ISMARA results: AR

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for AR_NR3C2

Z-value: 0.80

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Transcription factors associated with AR_NR3C2

Gene Symbol	Gene ID	Gene Info
AR Ensembl NCBI GeneCards UniProt	ENSG00000169083.11	androgen receptor
NR3C2 Ensembl NCBI GeneCards UniProt	ENSG00000151623.10	nuclear receptor subfamily 3 group C member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
AR	hg19_v2_chrX_+_66764375_66764465	-0.91	2.7e-08	Click!
NR3C2	hg19_v2_chr4_-_149363662_149363688	0.88	2.3e-07	Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

No targets for AR_NR3C2

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.8	GO:0050716	positive regulation of interleukin-1 secretion(GO:0050716)
2.2	6.7	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.2	6.2	GO:0071294	cellular response to zinc ion(GO:0071294)
0.9	4.5	GO:0010273	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.1	2.4	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.4	2.3	GO:0036018	cellular response to erythropoietin(GO:0036018)
0.4	2.2	GO:0002906	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0	1.7	GO:0015695	organic cation transport(GO:0015695)
0.2	1.6	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
0.4	1.4	GO:0010983	positive regulation of high-density lipoprotein particle clearance(GO:0010983)

Showing 1 to 10 of 29 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.8	GO:0071682	endocytic vesicle lumen(GO:0071682)
0.0	5.7	GO:0000790	nuclear chromatin(GO:0000790)
0.3	2.2	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.0	1.0	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	0.5	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.4	GO:0033162	melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0	0.3	GO:0048188	Set1C/COMPASS complex(GO:0048188)
0.0	0.3	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.2	GO:0005671	Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0	0.1	GO:0005713	recombination nodule(GO:0005713)

Showing 1 to 10 of 11 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	7.8	GO:0042056	chemoattractant activity(GO:0042056)
0.0	6.7	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3	4.5	GO:0046870	cadmium ion binding(GO:0046870)
0.3	2.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	1.7	GO:0019534	toxin transporter activity(GO:0019534)
0.5	1.6	GO:0002113	interleukin-33 binding(GO:0002113)
0.1	1.4	GO:0004465	lipoprotein lipase activity(GO:0004465)
0.0	1.3	GO:0031492	nucleosomal DNA binding(GO:0031492)
0.2	1.1	GO:0004556	alpha-amylase activity(GO:0004556)
0.0	1.0	GO:0031432	titin binding(GO:0031432)

Showing 1 to 10 of 26 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	6.5	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	4.5	PID AP1 PATHWAY	AP-1 transcription factor network
0.0	2.4	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	1.2	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	1.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.3	PID EPO PATHWAY	EPO signaling pathway

Showing 1 to 7 of 7 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	7.8	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.0	5.9	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	2.2	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.0	1.7	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	1.3	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.1	1.1	REACTOME DIGESTION OF DIETARY CARBOHYDRATE	Genes involved in Digestion of dietary carbohydrate
0.0	0.5	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.3	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.3	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.3	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions

Showing 1 to 10 of 11 entries

Results for AR_NR3C2

Z-value: 0.80

Motif logo

Transcription factors associated with AR_NR3C2

Activity-expression correlation:

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

No targets for AR_NR3C2

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: