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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZNF274

Z-value: 0.64

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Transcription factors associated with ZNF274

Gene Symbol Gene ID Gene Info
ZNF274
ENSG00000171606.13 zinc finger protein 274

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF274hg19_v2_chr19_+_58694396_58694485-0.252.8e-01Click!

Activity profile of ZNF274 motif

Sorted Z-values of ZNF274 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr19_-_56109119 3.41 ENST00000587678.1
FIZ1
FLT3-interacting zinc finger 1
chr6_-_127780510 2.85 ENST00000487331.2
ENST00000483725.3
KIAA0408
KIAA0408
chr12_+_113344755 1.86 ENST00000550883.1
OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr8_-_19540266 1.79 ENST00000311540.4
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr8_-_19540086 1.78 ENST00000332246.6
CSGALNACT1
chondroitin sulfate N-acetylgalactosaminyltransferase 1
chr19_+_6887571 1.66 ENST00000250572.8
ENST00000381407.5
ENST00000312053.4
ENST00000450315.3
ENST00000381404.4
EMR1
egf-like module containing, mucin-like, hormone receptor-like 1
chr1_+_45205478 1.37 ENST00000452259.1
ENST00000372224.4
KIF2C
kinesin family member 2C
chr1_+_45205498 1.31 ENST00000372218.4
KIF2C
kinesin family member 2C
chr4_+_15704573 1.27 ENST00000265016.4
BST1
bone marrow stromal cell antigen 1
chr15_+_89164560 1.25 ENST00000379231.3
ENST00000559528.1
AEN
apoptosis enhancing nuclease
chr4_+_15704679 1.24 ENST00000382346.3
BST1
bone marrow stromal cell antigen 1
chr7_-_73038822 0.99 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
MLXIPL
MLX interacting protein-like
chr20_+_60174827 0.90 ENST00000543233.1
CDH4
cadherin 4, type 1, R-cadherin (retinal)
chr15_+_89164520 0.85 ENST00000332810.3
AEN
apoptosis enhancing nuclease
chrX_+_52920336 0.81 ENST00000452154.2
FAM156B
family with sequence similarity 156, member B
chr6_+_30687978 0.79 ENST00000327892.8
ENST00000435534.1
TUBB
tubulin, beta class I
chr16_+_29818857 0.74 ENST00000567444.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chr17_-_73636019 0.68 ENST00000580707.1
RECQL5
RecQ protein-like 5
chr12_-_89919965 0.63 ENST00000548729.1
POC1B-GALNT4
POC1B-GALNT4 readthrough
chr2_+_178977143 0.62 ENST00000286070.5
RBM45
RNA binding motif protein 45
chr2_+_9696028 0.59 ENST00000607241.1
RP11-214N9.1
RP11-214N9.1
chr19_+_46498704 0.59 ENST00000595358.1
ENST00000594672.1
ENST00000536603.1
CCDC61
coiled-coil domain containing 61
chr12_-_54653313 0.58 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chr16_+_29819096 0.58 ENST00000568411.1
ENST00000563012.1
ENST00000562557.1
MAZ
MYC-associated zinc finger protein (purine-binding transcription factor)
chrX_+_119737806 0.53 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chr3_-_38992052 0.46 ENST00000302328.3
ENST00000450244.1
ENST00000444237.2
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr12_-_89920030 0.39 ENST00000413530.1
ENST00000547474.1
GALNT4
POC1B-GALNT4
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
POC1B-GALNT4 readthrough
chr17_+_41132564 0.35 ENST00000361677.1
ENST00000589705.1
RUNDC1
RUN domain containing 1
chr18_+_9103957 0.34 ENST00000400033.1
NDUFV2
NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa
chr5_+_32531893 0.33 ENST00000512913.1
SUB1
SUB1 homolog (S. cerevisiae)
chr19_+_7584088 0.33 ENST00000394341.2
ZNF358
zinc finger protein 358
chr5_+_121465207 0.29 ENST00000296600.4
ZNF474
zinc finger protein 474
chr22_+_39353527 0.29 ENST00000249116.2
APOBEC3A
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
chr17_-_41132410 0.29 ENST00000409446.3
ENST00000453594.1
ENST00000409399.1
ENST00000421990.2
PTGES3L
PTGES3L-AARSD1
prostaglandin E synthase 3 (cytosolic)-like
PTGES3L-AARSD1 readthrough
chr19_+_41949054 0.28 ENST00000378187.2
C19orf69
chromosome 19 open reading frame 69
chr16_+_31470179 0.26 ENST00000538189.1
ENST00000268314.4
ARMC5
armadillo repeat containing 5
chr2_+_11864458 0.25 ENST00000396098.1
ENST00000396099.1
ENST00000425416.2
LPIN1
lipin 1
chr5_-_173043591 0.24 ENST00000285908.5
ENST00000480951.1
ENST00000311086.4
BOD1
biorientation of chromosomes in cell division 1
chr3_-_38991853 0.24 ENST00000456224.3
SCN11A
sodium channel, voltage-gated, type XI, alpha subunit
chr6_+_31553978 0.23 ENST00000376096.1
ENST00000376099.1
ENST00000376110.3
LST1
leukocyte specific transcript 1
chr5_+_121465234 0.23 ENST00000504912.1
ENST00000505843.1
ZNF474
zinc finger protein 474
chr16_+_31470143 0.23 ENST00000457010.2
ENST00000563544.1
ARMC5
armadillo repeat containing 5
chr19_+_4153598 0.21 ENST00000078445.2
ENST00000252587.3
ENST00000595923.1
ENST00000602257.1
ENST00000602147.1
CREB3L3
cAMP responsive element binding protein 3-like 3
chr3_-_160117301 0.20 ENST00000326448.7
ENST00000498409.1
ENST00000475677.1
ENST00000478536.1
IFT80
intraflagellar transport 80 homolog (Chlamydomonas)
chr5_-_74162739 0.18 ENST00000513277.1
FAM169A
family with sequence similarity 169, member A
chr6_+_31553901 0.17 ENST00000418507.2
ENST00000438075.2
ENST00000376100.3
ENST00000376111.4
LST1
leukocyte specific transcript 1
chr4_-_121993673 0.14 ENST00000379692.4
NDNF
neuron-derived neurotrophic factor
chr13_-_74993252 0.12 ENST00000325811.1
AL355390.1
Uncharacterized protein
chr19_+_6135646 0.11 ENST00000588304.1
ENST00000588485.1
ENST00000588722.1
ENST00000591403.1
ENST00000586696.1
ENST00000589401.1
ENST00000252669.5
ACSBG2
acyl-CoA synthetase bubblegum family member 2
chr17_-_7145106 0.09 ENST00000577035.1
GABARAP
GABA(A) receptor-associated protein
chr5_-_74162605 0.08 ENST00000389156.4
ENST00000510496.1
ENST00000380515.3
FAM169A
family with sequence similarity 169, member A
chr9_+_125512019 0.08 ENST00000373684.1
ENST00000304720.2
OR1L6
olfactory receptor, family 1, subfamily L, member 6
chr11_+_59705928 0.06 ENST00000398992.1
OOSP1
oocyte secreted protein 1
chr14_-_24047965 0.05 ENST00000397118.3
ENST00000356300.4
JPH4
junctophilin 4
chr16_+_29127282 0.04 ENST00000562902.1
RP11-426C22.5
RP11-426C22.5
chr1_+_47533160 0.02 ENST00000334194.3
CYP4Z1
cytochrome P450, family 4, subfamily Z, polypeptide 1
chr20_-_1638408 0.01 ENST00000303415.3
ENST00000381583.2
SIRPG
signal-regulatory protein gamma
chr20_-_1638360 0.01 ENST00000216927.4
ENST00000344103.4
SIRPG
signal-regulatory protein gamma
chr2_-_42991257 0.00 ENST00000378661.2
OXER1
oxoeicosanoid (OXE) receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF274

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.6 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.2 2.7 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.2 0.5 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.7 GO:1990414 replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.1 1.0 GO:0090324 negative regulation of oxidative phosphorylation(GO:0090324)
0.1 2.5 GO:0090022 regulation of neutrophil chemotaxis(GO:0090022)
0.0 0.3 GO:0070383 DNA cytosine deamination(GO:0070383)
0.0 0.2 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 2.1 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 1.9 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.7 GO:0051930 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.0 0.9 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.1 0.3 GO:0045272 plasma membrane respiratory chain complex I(GO:0045272)
0.0 0.8 GO:0005641 nuclear envelope lumen(GO:0005641)
0.0 2.7 GO:0035371 microtubule plus-end(GO:0035371)
0.0 3.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 0.6 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.7 GO:0001518 voltage-gated sodium channel complex(GO:0001518)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.5 GO:0050135 NAD(P)+ nucleosidase activity(GO:0050135)
0.5 3.6 GO:0008955 peptidoglycan glycosyltransferase activity(GO:0008955)
0.2 2.7 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 1.9 GO:0001730 2'-5'-oligoadenylate synthetase activity(GO:0001730)
0.1 0.7 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 0.3 GO:0047844 deoxycytidine deaminase activity(GO:0047844)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 3.4 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.0 0.8 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.7 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 2.1 GO:0004527 exonuclease activity(GO:0004527)
0.0 0.3 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 3.3 PID AURORA B PATHWAY Aurora B signaling
0.0 2.1 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 2.7 REACTOME KINESINS Genes involved in Kinesins
0.0 1.9 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 1.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)