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SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ZNF8

Z-value: 0.33

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Transcription factors associated with ZNF8

Gene Symbol Gene ID Gene Info
ZNF8
ENSG00000083842.8 zinc finger protein 8
ZNF8
ENSG00000273439.1 zinc finger protein 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF8hg19_v2_chr19_+_58790314_58790358-0.174.8e-01Click!

Activity profile of ZNF8 motif

Sorted Z-values of ZNF8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_58345569 0.93 ENST00000528954.1
ENST00000528489.1
LPXN
leupaxin
chr2_+_169926047 0.83 ENST00000428522.1
ENST00000450153.1
ENST00000421653.1
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr6_+_106959718 0.71 ENST00000369066.3
AIM1
absent in melanoma 1
chr19_+_35739897 0.70 ENST00000605618.1
ENST00000427250.1
ENST00000601623.1
LSR
lipolysis stimulated lipoprotein receptor
chr19_+_35739782 0.60 ENST00000347609.4
LSR
lipolysis stimulated lipoprotein receptor
chr4_+_186347388 0.57 ENST00000511138.1
ENST00000511581.1
C4orf47
chromosome 4 open reading frame 47
chr1_+_70671363 0.57 ENST00000370951.1
ENST00000370950.3
ENST00000405432.1
ENST00000454435.2
SRSF11
serine/arginine-rich splicing factor 11
chr6_+_116601265 0.49 ENST00000452085.3
DSE
dermatan sulfate epimerase
chr6_+_29691198 0.49 ENST00000440587.2
ENST00000434407.2
HLA-F
major histocompatibility complex, class I, F
chr11_+_46402583 0.46 ENST00000359803.3
MDK
midkine (neurite growth-promoting factor 2)
chr1_-_55266926 0.40 ENST00000371276.4
TTC22
tetratricopeptide repeat domain 22
chr17_-_27169745 0.36 ENST00000583307.1
ENST00000581229.1
ENST00000582266.1
ENST00000577376.1
ENST00000577682.1
ENST00000581381.1
ENST00000341217.5
ENST00000581407.1
ENST00000583522.1
FAM222B
family with sequence similarity 222, member B
chr9_-_32552551 0.34 ENST00000360538.2
ENST00000379858.1
TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr6_-_116601044 0.33 ENST00000368608.3
TSPYL1
TSPY-like 1
chr4_+_170541678 0.32 ENST00000360642.3
ENST00000512813.1
CLCN3
chloride channel, voltage-sensitive 3
chr6_+_18155560 0.32 ENST00000546309.2
ENST00000388870.2
ENST00000397244.1
KDM1B
lysine (K)-specific demethylase 1B
chr11_+_13690249 0.30 ENST00000532701.1
FAR1
fatty acyl CoA reductase 1
chr12_-_46662888 0.28 ENST00000546893.1
SLC38A1
solute carrier family 38, member 1
chr19_+_37998031 0.27 ENST00000586138.1
ENST00000588578.1
ENST00000587986.1
ZNF793
zinc finger protein 793
chr1_-_100715372 0.25 ENST00000370131.3
ENST00000370132.4
DBT
dihydrolipoamide branched chain transacylase E2
chr7_+_117824086 0.24 ENST00000249299.2
ENST00000424702.1
NAA38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr13_+_45563721 0.23 ENST00000361121.2
GPALPP1
GPALPP motifs containing 1
chr11_+_69455855 0.22 ENST00000227507.2
ENST00000536559.1
CCND1
cyclin D1
chr17_+_34136459 0.20 ENST00000588240.1
ENST00000590273.1
ENST00000588441.1
ENST00000587272.1
ENST00000592237.1
ENST00000311979.3
TAF15
TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr1_+_186344883 0.20 ENST00000367470.3
C1orf27
chromosome 1 open reading frame 27
chr8_+_145064233 0.20 ENST00000529301.1
ENST00000395068.4
GRINA
glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
chr4_+_24797085 0.19 ENST00000382120.3
SOD3
superoxide dismutase 3, extracellular
chr6_+_53659746 0.19 ENST00000370888.1
LRRC1
leucine rich repeat containing 1
chr4_-_186347099 0.19 ENST00000505357.1
ENST00000264689.6
UFSP2
UFM1-specific peptidase 2
chr12_-_74686314 0.19 ENST00000551210.1
ENST00000515416.2
ENST00000549905.1
RP11-81H3.2
RP11-81H3.2
chr4_+_170541660 0.17 ENST00000513761.1
ENST00000347613.4
CLCN3
chloride channel, voltage-sensitive 3
chr9_+_1050331 0.17 ENST00000382255.3
ENST00000382251.3
ENST00000412350.2
DMRT2
doublesex and mab-3 related transcription factor 2
chr6_+_31939608 0.17 ENST00000375331.2
ENST00000375333.2
STK19
serine/threonine kinase 19
chr12_-_46662772 0.17 ENST00000549049.1
ENST00000439706.1
ENST00000398637.5
SLC38A1
solute carrier family 38, member 1
chr1_-_55266865 0.17 ENST00000371274.4
TTC22
tetratricopeptide repeat domain 22
chr4_+_170541835 0.16 ENST00000504131.2
CLCN3
chloride channel, voltage-sensitive 3
chr2_+_87144738 0.15 ENST00000559485.1
RGPD1
RANBP2-like and GRIP domain containing 1
chr8_-_109260897 0.15 ENST00000521297.1
ENST00000519030.1
ENST00000521440.1
ENST00000518345.1
ENST00000519627.1
ENST00000220849.5
EIF3E
eukaryotic translation initiation factor 3, subunit E
chr6_+_29691056 0.14 ENST00000414333.1
ENST00000334668.4
ENST00000259951.7
HLA-F
major histocompatibility complex, class I, F
chr3_+_49236910 0.13 ENST00000452691.2
ENST00000366429.2
CCDC36
coiled-coil domain containing 36
chr8_+_38244638 0.13 ENST00000526356.1
LETM2
leucine zipper-EF-hand containing transmembrane protein 2
chr1_+_25664408 0.12 ENST00000374358.4
TMEM50A
transmembrane protein 50A
chr4_-_52904425 0.11 ENST00000535450.1
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr10_+_1034338 0.11 ENST00000360803.4
ENST00000538293.1
GTPBP4
GTP binding protein 4
chr1_-_186344802 0.11 ENST00000451586.1
TPR
translocated promoter region, nuclear basket protein
chr2_-_172290482 0.11 ENST00000442541.1
ENST00000392599.2
ENST00000375258.4
METTL8
methyltransferase like 8
chr11_+_13690200 0.11 ENST00000354817.3
FAR1
fatty acyl CoA reductase 1
chr3_-_46000146 0.11 ENST00000438446.1
FYCO1
FYVE and coiled-coil domain containing 1
chr10_-_1034237 0.11 ENST00000381466.1
AL359878.1
Uncharacterized protein
chr7_+_1748798 0.10 ENST00000561626.1
ELFN1
extracellular leucine-rich repeat and fibronectin type III domain containing 1
chr10_-_73611046 0.10 ENST00000394934.1
ENST00000394936.3
PSAP
prosaposin
chr2_+_172290707 0.10 ENST00000375255.3
ENST00000539783.1
DCAF17
DDB1 and CUL4 associated factor 17
chr1_+_186344945 0.09 ENST00000419367.3
ENST00000287859.6
C1orf27
chromosome 1 open reading frame 27
chr13_+_53029564 0.09 ENST00000468284.1
ENST00000378034.3
ENST00000258607.5
ENST00000378037.5
CKAP2
cytoskeleton associated protein 2
chrX_+_129535937 0.09 ENST00000305536.6
ENST00000370947.1
RBMX2
RNA binding motif protein, X-linked 2
chr3_-_46759314 0.08 ENST00000315170.7
PRSS50
protease, serine, 50
chr17_+_48585794 0.07 ENST00000576179.1
ENST00000419930.1
MYCBPAP
MYCBP associated protein
chr2_+_173600565 0.07 ENST00000397081.3
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chr12_+_104235229 0.06 ENST00000551650.1
RP11-650K20.3
Uncharacterized protein
chr17_+_75181292 0.05 ENST00000431431.2
SEC14L1
SEC14-like 1 (S. cerevisiae)
chr2_+_173600514 0.05 ENST00000264111.6
RAPGEF4
Rap guanine nucleotide exchange factor (GEF) 4
chrX_+_128913906 0.05 ENST00000356892.3
SASH3
SAM and SH3 domain containing 3
chr11_+_46402482 0.04 ENST00000441869.1
MDK
midkine (neurite growth-promoting factor 2)
chr19_+_52074502 0.03 ENST00000545217.1
ENST00000262259.2
ENST00000596504.1
ZNF175
zinc finger protein 175
chr16_+_68573116 0.03 ENST00000570495.1
ENST00000563169.2
ENST00000564323.1
ENST00000562156.1
ENST00000573685.1
ZFP90
ZFP90 zinc finger protein
chr9_-_37576333 0.03 ENST00000541607.1
FBXO10
F-box protein 10
chr22_+_30163340 0.03 ENST00000330029.6
ENST00000401406.3
UQCR10
ubiquinol-cytochrome c reductase, complex III subunit X
chr12_-_122750957 0.03 ENST00000451053.2
VPS33A
vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr17_-_45908875 0.03 ENST00000351111.2
ENST00000414011.1
MRPL10
mitochondrial ribosomal protein L10
chr17_+_48585902 0.02 ENST00000452039.1
MYCBPAP
MYCBP associated protein
chr6_-_31763408 0.02 ENST00000444930.2
VARS
valyl-tRNA synthetase
chr8_-_61429315 0.02 ENST00000530725.1
ENST00000532232.1
RP11-163N6.2
RP11-163N6.2
chr9_-_94711007 0.00 ENST00000375715.1
ROR2
receptor tyrosine kinase-like orphan receptor 2
chr5_+_10353780 0.00 ENST00000449913.2
ENST00000503788.1
ENST00000274140.5
MARCH6
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
chr4_-_77069573 0.00 ENST00000264883.3
NUP54
nucleoporin 54kDa
chr13_-_25861530 0.00 ENST00000540661.1
MTMR6
myotubularin related protein 6
chr5_-_137911049 0.00 ENST00000297185.3
HSPA9
heat shock 70kDa protein 9 (mortalin)

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.3 GO:1904274 tricellular tight junction assembly(GO:1904274)
0.1 0.7 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.9 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.1 0.5 GO:0030421 defecation(GO:0030421)
0.1 0.4 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.1 0.8 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 0.6 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
0.0 0.1 GO:0060629 regulation of homologous chromosome segregation(GO:0060629)
0.0 0.1 GO:0045799 negative regulation of nucleobase-containing compound transport(GO:0032240) positive regulation of chromatin assembly or disassembly(GO:0045799) negative regulation of RNA export from nucleus(GO:0046832)
0.0 0.1 GO:0033341 regulation of collagen binding(GO:0033341)
0.0 0.3 GO:0042670 retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0 0.3 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.0 0.2 GO:0061055 myotome development(GO:0061055)
0.0 0.5 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 0.2 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0 0.2 GO:1902416 positive regulation of mRNA binding(GO:1902416)
0.0 0.1 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 GO:0061689 tricellular tight junction(GO:0061689)
0.1 0.6 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:0031417 NatC complex(GO:0031417)
0.0 0.2 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.9 GO:0002102 podosome(GO:0002102)
0.0 0.4 GO:0005779 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 0.1 GO:0016012 sarcoglycan complex(GO:0016012)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.1 0.5 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.6 GO:0046979 TAP2 binding(GO:0046979)
0.1 0.4 GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity(GO:0080019)
0.1 0.8 GO:0047035 alcohol dehydrogenase (NAD) activity(GO:0004022) testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0 0.3 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.0 0.3 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0 0.1 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.2 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0 0.4 GO:0005283 sodium:amino acid symporter activity(GO:0005283)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway