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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZEB1
Z-value: 9.14
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Transcription factors associated with ZEB1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZEB1 | hg19_v2_chr10_+_31608054_31608156 | -0.77 | 8.5e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_7165662 Show fit | 93.63 |
ENST00000571881.2
ENST00000360325.7 |
claudin 7 |
|
| chr1_-_209979375 Show fit | 51.61 |
ENST00000367021.3
|
interferon regulatory factor 6 |
|
| chr1_-_209979465 Show fit | 50.25 |
ENST00000542854.1
|
interferon regulatory factor 6 |
|
| chr1_-_27286897 Show fit | 46.94 |
ENST00000320567.5
|
chromosome 1 open reading frame 172 |
|
| chr1_-_153588765 Show fit | 46.49 |
ENST00000368701.1
ENST00000344616.2 |
S100 calcium binding protein A14 |
|
| chr8_+_95653302 Show fit | 41.77 |
ENST00000423620.2
ENST00000433389.2 |
epithelial splicing regulatory protein 1 |
|
| chr1_-_153588334 Show fit | 41.45 |
ENST00000476873.1
|
S100 calcium binding protein A14 |
|
| chr16_+_68678739 Show fit | 41.01 |
ENST00000264012.4
|
cadherin 3, type 1, P-cadherin (placental) |
|
| chr16_+_68679193 Show fit | 39.94 |
ENST00000581171.1
|
cadherin 3, type 1, P-cadherin (placental) |
|
| chr12_-_52911718 Show fit | 39.53 |
ENST00000548409.1
|
keratin 5 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZEB1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.0 | 223.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.8 | 169.7 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 3.1 | 162.8 | GO:0043616 | keratinocyte proliferation(GO:0043616) |
| 20.0 | 120.1 | GO:1904274 | tricellular tight junction assembly(GO:1904274) |
| 29.4 | 117.6 | GO:0060901 | regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910) |
| 9.6 | 115.4 | GO:0086073 | bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073) |
| 1.3 | 114.1 | GO:2000649 | regulation of sodium ion transmembrane transporter activity(GO:2000649) |
| 4.5 | 112.6 | GO:0090026 | positive regulation of monocyte chemotaxis(GO:0090026) |
| 2.7 | 98.4 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 3.1 | 74.0 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 594.6 | GO:0070062 | extracellular exosome(GO:0070062) |
| 3.0 | 212.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.2 | 209.5 | GO:0016604 | nuclear body(GO:0016604) |
| 14.0 | 168.2 | GO:0061689 | tricellular tight junction(GO:0061689) |
| 0.9 | 139.3 | GO:0097517 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.9 | 116.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 1.4 | 109.0 | GO:0045095 | keratin filament(GO:0045095) |
| 0.6 | 108.8 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 2.6 | 94.5 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.6 | 84.8 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 221.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.7 | 164.0 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.5 | 153.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.5 | 146.7 | GO:0044822 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 0.2 | 123.3 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 9.6 | 115.4 | GO:0086083 | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083) |
| 1.4 | 113.8 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 4.1 | 94.4 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.2 | 89.7 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.3 | 81.0 | GO:0003785 | actin monomer binding(GO:0003785) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 116.1 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 1.4 | 115.1 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
| 0.3 | 104.2 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.1 | 95.9 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.3 | 90.7 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.6 | 79.7 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.8 | 79.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.8 | 78.0 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 2.2 | 59.6 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 1.1 | 59.3 | PID IL3 PATHWAY | IL3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.9 | 228.8 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 2.9 | 139.7 | REACTOME CELL CELL JUNCTION ORGANIZATION | Genes involved in Cell-cell junction organization |
| 1.1 | 139.4 | REACTOME INTERFERON GAMMA SIGNALING | Genes involved in Interferon gamma signaling |
| 1.9 | 127.7 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.4 | 108.1 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.2 | 94.8 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.4 | 59.4 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 2.8 | 53.7 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.5 | 48.4 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.4 | 46.6 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |