO:0034498 early endosome to Golgi transport(GO:0034498)
0.0 0.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.1 GO:0021633 optic nerve structural organization(GO:0021633)
0.0 0.1 GO:0099612 protein localization to axon(GO:0099612)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.2 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
0.0 4.0 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.6 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.0 0.4 GO:0030478 actin cap(GO:0030478)
0.0 0.4 GO:0000243 commitment complex(GO:0000243)
0.0 0.2 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.1 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.6 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 0.5 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306)
0.0 0.6 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.8 GO:0019808 polyamine binding(GO:0019808)
0.2 2.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1 0.3 GO:0034353 RNA pyrophosphohydrolase activity(GO:0034353)
0.1 2.2 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 1.9 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.2 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.3 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.6 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.0 0.7 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0 0.3 GO:0004985 opioid receptor activity(GO:0004985)
0.0 0.2 GO:0097001 ceramide binding(GO:0097001)
0.0 0.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.5 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 3.6 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.9 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0010181 FMN binding(GO:0010181)
0.0 0.4 GO:0005523 tropomyosin binding(GO:0005523)
0.0 0.1 GO:0005497 androgen binding(GO:0005497)
0.0 0.5 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.5 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.1 GO:0034511 U3 snoRNA binding(GO:0034511)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 0.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 0.9 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.0 0.5 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.4 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing