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avrg: SARS-CoV-2 Analysis Results (GEO series: GSE147507)

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Results for ATF4

Z-value: 1.42

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.10 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_39916579-0.389.7e-02Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

No targets for ATF4

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0006433 glutamyl-tRNA aminoacylation(GO:0006424) prolyl-tRNA aminoacylation(GO:0006433)
0.7 4.1 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.5 1.6 GO:0039521 lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) suppression by virus of host autophagy(GO:0039521)
0.5 2.4 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.5 4.6 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.5 2.3 GO:0009257 10-formyltetrahydrofolate biosynthetic process(GO:0009257)
0.4 1.6 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.3 1.3 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.3 0.9 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.3 1.1 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.3 0.8 GO:0006429 glutaminyl-tRNA aminoacylation(GO:0006425) leucyl-tRNA aminoacylation(GO:0006429)
0.3 1.6 GO:0072752 cellular response to rapamycin(GO:0072752)
0.2 1.5 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 1.4 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.2 0.8 GO:0006421 asparaginyl-tRNA aminoacylation(GO:0006421)
0.2 0.6 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.2 1.7 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.1 0.3 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.1 0.4 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533)
0.1 0.7 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 1.9 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.4 GO:0070127 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966) tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.3 GO:0006522 alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080)
0.1 0.6 GO:0051012 microtubule sliding(GO:0051012)
0.1 0.7 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1 1.8 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 1.9 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 3.1 GO:0001504 neurotransmitter uptake(GO:0001504)
0.1 1.2 GO:2000194 regulation of female gonad development(GO:2000194)
0.1 1.6 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.0 0.4 GO:0061052 negative regulation of cell proliferation involved in contact inhibition(GO:0060244) negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.2 GO:0018963 insecticide metabolic process(GO:0017143) phthalate metabolic process(GO:0018963) cellular response to luteinizing hormone stimulus(GO:0071373)
0.0 0.2 GO:0006116 NADH oxidation(GO:0006116)
0.0 0.2 GO:0071279 cellular response to cobalt ion(GO:0071279)
0.0 0.1 GO:0045209 MAPK phosphatase export from nucleus(GO:0045208) MAPK phosphatase export from nucleus, leptomycin B sensitive(GO:0045209)
0.0 0.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.0 0.4 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.0 0.4 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.1 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
0.0 0.3 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.6 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.1 GO:0060356 leucine import(GO:0060356)
0.0 0.9 GO:0071431 tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0 0.3 GO:0051531 NFAT protein import into nucleus(GO:0051531)
0.0 0.0 GO:0035696 monocyte extravasation(GO:0035696) regulation of fertilization(GO:0080154) regulation of monocyte extravasation(GO:2000437)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 4.6 GO:0070552 BRISC complex(GO:0070552)
0.3 2.3 GO:0097452 GAIT complex(GO:0097452)
0.2 1.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 1.9 GO:0005828 kinetochore microtubule(GO:0005828)
0.1 2.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.1 1.8 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
0.1 1.6 GO:0031931 TORC1 complex(GO:0031931)
0.1 0.4 GO:1990037 Lewy body core(GO:1990037)
0.0 0.3 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 1.6 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.9 GO:0035861 site of double-strand break(GO:0035861)
0.0 0.2 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.3 GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0 0.4 GO:0071437 invadopodium(GO:0071437)
0.0 0.9 GO:0005876 spindle microtubule(GO:0005876)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0004827 glutamate-tRNA ligase activity(GO:0004818) proline-tRNA ligase activity(GO:0004827)
0.7 4.1 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.5 1.6 GO:0019778 Atg12 activating enzyme activity(GO:0019778) Atg8 activating enzyme activity(GO:0019779)
0.5 4.6 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.5 2.3 GO:0004329 formate-tetrahydrofolate ligase activity(GO:0004329)
0.4 1.6 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.3 1.3 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.3 1.1 GO:0004122 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
0.3 0.8 GO:0004823 glutamine-tRNA ligase activity(GO:0004819) leucine-tRNA ligase activity(GO:0004823)
0.2 1.5 GO:0052656 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 1.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.2 0.7 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.2 0.9 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 0.6 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.1 1.0 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 3.1 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
0.1 0.4 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.1 0.3 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.1 1.6 GO:0008494 translation activator activity(GO:0008494)
0.1 0.2 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1 0.4 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.1 1.8 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 1.6 GO:0002162 dystroglycan binding(GO:0002162)
0.0 1.0 GO:0008483 transaminase activity(GO:0008483)
0.0 0.6 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0 1.2 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 0.3 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 1.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.3 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0 1.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.9 GO:0000049 tRNA binding(GO:0000049)
0.0 0.6 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 0.2 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 0.3 PID IL5 PATHWAY IL5-mediated signaling events
0.0 2.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.4 PID EPHA2 FWD PATHWAY EPHA2 forward signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 11.4 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.1 3.8 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 1.8 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.1 0.9 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 1.5 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.8 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 1.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.0 0.9 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.0 0.4 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.7 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 1.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.0 0.4 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling