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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZIC1

Z-value: 0.90

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Transcription factors associated with ZIC1

Gene Symbol Gene ID Gene Info
ZIC1
ENSG00000152977.5 Zic family member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC1hg19_v2_chr3_+_147127142_1471271710.262.6e-01Click!

Activity profile of ZIC1 motif

Sorted Z-values of ZIC1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_107880508 3.93 ENST00000425651.2
NRCAM
neuronal cell adhesion molecule
chr11_+_67777751 3.56 ENST00000316367.6
ENST00000007633.8
ENST00000342456.6
ALDH3B1
aldehyde dehydrogenase 3 family, member B1
chr19_+_50169081 2.66 ENST00000246784.3
BCL2L12
BCL2-like 12 (proline rich)
chr3_+_14444063 2.51 ENST00000454876.2
ENST00000360861.3
ENST00000416216.2
SLC6A6
solute carrier family 6 (neurotransmitter transporter), member 6
chr17_-_43045439 2.12 ENST00000253407.3
C1QL1
complement component 1, q subcomponent-like 1
chr2_+_120189422 2.04 ENST00000306406.4
TMEM37
transmembrane protein 37
chr16_+_30996502 1.99 ENST00000353250.5
ENST00000262520.6
ENST00000297679.5
ENST00000562932.1
ENST00000574447.1
HSD3B7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
chr7_-_73256838 1.99 ENST00000297873.4
WBSCR27
Williams Beuren syndrome chromosome region 27
chr13_-_100624012 1.96 ENST00000267294.4
ZIC5
Zic family member 5
chr11_-_74022658 1.90 ENST00000427714.2
ENST00000331597.4
P4HA3
prolyl 4-hydroxylase, alpha polypeptide III
chr11_+_22646739 1.87 ENST00000428556.2
AC103801.2
AC103801.2
chr17_+_60704762 1.81 ENST00000303375.5
MRC2
mannose receptor, C type 2
chr16_+_771663 1.76 ENST00000568916.1
FAM173A
family with sequence similarity 173, member A
chr17_-_3794021 1.72 ENST00000381769.2
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr7_-_107968999 1.52 ENST00000456431.1
NRCAM
neuronal cell adhesion molecule
chr11_-_559377 1.41 ENST00000486629.1
C11orf35
chromosome 11 open reading frame 35
chr16_+_67312049 1.38 ENST00000565899.1
PLEKHG4
pleckstrin homology domain containing, family G (with RhoGef domain) member 4
chr19_+_34287751 1.30 ENST00000590771.1
ENST00000589786.1
ENST00000284006.6
ENST00000588881.1
KCTD15
potassium channel tetramerization domain containing 15
chr16_-_67427389 1.27 ENST00000562206.1
ENST00000290942.5
ENST00000393957.2
TPPP3
tubulin polymerization-promoting protein family member 3
chr3_+_71803201 1.24 ENST00000304411.2
GPR27
G protein-coupled receptor 27
chr9_-_123639445 1.23 ENST00000312189.6
PHF19
PHD finger protein 19
chr16_-_2379688 1.15 ENST00000567910.1
ABCA3
ATP-binding cassette, sub-family A (ABC1), member 3
chrX_+_18725758 1.14 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
PPEF1
protein phosphatase, EF-hand calcium binding domain 1
chr7_-_107968921 1.11 ENST00000442580.1
NRCAM
neuronal cell adhesion molecule
chr15_+_80351910 1.09 ENST00000261749.6
ENST00000561060.1
ZFAND6
zinc finger, AN1-type domain 6
chr19_-_2740036 1.05 ENST00000586572.1
ENST00000269740.4
AC006538.4
SLC39A3
Uncharacterized protein
solute carrier family 39 (zinc transporter), member 3
chr14_-_65409502 1.04 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr10_-_33623564 1.04 ENST00000374875.1
ENST00000374822.4
NRP1
neuropilin 1
chr19_+_39647271 1.03 ENST00000599657.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr16_+_838614 1.01 ENST00000262315.9
ENST00000455171.2
CHTF18
CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)
chr2_-_46769694 1.00 ENST00000522587.1
ATP6V1E2
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E2
chr9_-_123639600 1.00 ENST00000373896.3
PHF19
PHD finger protein 19
chr1_-_244615425 0.99 ENST00000366535.3
ADSS
adenylosuccinate synthase
chr1_+_18958008 0.95 ENST00000420770.2
ENST00000400661.3
PAX7
paired box 7
chr17_-_3796334 0.95 ENST00000381771.2
ENST00000348335.2
ENST00000158166.5
CAMKK1
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr15_-_78112553 0.93 ENST00000562933.1
LINGO1
leucine rich repeat and Ig domain containing 1
chrX_+_70364667 0.92 ENST00000536169.1
ENST00000395855.2
ENST00000374051.3
ENST00000358741.3
NLGN3
neuroligin 3
chr12_-_106477805 0.89 ENST00000553094.1
ENST00000549704.1
NUAK1
NUAK family, SNF1-like kinase, 1
chr9_-_16870704 0.88 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2
basonuclin 2
chr8_+_25042192 0.88 ENST00000410074.1
DOCK5
dedicator of cytokinesis 5
chr10_-_33623826 0.84 ENST00000374867.2
NRP1
neuropilin 1
chr4_-_89444883 0.83 ENST00000273968.4
PYURF
PIGY upstream reading frame
chr19_+_42364460 0.81 ENST00000593863.1
RPS19
ribosomal protein S19
chr19_-_2739992 0.80 ENST00000545664.1
ENST00000589363.1
ENST00000455372.2
SLC39A3
solute carrier family 39 (zinc transporter), member 3
chr3_+_126243126 0.80 ENST00000319340.2
CHST13
carbohydrate (chondroitin 4) sulfotransferase 13
chr4_-_40632844 0.79 ENST00000505414.1
RBM47
RNA binding motif protein 47
chr11_+_208773 0.78 ENST00000528357.1
RIC8A
RIC8 guanine nucleotide exchange factor A
chr6_+_31730773 0.77 ENST00000415669.2
ENST00000425424.1
SAPCD1
suppressor APC domain containing 1
chr3_+_49027771 0.76 ENST00000475629.1
ENST00000444213.1
P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr8_-_144623595 0.73 ENST00000262577.5
ZC3H3
zinc finger CCCH-type containing 3
chr17_-_40428359 0.72 ENST00000293328.3
STAT5B
signal transducer and activator of transcription 5B
chr15_+_41245160 0.71 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr9_-_35103105 0.71 ENST00000452248.2
ENST00000356493.5
STOML2
stomatin (EPB72)-like 2
chrX_+_52926322 0.71 ENST00000430150.2
ENST00000452021.2
ENST00000412319.1
FAM156B
family with sequence similarity 156, member B
chr21_+_45148735 0.71 ENST00000327574.4
PDXK
pyridoxal (pyridoxine, vitamin B6) kinase
chr11_-_22647350 0.69 ENST00000327470.3
FANCF
Fanconi anemia, complementation group F
chr3_+_148847371 0.68 ENST00000296051.2
ENST00000460120.1
HPS3
Hermansky-Pudlak syndrome 3
chr7_-_37026108 0.68 ENST00000396045.3
ELMO1
engulfment and cell motility 1
chr5_+_140514782 0.65 ENST00000231134.5
PCDHB5
protocadherin beta 5
chr15_+_85523671 0.65 ENST00000310298.4
ENST00000557957.1
PDE8A
phosphodiesterase 8A
chr2_+_46769798 0.63 ENST00000238738.4
RHOQ
ras homolog family member Q
chr2_-_74779744 0.62 ENST00000409249.1
LOXL3
lysyl oxidase-like 3
chr7_-_4877677 0.61 ENST00000538469.1
RADIL
Ras association and DIL domains
chr1_+_89990431 0.60 ENST00000330947.2
ENST00000358200.4
LRRC8B
leucine rich repeat containing 8 family, member B
chr10_-_33624002 0.60 ENST00000432372.2
NRP1
neuropilin 1
chr4_+_14113592 0.58 ENST00000502759.1
ENST00000511200.1
ENST00000512754.1
ENST00000506739.1
LINC01085
long intergenic non-protein coding RNA 1085
chrX_+_46771711 0.58 ENST00000424392.1
ENST00000397189.1
PHF16
jade family PHD finger 3
chr17_+_5981270 0.57 ENST00000571973.1
WSCD1
WSC domain containing 1
chr10_-_64028466 0.57 ENST00000395265.1
ENST00000373789.3
ENST00000395260.3
RTKN2
rhotekin 2
chr22_-_30953587 0.56 ENST00000453479.1
GAL3ST1
galactose-3-O-sulfotransferase 1
chr15_+_77713222 0.56 ENST00000558176.1
HMG20A
high mobility group 20A
chr2_+_54951679 0.55 ENST00000356458.6
EML6
echinoderm microtubule associated protein like 6
chr7_+_29874341 0.55 ENST00000409290.1
ENST00000242140.5
WIPF3
WAS/WASL interacting protein family, member 3
chr13_-_30160925 0.53 ENST00000450494.1
SLC7A1
solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
chr14_-_65409438 0.53 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chrX_+_153770421 0.52 ENST00000369609.5
ENST00000369607.1
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chrX_+_77166172 0.51 ENST00000343533.5
ENST00000350425.4
ENST00000341514.6
ATP7A
ATPase, Cu++ transporting, alpha polypeptide
chr16_-_31100284 0.51 ENST00000280606.6
PRSS53
protease, serine, 53
chr4_+_95917383 0.51 ENST00000512312.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr14_+_57735614 0.50 ENST00000261558.3
AP5M1
adaptor-related protein complex 5, mu 1 subunit
chr6_+_44187242 0.49 ENST00000393844.1
SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr12_-_11036844 0.49 ENST00000428168.2
PRH1
proline-rich protein HaeIII subfamily 1
chr22_+_29702572 0.48 ENST00000407647.2
ENST00000416823.1
ENST00000428622.1
GAS2L1
growth arrest-specific 2 like 1
chrX_+_46771848 0.48 ENST00000218343.4
PHF16
jade family PHD finger 3
chr11_-_62689046 0.48 ENST00000306960.3
ENST00000543973.1
CHRM1
cholinergic receptor, muscarinic 1
chr2_-_97534312 0.47 ENST00000442264.1
SEMA4C
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chrX_+_24711997 0.46 ENST00000379068.3
ENST00000379059.3
POLA1
polymerase (DNA directed), alpha 1, catalytic subunit
chrX_-_129299638 0.46 ENST00000535724.1
ENST00000346424.2
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr16_-_4665023 0.45 ENST00000591897.1
UBALD1
UBA-like domain containing 1
chr1_+_89990378 0.45 ENST00000449440.1
LRRC8B
leucine rich repeat containing 8 family, member B
chr19_+_55987998 0.45 ENST00000591164.1
ZNF628
zinc finger protein 628
chr19_+_38880695 0.45 ENST00000587947.1
ENST00000338502.4
SPRED3
sprouty-related, EVH1 domain containing 3
chrX_-_129299847 0.44 ENST00000319908.3
ENST00000287295.3
AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
chr4_+_2626988 0.44 ENST00000509050.1
FAM193A
family with sequence similarity 193, member A
chr10_-_36813162 0.44 ENST00000440465.1
NAMPTL
nicotinamide phosphoribosyltransferase-like
chr17_-_62208169 0.44 ENST00000606895.1
ERN1
endoplasmic reticulum to nucleus signaling 1
chr4_-_40632140 0.43 ENST00000514782.1
RBM47
RNA binding motif protein 47
chr3_+_49057876 0.43 ENST00000326912.4
NDUFAF3
NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr19_+_54024251 0.43 ENST00000253144.9
ZNF331
zinc finger protein 331
chr1_-_211307315 0.42 ENST00000271751.4
KCNH1
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr22_+_46972975 0.41 ENST00000431155.1
GRAMD4
GRAM domain containing 4
chr7_-_65113280 0.40 ENST00000593865.1
AC104057.1
Protein LOC100996407
chr19_-_3028354 0.40 ENST00000586422.1
TLE2
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr17_-_56609302 0.39 ENST00000581607.1
ENST00000317256.6
ENST00000426861.1
ENST00000580809.1
ENST00000577729.1
ENST00000583291.1
SEPT4
septin 4
chr15_+_63340553 0.39 ENST00000334895.5
TPM1
tropomyosin 1 (alpha)
chr16_+_3185125 0.39 ENST00000576416.1
ZNF213
zinc finger protein 213
chr11_+_64002292 0.39 ENST00000426086.2
VEGFB
vascular endothelial growth factor B
chr6_-_3912207 0.38 ENST00000566733.1
RP1-140K8.5
RP1-140K8.5
chr11_+_7598239 0.37 ENST00000525597.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr17_-_39203519 0.37 ENST00000542137.1
ENST00000391419.3
KRTAP2-1
keratin associated protein 2-1
chr17_-_5372229 0.37 ENST00000433302.3
DHX33
DEAH (Asp-Glu-Ala-His) box polypeptide 33
chr2_-_74780176 0.36 ENST00000409549.1
LOXL3
lysyl oxidase-like 3
chr17_-_67057047 0.36 ENST00000495634.1
ENST00000453985.2
ENST00000585714.1
ABCA9
ATP-binding cassette, sub-family A (ABC1), member 9
chr16_-_4664860 0.36 ENST00000587615.1
ENST00000587649.1
ENST00000590965.1
ENST00000591401.1
ENST00000283474.7
UBALD1
UBA-like domain containing 1
chr19_-_6433765 0.35 ENST00000321510.6
SLC25A41
solute carrier family 25, member 41
chr4_-_40632881 0.35 ENST00000511598.1
RBM47
RNA binding motif protein 47
chr22_+_41956767 0.35 ENST00000306149.7
CSDC2
cold shock domain containing C2, RNA binding
chr14_+_101361107 0.34 ENST00000553584.1
ENST00000554852.1
MEG8
maternally expressed 8 (non-protein coding)
chr20_+_61924532 0.34 ENST00000358894.6
ENST00000326996.6
ENST00000435874.1
COL20A1
collagen, type XX, alpha 1
chr15_+_73976715 0.34 ENST00000558689.1
ENST00000560786.2
ENST00000561213.1
ENST00000563584.1
ENST00000561416.1
CD276
CD276 molecule
chr17_-_61778528 0.34 ENST00000584645.1
LIMD2
LIM domain containing 2
chr11_-_57417367 0.33 ENST00000534810.1
YPEL4
yippee-like 4 (Drosophila)
chr14_+_57735636 0.32 ENST00000556995.1
AP5M1
adaptor-related protein complex 5, mu 1 subunit
chr3_+_32859510 0.32 ENST00000383763.5
TRIM71
tripartite motif containing 71, E3 ubiquitin protein ligase
chr1_-_231004220 0.31 ENST00000366663.5
C1orf198
chromosome 1 open reading frame 198
chr1_+_1567474 0.29 ENST00000356026.5
MMP23B
matrix metallopeptidase 23B
chr17_+_37894570 0.29 ENST00000394211.3
GRB7
growth factor receptor-bound protein 7
chr1_-_1711508 0.29 ENST00000378625.1
NADK
NAD kinase
chr1_+_233749739 0.28 ENST00000366621.3
KCNK1
potassium channel, subfamily K, member 1
chr4_+_95916947 0.27 ENST00000506363.1
BMPR1B
bone morphogenetic protein receptor, type IB
chr8_-_22526597 0.27 ENST00000519513.1
ENST00000276416.6
ENST00000520292.1
ENST00000522268.1
BIN3
bridging integrator 3
chr2_-_98280383 0.27 ENST00000289228.5
ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr10_+_60094735 0.26 ENST00000373910.4
UBE2D1
ubiquitin-conjugating enzyme E2D 1
chr17_-_53809473 0.26 ENST00000575734.1
TMEM100
transmembrane protein 100
chr14_+_57735725 0.26 ENST00000431972.2
AP5M1
adaptor-related protein complex 5, mu 1 subunit
chr1_-_89641680 0.26 ENST00000294671.2
GBP7
guanylate binding protein 7
chr11_+_15095108 0.26 ENST00000324229.6
ENST00000533448.1
CALCB
calcitonin-related polypeptide beta
chr4_-_40632757 0.25 ENST00000511902.1
ENST00000505220.1
RBM47
RNA binding motif protein 47
chr12_+_27091387 0.25 ENST00000544111.1
FGFR1OP2
FGFR1 oncogene partner 2
chr2_+_7118755 0.24 ENST00000433456.1
RNF144A
ring finger protein 144A
chr2_-_142888573 0.23 ENST00000434794.1
LRP1B
low density lipoprotein receptor-related protein 1B
chr19_-_42931567 0.23 ENST00000244289.4
LIPE
lipase, hormone-sensitive
chr1_+_95699740 0.22 ENST00000429514.2
ENST00000263893.6
RWDD3
RWD domain containing 3
chr1_+_16348497 0.21 ENST00000439316.2
CLCNKA
chloride channel, voltage-sensitive Ka
chr11_-_57417405 0.21 ENST00000524669.1
ENST00000300022.3
YPEL4
yippee-like 4 (Drosophila)
chr3_-_53080047 0.21 ENST00000482396.1
ENST00000358080.2
ENST00000296295.6
ENST00000394752.3
SFMBT1
Scm-like with four mbt domains 1
chr4_+_66536248 0.21 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
RP11-807H7.1
chr17_-_5372068 0.21 ENST00000572490.1
DHX33
DEAH (Asp-Glu-Ala-His) box polypeptide 33
chr10_+_47658234 0.21 ENST00000447511.2
ENST00000537271.1
ANTXRL
anthrax toxin receptor-like
chr1_+_1567546 0.21 ENST00000378675.3
MMP23B
matrix metallopeptidase 23B
chr13_-_29069232 0.21 ENST00000282397.4
ENST00000541932.1
ENST00000539099.1
FLT1
fms-related tyrosine kinase 1
chr19_+_42773371 0.20 ENST00000571942.2
CIC
capicua transcriptional repressor
chr16_+_2255841 0.20 ENST00000301725.7
MLST8
MTOR associated protein, LST8 homolog (S. cerevisiae)
chr1_+_16348366 0.20 ENST00000375692.1
ENST00000420078.1
CLCNKA
chloride channel, voltage-sensitive Ka
chr17_-_5372271 0.20 ENST00000225296.3
DHX33
DEAH (Asp-Glu-Ala-His) box polypeptide 33
chr19_-_50168962 0.19 ENST00000599223.1
ENST00000593922.1
ENST00000600022.1
ENST00000596765.1
ENST00000599144.1
ENST00000596822.1
ENST00000598108.1
ENST00000601373.1
ENST00000595034.1
ENST00000601291.1
IRF3
interferon regulatory factor 3
chr7_-_135412925 0.19 ENST00000354042.4
SLC13A4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr19_+_10563567 0.18 ENST00000344979.3
PDE4A
phosphodiesterase 4A, cAMP-specific
chr1_+_161087873 0.18 ENST00000368009.2
ENST00000368007.4
ENST00000368008.1
ENST00000392190.5
NIT1
nitrilase 1
chr9_-_79267432 0.18 ENST00000424866.1
PRUNE2
prune homolog 2 (Drosophila)
chr17_-_6947225 0.18 ENST00000574600.1
ENST00000308009.1
ENST00000447225.1
SLC16A11
solute carrier family 16, member 11
chr15_+_77712993 0.18 ENST00000336216.4
ENST00000381714.3
ENST00000558651.1
HMG20A
high mobility group 20A
chr3_-_58563094 0.17 ENST00000464064.1
FAM107A
family with sequence similarity 107, member A
chr4_-_40632605 0.16 ENST00000514014.1
RBM47
RNA binding motif protein 47
chr17_+_40458130 0.16 ENST00000587646.1
STAT5A
signal transducer and activator of transcription 5A
chr22_-_24622080 0.16 ENST00000425408.1
GGT5
gamma-glutamyltransferase 5
chr1_+_207039154 0.16 ENST00000367096.3
ENST00000391930.2
IL20
interleukin 20
chr3_+_141105705 0.16 ENST00000513258.1
ZBTB38
zinc finger and BTB domain containing 38
chr7_-_102789629 0.15 ENST00000417955.1
ENST00000341533.4
ENST00000425379.1
NAPEPLD
N-acyl phosphatidylethanolamine phospholipase D
chr4_-_66536057 0.15 ENST00000273854.3
EPHA5
EPH receptor A5
chrX_+_46772065 0.14 ENST00000455411.1
PHF16
jade family PHD finger 3
chr1_-_204436344 0.14 ENST00000367184.2
PIK3C2B
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
chr6_+_41755389 0.14 ENST00000398884.3
ENST00000398881.3
TOMM6
translocase of outer mitochondrial membrane 6 homolog (yeast)
chr2_-_68546530 0.13 ENST00000409559.3
CNRIP1
cannabinoid receptor interacting protein 1
chr10_-_101945771 0.13 ENST00000370408.2
ENST00000407654.3
ERLIN1
ER lipid raft associated 1
chr5_-_64920115 0.13 ENST00000381018.3
ENST00000274327.7
TRIM23
tripartite motif containing 23
chr11_+_64001962 0.13 ENST00000309422.2
VEGFB
vascular endothelial growth factor B
chrY_+_4868267 0.13 ENST00000333703.4
PCDH11Y
protocadherin 11 Y-linked
chr22_-_23922410 0.13 ENST00000249053.3
IGLL1
immunoglobulin lambda-like polypeptide 1
chr7_+_2671663 0.13 ENST00000407643.1
TTYH3
tweety family member 3
chr15_+_96904487 0.13 ENST00000600790.1
AC087477.1
Uncharacterized protein
chr12_+_27091316 0.13 ENST00000229395.3
FGFR1OP2
FGFR1 oncogene partner 2
chr4_-_186733119 0.12 ENST00000419063.1
SORBS2
sorbin and SH3 domain containing 2
chr3_-_50329835 0.12 ENST00000429673.2
IFRD2
interferon-related developmental regulator 2
chr6_+_31540056 0.12 ENST00000418386.2
LTA
lymphotoxin alpha
chr2_+_90248739 0.12 ENST00000468879.1
IGKV1D-43
immunoglobulin kappa variable 1D-43
chrX_+_71354000 0.12 ENST00000510661.1
ENST00000535692.1
NHSL2
NHS-like 2
chr6_-_168720382 0.12 ENST00000610183.1
ENST00000607983.1
ENST00000366795.3
DACT2
dishevelled-binding antagonist of beta-catenin 2
chr4_-_66536196 0.12 ENST00000511294.1
EPHA5
EPH receptor A5
chr1_+_44870866 0.12 ENST00000355387.2
ENST00000361799.2
RNF220
ring finger protein 220
chr10_+_115469134 0.11 ENST00000452490.2
CASP7
caspase 7, apoptosis-related cysteine peptidase
chr17_-_7080883 0.11 ENST00000570576.1
ASGR1
asialoglycoprotein receptor 1
chr1_+_22963158 0.11 ENST00000438241.1
C1QA
complement component 1, q subcomponent, A chain
chr10_+_21823079 0.11 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr5_-_149516966 0.10 ENST00000517957.1
PDGFRB
platelet-derived growth factor receptor, beta polypeptide
chr1_+_22962948 0.10 ENST00000374642.3
C1QA
complement component 1, q subcomponent, A chain
chr4_-_121993673 0.10 ENST00000379692.4
NDNF
neuron-derived neurotrophic factor
chr11_-_73309228 0.10 ENST00000356467.4
ENST00000064778.4
FAM168A
family with sequence similarity 168, member A
chr5_+_112312454 0.09 ENST00000543319.1
DCP2
decapping mRNA 2
chr12_-_2966193 0.09 ENST00000382678.3
AC005841.1
Uncharacterized protein ENSP00000372125

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0099558 maintenance of synapse structure(GO:0099558)
0.5 2.5 GO:0061552 vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.4 1.2 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.4 6.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 0.7 GO:1901860 positive regulation of mitochondrial DNA metabolic process(GO:1901860)
0.2 0.7 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.2 3.6 GO:0046185 aldehyde catabolic process(GO:0046185)
0.2 0.8 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.2 1.0 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.2 1.0 GO:0018057 peptidyl-lysine oxidation(GO:0018057)
0.2 0.9 GO:0060024 rhythmic synaptic transmission(GO:0060024) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.2 2.3 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.2 2.0 GO:0035754 B cell chemotaxis(GO:0035754)
0.2 2.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.1 2.7 GO:2000773 negative regulation of cellular senescence(GO:2000773)
0.1 0.9 GO:0000255 allantoin metabolic process(GO:0000255)
0.1 0.9 GO:0090650 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
0.1 0.5 GO:0071284 cellular response to lead ion(GO:0071284)
0.1 1.0 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.1 0.5 GO:0006272 leading strand elongation(GO:0006272)
0.1 0.8 GO:0048165 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.1 0.9 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.1 0.5 GO:0015862 uridine transport(GO:0015862)
0.1 1.0 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.1 0.7 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.1 0.3 GO:0014839 myoblast migration involved in skeletal muscle regeneration(GO:0014839)
0.1 1.9 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.1 0.5 GO:0003056 regulation of vascular smooth muscle contraction(GO:0003056)
0.1 0.4 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.1 0.9 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 0.5 GO:1903826 arginine transmembrane transport(GO:1903826)
0.1 0.1 GO:0002874 regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) positive regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002925)
0.1 0.5 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 0.3 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
0.0 0.4 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.0 0.4 GO:1901142 insulin metabolic process(GO:1901142)
0.0 0.4 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 2.7 GO:0072348 sulfur compound transport(GO:0072348)
0.0 0.2 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.0 0.6 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.0 1.8 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.3 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.1 GO:0060981 cell migration involved in coronary angiogenesis(GO:0060981)
0.0 0.8 GO:0042074 cell migration involved in gastrulation(GO:0042074)
0.0 1.1 GO:0072662 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 1.1 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 0.7 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.2 GO:1903998 regulation of eating behavior(GO:1903998)
0.0 1.0 GO:0090383 phagosome acidification(GO:0090383)
0.0 0.1 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.0 0.3 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.0 0.9 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.4 GO:0015866 ADP transport(GO:0015866)
0.0 0.5 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.3 GO:0060842 arterial endothelial cell differentiation(GO:0060842)
0.0 0.8 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.1 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.0 0.7 GO:1903206 negative regulation of hydrogen peroxide-induced cell death(GO:1903206)
0.0 1.8 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.4 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.0 0.7 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.8 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.3 GO:1902916 positive regulation of protein polyubiquitination(GO:1902916)
0.0 0.8 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 0.3 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0 0.1 GO:0072733 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.0 0.3 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.8 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.0 0.2 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0 0.7 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.2 GO:0045618 positive regulation of keratinocyte differentiation(GO:0045618)
0.0 0.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.2 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.3 1.1 GO:0044301 climbing fiber(GO:0044301)
0.2 2.5 GO:0097443 sorting endosome(GO:0097443)
0.2 5.7 GO:0043194 axon initial segment(GO:0043194)
0.2 0.7 GO:0031084 BLOC-2 complex(GO:0031084)
0.1 0.4 GO:1990597 AIP1-IRE1 complex(GO:1990597)
0.1 0.6 GO:0005874 microtubule(GO:0005874)
0.1 1.0 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.1 0.2 GO:0005602 complement component C1 complex(GO:0005602)
0.1 0.5 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.1 0.7 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 0.3 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.1 0.8 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 2.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 1.0 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.7 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0 0.4 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.1 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.7 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.4 GO:0097227 sperm annulus(GO:0097227)
0.0 0.4 GO:0032059 bleb(GO:0032059)
0.0 3.6 GO:0035579 specific granule membrane(GO:0035579)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.9 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.2 2.0 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 6.6 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 0.7 GO:0008478 pyridoxal kinase activity(GO:0008478)
0.2 1.9 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.2 3.6 GO:0004028 3-chloroallyl aldehyde dehydrogenase activity(GO:0004028) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.2 2.6 GO:0038085 vascular endothelial growth factor binding(GO:0038085)
0.2 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.1 0.5 GO:0016532 superoxide dismutase copper chaperone activity(GO:0016532) copper-dependent protein binding(GO:0032767)
0.1 0.8 GO:0047756 chondroitin 4-sulfotransferase activity(GO:0047756)
0.1 1.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.1 0.5 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.1 1.0 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.1 1.0 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1 0.5 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 2.3 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.1 0.2 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.1 0.2 GO:0045518 interleukin-22 receptor binding(GO:0045518)
0.1 0.5 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.8 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.1 0.9 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.5 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
0.1 0.7 GO:1901612 cardiolipin binding(GO:1901612)
0.1 0.4 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.8 GO:0000182 rDNA binding(GO:0000182)
0.0 1.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 1.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.0 0.6 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 1.8 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 2.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.9 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.2 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.0 1.0 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 3.5 GO:0002039 p53 binding(GO:0002039)
0.0 0.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.8 GO:0031418 L-ascorbic acid binding(GO:0031418)
0.0 2.3 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.8 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.1 GO:0032427 GBD domain binding(GO:0032427)
0.0 1.0 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.0 0.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 0.2 GO:0004534 5'-3' exoribonuclease activity(GO:0004534)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 0.3 GO:0035198 miRNA binding(GO:0035198)
0.0 0.3 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 1.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0035005 lipid kinase activity(GO:0001727) 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.7 GO:0070412 R-SMAD binding(GO:0070412)
0.0 1.1 GO:0030145 manganese ion binding(GO:0030145)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.2 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 0.9 PID IL5 PATHWAY IL5-mediated signaling events
0.0 1.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.7 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 2.0 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.1 5.7 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 1.8 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.9 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 2.7 REACTOME POST NMDA RECEPTOR ACTIVATION EVENTS Genes involved in Post NMDA receptor activation events
0.0 0.5 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 0.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 1.0 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.0 0.5 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.0 1.8 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 1.0 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.2 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.7 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.8 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.3 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.0 0.5 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.7 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0 0.8 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex