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SARS-CoV-2 Analysis Results (GEO series: GSE147507)
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Results for ZIC3_ZIC4
Z-value: 1.00
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Transcription factors associated with ZIC3_ZIC4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZIC3 | hg19_v2_chrX_+_136648643_136648711 | 0.44 | 5.2e-02 | Click! |
| ZIC4 | hg19_v2_chr3_-_147124547_147124647 | 0.02 | 9.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZIC3_ZIC4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.2 | GO:0099558 | maintenance of synapse structure(GO:0099558) |
| 0.2 | 4.6 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 1.4 | 4.3 | GO:0017186 | peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186) |
| 0.8 | 4.1 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
| 0.1 | 3.5 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.2 | 3.2 | GO:0061087 | positive regulation of histone H3-K27 methylation(GO:0061087) |
| 0.8 | 3.1 | GO:0002432 | granuloma formation(GO:0002432) |
| 0.1 | 3.1 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.1 | 3.1 | GO:0072662 | protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663) |
| 0.4 | 3.0 | GO:0097473 | cellular response to high light intensity(GO:0071486) retinal rod cell apoptotic process(GO:0097473) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.7 | GO:0035580 | specific granule lumen(GO:0035580) |
| 1.3 | 5.2 | GO:0044301 | climbing fiber(GO:0044301) |
| 0.0 | 4.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 4.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 3.9 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 3.4 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.2 | 3.1 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.1 | 2.9 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 2.4 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.8 | 2.3 | GO:0098855 | HCN channel complex(GO:0098855) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 4.6 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 1.4 | 4.3 | GO:0016603 | glutaminyl-peptide cyclotransferase activity(GO:0016603) |
| 0.0 | 4.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 3.8 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 3.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) |
| 0.2 | 3.1 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.1 | 2.9 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 2.9 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.6 | 2.8 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.1 | 2.8 | GO:0003746 | translation elongation factor activity(GO:0003746) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.7 | PID MYC REPRESS PATHWAY | Validated targets of C-MYC transcriptional repression |
| 0.0 | 2.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 2.8 | SA TRKA RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.2 | 2.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 2.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 2.3 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 0.1 | 2.0 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.1 | 1.7 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.0 | 1.7 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 0.0 | 1.7 | ST T CELL SIGNAL TRANSDUCTION | T Cell Signal Transduction |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.6 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.0 | 3.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.4 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 3.4 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 3.1 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.1 | 2.9 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |
| 0.1 | 2.8 | REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS | Genes involved in Glycogen breakdown (glycogenolysis) |
| 0.2 | 2.6 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.1 | 2.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |
| 0.0 | 2.5 | REACTOME G ALPHA S SIGNALLING EVENTS | Genes involved in G alpha (s) signalling events |