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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZKSCAN3

Z-value: 0.58

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Transcription factors associated with ZKSCAN3

Gene Symbol Gene ID Gene Info
ZKSCAN3
ENSG00000189298.9 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZKSCAN3hg19_v2_chr6_+_28317685_28317761-0.483.2e-02Click!

Activity profile of ZKSCAN3 motif

Sorted Z-values of ZKSCAN3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_+_39786962 3.62 ENST00000333625.2
IFNL1
interferon, lambda 1
chrX_-_153775760 1.85 ENST00000440967.1
ENST00000393564.2
ENST00000369620.2
G6PD
glucose-6-phosphate dehydrogenase
chrX_-_153775426 1.72 ENST00000393562.2
G6PD
glucose-6-phosphate dehydrogenase
chr15_-_41624685 1.71 ENST00000560640.1
ENST00000220514.3
OIP5
Opa interacting protein 5
chr15_+_41624892 1.44 ENST00000260359.6
ENST00000450318.1
ENST00000450592.2
ENST00000559596.1
ENST00000414849.2
ENST00000560747.1
ENST00000560177.1
NUSAP1
nucleolar and spindle associated protein 1
chr1_+_66258846 1.43 ENST00000341517.4
PDE4B
phosphodiesterase 4B, cAMP-specific
chr19_-_39735646 1.40 ENST00000413851.2
IFNL3
interferon, lambda 3
chr17_+_18625336 1.28 ENST00000395671.4
ENST00000571542.1
ENST00000395672.2
ENST00000414850.2
ENST00000424146.2
TRIM16L
tripartite motif containing 16-like
chr19_+_39759154 1.14 ENST00000331982.5
IFNL2
interferon, lambda 2
chr10_+_6779326 1.14 ENST00000417112.1
RP11-554I8.2
RP11-554I8.2
chr18_-_74728998 1.00 ENST00000359645.3
ENST00000397875.3
ENST00000397869.3
ENST00000578193.1
ENST00000578873.1
ENST00000397866.4
ENST00000528160.1
ENST00000527041.1
ENST00000526111.1
ENST00000397865.5
ENST00000382582.3
MBP
myelin basic protein
chr2_+_191745560 0.96 ENST00000338435.4
GLS
glutaminase
chr2_-_167232484 0.91 ENST00000375387.4
ENST00000303354.6
ENST00000409672.1
SCN9A
sodium channel, voltage-gated, type IX, alpha subunit
chr16_-_1429010 0.72 ENST00000513783.1
UNKL
unkempt family zinc finger-like
chr7_-_37382683 0.71 ENST00000455879.1
ELMO1
engulfment and cell motility 1
chr16_-_28506840 0.64 ENST00000569430.1
CLN3
ceroid-lipofuscinosis, neuronal 3
chrX_+_153775869 0.61 ENST00000424839.1
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr1_-_935361 0.60 ENST00000484667.2
HES4
hes family bHLH transcription factor 4
chr7_+_155089486 0.56 ENST00000340368.4
ENST00000344756.4
ENST00000425172.1
ENST00000342407.5
INSIG1
insulin induced gene 1
chr17_+_36908984 0.55 ENST00000225426.4
ENST00000579088.1
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr5_+_65018017 0.51 ENST00000380985.5
ENST00000502464.1
NLN
neurolysin (metallopeptidase M3 family)
chrX_+_153775821 0.50 ENST00000263518.6
ENST00000470142.1
ENST00000393549.2
ENST00000455588.2
ENST00000369602.3
IKBKG
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr5_-_180235755 0.48 ENST00000502678.1
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr19_+_32836499 0.48 ENST00000311921.4
ENST00000544431.1
ENST00000355898.5
ZNF507
zinc finger protein 507
chr7_+_155090271 0.46 ENST00000476756.1
INSIG1
insulin induced gene 1
chr5_-_65017921 0.43 ENST00000381007.4
SGTB
small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta
chr11_-_64013288 0.42 ENST00000542235.1
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr14_-_80697396 0.42 ENST00000557010.1
DIO2
deiodinase, iodothyronine, type II
chr10_+_123922941 0.36 ENST00000360561.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr15_+_74610894 0.35 ENST00000558821.1
ENST00000268082.4
CCDC33
coiled-coil domain containing 33
chr12_+_109535373 0.33 ENST00000242576.2
UNG
uracil-DNA glycosylase
chr7_-_155089251 0.33 ENST00000609974.1
AC144652.1
AC144652.1
chr16_+_2479390 0.33 ENST00000397066.4
CCNF
cyclin F
chr22_-_28392227 0.33 ENST00000431039.1
TTC28
tetratricopeptide repeat domain 28
chr2_+_191745535 0.32 ENST00000320717.3
GLS
glutaminase
chr12_+_100867694 0.30 ENST00000392986.3
ENST00000549996.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr19_-_4182530 0.30 ENST00000601571.1
ENST00000601488.1
ENST00000305232.6
ENST00000381935.3
ENST00000337491.2
SIRT6
sirtuin 6
chr6_-_31508304 0.28 ENST00000376177.2
DDX39B
DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
chr11_-_67272794 0.28 ENST00000436757.2
ENST00000356404.3
PITPNM1
phosphatidylinositol transfer protein, membrane-associated 1
chr22_+_50312379 0.27 ENST00000407217.3
ENST00000403427.3
CRELD2
cysteine-rich with EGF-like domains 2
chr1_-_115259337 0.26 ENST00000369535.4
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
chr3_-_122512619 0.26 ENST00000383659.1
ENST00000306103.2
HSPBAP1
HSPB (heat shock 27kDa) associated protein 1
chr12_+_109535923 0.25 ENST00000336865.2
UNG
uracil-DNA glycosylase
chr17_+_32597232 0.25 ENST00000378569.2
ENST00000200307.4
ENST00000394627.1
ENST00000394630.3
CCL7
chemokine (C-C motif) ligand 7
chr22_+_50312316 0.23 ENST00000328268.4
CRELD2
cysteine-rich with EGF-like domains 2
chr12_+_100867486 0.23 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr13_-_111567353 0.23 ENST00000310847.4
ENST00000267339.2
ENST00000375758.5
ANKRD10
ankyrin repeat domain 10
chr11_+_66610883 0.22 ENST00000309657.3
ENST00000524506.1
RCE1
Ras converting CAAX endopeptidase 1
chr10_+_21823079 0.22 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
MLLT10
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
chr1_+_226250379 0.21 ENST00000366815.3
ENST00000366814.3
H3F3A
H3 histone, family 3A
chr17_-_62499334 0.20 ENST00000579996.1
DDX5
DEAD (Asp-Glu-Ala-Asp) box helicase 5
chr19_-_4182497 0.18 ENST00000597896.1
SIRT6
sirtuin 6
chr22_-_50312052 0.17 ENST00000330817.6
ALG12
ALG12, alpha-1,6-mannosyltransferase
chr17_-_60142609 0.16 ENST00000397786.2
MED13
mediator complex subunit 13
chr7_+_1084206 0.13 ENST00000444847.1
GPR146
G protein-coupled receptor 146
chr6_+_12749657 0.12 ENST00000406205.2
PHACTR1
phosphatase and actin regulator 1
chr11_-_64013663 0.10 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr1_-_86622421 0.10 ENST00000370571.2
COL24A1
collagen, type XXIV, alpha 1
chrX_+_23352133 0.10 ENST00000379361.4
PTCHD1
patched domain containing 1
chr16_-_4039001 0.09 ENST00000576936.1
ADCY9
adenylate cyclase 9
chr6_+_116850174 0.05 ENST00000416171.2
ENST00000368597.2
ENST00000452373.1
ENST00000405399.1
FAM26D
family with sequence similarity 26, member D
chr14_-_106069247 0.05 ENST00000479229.1
RP11-731F5.1
RP11-731F5.1
chr12_-_3982511 0.05 ENST00000427057.2
ENST00000228820.4
PARP11
poly (ADP-ribose) polymerase family, member 11
chr22_+_50312274 0.05 ENST00000404488.3
CRELD2
cysteine-rich with EGF-like domains 2
chr12_+_100867733 0.05 ENST00000546380.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr1_-_99470558 0.05 ENST00000370188.3
LPPR5
Lipid phosphate phosphatase-related protein type 5
chr19_-_42348692 0.04 ENST00000330743.3
ENST00000601246.1
LYPD4
LY6/PLAUR domain containing 4
chr19_+_52693259 0.03 ENST00000322088.6
ENST00000454220.2
ENST00000444322.2
ENST00000477989.1
PPP2R1A
protein phosphatase 2, regulatory subunit A, alpha
chrX_+_85403487 0.01 ENST00000373125.4
DACH2
dachshund homolog 2 (Drosophila)
chr1_-_19811132 0.00 ENST00000433834.1
CAPZB
capping protein (actin filament) muscle Z-line, beta

Network of associatons between targets according to the STRING database.

First level regulatory network of ZKSCAN3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 3.6 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.4 3.6 GO:0032696 negative regulation of interleukin-13 production(GO:0032696)
0.3 1.0 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.2 1.3 GO:0006543 glutamine catabolic process(GO:0006543)
0.2 1.0 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209)
0.2 0.6 GO:0035752 lysosomal lumen pH elevation(GO:0035752)
0.2 0.5 GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis(GO:0003245) histone H3-K9 deacetylation(GO:1990619)
0.1 0.6 GO:2001248 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.1 0.5 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1 1.4 GO:1901078 negative regulation of relaxation of muscle(GO:1901078) negative regulation of relaxation of cardiac muscle(GO:1901898)
0.1 0.2 GO:0071586 CAAX-box protein processing(GO:0071586) CAAX-box protein maturation(GO:0080120)
0.1 1.4 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.1 0.2 GO:0060623 pericentric heterochromatin assembly(GO:0031508) regulation of chromosome condensation(GO:0060623)
0.1 0.5 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.0 1.7 GO:0031055 chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0 0.3 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0 1.1 GO:0002385 mucosal immune response(GO:0002385)
0.0 0.9 GO:0048266 behavioral response to pain(GO:0048266)
0.0 0.6 GO:0045008 depyrimidination(GO:0045008)
0.0 0.3 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.4 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.3 GO:0010826 negative regulation of centrosome duplication(GO:0010826)
0.0 1.1 GO:0043276 anoikis(GO:0043276)
0.0 1.4 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.7 GO:0016601 Rac protein signal transduction(GO:0016601)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0032002 interleukin-28 receptor complex(GO:0032002)
0.3 1.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.5 GO:0031933 telomeric heterochromatin(GO:0031933)
0.1 1.0 GO:0033269 internode region of axon(GO:0033269)
0.1 1.7 GO:0010369 chromocenter(GO:0010369)
0.0 1.1 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 1.4 GO:0000930 gamma-tubulin complex(GO:0000930)
0.0 0.9 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.6 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.2 GO:0001740 Barr body(GO:0001740)
0.0 0.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 0.3 GO:0005688 U6 snRNP(GO:0005688)
0.0 1.4 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.6 GO:0005719 nuclear euchromatin(GO:0005719)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.6 GO:0004345 glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.2 1.1 GO:1990450 linear polyubiquitin binding(GO:1990450)
0.2 0.5 GO:0032129 histone deacetylase activity (H3-K9 specific)(GO:0032129) NAD-dependent histone deacetylase activity (H3-K9 specific)(GO:0046969)
0.2 1.3 GO:0004359 glutaminase activity(GO:0004359)
0.1 0.6 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
0.1 0.6 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.1 1.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.5 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.1 0.4 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 0.3 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
0.0 0.3 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.9 GO:0031402 sodium ion binding(GO:0031402)
0.0 1.4 GO:0043015 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) gamma-tubulin binding(GO:0043015)
0.0 0.2 GO:0035500 MH2 domain binding(GO:0035500)
0.0 6.2 GO:0005125 cytokine activity(GO:0005125)
0.0 0.3 GO:0008526 phosphatidylinositol transporter activity(GO:0008526)
0.0 0.6 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 0.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.0 0.7 PID IL8 CXCR2 PATHWAY IL8- and CXCR2-mediated signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.1 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.0 1.3 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.0 1.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 1.5 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 0.3 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.4 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.7 REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis