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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZFHX3

Z-value: 0.56

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Transcription factors associated with ZFHX3

Gene Symbol Gene ID Gene Info
ZFHX3
ENSG00000140836.10 zinc finger homeobox 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZFHX3hg19_v2_chr16_-_73093597_730935970.252.9e-01Click!

Activity profile of ZFHX3 motif

Sorted Z-values of ZFHX3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_155511887 3.01 ENST00000302053.3
ENST00000403106.3
FGA
fibrinogen alpha chain
chr22_-_30970560 2.52 ENST00000402369.1
ENST00000406361.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr17_-_64225508 1.93 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr19_-_36304201 1.93 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr11_+_71934962 1.84 ENST00000543234.1
INPPL1
inositol polyphosphate phosphatase-like 1
chr9_-_123812542 1.79 ENST00000223642.1
C5
complement component 5
chr17_-_26697304 1.78 ENST00000536498.1
VTN
vitronectin
chr22_-_30970498 1.43 ENST00000431313.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr8_-_145754428 1.24 ENST00000527462.1
ENST00000313465.5
ENST00000524821.1
C8orf82
chromosome 8 open reading frame 82
chr11_-_61687739 1.13 ENST00000531922.1
ENST00000301773.5
RAB3IL1
RAB3A interacting protein (rabin3)-like 1
chr19_-_58864848 1.10 ENST00000263100.3
A1BG
alpha-1-B glycoprotein
chr17_+_4692230 1.09 ENST00000331264.7
GLTPD2
glycolipid transfer protein domain containing 2
chr20_-_33735070 1.00 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
EDEM2
ER degradation enhancer, mannosidase alpha-like 2
chr11_-_559377 0.95 ENST00000486629.1
C11orf35
chromosome 11 open reading frame 35
chrX_-_110655306 0.90 ENST00000371993.2
DCX
doublecortin
chrX_-_15288154 0.85 ENST00000380483.3
ENST00000380485.3
ENST00000380488.4
ASB9
ankyrin repeat and SOCS box containing 9
chr19_+_50016610 0.82 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr19_+_54466179 0.79 ENST00000270458.2
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr12_+_54410664 0.60 ENST00000303406.4
HOXC4
homeobox C4
chr20_+_42187682 0.59 ENST00000373092.3
ENST00000373077.1
SGK2
serum/glucocorticoid regulated kinase 2
chr19_-_46234119 0.57 ENST00000317683.3
FBXO46
F-box protein 46
chr14_-_54425475 0.53 ENST00000559642.1
BMP4
bone morphogenetic protein 4
chr16_+_87636474 0.52 ENST00000284262.2
JPH3
junctophilin 3
chr7_+_130126012 0.51 ENST00000341441.5
MEST
mesoderm specific transcript
chr20_+_42187608 0.43 ENST00000373100.1
SGK2
serum/glucocorticoid regulated kinase 2
chr2_-_87248975 0.42 ENST00000409310.2
ENST00000355705.3
PLGLB1
plasminogen-like B1
chr17_-_26733179 0.41 ENST00000440501.1
ENST00000321666.5
SLC46A1
solute carrier family 46 (folate transporter), member 1
chr7_-_7575477 0.39 ENST00000399429.3
COL28A1
collagen, type XXVIII, alpha 1
chr7_+_130126165 0.36 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
MEST
mesoderm specific transcript
chrX_-_18690210 0.36 ENST00000379984.3
RS1
retinoschisin 1
chr17_-_39156138 0.35 ENST00000391587.1
KRTAP3-2
keratin associated protein 3-2
chr3_-_114477787 0.34 ENST00000464560.1
ZBTB20
zinc finger and BTB domain containing 20
chr7_+_150725510 0.34 ENST00000461373.1
ENST00000358849.4
ENST00000297504.6
ENST00000542328.1
ENST00000498578.1
ENST00000356058.4
ENST00000477719.1
ENST00000477092.1
ABCB8
ATP-binding cassette, sub-family B (MDR/TAP), member 8
chr2_+_105050794 0.34 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
AC013402.2
long intergenic non-protein coding RNA 1102
chr3_+_35722424 0.30 ENST00000396481.2
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr22_-_30642728 0.29 ENST00000403987.3
LIF
leukemia inhibitory factor
chr3_+_35722487 0.28 ENST00000441454.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr5_+_60933634 0.28 ENST00000505642.1
C5orf64
chromosome 5 open reading frame 64
chr2_+_133174147 0.28 ENST00000329321.3
GPR39
G protein-coupled receptor 39
chr15_+_76352178 0.24 ENST00000388942.3
C15orf27
chromosome 15 open reading frame 27
chr14_+_39703112 0.24 ENST00000555143.1
ENST00000280082.3
MIA2
melanoma inhibitory activity 2
chr11_-_74800799 0.22 ENST00000305159.3
OR2AT4
olfactory receptor, family 2, subfamily AT, member 4
chr3_+_77088989 0.22 ENST00000461745.1
ROBO2
roundabout, axon guidance receptor, homolog 2 (Drosophila)
chrM_+_9207 0.21 ENST00000362079.2
MT-CO3
mitochondrially encoded cytochrome c oxidase III
chr11_+_8040739 0.20 ENST00000534099.1
TUB
tubby bipartite transcription factor
chr12_+_53835508 0.19 ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
ENST00000541275.1
PRR13
PCBP2
proline rich 13
poly(rC) binding protein 2
chr5_+_140625147 0.19 ENST00000231173.3
PCDHB15
protocadherin beta 15
chr2_+_190541153 0.19 ENST00000313581.4
ENST00000438402.2
ENST00000431575.2
ENST00000281412.6
ANKAR
ankyrin and armadillo repeat containing
chr1_+_170632250 0.18 ENST00000367760.3
PRRX1
paired related homeobox 1
chrM_+_10053 0.16 ENST00000361227.2
MT-ND3
mitochondrially encoded NADH dehydrogenase 3
chrX_+_9431324 0.16 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr12_+_131438443 0.16 ENST00000261654.5
GPR133
G protein-coupled receptor 133
chr6_-_116447283 0.16 ENST00000452729.1
ENST00000243222.4
COL10A1
collagen, type X, alpha 1
chr6_-_152793728 0.16 ENST00000495090.2
SYNE1
spectrin repeat containing, nuclear envelope 1
chr19_+_926000 0.16 ENST00000263620.3
ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chr7_+_100026406 0.16 ENST00000414441.1
MEPCE
methylphosphate capping enzyme
chr8_+_98900132 0.15 ENST00000520016.1
MATN2
matrilin 2
chr14_-_83262540 0.15 ENST00000554451.1
RP11-11K13.1
RP11-11K13.1
chr7_+_48211048 0.15 ENST00000435803.1
ABCA13
ATP-binding cassette, sub-family A (ABC1), member 13
chr22_-_30722912 0.15 ENST00000215790.7
TBC1D10A
TBC1 domain family, member 10A
chr12_-_2944184 0.14 ENST00000337508.4
NRIP2
nuclear receptor interacting protein 2
chr6_-_31681839 0.14 ENST00000409239.1
ENST00000461287.1
LY6G6E
XXbac-BPG32J3.20
lymphocyte antigen 6 complex, locus G6E (pseudogene)
Uncharacterized protein
chr12_-_11184006 0.13 ENST00000390675.2
TAS2R31
taste receptor, type 2, member 31
chr2_-_40680578 0.13 ENST00000455476.1
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr20_-_21494654 0.13 ENST00000377142.4
NKX2-2
NK2 homeobox 2
chrY_-_20935572 0.13 ENST00000382852.1
ENST00000344884.4
ENST00000304790.3
HSFY2
heat shock transcription factor, Y linked 2
chr6_+_161123270 0.12 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG
plasminogen
chr6_+_25754927 0.12 ENST00000377905.4
ENST00000439485.2
SLC17A4
solute carrier family 17, member 4
chr4_-_68829226 0.12 ENST00000396188.2
TMPRSS11A
transmembrane protease, serine 11A
chrY_+_20708557 0.11 ENST00000307393.2
ENST00000309834.4
ENST00000382856.2
HSFY1
heat shock transcription factor, Y-linked 1
chr9_-_95298254 0.11 ENST00000444490.2
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr3_+_46919235 0.11 ENST00000449590.1
PTH1R
parathyroid hormone 1 receptor
chr4_-_69111401 0.11 ENST00000332644.5
TMPRSS11B
transmembrane protease, serine 11B
chr16_-_15474904 0.11 ENST00000534094.1
NPIPA5
nuclear pore complex interacting protein family, member A5
chr1_-_160549235 0.10 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
CD84
CD84 molecule
chr9_+_44868935 0.10 ENST00000448436.2
RP11-160N1.10
RP11-160N1.10
chr20_-_7921090 0.09 ENST00000378789.3
HAO1
hydroxyacid oxidase (glycolate oxidase) 1
chr6_-_32374900 0.09 ENST00000374995.3
ENST00000374993.1
ENST00000414363.1
ENST00000540315.1
ENST00000544175.1
ENST00000429232.2
ENST00000454136.3
ENST00000446536.2
BTNL2
butyrophilin-like 2 (MHC class II associated)
chr12_+_80750134 0.08 ENST00000546620.1
OTOGL
otogelin-like
chr4_+_3443614 0.08 ENST00000382774.3
ENST00000511533.1
HGFAC
HGF activator
chr6_-_161085291 0.07 ENST00000316300.5
LPA
lipoprotein, Lp(a)
chr11_+_22696314 0.06 ENST00000532398.1
ENST00000433790.1
GAS2
growth arrest-specific 2
chr9_-_215744 0.06 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr7_+_143806607 0.06 ENST00000408979.2
OR2A2
olfactory receptor, family 2, subfamily A, member 2
chr3_-_49066811 0.05 ENST00000442157.1
ENST00000326739.4
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr12_-_10321754 0.05 ENST00000539518.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chr4_-_149365827 0.04 ENST00000344721.4
NR3C2
nuclear receptor subfamily 3, group C, member 2
chr1_+_63063152 0.04 ENST00000371129.3
ANGPTL3
angiopoietin-like 3
chr12_-_91546926 0.04 ENST00000550758.1
DCN
decorin
chr1_-_168464875 0.03 ENST00000422253.1
RP5-968D22.3
RP5-968D22.3
chr22_-_22337204 0.03 ENST00000430142.1
ENST00000357179.5
TOP3B
topoisomerase (DNA) III beta
chr1_-_247921982 0.03 ENST00000408896.2
OR1C1
olfactory receptor, family 1, subfamily C, member 1
chr9_-_95298314 0.03 ENST00000344604.5
ENST00000375540.1
ECM2
extracellular matrix protein 2, female organ and adipocyte specific
chr12_+_59989918 0.02 ENST00000547379.1
ENST00000549465.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr14_+_23709555 0.02 ENST00000430154.2
C14orf164
chromosome 14 open reading frame 164
chr14_-_104408645 0.02 ENST00000557640.1
RD3L
retinal degeneration 3-like
chr5_+_118690466 0.02 ENST00000503646.1
TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr11_-_58378759 0.01 ENST00000601906.1
AP001350.1
Uncharacterized protein
chr14_+_95027772 0.01 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_-_100356551 0.00 ENST00000209665.4
ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr12_+_59989791 0.00 ENST00000552432.1
SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr8_+_92114060 0.00 ENST00000518304.1
LRRC69
leucine rich repeat containing 69

Network of associatons between targets according to the STRING database.

First level regulatory network of ZFHX3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.9 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.3 1.8 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
0.3 1.9 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.3 0.8 GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor(GO:0002416)
0.2 3.0 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 1.0 GO:0036509 trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.2 1.9 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1 0.5 GO:2000007 apoptotic process involved in endocardial cushion morphogenesis(GO:0003277) intermediate mesoderm morphogenesis(GO:0048390) intermediate mesoderm formation(GO:0048391) intermediate mesodermal cell differentiation(GO:0048392) regulation of cardiac muscle fiber development(GO:0055018) positive regulation of cardiac muscle fiber development(GO:0055020) bud dilation involved in lung branching(GO:0060503) BMP signaling pathway involved in ureter morphogenesis(GO:0061149) renal system segmentation(GO:0061150) BMP signaling pathway involved in renal system segmentation(GO:0061151) pulmonary artery endothelial tube morphogenesis(GO:0061155) regulation of transcription from RNA polymerase II promoter involved in mesonephros development(GO:0061216) BMP signaling pathway involved in nephric duct formation(GO:0071893) negative regulation of branch elongation involved in ureteric bud branching(GO:0072096) negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway(GO:0072097) anterior/posterior pattern specification involved in ureteric bud development(GO:0072099) specification of ureteric bud anterior/posterior symmetry(GO:0072100) specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway(GO:0072101) ureter epithelial cell differentiation(GO:0072192) negative regulation of mesenchymal cell proliferation involved in ureter development(GO:0072200) positive regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901964) cardiac jelly development(GO:1905072) regulation of metanephric S-shaped body morphogenesis(GO:2000004) negative regulation of metanephric S-shaped body morphogenesis(GO:2000005) regulation of metanephric comma-shaped body morphogenesis(GO:2000006) negative regulation of metanephric comma-shaped body morphogenesis(GO:2000007)
0.1 1.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.4 GO:0036367 adaptation of rhodopsin mediated signaling(GO:0016062) light adaption(GO:0036367)
0.1 0.4 GO:0051958 methotrexate transport(GO:0051958)
0.1 0.3 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.0 0.1 GO:0021530 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0 1.8 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.2 GO:0061364 negative regulation of negative chemotaxis(GO:0050925) apoptotic process involved in luteolysis(GO:0061364)
0.0 0.1 GO:0009441 glycolate metabolic process(GO:0009441)
0.0 0.8 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 0.1 GO:0032661 regulation of interleukin-18 production(GO:0032661)
0.0 0.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
0.0 0.2 GO:0048664 neuron fate determination(GO:0048664)
0.0 0.1 GO:0046373 arabinose metabolic process(GO:0019566) L-arabinose metabolic process(GO:0046373)
0.0 0.2 GO:0040031 snRNA modification(GO:0040031)
0.0 0.5 GO:0035640 exploration behavior(GO:0035640)
0.0 0.1 GO:0098735 positive regulation of the force of heart contraction(GO:0098735)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.8 GO:0071062 rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.2 1.8 GO:0005579 membrane attack complex(GO:0005579)
0.2 3.0 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.9 GO:0031089 platelet dense granule lumen(GO:0031089)
0.0 0.5 GO:0030314 junctional membrane complex(GO:0030314)
0.0 0.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.0 0.1 GO:0044279 other organism cell membrane(GO:0044218) other organism membrane(GO:0044279)
0.0 1.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.2 GO:0045277 respiratory chain complex IV(GO:0045277)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.9 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.4 1.9 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.3 3.9 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.2 0.8 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.8 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.1 0.3 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
0.1 0.4 GO:0015350 methotrexate transporter activity(GO:0015350)
0.1 1.0 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 1.8 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:1904854 proteasome core complex binding(GO:1904854)
0.0 1.8 GO:0008009 chemokine activity(GO:0008009)
0.0 0.5 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.1 GO:0070052 collagen V binding(GO:0070052)
0.0 1.0 GO:0017081 chloride channel regulator activity(GO:0017081)
0.0 0.1 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 0.2 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.0 0.8 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.1 GO:0004991 parathyroid hormone receptor activity(GO:0004991)
0.0 0.2 GO:0008046 axon guidance receptor activity(GO:0008046)
0.0 0.5 GO:0015278 calcium-release channel activity(GO:0015278) ligand-gated calcium channel activity(GO:0099604)
0.0 0.4 GO:0070492 phosphatidylinositol-5-phosphate binding(GO:0010314) oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0099580 ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0 0.1 GO:0046556 alpha-L-arabinofuranosidase activity(GO:0046556)
0.0 0.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.8 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.0 1.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.1 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 3.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.0 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 1.7 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 1.8 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling