ISMARA results: ATF2_ATF1

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ATF2_ATF1_ATF3

Z-value: 0.66

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Transcription factors associated with ATF2_ATF1_ATF3

Gene Symbol	Gene ID	Gene Info
ATF2 Ensembl NCBI GeneCards UniProt	ENSG00000115966.12	activating transcription factor 2
ATF1 Ensembl NCBI GeneCards UniProt	ENSG00000123268.4	activating transcription factor 1
ATF3 Ensembl NCBI GeneCards UniProt	ENSG00000162772.12	activating transcription factor 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ATF2	hg19_v2_chr2_-_176032843_176032941	0.58	8.0e-03	Click!
ATF3	hg19_v2_chr1_+_212782012_212782257	-0.56	1.1e-02	Click!
ATF1	hg19_v2_chr12_+_51158263_51158395	0.54	1.3e-02	Click!

Activity profile of ATF2_ATF1_ATF3 motif

Sorted Z-values of ATF2_ATF1_ATF3 motif

No targets for ATF2_ATF1_ATF3

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF2_ATF1_ATF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	1.5	GO:0045109	intermediate filament organization(GO:0045109)
0.1	1.4	GO:0015693	magnesium ion transport(GO:0015693)
0.2	1.3	GO:0048388	endosomal lumen acidification(GO:0048388)
0.1	1.3	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.4	1.2	GO:0021503	neural fold bending(GO:0021503)
0.0	1.1	GO:0034063	stress granule assembly(GO:0034063)
0.3	1.0	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.3	1.0	GO:0070512	regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
0.1	1.0	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.2	0.9	GO:1902269	positive regulation of polyamine transmembrane transport(GO:1902269)

Showing 1 to 10 of 316 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.1	GO:0005882	intermediate filament(GO:0005882)
0.1	1.8	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	1.5	GO:0016592	mediator complex(GO:0016592)
0.0	1.5	GO:0097517	stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1	1.4	GO:0036020	endolysosome membrane(GO:0036020)
0.1	1.3	GO:0000813	ESCRT I complex(GO:0000813)
0.1	1.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.2	1.0	GO:0031436	BRCA1-BARD1 complex(GO:0031436)
0.1	1.0	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
0.0	1.0	GO:0044232	organelle membrane contact site(GO:0044232)

Showing 1 to 10 of 132 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.2	1.5	GO:0042289	MHC class II protein binding(GO:0042289)
0.1	1.5	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	1.5	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.2	1.3	GO:0072320	volume-sensitive chloride channel activity(GO:0072320)
0.0	1.3	GO:0008536	Ran GTPase binding(GO:0008536)
0.2	1.2	GO:0050115	myosin-light-chain-phosphatase activity(GO:0050115)
0.0	1.2	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	1.2	GO:0070888	E-box binding(GO:0070888)
0.0	1.1	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)

Showing 1 to 10 of 211 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
3.1	PID PLK1 PATHWAY	PLK1 signaling events
1.6	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
1.6	PID TGFBR PATHWAY	TGF-beta receptor signaling
1.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
1.5	PID FANCONI PATHWAY	Fanconi anemia pathway
1.4	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
1.3	PID NECTIN PATHWAY	Nectin adhesion pathway
1.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
1.2	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.9	PID HES HEY PATHWAY	Notch-mediated HES/HEY network

Showing 1 to 10 of 25 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	2.7	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	1.7	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	1.4	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	1.3	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	1.2	REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS	Genes involved in Activation of ATR in response to replication stress
0.0	1.2	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.1	1.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	1.1	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	1.1	REACTOME KINESINS	Genes involved in Kinesins
0.0	1.1	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends

Showing 1 to 10 of 49 entries

Results for ATF2_ATF1_ATF3

Z-value: 0.66

Motif logo

Transcription factors associated with ATF2_ATF1_ATF3

Activity-expression correlation:

Activity profile of ATF2_ATF1_ATF3 motif

Sorted Z-values of ATF2_ATF1_ATF3 motif

No targets for ATF2_ATF1_ATF3

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF2_ATF1_ATF3

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: