ISMARA results: AIRE

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for AIRE

Z-value: 0.49

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Transcription factors associated with AIRE

Gene Symbol	Gene ID	Gene Info
AIRE Ensembl NCBI GeneCards UniProt	ENSG00000160224.12	autoimmune regulator

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
AIRE	hg19_v2_chr21_+_45705752_45705767	-0.09	7.0e-01	Click!

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

No targets for AIRE

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	1.1	GO:0010107	potassium ion import(GO:0010107)
0.0	0.9	GO:0010765	positive regulation of sodium ion transport(GO:0010765)
0.0	0.8	GO:0044364	killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.1	0.5	GO:0007499	ectoderm and mesoderm interaction(GO:0007499)
0.1	0.5	GO:0097461	ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.0	0.5	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0	0.5	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
0.0	0.4	GO:1900623	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0	0.4	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)

Showing 1 to 10 of 29 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0070469	respiratory chain(GO:0070469)
0.0	1.0	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.5	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1	0.4	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0	0.3	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.3	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.2	GO:0036338	viral envelope(GO:0019031) viral membrane(GO:0036338)
0.0	0.2	GO:0031211	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0036457	keratohyalin granule(GO:0036457)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)

Showing 1 to 10 of 10 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.4	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	1.1	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.6	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1	0.5	GO:0008823	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	0.5	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.0	0.4	GO:0016681	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.4	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.3	GO:0005132	type I interferon receptor binding(GO:0005132)
0.1	0.2	GO:0004657	proline dehydrogenase activity(GO:0004657)
0.0	0.2	GO:0016454	serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)

Showing 1 to 10 of 14 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.4	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.

Showing 1 to 2 of 2 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.1	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0	0.4	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation

Showing 1 to 2 of 2 entries

Results for AIRE

Z-value: 0.49

Motif logo

Transcription factors associated with AIRE

Activity-expression correlation:

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

No targets for AIRE

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: