ISMARA results: ATF4

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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ATF4

Z-value: 1.42

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Transcription factors associated with ATF4

Gene Symbol	Gene ID	Gene Info
ATF4 Ensembl NCBI GeneCards UniProt	ENSG00000128272.10	activating transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ATF4	hg19_v2_chr22_+_39916558_39916579	-0.38	9.7e-02	Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

No targets for ATF4

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.6	GO:0019264	glycine biosynthetic process from serine(GO:0019264)
0.7	4.1	GO:0006436	tryptophanyl-tRNA aminoacylation(GO:0006436)
0.1	3.1	GO:0001504	neurotransmitter uptake(GO:0001504)
0.5	2.4	GO:0051083	'de novo' cotranslational protein folding(GO:0051083)
0.8	2.3	GO:0006433	glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.5	2.3	GO:0009257	10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.1	1.9	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1	1.9	GO:0070933	histone H4 deacetylation(GO:0070933)
0.1	1.8	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.2	1.7	GO:0006564	L-serine biosynthetic process(GO:0006564)

Showing 1 to 10 of 45 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.6	GO:0070552	BRISC complex(GO:0070552)
0.1	2.4	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.3	2.3	GO:0097452	GAIT complex(GO:0097452)
0.1	1.9	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	1.9	GO:0035861	site of double-strand break(GO:0035861)
0.1	1.8	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.1	1.6	GO:0031931	TORC1 complex(GO:0031931)
0.0	1.6	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.2	1.3	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.9	GO:0005876	spindle microtubule(GO:0005876)

Showing 1 to 10 of 15 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	4.6	GO:0008732	glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.7	4.1	GO:0004830	tryptophan-tRNA ligase activity(GO:0004830)
0.1	3.1	GO:0005283	sodium:amino acid symporter activity(GO:0005283)
0.8	2.3	GO:0004827	glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.5	2.3	GO:0004329	formate-tetrahydrofolate ligase activity(GO:0004329)
0.1	1.8	GO:0034185	apolipoprotein binding(GO:0034185)
0.5	1.6	GO:0019778	Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.4	1.6	GO:0004822	isoleucine-tRNA ligase activity(GO:0004822)
0.1	1.6	GO:0008494	translation activator activity(GO:0008494)
0.1	1.6	GO:0002162	dystroglycan binding(GO:0002162)

Showing 1 to 10 of 33 entries

Gene overrepresentation in C2:CP category:

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Total log-likelihood	Term	Description
2.2	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.6	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.4	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.3	PID IL5 PATHWAY	IL5-mediated signaling events

Showing 1 to 4 of 4 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	11.4	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.1	3.8	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	2.8	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	1.8	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	1.6	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0	1.5	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	1.3	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	1.1	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.1	0.9	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.9	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA

Showing 1 to 10 of 15 entries

Results for ATF4

Z-value: 1.42

Motif logo

Transcription factors associated with ATF4

Activity-expression correlation:

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

No targets for ATF4

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: